{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:20:00Z","timestamp":1759332000375},"reference-count":73,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Clin Microbiol Antimicrob"],"DOI":"10.1186\/1476-0711-3-10","type":"journal-article","created":{"date-parts":[[2004,6,9]],"date-time":"2004-06-09T06:22:53Z","timestamp":1086762173000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["A second-generation anti TB vaccine is long overdue"],"prefix":"10.1186","volume":"3","author":[{"given":"Mauricio","family":"Casta\u00f1\u00f3n-Arreola","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yolanda","family":"L\u00f3pez-Vidal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2004,6,3]]},"reference":[{"key":"28_CR1","first-page":"14","volume":"51","author":"KM De Cock","year":"1998","unstructured":"De Cock KM, Dworkin MS: HIV infection and TB. World Health. 1998, 51: 14-25.","journal-title":"World Health"},{"key":"28_CR2","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1128\/IAI.70.2.672-678.2002","volume":"70","author":"L Brandt","year":"2002","unstructured":"Brandt L, Feino Cunha J, Weinreich Olsen A, Chilima B, Hirsch P, Appelberg R, Andersen P: Failure of the Mycobacterium bovis BCG vaccine: some species of environmental mycobacteria block multiplication of BCG and induction of protective immunity to tuberculosis. Infect Immun. 2002, 70: 672-678. 10.1128\/IAI.70.2.672-678.2002","journal-title":"Infect Immun"},{"key":"28_CR3","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1001\/jama.1994.03510330076038","volume":"271","author":"GA Colditz","year":"1994","unstructured":"Colditz GA, Brewer TF, Berkey CS, Wilson ME, Burdick E, Fineberg HV, Mosteller F: Efficacy of BCG Vaccine in the Prevention of Tuberculosis. Meta-analysis of the published literature. JAMA. 1994, 271: 698-702. 10.1001\/jama.271.9.698","journal-title":"JAMA"},{"issue":"Suppl 3","key":"28_CR4","doi-asserted-by":"publisher","first-page":"S64","DOI":"10.1086\/314072","volume":"31","author":"TF Brewer","year":"2000","unstructured":"Brewer TF: Preventing Tuberculosis with Bacillus Calmette-Gu\u00e8rin Vaccine: A Meta-Analysis of the Literature. Clin Infect Dis. 2000, 31 (Suppl 3): S64-S67. 10.1086\/314072","journal-title":"Clin Infect Dis"},{"issue":"Suppl 3","key":"28_CR5","doi-asserted-by":"publisher","first-page":"S81","DOI":"10.1086\/314067","volume":"31","author":"N Buu","year":"2000","unstructured":"Buu N, Sanchez F, Schurr E: The BCG host-resistance gene. Clin Infect Dis. 2000, 31 (Suppl 3): S81-S85. 10.1086\/314067","journal-title":"Clin Infect Dis"},{"key":"28_CR6","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1016\/S0264-410X(01)00436-4","volume":"20","author":"BM Buddle","year":"2002","unstructured":"Buddle BM, Wards BJ, Aldwell FE, Collins DM, de Lisle GW: Influence of sensitization to environmental mycobacteria on subsequent vaccination against bovine tuberculosis. Vaccine. 2002, 20: 1126-1133. 10.1016\/S0264-410X(01)00436-4","journal-title":"Vaccine"},{"key":"28_CR7","first-page":"139","volume":"59","author":"BM Buddle","year":"1978","unstructured":"Phenotypes of BCG-vaccines seed lot strains: results of an international cooperative study. International Union against Tuberculosis. Tubercle. 1978, 59: 139-142.","journal-title":"International Union against Tuberculosis"},{"key":"28_CR8","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/S0092-1157(83)80042-0","volume":"11","author":"TW Osborn","year":"1983","unstructured":"Osborn TW: BCG vaccine: an investigation of colony morphology from four different strains after their introduction as seed for vaccine preparation in four production laboratories. J Biol Stand. 