{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T08:06:17Z","timestamp":1794557177310,"version":"4.9.1"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Clin Microbiol Antimicrob"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The term \u2019Multidrug-resistant\u2019 (MDR) applies to a bacterium that is simultaneously resistant to a number of antimicrobials belonging to different chemical classes. The effectiveness of currently available antmicrobial drugs is decreasing due to the increasing number of resistant strains causing infections so that available therapeutic options for such organisms are severely limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of this study was to determine multidrug-resistance rate of bacterial isolates that caused wound infections.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A Hospital based cross-sectional study was conducted on 322 wound samples taken from consecutive patients seen at inpatient and outpatient department of Jimma University Specialized Hospital from June to December 2011. Swabs from surgical incisions, burns, abscess and traumatic wounds were collected aseptically using Levine\u2019s technique. Bacteriological culture and examination was done following standard microbiological techniques. Multidrug-resistance test was performed by disk diffusion method against 10 classes of antimicrobials. The data was analyzed for descriptive statistics using SPSS version 16 and Microsoft Excel.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The overall MDR among gram positive and gram negative bacterial isolates were (77%) and (59.3%) respectively. About, 86.2%\u2009\n                      <jats:italic>S.aureus<\/jats:italic>\n                      and 28.6% of Coagulase negative\n                      <jats:italic>Staphylococci<\/jats:italic>\n                      became MDR. Nearly 30.1% of\n                      <jats:italic>S.aureus<\/jats:italic>\n                      was resistant to six classes of antimicrobials. The average MDR rate of\n                      <jats:italic>Proteus<\/jats:italic>\n                      ,\n                      <jats:italic>Klebsiella<\/jats:italic>\n                      , and\n                      <jats:italic>Providencia<\/jats:italic>\n                      species was 74.8%, 69.6% and 75% in that order. Nearly, 30.8% of\n                      <jats:italic>Proteus sp<\/jats:italic>\n                      , 32.6% of\n                      <jats:italic>Klebsiella<\/jats:italic>\n                      sp and 61% of\n                      <jats:italic>Citrobacter<\/jats:italic>\n                      sp were resistance to 4 classes each. Surprisingly, the average MDR rate for\n                      <jats:italic>Citrobacter<\/jats:italic>\n                      sp was 100%. About (76.7%) of\n                      <jats:italic>S.aureus<\/jats:italic>\n                      was Oxacillin\/Methicillin resistant while (16.4%) were Vancomycin resistant.\n                      <jats:italic>Proteus<\/jats:italic>\n                      species was the predominant isolates (27.9%) followed by\n                      <jats:italic>P.aeruginosa<\/jats:italic>\n                      and\n                      <jats:italic>S.aureus<\/jats:italic>\n                      (19.3%) and (19%) respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study indicated that, the overall rate of MDR bacterial pathogens that caused wound infection was very high and many of the isolates were also identified as resistant to three or more classes of antimicrobials. Such widespread resistance to antimicrobial classes is something serious because a few treatment options remain for patients with wound infections. Periodic monitoring of etiology and antimicrobial susceptibility in areas where there is no culture facility is essential to assists physician in selection of chemotherapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/1476-0711-12-17","type":"journal-article","created":{"date-parts":[[2013,7,24]],"date-time":"2013-07-24T11:00:08Z","timestamp":1374663608000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":88,"title":["Multidrug-resistant bacterial isolates in infected wounds at Jimma University Specialized Hospital, Ethiopia"],"prefix":"10.1186","volume":"12","author":[{"given":"Girma","family":"Godebo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gebre","family":"Kibru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Himanot","family":"Tassew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,7,23]]},"reference":[{"key":"293_CR1","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1111\/j.1469-0691.2011.03570.x","volume":"18","author":"AP Magiorakos","year":"2012","unstructured":"Magiorakos AP, Srinivasan A, Carey RB, et al: Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance. 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