{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T00:13:34Z","timestamp":1793232814320,"version":"4.5.0"},"reference-count":96,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2014,6,19]],"date-time":"2014-06-19T00:00:00Z","timestamp":1403136000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nutr J"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1186\/1475-2891-13-63","type":"journal-article","created":{"date-parts":[[2014,6,19]],"date-time":"2014-06-19T03:02:38Z","timestamp":1403146958000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":146,"title":["Hydroxybenzoic acid isomers and the cardiovascular system"],"prefix":"10.1186","volume":"13","author":[{"given":"Bernhard HJ","family":"Juurlink","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haya J","family":"Azouz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alaa MZ","family":"Aldalati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basmah MH","family":"AlTinawi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Ganguly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,6,19]]},"reference":[{"key":"796_CR1","first-page":"9","volume-title":"National Research Council of Canada PBI Bulletin, Issue 1. Plants That Heal","author":"BHJ Juurlink","year":"2003","unstructured":"Juurlink BHJ: The beginning of the nutri-geno-proteo-metabolo-mics era of nutritional studies. National Research Council of Canada PBI Bulletin, Issue 1. Plants That Heal. 2003, 9-13."},{"key":"796_CR2","first-page":"12","volume":"61","author":"R Bressler","year":"2006","unstructured":"Bressler R: Grapefruit juice and drug interactions. Exploring mechanisms of this interaction and potential toxicity for certain drugs. Geriatrics. 2006, 61: 12-18.","journal-title":"Geriatrics"},{"key":"796_CR3","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1111\/j.1365-2184.2006.00377.x","volume":"39","author":"JG Mahdi","year":"2006","unstructured":"Mahdi JG, Mahdi AJ, Mahdi AJ, Bowen ID: The historical analysis of aspirin discovery, its relation to the willow tree and antiproliferative and anticancer potential. Cell Prolif. 2006, 39: 147-155.","journal-title":"Cell Prolif"},{"key":"796_CR4","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/S0248-8663(00)88720-2","volume":"21","author":"H L\u00e9vesque","year":"2000","unstructured":"L\u00e9vesque H, Lafont O: L\u2019aspirine \u00e0 travers les si\u00e8cles: rappel historique. Rev Med Interne. 2000, 21: 8-17.","journal-title":"Rev Med Interne"},{"key":"796_CR5","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/S0049-3848(03)00379-7","volume":"110","author":"JR Vane","year":"2003","unstructured":"Vane JR, Botting RM: The mechanism of action of aspirin. Thromb Res. 2003, 110: 255-258.","journal-title":"Thromb Res"},{"key":"796_CR6","first-page":"470","volume":"4","author":"N Chiang","year":"2004","unstructured":"Chiang N, Serhan CN: Aspirin triggers formation of anti-inflammatory mediators: New mechanism for an old drug. Discov Med. 2004, 4: 470-475.","journal-title":"Discov Med"},{"key":"796_CR7","doi-asserted-by":"publisher","first-page":"2399","DOI":"10.1073\/pnas.89.6.2399","volume":"89","author":"Y Zhang","year":"1992","unstructured":"Zhang Y, Talalay P, Cho CG, Posner GH: A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure. Proc Natl Acad Sci U S A. 1992, 89: 2399-2403.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"796_CR8","doi-asserted-by":"publisher","first-page":"10367","DOI":"10.1073\/pnas.94.19.10367","volume":"94","author":"JW Fahey","year":"1997","unstructured":"Fahey JW, Zhang Y, Talalay P: Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens. Proc Natl Acad Sci U S A. 1997, 94: 10367-10372.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"796_CR9","doi-asserted-by":"publisher","first-page":"11908","DOI":"10.1073\/pnas.172398899","volume":"99","author":"AT Dinkova-Kostova","year":"2002","unstructured":"Dinkova-Kostova AT, Holtzclaw WD, Cole RN, Itoh K, Wakabayashi N, Katoh Y, Yamamoto M, Talalay P: Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants. Proc Natl Acad Sci U S A. 2002, 99: 11908-11913.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"796_CR10","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1007\/128_2012_339","volume":"329","author":"TW Kensler","year":"2013","unstructured":"Kensler TW, Egner PA, Agyeman AS, Visvanathan K, Groopman JD, Chen JG, Chen TY, Fahey JW, Talalay P: Keap1-nrf2 signaling: a target for cancer prevention by sulforaphane. Top Curr Chem. 2013, 329: 163-177.","journal-title":"Top Curr Chem"},{"key":"796_CR11","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1139\/y00-120","volume":"79","author":"BH Juurlink","year":"2001","unstructured":"Juurlink BH: Therapeutic potential of dietary phase 2 enzyme inducers in ameliorating diseases that have an underlying inflammatory component. Can J Physiol Pharmacol. 