1983, 11: 19-27.","journal-title":"J Biol Stand"},{"key":"28_CR9","doi-asserted-by":"publisher","first-page":"1520","DOI":"10.1126\/science.284.5419.1520","volume":"284","author":"MA Behr","year":"1999","unstructured":"Behr MA, Wilson MA, Gill WP, Salamon H, Schoolnik GK, Rane S, Samll PM: Comparative Genomics of BCG Vaccines by Whole-Genome DNA Microarray. Science. 1999, 284: 1520-1522. 10.1126\/science.284.5419.1520","journal-title":"Science"},{"key":"28_CR10","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1054\/tuld.1999.0206","volume":"79","author":"T Oettinger","year":"1999","unstructured":"Oettinger T, Jorgensen M, Ladefoged A, Haslov K, Andersen P: Development of the Mycobacterium bovis BCG vaccine: review of the historical and biochemical evidence for a genealogical tree. Tuber Lung Dis. 1999, 79: 243-250. 10.1054\/tuld.1999.0206","journal-title":"Tuber Lung Dis"},{"key":"28_CR11","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1016\/S0264-410X(98)00277-1","volume":"17","author":"MA Behr","year":"1999","unstructured":"Behr MA, Small PM: A historical and molecular phylogeny of BCG strains. Vaccine. 1999, 17: 915-922. 10.1016\/S0264-410X(98)00277-1","journal-title":"Vaccine"},{"key":"28_CR12","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1080\/003655401300077180","volume":"33","author":"MA Behr","year":"2001","unstructured":"Behr MA: Correlation between BCG genomics and protective efficacy. Scand J Infect Dis. 2001, 33: 249-252. 10.1080\/003655401300077180","journal-title":"Scand J Infect Dis"},{"key":"28_CR13","first-page":"3047","volume":"132","author":"C Abou-Zeid","year":"1986","unstructured":"Abou-Zeid C, Smith I, Grange J, Steele J, Rook G: Subdivision of daughter satrains of bacille Calmete-Gu\u00e8rin (BCG) according to several protein patterns. J Gen Microbiol. 1986, 132: 3047-3053.","journal-title":"J Gen Microbiol"},{"key":"28_CR14","doi-asserted-by":"publisher","first-page":"1601","DOI":"10.1099\/13500872-141-7-1601","volume":"141","author":"T Matsuo","year":"1995","unstructured":"Matsuo T, Matsumoto S, Ohara N, Kitaura H, Mizuno A, Yamada T: Differential transcription of the MPB70 genes in two major groups of Mycobacterium bovis BCG substrains. Microbiology. 1995, 141: 1601-1607.","journal-title":"Microbiology"},{"key":"28_CR15","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1128\/iai.61.5.1730-1734.1993","volume":"61","author":"H Li","year":"1993","unstructured":"Li H, Ulstrup JC, Jonassen TO, Melby K, Nagai S, Harboe M: Evidence for absence of the MPB64 gene in some substrains of Mycobacterium bovis BCG. Infect Immun. 1993, 61: 1730-1734.","journal-title":"Infect Immun"},{"key":"28_CR16","doi-asserted-by":"publisher","first-page":"3394","DOI":"10.1128\/JB.182.12.3394-3399.2000","volume":"182","author":"MA Behr","year":"2000","unstructured":"Behr MA, Schroeder BG, Brinkman JN, Slayden RA, Barry CE: A point mutation en the mma3 gene is responsible for impaired methoxy mycolic acid production in Mycobacterium bovis BCG strains obtained after 1927. J Bacteriol. 2000, 182: 3394-3399. 10.1128\/JB.182.12.3394-3399.2000","journal-title":"J Bacteriol"},{"key":"28_CR17","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1128\/IAI.67.4.2035-2039.1999","volume":"67","author":"J Gobin","year":"1999","unstructured":"Gobin J, Wong DK, Gibson BW, Horwitz MA: Characterization of exochelins of the Mycobacterium bovis type strain and BCG substrains. Infect Immun. 1999, 67: 2035-2039.","journal-title":"Infect Immun"},{"key":"28_CR18","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/S0163-7827(98)00008-3","volume":"37","author":"CE Barry 3rd","year":"1998","unstructured":"Barry CE, Lee RE, Madluli K, Sampson AE, Schroeder BG, Slayden RA, Yuan Y: Mycolic acids: structure biosynthesis and physiological functions. Prog Lipid Res. 1998, 37: 143-179. 