{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T13:04:37Z","timestamp":1759496677165},"reference-count":13,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Malar J"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1186\/1475-2875-14-8","type":"journal-article","created":{"date-parts":[[2015,6,18]],"date-time":"2015-06-18T07:27:38Z","timestamp":1434612458000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Efficacy and pharmacokinetic evaluation of a novel anti-malarial compound (NP046) in a mouse model"],"prefix":"10.1186","volume":"14","author":[{"given":"Efrem T","family":"Abay","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan H","family":"van der Westuizen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth J","family":"Swart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liezl","family":"Gibhard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina","family":"Lawrence","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ntokozo","family":"Dambuza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anke","family":"Wilhelm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kendrekar","family":"Pravin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lubbe","family":"Wiesner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,1,6]]},"reference":[{"key":"3683_CR1","volume-title":"Malaria Fact Sheet on the World Malaria Report 2013","author":"WHO Media Centre","year":"2013","unstructured":"WHO Media Centre: Malaria Fact Sheet on the World Malaria Report 2013. 2013.  , pp. 1\u20133 [http:\/\/www.who.int\/malaria\/media\/world_malaria_report_2013\/en\/]"},{"key":"3683_CR2","volume-title":"Global report on anti-malarial drug efficacy and drug resistance 2000 \u2013 2010","author":"WHO","year":"2010","unstructured":"WHO: Global report on anti-malarial drug efficacy and drug resistance 2000 \u2013 2010. Geneva, Switzerland; 2010.   http:\/\/www.who.int\/malaria\/publications\/atoz\/9789241500470\/en"},{"key":"3683_CR3","doi-asserted-by":"crossref","first-page":"641","DOI":"10.4269\/ajtmh.2007.76.641","volume":"76","author":"AP Alker","year":"2007","unstructured":"Alker AP, Lim P, Sem R, Shah NK, Yi P, Bouth DM, et al.: PFMDR1\n                  and\n                  in vivo\n                  resistance to artesunate-mefloquine in falciparum malaria on the Cambodian-Thai border.\n                  Am J Trop Med Hyg. 2007, 76:641\u20137.","journal-title":"Am J Trop Med Hyg"},{"key":"3683_CR4","volume-title":"The synthesis and biological activity of nitrogen containing chalcones and analogues, PhD thesis","author":"A Wilhelm-Mouton","year":"2013","unstructured":"Wilhelm-Mouton A: The synthesis and biological activity of nitrogen containing chalcones and analogues, PhD thesis. University of the Free State; 2013.   http:\/\/etd.uovs.ac.za\/cgi-bin\/ETD-browse\/view_etd?URN=etd-10092014-150412"},{"key":"3683_CR5","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.molbiopara.2004.04.007","volume":"137","author":"B Franke-Fayard","year":"2004","unstructured":"Franke-Fayard B, Trueman H, Ramesar J, Mendoza J, van der Keur M, van der Linden R, et al.: A\n                  Plasmodium berghei\n                  reference line that constitutively expresses GFP at a high level throughout the complete life cycle.\n                  Mol Biochem Parasitol. 2004, 137:23\u201333. 10.1016\/j.molbiopara.2004.04.007","journal-title":"Mol Biochem Parasitol"},{"key":"3683_CR6","first-page":"333","volume":"4","author":"P Melariri","year":"2012","unstructured":"Melariri P, Campbell W, Etusim P, Smith P: In vitro\n                  and\n                  in vivo\n                  antimalarial activity of linolenic and linoleic acids and their methyl esters.\n                  Adv Stud Biol. 2012, 4:333\u201349.","journal-title":"Adv Stud Biol"},{"key":"3683_CR7","doi-asserted-by":"publisher","first-page":"261","DOI":"10.2174\/138945009787581203","volume":"10","author":"AU Krettli","year":"2009","unstructured":"Krettli AU, Adebayo JO, Krettli LG: Testing of natural products and synthetic molecules aiming at new antimalarials.\n                  Curr Drug Targets. 2009, 10:261\u201370. 10.2174\/138945009787581203","journal-title":"Curr Drug Targets"},{"key":"3683_CR8","first-page":"80","volume":"1","author":"AN Allam","year":"2011","unstructured":"Allam AN, El Gamal SS, Naggar VF: Bioavailability: A pharmaceutical review.\n                  J Novel Drug Deliv Tech. 2011, 1:80\u201396.","journal-title":"J Novel Drug Deliv Tech"},{"key":"3683_CR9","first-page":"7.5.1","volume-title":"Current Protocols in Pharmacology","author":"N Dow","year":"2002","unstructured":"Dow N: Determination of Compound Binding to Plasma Proteins. In Current Protocols in Pharmacology. John Wiley & Sons Inc; 2002:7.5.1\u20137.5.14. Wiley Online Library,   http:\/\/www.onlinelibrary.wiley.com\/doi\/10.1002\/0471141755.ph0705s18\/figures"},{"key":"3683_CR10","volume-title":"Drug-like properties: Concepts, structure design and methods: from adme to toxicity optimization","author":"EH Kerns","year":"2008","unstructured":"Kerns EH, Di L: Drug-like properties: Concepts, structure design and methods: from adme to toxicity optimization. 1st edition. Amsterdam, the Netherlands: Academic Press\/Elsevier; 2008.","edition":"1"},{"key":"3683_CR11","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1590\/S0100-879X2011007500060","volume":"44","author":"JM Kratz","year":"2011","unstructured":"Kratz JM, Teixeira MR, Koester LS, Sim\u00f5es CMO: An HPLC-UV method for the measurement of permeability of marker drugs in the Caco-2 cell assay.\n                  Braz J Med Biol Res. 2011, 44:531\u20137. 10.1590\/S0100-879X2011007500060","journal-title":"Braz J Med Biol Res"},{"key":"3683_CR12","doi-asserted-by":"publisher","first-page":"1950","DOI":"10.1016\/j.chroma.2010.01.071","volume":"1217","author":"YW Alelyunas","year":"2010","unstructured":"Alelyunas YW, Pelosi-Kilby L, Turcotte P, Kary M, Spreen RC: A high throughput dried DMSO Log D lipophilicity measurement based on 96-well shake-flask and atmospheric pressure photoionization mass spectrometer detection.\n                  J Chromatography A. 2010, 1217:1950\u20135. 10.1016\/j.chroma.2010.01.071","journal-title":"J Chromatography A"},{"key":"3683_CR13","volume-title":"Oral absorption, intestinal metabolism and human oral bioavailability","author":"A El-Kattan","year":"2012","unstructured":"El-Kattan A, Varma M: Oral absorption, intestinal metabolism and human oral bioavailability. USA: Pharmacokinetics, Dynamics and Metabolism Department, Pfizer Inc; 2012. Retrieved: March 03, 2012, from   http:\/\/www.cdn.intechweb.org\/pdfs\/29240.pdf"}],"container-title":["Malaria Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1475-2875-14-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T08:46:47Z","timestamp":1630572407000},"score":1,"resource":{"primary":{"URL":"https:\/\/malariajournal.biomedcentral.com\/articles\/10.1186\/1475-2875-14-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,6]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["3683"],"URL":"https:\/\/doi.org\/10.1186\/1475-2875-14-8","relation":{},"ISSN":["1475-2875"],"issn-type":[{"value":"1475-2875","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,6]]},"assertion":[{"value":"13 October 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 December 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 January 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"8"}}