2001, 79: 266-282.","journal-title":"Can J Physiol Pharmacol"},{"key":"796_CR12","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.atherosclerosis.2012.08.032","volume":"225","author":"BH Juurlink","year":"2012","unstructured":"Juurlink BH: Dietary Nrf2 activators inhibit atherogenic processes. Atherosclerosis. 2012, 225: 29-33.","journal-title":"Atherosclerosis"},{"key":"796_CR13","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1111\/j.1750-3639.2000.tb00252.x","volume":"10","author":"JW Christman","year":"2000","unstructured":"Christman JW, Blackwell TS, Juurlink BH: Redox regulation of nuclear factor kappa B: therapeutic potential for attenuating inflammatory responses. Brain Pathol. 2000, 10: 153-162.","journal-title":"Brain Pathol"},{"key":"796_CR14","doi-asserted-by":"publisher","first-page":"7094","DOI":"10.1073\/pnas.0402004101","volume":"101","author":"L Wu","year":"2004","unstructured":"Wu L, Noyan Ashraf MH, Facci M, Wang R, Paterson PG, Ferrie A, Juurlink BH: Dietary approach to attenuate oxidative stress, hypertension, and inflammation in the cardiovascular system. Proc Natl Acad Sci U S A. 2004, 101: 7094-7099.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"796_CR15","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1038\/ajh.2011.200","volume":"25","author":"GV Senanayake","year":"2012","unstructured":"Senanayake GV, Banigesh A, Wu L, Lee P, Juurlink BH: The dietary phase 2 protein inducer sulforaphane can normalize the kidney epigenome and improve blood pressure in hypertensive rats. Am J Hypertens. 2012, 25: 229-235.","journal-title":"Am J Hypertens"},{"key":"796_CR16","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1096\/fj.05-4889fje","volume":"20","author":"MH Noyan-Ashraf","year":"2006","unstructured":"Noyan-Ashraf MH, Wu L, Wang R, Juurlink BH: Dietary approaches to positively influence fetal determinants of adult health. FASEB J. 2006, 20: 371-373.","journal-title":"FASEB J"},{"key":"796_CR17","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1207\/s15327914nc5501_7","volume":"55","author":"TA Shapiro","year":"2006","unstructured":"Shapiro TA, Fahey JW, Dinkova-Kostova AT, Holtzclaw WD, Stephenson KK, Wade KL, Ye L, Talalay P: Safety, tolerance, and metabolism of broccoli sprout glucosinolates and isothiocyanates: a clinical phase I study. Nutr Cancer. 2006, 55: 53-62.","journal-title":"Nutr Cancer"},{"key":"796_CR18","doi-asserted-by":"publisher","first-page":"767","DOI":"10.3109\/09637486.2012.665043","volume":"63","author":"Z Bahadoran","year":"2012","unstructured":"Bahadoran Z, Tohidi M, Nazeri P, Mehran M, Azizi F, Mirmiran P: Effect of broccoli sprouts on insulin resistance in type 2 diabetic patients: a randomized double-blind clinical trial. Int J Food Sci Nutr. 2012, 63: 767-771.","journal-title":"Int J Food Sci Nutr"},{"key":"796_CR19","doi-asserted-by":"publisher","first-page":"1819","DOI":"10.1097\/00004872-200110000-00016","volume":"19","author":"L Wu","year":"2001","unstructured":"Wu L, Juurlink BH: The impaired glutathione system and its up-regulation by sulforaphane in vascular smooth muscle cells from spontaneously hypertensive rats. J Hypertens. 2001, 19: 1819-1825.","journal-title":"J Hypertens"},{"key":"796_CR20","first-page":"7871","volume":"50","author":"SR Spencer","year":"1990","unstructured":"Spencer SR, Wilczak CA, Talalay P: Induction of glutathione transferases and NAD(P)H:quinone reductase by fumaric acid derivatives in rodent cells and tissues. Cancer Res. 1990, 50: 7871-7875.","journal-title":"Cancer Res"},{"key":"796_CR21","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1007\/s40263-014-0155-5","volume":"28","author":"CB Burness","year":"2014","unstructured":"Burness CB, Deeks ED: Dimethyl fumarate: a review of its use in patients with relapsing-remitting multiple sclerosis. CNS Drugs. 2014, 28: 373-387.","journal-title":"CNS Drugs"},{"key":"796_CR22","first-page":"647","volume":"88","author":"AL Piberger","year":"2014","unstructured":"Piberger AL, Koberle B, Hartwig A: The broccoli-born isothiocyanate sulforaphane impairs nucleotide excision repair: XPA as one potential target. Arch Toxicol. 2014, 88: 647-658.","journal-title":"Arch Toxicol"},{"key":"796_CR23","volume-title":"The Effect of a Dietary Phase 2 Protein Inducer on Inflammatory Parameters in Blood and Liver of Spontaneously Hypertensive Stroke-Prone Rats","author":"MR Facci","year":"2004","unstructured":"Facci MR: The Effect of a Dietary Phase 2 Protein Inducer on Inflammatory Parameters in Blood and Liver of Spontaneously Hypertensive Stroke-Prone Rats. 2004, Department of Anatomy & Cell Biology: Master\u2019s University of Saskatchewan"},{"key":"796_CR24","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.canlet.2008.04.018","volume":"269","author":"JD Clarke","year":"2008","unstructured":"Clarke JD, Dashwood RH, Ho E: Multi-targeted prevention of cancer by sulforaphane. Cancer Lett. 2008, 269: 291-304.","journal-title":"Cancer Lett"},{"key":"796_CR25","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/S0031-9422(00)00316-2","volume":"56","author":"JW Fahey","year":"2001","unstructured":"Fahey JW, Zalcmann AT, Talalay P: The chemical diversity and distribution of glucosinolates and isothiocyanates among plants. Phytochemistry. 