10.1016\/S0163-7827(98)00008-3","journal-title":"Prog Lipid Res"},{"key":"28_CR19","doi-asserted-by":"publisher","first-page":"3933","DOI":"10.1128\/IAI.68.7.3933-3940.2000","volume":"68","author":"AS Mustafa","year":"2000","unstructured":"Mustafa AS, Shaban FA, Abal AT, Al-Attyah R, Wiker HG, Lundin KEA, Oftung F, Huygen K: Identification and HLA restriction on Naturally Derived Th1-Cell Epitopes from the secreted Mycobacterium tuberculosis Antigen 85B Recognized by Antigen-Specific Human CD4+ T-Cell Lines. Infect and Immun. 2000, 68: 3933-3940. 10.1128\/IAI.68.7.3933-3940.2000.","journal-title":"Infect and Immun"},{"key":"28_CR20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/iai.64.1.1-9.1996","volume":"64","author":"MRR Lagranderie","year":"1996","unstructured":"Lagranderie MRR, Balazuc AM, Deriaud E, Leclerc CD, Gheorghiu M: Comparison of immune response of mice immunized with five different Mycobacterium bovis BCG vaccine strains. Infect Immun. 1996, 64: 1-9.","journal-title":"Infect Immun"},{"key":"28_CR21","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/S1471-4914(00)01901-8","volume":"7","author":"DN McMurray","year":"2001","unstructured":"McMurray DN: Disease model: pulmonary tuberculosis. Trends Mol Med. 2001, 7: 135-137. 10.1016\/S1471-4914(00)01901-8","journal-title":"Trends Mol Med"},{"issue":"Suppl 3","key":"28_CR22","doi-asserted-by":"publisher","first-page":"S68","DOI":"10.1086\/314071","volume":"31","author":"D Smith","year":"2000","unstructured":"Smith D, Wiegeshaus E, Balasubramanian V: Animal models for experimental tuberculosis. Clin Infect Dis. 2000, 31 (Suppl 3): S68-S70. 10.1086\/314071","journal-title":"Clin Infect Dis"},{"key":"28_CR23","first-page":"26","volume":"89","author":"R Hernandez Pando","year":"1996","unstructured":"Hernandez Pando R, Orozco H, Samperi A, Pavon L, Velasquillo C, Larriva-Shd J, Alcocer JM, Madid MV: Correlation between the kinetics of Th1, Th2 cells and pathology in a murine model of experimental pulmonary tuberculosis. Immunology. 1996, 89: 26-33.","journal-title":"Immunology"},{"key":"28_CR24","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1038\/31159","volume":"393","author":"ST Cole","year":"1998","unstructured":"Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, Gordon S, Eiglmeier K, Gas S, Barry CE: Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature. 1998, 393: 537-544. 10.1038\/24206","journal-title":"Nature"},{"key":"28_CR25","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1080\/00365540110026971","volume":"33","author":"R Louise","year":"2001","unstructured":"Louise R, Skjot V, Agger EM, Andersen P: Antigen discovery and tuberculosis vaccine development in the post-genomic era. Scand J Infect Dis. 2001, 33: 643-647. 10.1080\/00365540110026971","journal-title":"Scand J Infect Dis"},{"key":"28_CR26","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/S1369-5274(00)00119-3","volume":"3","author":"R Rappuoli","year":"2000","unstructured":"Rappuoli R: Reverse vaccinology. Curr Opin Microbiol. 2000, 3: 445-450. 10.1016\/S1369-5274(00)00119-3","journal-title":"Curr Opin Microbiol"},{"key":"28_CR27","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1086\/514132","volume":"176","author":"JJ Ellner","year":"1997","unstructured":"Ellner JJ: Review: The Immune Response in Human Tuberculosis-Implications for Tuberculosis Control. J Infect Dis. 1997, 176: 1351-1359.","journal-title":"J Infect Dis"},{"key":"28_CR28","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1046\/j.1365-2567.2002.01366.x","volume":"105","author":"GD Hussey","year":"2002","unstructured":"Hussey GD, Watkins ML, Goddard EA, Gottschalk S, Hughes EJ, Iloni K, Kibel MA, Ress SR: Neonatal mycobacterial specific cytotoxic T-lymphocyte and cytokine profiles in response to distinct BCG vaccination strategies. Immunology. 