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Children with ADHD have lower blood levels of long-chain Poly Unsaturated Fatty Acids (LC PUFAs) compared with children without ADHD, and following PUFA supplementation, have shown improvements in ADHD-related symptoms. One highly promising marine based LC PUFA preparation is the Omega-3-rich Lyprinol\/Omega XL which is a natural formulation containing standardised lipid extract of the New Zealand green lipped mussel (<jats:italic>Perna canaliculus<\/jats:italic>) known as PCSO-524\u00ae which contains a unique combination of free fatty acids, sterol esters, polar lipids and carotenoids. It is this unique combination of marine lipids that may assist in correcting the decreased levels of LC PUFA levels in children with symptoms of ADHD. The compound is a mixture belonging to a lipid group called sterol esters (SE). The fatty acids in the SE fraction are mainly myristic acid, palmitic acid, palmitoleic acid, stearic acid, oleic acid, linoleic acid, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA). Lyprinol\/Omega XL has previously been shown to contain a potent group of Omega-3 lipids that block the 5 - lipoxygenase metabolic pathway responsible for inflammation in the body.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>A randomized double blind placebo controlled trial will be utilized to assess the effects of 14\u00a0weeks administration of Lyprinol\/Omega XL versus placebo in 150 children aged 6 to 14\u00a0years with high levels of hyperactivity and inattention. Additionally, a range of cognitive, mood and central electrophysiological measures will be undertaken during the 14\u00a0week supplementation trial. The primary outcome measure, the Conners\u2019 Parent Rating Scales will be completed initially at baseline, then in weeks 4, 8, 10, 14 and then again at 4\u00a0weeks post-administration (week 18). The results will contribute to our understanding of the efficacy of marine based Omega-3\u00a0s with high anti-inflammatory actions on inattention and hyperactivity in children aged 6 to 14\u00a0years.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1475-2891-12-100","type":"journal-article","created":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T14:34:57Z","timestamp":1373985297000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A randomized controlled trial investigating the effects of PCSO-524\u00ae, a patented oil extract of the New Zealand green lipped mussel (Perna canaliculus), on the behaviour, mood, cognition and neurophysiology of children and adolescents (aged 6\u201314\u00a0years) experiencing clinical and sub-clinical levels of hyperactivity and inattention: study protocol ACTRN12610000978066"],"prefix":"10.1186","volume":"12","author":[{"given":"James D","family":"Kean","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Camfield","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerome","family":"Sarris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marni","family":"Kras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Silberstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Scholey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Con","family":"Stough","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,7,16]]},"reference":[{"issue":"11","key":"682_CR1","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1016\/j.biopsych.2004.10.020","volume":"57","author":"J Biederman","year":"2005","unstructured":"Biederman J: Attention-deficit\/hyperactivity disorder: a selective overview. 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