2001, 56: 5-51.","journal-title":"Phytochemistry"},{"key":"796_CR26","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.neuroscience.2012.07.060","volume":"227","author":"K Gopinath","year":"2012","unstructured":"Gopinath K, Sudhandiran G: Naringin modulates oxidative stress and inflammation in 3-nitropropionic acid-induced neurodegeneration through the activation of nuclear factor-erythroid 2-related factor-2 signalling pathway. Neuroscience. 2012, 227: 134-143.","journal-title":"Neuroscience"},{"key":"796_CR27","first-page":"217","volume":"4","author":"PC Ho","year":"2001","unstructured":"Ho PC, Saville DJ, Wanwimolruk S: Inhibition of human CYP3A4 activity by grapefruit flavonoids, furanocoumarins and related compounds. J Pharm Pharm Sci. 2001, 4: 217-227.","journal-title":"J Pharm Pharm Sci"},{"key":"796_CR28","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1067\/mcp.2000.110774","volume":"68","author":"DG Bailey","year":"2000","unstructured":"Bailey DG, Dresser GK, Kreeft JH, Munoz C, Freeman DJ, Bend JR: Grapefruit-felodipine interaction: effect of unprocessed fruit and probable active ingredients. Clin Pharmacol Ther. 2000, 68: 468-477.","journal-title":"Clin Pharmacol Ther"},{"key":"796_CR29","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1080\/00498250412331285481","volume":"34","author":"K Gross-Steinmeyer","year":"2004","unstructured":"Gross-Steinmeyer K, Stapleton PL, Liu F, Tracy JH, Bammler TK, Quigley SD, Farin FM, Buhler DR, Safe SH, Strom SC, Eaton DL: Phytochemical-induced changes in gene expression of carcinogen-metabolizing enzymes in cultured human primary hepatocytes. Xenobiotica. 2004, 34: 619-632.","journal-title":"Xenobiotica"},{"key":"796_CR30","doi-asserted-by":"publisher","first-page":"668","DOI":"10.2174\/138920008785821675","volume":"9","author":"C Fimognari","year":"2008","unstructured":"Fimognari C, Lenzi M, Hrelia P: Interaction of the isothiocyanate sulforaphane with drug disposition and metabolism: pharmacological and toxicological implications. Curr Drug Metab. 2008, 9: 668-678.","journal-title":"Curr Drug Metab"},{"key":"796_CR31","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1111\/j.1753-4887.1999.tb01815.x","volume":"57","author":"SL Booth","year":"1999","unstructured":"Booth SL, Centurelli MA: Vitamin K: a practical guide to the dietary management of patients on warfarin. Nutr Rev. 1999, 57: 288-296.","journal-title":"Nutr Rev"},{"key":"796_CR32","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1093\/chromsci\/47.5.345","volume":"47","author":"D Liu","year":"2009","unstructured":"Liu D, Su Z, Wang C, Gu M: Separation of five isomers of dihydroxybenzoic acid by high-speed counter-current chromatography with dual-rotation elution method. J Chromatogr Sci. 2009, 47: 345-348.","journal-title":"J Chromatogr Sci"},{"key":"796_CR33","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/0006-2952(88)90729-0","volume":"37","author":"M Grootveld","year":"1988","unstructured":"Grootveld M, Halliwell B: 2,3-Dihydroxybenzoic acid is a product of human aspirin metabolism. Biochem Pharmacol. 1988, 37: 271-280.","journal-title":"Biochem Pharmacol"},{"key":"796_CR34","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1007\/s12272-013-0172-9","volume":"37","author":"S Jiang","year":"2014","unstructured":"Jiang S, Yang J, Qian D, Guo J, Shang EX, Duan JA, Xu J: Rapid screening and identification of metabolites of quercitrin produced by the human intestinal bacteria using ultra performance liquid chromatography\/quadrupole-time-of-flight mass spectrometry. Arch Pharm Res. 2014, 37: 204-213.","journal-title":"Arch Pharm Res"},{"key":"796_CR35","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1016\/S0278-6915(02)00329-0","volume":"41","author":"Z Sroka","year":"2003","unstructured":"Sroka Z, Cisowski W: Hydrogen peroxide scavenging, antioxidant and anti-radical activity of some phenolic acids. Food Chem Toxicol. 2003, 41: 753-758.","journal-title":"Food Chem Toxicol"},{"key":"796_CR36","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1136\/jcp.51.7.502","volume":"51","author":"JR Paterson","year":"1998","unstructured":"Paterson JR, Blacklock C, Campbell G, Wiles D, Lawrence JR: The identification of salicylates as normal constituents of serum: a link between diet and health?. J Clin Pathol. 1998, 51: 502-505.","journal-title":"J Clin Pathol"},{"key":"796_CR37","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/S0021-9673(01)01098-6","volume":"927","author":"RA Muljono","year":"2001","unstructured":"Muljono RA, Darsono FL, Scheffer JJ, Verpoorte R: Assay of 2,3-dihydroxybenzoic acid and related compounds in plant materials by high-performance liquid chromatography. J Chromatogr A. 2001, 927: 39-45.","journal-title":"J Chromatogr A"},{"key":"796_CR38","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/0031-9422(95)00059-G","volume":"40","author":"A Sakushima","year":"1995","unstructured":"Sakushima A, Coskun M, Maoka T: Hydroxybenzoic acids from Boreava orientalis. Phytochemistry. 