2002, 105: 314-324. 10.1046\/j.1365-2567.2002.01366.x","journal-title":"Immunology"},{"key":"28_CR29","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1046\/j.1365-3083.2002.01049.x","volume":"55","author":"M Lagranderie","year":"2002","unstructured":"Lagranderie M, Balazuc AM, Abolhassani M, Chavarot P, Nahori MA, Thouron F, Milon G, Marchal G: Development of mixed Th1\/Th2 type immune response and protection against Mycobacterium tuberculosis after rectal or subcutaneous immunization of newborn and adult mice with Mycobacterium bovis BCG. Scand J Immunol. 2002, 55: 293-303. 10.1046\/j.1365-3083.2002.01049.x","journal-title":"Scand J Immunol"},{"key":"28_CR30","doi-asserted-by":"publisher","first-page":"5657","DOI":"10.1128\/IAI.68.10.5657-5662.2000","volume":"68","author":"MA Lagranderie","year":"2000","unstructured":"Lagranderie MA, Chavarot P, Balazuc AM, Marchal G: Mycobacterium bovis BCG induces similar immune responses and protection by rectal and parenteral immunization routes. Infect Immun. 2000, 68: 5657-5662. 10.1128\/IAI.68.10.5657-5662.2000","journal-title":"Infect Immun"},{"key":"28_CR31","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.1128\/IAI.70.3.1410-1416.2002","volume":"70","author":"U Palendira","year":"2002","unstructured":"Palendira U, Bean AG, Feng CG, Britton WJ: Lymphocyte recruitment and protective efficacy against pulmonary mycobacterial infection are independent of the route of prior Mycobacterium bovis BCG immunization. Infect Immun. 2002, 70: 1410-1416. 10.1128\/IAI.70.3.1410-1416.2002","journal-title":"Infect Immun"},{"key":"28_CR32","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1046\/j.1365-2249.2001.01667.x","volume":"126","author":"IV Lyadova","year":"2001","unstructured":"Lyadova IV, Vordermeier HM, Eruslanov EB, Khaidukov SV, Apt AS, Hewinson RG: Intranasal BCG vaccination protects BALB\/c mice against virulent Mycobacterium bovis and accelerates production of IFN-gamma in their lungs. Clin Exp Immunol. 2001, 126: 274-279. 10.1046\/j.1365-2249.2001.01667.x","journal-title":"Clin Exp Immunol"},{"key":"28_CR33","doi-asserted-by":"publisher","first-page":"5862","DOI":"10.4049\/jimmunol.167.10.5862","volume":"167","author":"T Hiroi","year":"2001","unstructured":"Hiroi T, Goto H, Someya K, Yanagita M, Honda M, Yamanaka N, Kiyono H: HIV mucosal vaccine: nasal immunization with rBCG-V3J1 induces a long term V3J1peptide-specific neutralizing immunity in Th1- and Th2-deficient conditions. J Immunol. 2001, 167: 5862-5867.","journal-title":"J Immunol"},{"key":"28_CR34","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1093\/clinids\/14.1.308","volume":"14","author":"N Rastogi","year":"1992","unstructured":"Rastogi N, McFadden J, Ottenhoff THM, van Eden W: First International Conference on the Pathogenesis of Mycobacterial Infections: A summary. Clin Infect Dis. 1992, 14: 308-312.","journal-title":"Clin Infect Dis"},{"key":"28_CR35","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1046\/j.1365-3083.1998.00419.x","volume":"48","author":"AS Mustafa","year":"1998","unstructured":"Mustafa AS, Amoudy HA, Wiker HG, Abal AT, Ravn P, Oftung F, Andersen P: Comparison of Antigen-Specific T-Cell Responses of Tuberculosis Patients using Complex or Single Antigens of Mycobacterium tuberculosis. Scand J Immunol. 1998, 48: 535-543. 10.1046\/j.1365-3083.1998.00419.x","journal-title":"Scand J Immunol"},{"key":"28_CR36","doi-asserted-by":"publisher","first-page":"4089","DOI":"10.1016\/S0264-410X(01)00155-4","volume":"19","author":"N Ohara","year":"2001","unstructured":"Ohara N, Yamada T: Recombinant BCG vaccines. Vaccine. 2001, 19: 4089-4098. 