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Supplements were tricalcium phosphate (CaP) and cholecalciferol (vitamin D<jats:sub>3<\/jats:sub>). At the beginning of the study (baseline), all subjects documented their normal nutritional habits in a dietary record for three successive days. After baseline, subjects were allocated to three intervention groups: CaP (additional 1\u00a0g calcium\/d), vitamin D<jats:sub>3<\/jats:sub>(additional 10\u00a0\u03bcg\/d) and CaP\u2009+\u2009vitamin D<jats:sub>3<\/jats:sub>. In the first two weeks, all groups consumed placebo bread, and afterwards, for eight weeks, the test bread according to the intervention group. In the last week of each study period (baseline, placebo, after four and eight weeks of intervention), a faecal (three days) and a urine (24\u00a0h) collection and a fasting blood sampling took place. Calcium, phosphorus, magnesium and iron were determined in faeces, urine and blood. Bone formation and resorption markers were analysed in blood and urine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After four and eight weeks, CaP and CaP\u2009+\u2009vitamin D<jats:sub>3<\/jats:sub>supplementations increased faecal excretion of calcium and phosphorus significantly compared to placebo. Due to the vitamin D<jats:sub>3<\/jats:sub>supplementations (vitamin D<jats:sub>3<\/jats:sub>, CaP\u2009+\u2009vitamin D<jats:sub>3<\/jats:sub>), the plasma 25-(OH)D concentration significantly increased after eight weeks compared to placebo. The additional application of CaP led to a significant increase of the 25-(OH)D concentration already after four weeks. Bone resorption and bone formation markers were not influenced by any intervention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Supplementation with daily 10\u00a0\u03bcg vitamin D<jats:sub>3<\/jats:sub>significantly increases plasma 25-(OH)D concentration. The combination with daily 1\u00a0g calcium (as CaP) has a further increasing effect on the 25-(OH)D concentration. Both CaP alone and in combination with vitamin D<jats:sub>3<\/jats:sub>have no beneficial effect on bone remodelling markers and on the metabolism of calcium, phosphorus, magnesium and iron.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial registration<\/jats:title><jats:p><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\/show\/NCT01297023\" ext-link-type=\"uri\">NCT01297023<\/jats:ext-link><\/jats:p><\/jats:sec>","DOI":"10.1186\/1475-2891-13-6","type":"journal-article","created":{"date-parts":[[2014,1,17]],"date-time":"2014-01-17T17:28:07Z","timestamp":1389979687000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Effect of calcium phosphate and vitamin D3supplementation on bone remodelling and metabolism of calcium, phosphorus, magnesium and iron"],"prefix":"10.1186","volume":"13","author":[{"given":"Ulrike","family":"Trautvetter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadja","family":"Neef","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Leiterer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Kiehntopf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen","family":"Kratzsch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerhard","family":"Jahreis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,1,17]]},"reference":[{"key":"747_CR1","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1111\/j.1529-8019.2009.01286.x","volume":"23","author":"B Lehmann","year":"2010","unstructured":"Lehmann B, Meurer M: Vitamin D metabolism. 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