1995, 40: 257-261.","journal-title":"Phytochemistry"},{"key":"796_CR39","first-page":"126","volume":"4","author":"G Shibumon","year":"2011","unstructured":"Shibumon G, Benny PJ, Kuriakose S, Cincy G: Antibiotic acivity of 2,3-dihydroxybenzoic acid isolated from Flacourtia inermis fruit against multidrug resistant bacteria. Asian J Pharm Clin rese. 2011, 4: 126-130.","journal-title":"Asian J Pharm Clin rese"},{"key":"796_CR40","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1021\/jf00078a018","volume":"35","author":"AM Torres","year":"1987","unstructured":"Torres AM, Maulastovicka T, Rezaaiyan R: Total Phenolics and high-performance liquid chromatography of phenolic acids of avocado. J Agr Food Chem. 1987, 35: 921-925.","journal-title":"J Agr Food Chem"},{"key":"796_CR41","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1021\/jf035073r","volume":"52","author":"K Zhang","year":"2004","unstructured":"Zhang K, Zuo Y: GC-MS determination of flavonoids and phenolic and benzoic acids in human plasma after consumption of cranberry juice. J Agric Food Chem. 2004, 52: 222-227.","journal-title":"J Agric Food Chem"},{"key":"796_CR42","doi-asserted-by":"publisher","first-page":"3789","DOI":"10.1021\/jf020055f","volume":"50","author":"Y Zuo","year":"2002","unstructured":"Zuo Y, Wang C, Zhang J: Separation, Characterization, and quantitation of benzoic and phenolic antioxidants in American cranberry fruit by GC-MS. J Agr Food Chem. 2002, 50: 3789-3794.","journal-title":"J Agr Food Chem"},{"key":"796_CR43","doi-asserted-by":"publisher","first-page":"2020","DOI":"10.1021\/jf960914y","volume":"45","author":"H Esaki","year":"1997","unstructured":"Esaki H, Onozaki H, Kawakishi S, Osawa T: Antioxidant activity and isolation from soybeans fermented with Aspergillus spp. J Agr Food Chem. 1997, 45: 2020-2024.","journal-title":"J Agr Food Chem"},{"key":"796_CR44","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1006\/abbi.1995.1394","volume":"321","author":"C Sappey","year":"1995","unstructured":"Sappey C, Boelaert JR, Legrand-Poels S, Grady RW, Piette J: NF-kappa B transcription factor activation by hydrogen peroxide can be decreased by 2,3-dihydroxybenzoic acid and its ethyl ester derivative. Arch Biochem Biophys. 1995, 321: 263-270.","journal-title":"Arch Biochem Biophys"},{"key":"796_CR45","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1001\/archsurg.1985.01390320061012","volume":"120","author":"RA Pearce","year":"1985","unstructured":"Pearce RA, Finley RJ, Mustard RA, Duff JH: 2,3-Dihydroxybenzoic acid. Effect on mortality rate in a septic rat model. Arch Surg. 1985, 120: 937-940.","journal-title":"Arch Surg"},{"key":"796_CR46","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1006\/bbrc.2000.3123","volume":"274","author":"B Hinz","year":"2000","unstructured":"Hinz B, Kraus V, Pahl A, Brune K: Salicylate metabolites inhibit cyclooxygenase-2-dependent prostaglandin E(2) synthesis in murine macrophages. Biochem Biophys Res Commun. 2000, 274: 197-202.","journal-title":"Biochem Biophys Res Commun"},{"key":"796_CR47","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.ejphar.2005.03.012","volume":"513","author":"K Ashidate","year":"2005","unstructured":"Ashidate K, Kawamura M, Mimura D, Tohda H, Miyazaki S, Teramoto T, Yamamoto Y, Hirata Y: Gentisic acid, an aspirin metabolite, inhibits oxidation of low-density lipoprotein and the formation of cholesterol ester hydroperoxides in human plasma. Eur J Pharmacol. 2005, 513: 173-179.","journal-title":"Eur J Pharmacol"},{"key":"796_CR48","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/S0014-5793(00)01289-8","volume":"470","author":"M Exner","year":"2000","unstructured":"Exner M, Hermann M, Hofbauer R, Kapiotis S, Speiser W, Held I, Seelos C, Gmeiner BM: The salicylate metabolite gentisic acid, but not the parent drug, inhibits glucose autoxidation-mediated atherogenic modification of low density lipoprotein. FEBS Lett. 2000, 470: 47-50.","journal-title":"FEBS Lett"},{"key":"796_CR49","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1093\/jn\/136.1.11","volume":"136","author":"CT Yeh","year":"2006","unstructured":"Yeh CT, Yen GC: Induction of hepatic antioxidant enzymes by phenolic acids in rats is accompanied by increased levels of multidrug resistance-associated protein 3 mRNA expression. J Nutr. 2006, 136: 11-15.","journal-title":"J Nutr"},{"key":"796_CR50","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1080\/14756360802560867","volume":"24","author":"SJ Lee","year":"2009","unstructured":"Lee SJ, Park WH, Park SD, Moon HI: Aldose reductase inhibitors from Litchi chinensis Sonn. J Enzyme Inhib Med Chem. 2009, 24: 957-959.","journal-title":"J Enzyme Inhib Med Chem"},{"key":"796_CR51","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/S0090-9556(24)14906-9","volume":"27","author":"I Dupont","year":"1999","unstructured":"Dupont I, Berthou F, Bodenez P, Bardou L, Guirriec C, Stephan N, Dreano Y, Lucas D: Involvement of cytochromes P-450 2E1 and 3A4 in the 5-hydroxylation of salicylate in humans. Drug Metab Dispos. 