10.1016\/S0264-410X(01)00155-4","journal-title":"Vaccine"},{"key":"28_CR37","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1046\/j.1440-1711.2000.00937.x","volume":"78","author":"DM Collins","year":"2000","unstructured":"Collins DM: New tuberculosis vaccines based on attenuated strains of the Mycobacterium tuberculosis complex. Immunol Cell Biol. 2000, 78: 342-348. 10.1046\/j.1440-1711.2000.00937.x","journal-title":"Immunol Cell Biol"},{"key":"28_CR38","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1023\/A:1017215720949","volume":"20","author":"K Pehler","year":"2000","unstructured":"Pehler K, Brasky KM, Butler TM, Attanasio R: Mycobacterium tuberculosis-secreted protein antigens: immunogenicity in baboons. J Clin Immunol. 2000, 20: 306-316. 10.1023\/A:1017215720949","journal-title":"J Clin Immunol"},{"key":"28_CR39","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/S0928-8244(98)00002-9","volume":"20","author":"G Freer","year":"1998","unstructured":"Freer G, Florio W, Dallacasa B, Castagna B, Maisetta G, Batoni G, Corsini V, Senesi S, Campa M: Characterization of antigens recognized by new monoclonal antibodies raised against culture filtrate proteins of Mycobacterium bovis bacillus Calmette-Gu\u00e8rin. FEMS Immunology and Med Microbiol. 1998, 20: 129-138. 10.1016\/S0928-8244(98)00002-9.","journal-title":"FEMS Immunology and Med Microbiol"},{"key":"28_CR40","doi-asserted-by":"crossref","first-page":"3038","DOI":"10.1128\/iai.64.8.3038-3047.1996","volume":"64","author":"G Harth","year":"1996","unstructured":"Harth G, Lee B-Y, Wang J, Clemens DL, Horwitz MA: Novel Insights into the Genetics, Biochemistry, and Immunocytochemistry of the 30-Kilodalton Major Extracellular Protein of Mycobacterium tuberculosis. Infect Immun. 1996, 64: 3038-3047.","journal-title":"Infect Immun"},{"key":"28_CR41","doi-asserted-by":"publisher","first-page":"2100","DOI":"10.1128\/IAI.70.4.2100-2107.2002","volume":"70","author":"AL Moreira","year":"2002","unstructured":"Moreira AL, Tsenova L, Aman MH, Bekker LG, Freeman S, Mangaliso B, Schroder U, Jagirdar J, Rom WN, Tovey MG: Mycobacterial antigens exacerbate disease manifestations in Mycobacterium tuberculosis-infected mice. Infect Immun. 2002, 70: 2100-2107. 10.1128\/IAI.70.4.2100-2107.2002","journal-title":"Infect Immun"},{"key":"28_CR42","doi-asserted-by":"publisher","first-page":"2773","DOI":"10.1128\/IAI.69.5.2773-2778.2001","volume":"69","author":"A Weinrich Olsen","year":"2001","unstructured":"Weinrich Olsen A, van Pinxteren LA, Meng Okkels L, Birk Rasmussen P, Andersen P: Protection of mice with a tuberculosis subunit vaccine based on a fusion protein of antigen 85b and esat-6. Infect Immun. 2001, 69: 2773-2778. 10.1128\/IAI.69.5.2773-2778.2001","journal-title":"Infect Immun"},{"key":"28_CR43","doi-asserted-by":"publisher","first-page":"1336","DOI":"10.1086\/323044","volume":"33","author":"BA Wu-Hsieh","year":"2001","unstructured":"Wu-Hsieh BA, Chen CK, Chang JH, Lai SY, Wu CH, Cheng WC, Andersen P, Doherty TM: Long-lived immune response to early secretory antigenic target 6 in individuals who had recovered from tuberculosis. Clin Infect Dis. 2001, 33: 1336-1340. 10.1086\/323044","journal-title":"Clin Infect Dis"},{"key":"28_CR44","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1128\/IAI.67.4.1702-1707.1999","volume":"67","author":"AT Kamath","year":"1999","unstructured":"Kamath AT, Feng CG, Macdonald M, Brioscole H, Brotton WJ: Differential protective Efficacy of DNA Vaccines Expressing Secreted Proteins of Mycobacterium tuberculosis. Infect Immun. 1999, 67: 1702-1707.","journal-title":"Infect Immun"},{"key":"28_CR45","first-page":"5921","volume-title":"J Immunol","author":"X Zhu","year":"1997","unstructured":"Zhu X, Venkataprasad N, Thangaraj HS, Hill M, Singh M, Ivanyi J, Vordermeier HM: Function and Specificity of T Cells Following Nucleic Acid Vaccination of Mice Against Mycobacterium tuberculosis Infection. J Immunol. 