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The objective of this study was to evaluate the physicochemical compatibility of high concentrations of calcium associated with organic phosphate and its influence on the stability of AIO admixtures for neonatal use.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Three TPN admixture formulas were prepared in multilayered bags. The calcium content of the admixtures was adjusted to 0, 46.5 or 93 mg\/100 ml in the presence of a fixed organic phosphate concentration as well as lipids, amino acids, inorganic salts, glucose, vitamins and oligoelements at pH 5.5. Each admixture was stored at 4\u00b0C, 25\u00b0C or 37\u00b0C and evaluated over a period of 7 days. The physicochemical stability parameters evaluated were visual aspect, pH, sterility, osmolality, peroxide formation, precipitation, and the size of lipid globules.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Color alterations occurred from the first day on, and reversible lipid film formation from the third day of study for the admixtures stored at 25\u00b0C and 37\u00b0C. According to the parameters evaluated, the admixtures were stable at 4\u00b0C; and none of them presented precipitated particles due to calcium\/phosphate incompatibility or lipid globules larger than 5 \u03bcm, which is the main parameter currently used to evaluate lipid emulsion stability. The admixtures maintained low peroxide levels and osmolarity was appropriate for parenteral administration.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>The total calcium and calcium\/phosphorus ratios studied appeared not to influence the physicochemical compatibility and stability of AIO admixtures.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1475-2891-8-51","type":"journal-article","created":{"date-parts":[[2009,10,27]],"date-time":"2009-10-27T10:30:03Z","timestamp":1256639403000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Influence of the calcium concentration in the presence of organic phosphorus on the physicochemical compatibility and stability of all-in-one admixtures for neonatal use"],"prefix":"10.1186","volume":"8","author":[{"given":"Daniela de Oliveira","family":"Ribeiro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca Waruar","family":"Lobo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00e1dia Maria","family":"Volpato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ven\u00edcio F\u00e9o","family":"da Veiga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00facio Mendes","family":"Cabral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria Pereira","family":"de Sousa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,10,26]]},"reference":[{"key":"249_CR1","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1203\/01.PDR.0000151693.46655.66","volume":"58","author":"AGS Philip","year":"2005","unstructured":"Philip AGS: The evolution of neonatology. 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