1999, 27: 322-326.","journal-title":"Drug Metab Dispos"},{"key":"796_CR52","doi-asserted-by":"publisher","first-page":"114","DOI":"10.3945\/jn.113.184663","volume":"144","author":"Y Zhu","year":"2014","unstructured":"Zhu Y, Shurlknight KL, Chen X, Sang S: Identification and pharmacokinetics of novel alkylresorcinol metabolites in human urine, new candidate biomarkers for whole-grain wheat and rye intake. J Nutr. 2014, 144: 114-122.","journal-title":"J Nutr"},{"key":"796_CR53","doi-asserted-by":"publisher","first-page":"381","DOI":"10.3109\/09637480903517788","volume":"61","author":"P Latocha","year":"2010","unstructured":"Latocha P, Krupa T, Wolosiak R, Worobiej E, Wilczak J: Antioxidant activity and chemical difference in fruit of different Actinidia sp. Int J Food Sci Nutr. 2010, 61: 381-394.","journal-title":"Int J Food Sci Nutr"},{"key":"796_CR54","doi-asserted-by":"publisher","first-page":"4942","DOI":"10.3390\/molecules18054942","volume":"18","author":"A Lopez","year":"2013","unstructured":"Lopez A, de Tangil MS, Vega-Orellana O, Ramirez AS, Rico M: Phenolic constituents, antioxidant and preliminary antimycoplasmic activities of leaf skin and flowers of Aloe vera (L.) Burm. f. (syn. A. barbadensis Mill.) from the Canary Islands (Spain). Molecules. 2013, 18: 4942-4954.","journal-title":"Molecules"},{"key":"796_CR55","doi-asserted-by":"publisher","first-page":"311","DOI":"10.3109\/09637486.2013.860584","volume":"65","author":"M Karaman","year":"2013","unstructured":"Karaman M, Stahl M, Vulic J, Vesic M, Canadanovic-Brunet J: Wild-growing lignicolous mushroom species as sources of novel agents with antioxidative and antibacterial potentials. Int J Food Sci Nutr. 2013, 65: 311-319.","journal-title":"Int J Food Sci Nutr"},{"key":"796_CR56","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.foodchem.2008.11.086","volume":"115","author":"WR Russell","year":"2009","unstructured":"Russell WR, Labat A, Scobbie L, Duncan GJ, Duthie GG: Phenolic acid content of fruits commonly consumed and locally produced in Scotland. Food Chem. 2009, 115: 100-104.","journal-title":"Food Chem"},{"key":"796_CR57","doi-asserted-by":"publisher","first-page":"1548","DOI":"10.1021\/jf0260040","volume":"51","author":"S Floridi","year":"2003","unstructured":"Floridi S, Montanari L, Marconi O, Fantozzi P: Detrmination of free phenolic acids in wort and beer by coulometric array detection. J Agr Food Chem. 2003, 51: 1548-1554.","journal-title":"J Agr Food Chem"},{"key":"796_CR58","doi-asserted-by":"publisher","first-page":"2118","DOI":"10.1021\/jf040411p","volume":"53","author":"R Zadernowski","year":"2005","unstructured":"Zadernowski R, Naczk M, Nesterowicz J: Phenolic acid profiles in some small berries. J Agr Food Chem. 2005, 53: 2118-2124.","journal-title":"J Agr Food Chem"},{"key":"796_CR59","doi-asserted-by":"publisher","first-page":"4428","DOI":"10.1021\/jf9029578","volume":"58","author":"R Horax","year":"2010","unstructured":"Horax R, Hettiarachchy N, Chen P: Extraction, quantification, and antioxidant activities of phenolics from pericarp and seeds of bitter melons (Momordica charantia) harvested at three maturity stages (Immature, Mature, and ripe). J Agr Food Chem. 2010, 58: 4428-4433.","journal-title":"J Agr Food Chem"},{"key":"796_CR60","doi-asserted-by":"publisher","first-page":"8116","DOI":"10.1021\/jf058057y","volume":"53","author":"FA Ayaz","year":"2005","unstructured":"Ayaz FA, Hayirlioglu-Ayaz A, Gruz J, Novak O, Strnad M: Separation, characterization, and quantitation of phenolic acids in a little known blueberry (Vaccinium arctostaphylos L.) fruit by HPLC-MS. J Agr Food Chem. 2005, 53: 8116-8122.","journal-title":"J Agr Food Chem"},{"key":"796_CR61","doi-asserted-by":"publisher","first-page":"3871","DOI":"10.1021\/jf970183h","volume":"45","author":"GJ Soleas","year":"1997","unstructured":"Soleas GJ, Dam J, Carey M, Goldberg DM: Toward fingerprinting of wines: Cultivar-related patterns of polyphenolic constituents in Ontario Wines. J Agr Food Chem. 1997, 45: 3871-3880.","journal-title":"J Agr Food Chem"},{"key":"796_CR62","doi-asserted-by":"publisher","first-page":"C954","DOI":"10.1111\/j.1750-3841.2012.02867.x","volume":"77","author":"I Sedej","year":"2012","unstructured":"Sedej I, Sakac M, Mandic A, Misan A, Tumbas V, Canadanovic-Brunet J: Buckwheat (Fagopyrum esculentum Moench) grain and fractions: antioxidant compounds and activities. J Food Sci. 2012, 77: C954-C959.","journal-title":"J Food Sci"},{"key":"796_CR63","doi-asserted-by":"publisher","first-page":"C394","DOI":"10.1111\/j.1750-3841.2011.02606.x","volume":"77","author":"C Li","year":"2012","unstructured":"Li C, Tang Z, Huang M, Tao N, Feng B, Huang S: Antioxidant efficacy of extracts produced from pickled and dried mustard in rapeseed and peanut oils. J Food