1997, 5921-5926."},{"key":"28_CR46","doi-asserted-by":"publisher","first-page":"2155","DOI":"10.1016\/S0264-410X(99)00540-X","volume":"18","author":"S Morris","year":"2000","unstructured":"Morris S, Kelley C, Howard A, Li Z, Collins F: The immunogenicity of single and combination DNA vaccines against tuberculosis. Vaccine. 2000, 18: 2155-2163. 10.1016\/S0264-410X(99)00540-X","journal-title":"Vaccine"},{"key":"28_CR47","doi-asserted-by":"publisher","first-page":"3854","DOI":"10.1128\/IAI.68.7.3854-3860.2000","volume":"68","author":"A Tanghe","year":"2000","unstructured":"Tanghe A, Denis O, Lambrecht B, Motte V, van der Berg T, Huygen K: Tuberculosis DNA Vaccine Encoding Ag85A Is Immunogenic and Protective When Administered by Intramuscular Needle Injection but Not by Epidermal Gene Gun Bombardment. Infect Immun. 2000, 68: 3854-3860. 10.1128\/IAI.68.7.3854-3860.2000","journal-title":"Infect Immun"},{"key":"28_CR48","doi-asserted-by":"publisher","first-page":"1949","DOI":"10.1128\/IAI.70.4.1949-1956.2002","volume":"70","author":"U Palendira","year":"2002","unstructured":"Palendira U, Kamath AT, Feng CG, Martin E, Chaplin PJ, Triccas JA, Britton WJ: Co expression of interleukin-12 chains by a self-splicing vector increases the protective cellular immune response of DNA and Mycobacterium bovis BCG vaccines against Mycobacterium tuberculosis. Infect Immun. 2002, 70: 1949-1956. 10.1128\/IAI.70.4.1949-1956.2002","journal-title":"Infect Immun"},{"key":"28_CR49","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.1128\/IAI.69.3.1433-1439.2001","volume":"69","author":"FA Post","year":"2001","unstructured":"Post FA, Manca C, Neyrolles O, Ryffel B, Young DB, Kaplan G: Mycobacterium tuberculosis 19-kilodalton lipoprotein inhibits Mycobacterium smegmatis-induced cytokine production by human macrophages in vitro. Infect Immun. 2001, 69: 1433-1349. 10.1128\/IAI.69.3.1433-1439.2001","journal-title":"Infect Immun"},{"key":"28_CR50","doi-asserted-by":"publisher","first-page":"2159","DOI":"10.1128\/IAI.70.4.2159-2165.2002","volume":"70","author":"MA Chambers","year":"2002","unstructured":"Chambers MA, Williams A, Hatch G, Gavier-Widen D, Hall G, Huygen K, Lowrie D, Marsh PD, Hewinson RG: Vaccination of guinea pigs with DNA encoding the mycobacterial antigen MPB83 influences pulmonary pathology but not haematogenous spread following aerogenic infection with Mycobacterium bovis. Infect Immun. 2002, 70: 2159-2165. 10.1128\/IAI.70.4.2159-2165.2002","journal-title":"Infect Immun"},{"key":"28_CR51","doi-asserted-by":"publisher","first-page":"3674","DOI":"10.1128\/IAI.68.6.3674-3679.2000","volume":"68","author":"OC Turner","year":"2000","unstructured":"Turner OC, Roberts AD, Frank AA, Phalen SW, McMurray DMM, Content J, Denis O, D'Souza S, Tanghe A, Huygen K, Orme IM: Lack of Protection in Mice and Necrotizing Bronchointerstitial Pneumonia with Bronchiolitis in Guinea Pigs Immunized with Vaccines Directed against the hsp60 Molecule of Mycobacterium tuberculosis. Infect Immun. 2000, 68: 3674-3679. 10.1128\/IAI.68.6.3674-3679.2000","journal-title":"Infect Immun"},{"key":"28_CR52","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1046\/j.1365-2567.1997.00358.x","volume":"92","author":"X Zhu","year":"1997","unstructured":"Zhu X, Venkataprasad N, Ivanyi J, Vordermeier HM: Vaccination with recombinant vaccinia viruses protects mice against Mycobacterium tuberculosis infection. Immunology. 1997, 92: 6-9. 