Sci. 2012, 77: C394-C400.","journal-title":"J Food Sci"},{"key":"796_CR64","doi-asserted-by":"publisher","first-page":"154606","DOI":"10.1155\/2013\/154606","volume":"2013","author":"N Prasad","year":"2013","unstructured":"Prasad N, Yang B, Kong KW, Khoo HE, Sun J, Azlan A, Ismail A, Romli ZB: Phytochemicals and Antioxidant Capacity from Nypa fruticans Wurmb. Fruit. Evid Based Complement Alternat Med. 2013, 2013: 154606-","journal-title":"Evid Based Complement Alternat Med"},{"key":"796_CR65","doi-asserted-by":"publisher","first-page":"2398","DOI":"10.1021\/jf9810261","volume":"47","author":"HM Dawes","year":"1999","unstructured":"Dawes HM, Keene JB: Phenolic composition of kiwifruit juice. J Agric Food Chem. 1999, 47: 2398-2403.","journal-title":"J Agric Food Chem"},{"key":"796_CR66","doi-asserted-by":"publisher","first-page":"C779","DOI":"10.1111\/j.1750-3841.2012.02756.x","volume":"77","author":"D Godevac","year":"2012","unstructured":"Godevac D, Tesevic V, Vajs V, Milosavljevic S, Zdunic G, Dordevic B, Stankovic M: Chemical composition of currant seed extracts and their protective effect on human lymphocytes DNA. J Food Sci. 2012, 77: C779-C783.","journal-title":"J Food Sci"},{"key":"796_CR67","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1631\/jzus.B1100137","volume":"13","author":"WY Huang","year":"2012","unstructured":"Huang WY, Zhang HC, Liu WX, Li CY: Survey of antioxidant capacity and phenolic composition of blueberry, blackberry, and strawberry in Nanjing. J Zhejiang Univ Sci B. 2012, 13: 94-102.","journal-title":"J Zhejiang Univ Sci B"},{"key":"796_CR68","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1016\/j.foodchem.2013.01.065","volume":"139","author":"AA Memon","year":"2013","unstructured":"Memon AA, Memon N, Bhanger MI, Luthria DL: Assay of phenolic compounds from four species of ber (Ziziphus mauritiana L.) fruits: comparison of three base hydrolysis procedure for quantification of total phenolic acids. Food Chem. 2013, 139: 496-502.","journal-title":"Food Chem"},{"key":"796_CR69","doi-asserted-by":"publisher","first-page":"11551","DOI":"10.1021\/jf303712e","volume":"60","author":"J Li","year":"2012","unstructured":"Li J, Deng Y, Yuan C, Pan L, Chai H, Keller WJ, Kinghorn AD: Antioxidant and quinone reductase-inducing constituents of black chokeberry (Aronia melanocarpa) fruits. J Agric Food Chem. 2012, 60: 11551-11559.","journal-title":"J Agric Food Chem"},{"key":"796_CR70","doi-asserted-by":"publisher","first-page":"12657","DOI":"10.3390\/molecules171112657","volume":"17","author":"H Palafox-Carlos","year":"2012","unstructured":"Palafox-Carlos H, Gil-Chavez J, Sotelo-Mundo RR, Namiesnik J, Gorinstein S, Gonzalez-Aguilar GA: Antioxidant interactions between major phenolic compounds found in \u2018Ataulfo\u2019 mango pulp: chlorogenic, gallic, protocatechuic and vanillic acids. Molecules. 2012, 17: 12657-12664.","journal-title":"Molecules"},{"key":"796_CR71","doi-asserted-by":"publisher","first-page":"2901","DOI":"10.2174\/092986712800672102","volume":"19","author":"R Masella","year":"2012","unstructured":"Masella R, Santangelo C, D\u2019Archivio M, Li Volti G, Giovannini C, Galvano F: Protocatechuic acid and human disease prevention: biological activities and molecular mechanisms. Curr Med Chem. 2012, 19: 2901-2917.","journal-title":"Curr Med Chem"},{"key":"796_CR72","doi-asserted-by":"publisher","first-page":"4631","DOI":"10.1021\/jf800161u","volume":"56","author":"LA Pacheco-Palencia","year":"2008","unstructured":"Pacheco-Palencia LA, Mertens-Talcott S, Talcott ST: Chemical composition, antioxidant properties, and thermal stability of a phytochemical-enriched oil from A\u00e7ai (Euterpe oleracea Mart.). J Agr Food Chem. 2008, 56: 4631-4636.","journal-title":"J Agr Food Chem"},{"key":"796_CR73","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1111\/j.1365-2621.2010.02227.x","volume":"45","author":"S Poovarodom","year":"2010","unstructured":"Poovarodom S, Haruenkit R, Vearasilp S, Namiesnik J, Cvikrov\u00e1 M, Martincov\u00e1 O, Ezra A, Suhaj M, Ruamuke P, Gorinstein S: Comparative characterization of durian, mango and avocado. Int J Food Sci Tech. 2010, 45: 921-929.","journal-title":"Int J Food Sci Tech"},{"key":"796_CR74","doi-asserted-by":"publisher","first-page":"4418","DOI":"10.1021\/jf800038h","volume":"56","author":"S Gorinstein","year":"2008","unstructured":"Gorinstein S, Leontowicz H, Leontowicz M, Namiesnik J, Najman K, Drzewiecki J, Cvikrov\u00e1 M, Martincov\u00e1 O, Katrich E, Trakhtenberg S: Comparison of main bioactive compounds and antioxidant activities in garlic and white and red onions after treatment protocols. J Agr Food Chem. 2008, 56: 4418-4426.","journal-title":"J Agr Food Chem"},{"key":"796_CR75","doi-asserted-by":"publisher","first-page":"3927","DOI":"10.1021\/jf9024823","volume":"58","author":"R Koli","year":"2010","unstructured":"Koli R, Erlund I, Jula A, Marniemi J, Mattila P, Alfthan G: Bioavailability of various polyphenols from a diet containing moderate amounts of berries. J Agr Food Chem. 2010, 58: 3927-3932.","journal-title":"J Agr Food Chem"},{"key":"796_CR76","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1016\/j.foodchem.2008.06.030","volume":"112","author":"R Zadernowski","year":"2009","unstructured":"Zadernowski R, Czaplicki S, Naczk M: Phenolic acid profiles of mangosteen fruits (Garcinia mangostana). Food Chem. 2009, 112: 685-689.","journal-title":"Food Chem"},{"key":"796_CR77","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.foodchem.2010.06.030","volume":"124","author":"J Gruz","year":"2011","unstructured":"Gruz J, Ayaz FA, Torun H, Strnad M: Phenolic acid content and radical scavenging activity of extracts from medlar (Mespilus germanica L.) fruit at different stages of ripening. Food Chem. 2011, 124: 271-277.","journal-title":"Food Chem"},{"key":"796_CR78","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/S0308-8146(00)00322-8","volume":"73","author":"L Liberatore","year":"2001","unstructured":"Liberatore L, Procida G, D\u2019Alessandro N, Cichelli A: Solid-phase extraction and gas chromatographic analysis of phenolic compounds in virgin olive oil. Food Chem. 2001, 73: 119-124.","journal-title":"Food Chem"},{"key":"796_CR79","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/0021-9673(94)01046-H","volume":"695","author":"F Buiarelli","year":"1995","unstructured":"Buiarelli F, Cartoni G, Coccioli F, Levetsovitou Z: Determination of phenolic acids in wine by high-performance liquid chromatography with microbore column. J Chrom A. 1995, 695: 229-235.","journal-title":"J Chrom A"},{"key":"796_CR80","volume-title":"Database (Oxford)","author":"V Neveu","year":"2010","unstructured":"Neveu V, Perez-Jim\u00e9nez J, Crespy V, du Chaffaut L, Mennen L, Knox C, Eisner R, Cruz J, Wishart D, Scalbert A: Phenol-Explorer: An online comprehensive database on polyphenol contents in foods. Database (Oxford). 2010, 2010: doi:10.1093\/database\/bap024, 9 pages available at: http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2860900\/"},{"key":"796_CR81","volume-title":"Database (Oxford)","author":"C Manach","year":"2013","unstructured":"Manach C, Knox C, Eisner R, Wishart D, Scalbert A: Phenol-Explorer 3.0: a major update of the Phenol-Explorer database to incorporate data on the effects of food processing on polyphenol content. Database (Oxford). 2013, 2013: doi:10.1093\/database\/bat07, 8 pages available at: http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3792339\/"},{"key":"796_CR82","volume-title":"Database (Oxford)","author":"JA Rothwell","year":"2012","unstructured":"Rothwell JA, Urpi-Sarda M, Boto-Ordo\u00f1ez M, Knox C, Llorach R, Eisner R, Cruz J, Neveu V, Wishart D, Manach C, Andres-Lacueva C, Scalbert A: Phenol-Explorer-2: A major update of the Phenol-Explorer database integrating data on polyphenol metabolism and pharmacokinetics in humans and experimental animals. Database (Oxford). 2012, 2012: doi:10.1093\/database\/bas031, 8 pages available at: http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3414821\/"},{"key":"796_CR83","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.jnutbio.2010.03.008","volume":"22","author":"R Vari","year":"2011","unstructured":"Vari R, D\u2019Archivio M, Filesi C, Carotenuto S, Scazzocchio B, Santangelo C, Giovannini C, Masella R: Protocatechuic acid induces antioxidant\/detoxifying enzyme expression through JNK-mediated Nrf2 activation in murine macrophages. J Nutr Biochem. 2011, 22: 409-417.","journal-title":"J Nutr Biochem"},{"key":"796_CR84","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1093\/jn\/134.4.785","volume":"134","author":"R Masella","year":"2004","unstructured":"Masella R, Vari R, D\u2019Archivio M, Di Benedetto R, Matarrese P, Malorni W, Scazzocchio B, Giovannini C: Extra virgin olive oil biophenols inhibit cell-mediated oxidation of LDL by increasing the mRNA transcription of glutathione-related enzymes. J Nutr. 2004, 134: 785-791.","journal-title":"J Nutr"},{"key":"796_CR85","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1515\/JBCPP.2010.21.1.79","volume":"21","author":"R Harini","year":"2010","unstructured":"Harini R, Pugalendi KV: Antihyperglycemic effect of protocatechuic acid on streptozotocin-diabetic rats. J Basic Clin Physiol Pharmacol. 2010, 21: 79-91.","journal-title":"J Basic Clin Physiol Pharmacol"},{"key":"796_CR86","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1124\/jpet.112.192799","volume":"341","author":"C Liu","year":"2012","unstructured":"Liu C, Kuei C, Zhu J, Yu J, Zhang L, Shih A, Mirzadegan T, Shelton J, Sutton S, Connelly MA, Lee G, Carruthers N, Wu J, Lovenberg TW: 3,5-Dihydroxybenzoic acid, a specific agonist for hydroxycarboxylic acid 1, inhibits lipolysis in adipocytes. J Pharmacol Exp Ther. 2012, 341: 794-801.","journal-title":"J Pharmacol Exp Ther"},{"key":"796_CR87","doi-asserted-by":"crossref","first-page":"467","DOI":"10.2147\/VHRM.S1023","volume":"3","author":"A Vogt","year":"2007","unstructured":"Vogt A, Kassner U, Hostalek U, Steinhagen-Thiessen E: Prolonged-release nicotinic acid for the management of dyslipidemia: an update including results from the NAUTILUS study. Vasc Health Risk Manag. 2007, 3: 467-479.","journal-title":"Vasc Health Risk Manag"},{"key":"796_CR88","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1039\/c0fo00132e","volume":"1","author":"M Monagas","year":"2010","unstructured":"Monagas M, Urpi-Sarda M, Sanchez-Patan F, Llorach R, Garrido I, Gomez-Cordoves C, Andres-Lacueva C, Bartolome B: Insights into the metabolism and microbial biotransformation of dietary flavan-3-ols and the bioactivity of their metabolites. Food Funct. 2010, 1: 233-253.","journal-title":"Food Funct"},{"key":"796_CR89","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1093\/pcp\/pcd025","volume":"41","author":"U Takahama","year":"2000","unstructured":"Takahama U, Hirota S: Deglucosidation of quercetin glucosides to the aglycone and formation of antifungal agents by peroxidase-dependent oxidation of quercetin on browning of onion scales. Plant Cell Physiol. 2000, 41: 1021-1029.","journal-title":"Plant Cell Physiol"},{"key":"796_CR90","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1002\/biof.5520080119","volume":"8","author":"PG Pietta","year":"1998","unstructured":"Pietta PG, Simonetti P, Gardana C, Brusamolino A, Morazzoni P, Bombardelli E: Catechin metabolites after intake of green tea infusions. Biofactors. 1998, 8: 111-118.","journal-title":"Biofactors"},{"key":"796_CR91","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1093\/jn\/137.9.2043","volume":"137","author":"P Vitaglione","year":"2007","unstructured":"Vitaglione P, Donnarumma G, Napolitano A, Galvano F, Gallo A, Scalfi L, Fogliano V: Protocatechuic acid is the major human metabolite of cyanidin-glucosides. J Nutr. 2007, 137: 2043-2048.","journal-title":"J Nutr"},{"key":"796_CR92","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.jchromb.2012.09.032","volume":"908","author":"W Chen","year":"2012","unstructured":"Chen W, Wang D, Wang LS, Bei D, Wang J, See WA, Mallery SR, Stoner GD, Liu Z: Pharmacokinetics of protocatechuic acid in mouse and its quantification in human plasma using LC-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2012, 908: 39-44.","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"796_CR93","doi-asserted-by":"publisher","first-page":"3927","DOI":"10.1021\/jf9024823","volume":"58","author":"R Koli","year":"2010","unstructured":"Koli R, Erlund I, Jula A, Marniemi J, Mattila P, Alfthan G: Bioavailability of various polyphenols from a diet containing moderate amounts of berries. J Agric Food Chem. 2010, 58: 3927-3932.","journal-title":"J Agric Food Chem"},{"key":"796_CR94","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1002\/mnfr.201300322","volume":"58","author":"RM de Ferrars","year":"2013","unstructured":"de Ferrars RM, Cassidy A, Curtis P, Kay CD: Phenolic metabolites of anthocyanins following a dietary intervention study in post-menopausal women. Mol Nutr Food Res. 2013, 58: 490-502.","journal-title":"Mol Nutr Food Res"},{"key":"796_CR95","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1016\/j.fct.2007.10.006","volume":"46","author":"HK Na","year":"2008","unstructured":"Na HK, Surh YJ: Modulation of Nrf2-mediated antioxidant and detoxifying enzyme induction by the green tea polyphenol EGCG. Food Chem Toxicol. 2008, 46: 1271-1278.","journal-title":"Food Chem Toxicol"},{"key":"796_CR96","doi-asserted-by":"publisher","first-page":"33747","DOI":"10.1074\/jbc.M110.163485","volume":"285","author":"AT Dinkova-Kostova","year":"2010","unstructured":"Dinkova-Kostova AT, Talalay P, Sharkey J, Zhang Y, Holtzclaw WD, Wang XJ, David E, Schiavoni KH, Finlayson S, Mierke DF, Honda T: An exceptionally potent inducer of cytoprotective enzymes: elucidation of the structural features that determine inducer potency and reactivity with Keap1. J Biol Chem. 2010, 285: 33747-33755.","journal-title":"J Biol Chem"}],"container-title":["Nutrition Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1475-2891-13-63.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1475-2891-13-63\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1475-2891-13-63","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1475-2891-13-63.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T11:28:29Z","timestamp":1746271709000},"score":1,"resource":{"primary":{"URL":"https:\/\/nutritionj.biomedcentral.com\/articles\/10.1186\/1475-2891-13-63"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,19]]},"references-count":96,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["796"],"URL":"https:\/\/doi.org\/10.1186\/1475-2891-13-63","relation":{},"ISSN":["1475-2891"],"issn-type":[{"value":"1475-2891","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,19]]},"assertion":[{"value":"20 February 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 June 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 June 2014","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"63"}}