10.1046\/j.1365-2567.1997.00358.x","journal-title":"Immunology"},{"key":"28_CR53","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1128\/IAI.70.1.292-302.2002","volume":"70","author":"G Delogu","year":"2002","unstructured":"Delogu G, Li A, Repique C, Collins F, Morris SL: DNA vaccine combinations expressing either tissue plasminogen activator signal sequence fusion proteins or ubiquitin-conjugated antigens induce sustained protective immunity in a mouse model of pulmonary tuberculosis. Infect Immun. 2002, 70: 292-302. 10.1128\/IAI.70.1.292-302.2002","journal-title":"Infect Immun"},{"key":"28_CR54","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1054\/tube.2000.0265","volume":"81","author":"DN McMurray","year":"2001","unstructured":"McMurray DN: A coordinated strategy for evaluating new vaccines for human and animal tuberculosis. Tuberculosis. 2001, 81: 141-146. 10.1054\/tube.2000.0265","journal-title":"Tuberculosis"},{"key":"28_CR55","doi-asserted-by":"crossref","first-page":"3091","DOI":"10.1128\/jb.178.11.3091-3098.1996","volume":"178","author":"A Baulard","year":"1996","unstructured":"Baulard A, Kremer L, Locht C: Efficient Homologous Recombination in Fast-Growing and Slow-Growing Mycobacteria. J Bacteriol. 1996, 178: 3091-3098.","journal-title":"J Bacteriol"},{"key":"28_CR56","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1128\/IAI.67.6.2867-2873.1999","volume":"67","author":"M Jackson","year":"1999","unstructured":"Jackson M, Phalen SW, Lagranderie M, Ensergueix D, Chavarot P, Marchal G, McMurray DN, Gicquel B, Guilhot C: Persistence and protective efficacy of a Mycobacterium tuberculosis auxotroph vaccine. Infect Immun. 1999, 67: 2867-2873.","journal-title":"Infect Immun"},{"key":"28_CR57","doi-asserted-by":"publisher","first-page":"7094","DOI":"10.1128\/IAI.68.12.7094-7099.2000","volume":"68","author":"MA Chambers","year":"2000","unstructured":"Chambers MA, Williams A, Gavier-Widen D, Whelan A, Hall G, Marsh PD, Bloom BR, Jacobs WR, Hewinson RG: Identification of a Mycobacterium bovis BCG auxotrophic mutant that protects guinea pigs against M. bovis and haematogenous spread of Mycobacterium tuberculosis without sensitization to tuberculin. Infect Immun. 2000, 68: 7094-7099. 10.1128\/IAI.68.12.7094-7099.2000","journal-title":"Infect Immun"},{"key":"28_CR58","doi-asserted-by":"crossref","first-page":"2624","DOI":"10.1128\/IAI.67.5.2624-2626.1999","volume":"67","author":"GW De Lisle","year":"1999","unstructured":"De Lisle GW, Wilson T, Collins DM, Buddle BM: Vaccination of guinea pigs with nutritionally impaired avirulent mutants of Mycobacterium bovis protects against tuberculosis. Infect Immun. 1999, 67: 2624-2626.","journal-title":"Infect Immun"},{"key":"28_CR59","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1054\/tuld.2000.0244","volume":"80","author":"BJ Wards","year":"2000","unstructured":"Wards BJ, de Lisle GW, Collins DM: An esat6 knockout mutant of Mycobacterium bovis produced by homologous recombination will contribute to the development of a live tuberculosis vaccine. Tuber Lung Dis. 2000, 80: 185-189. 10.1054\/tuld.2000.0244","journal-title":"Tuber Lung Dis"},{"key":"28_CR60","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1054\/tube.2000.0269","volume":"81","author":"SV Gordon","year":"2001","unstructured":"Gordon SV, Eiglmeier K, Garnier T, Brosch R, Parkhill J, Barrell B, Cole ST, Hewinson RG: Genomics of Mycobacterium bovis. Tuberculosis. 2001, 81: 157-163. 10.1054\/tube.2000.0269","journal-title":"Tuberculosis"},{"key":"28_CR61","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1128\/IAI.70.2.1010-1013.2002","volume":"70","author":"JS Spencer","year":"2002","unstructured":"Spencer JS, Marques MAM, Lima MCBS, Junqueira-Kipnis AP, Gregory BC, Truman RW, Brennan PJ: Antigenic Specificity of the Mycobacterium leprae Homologue of ESAT-6. Infect Immun. 2002, 70: 1010-1013. 10.1128\/IAI.70.2.1010-1013.2002","journal-title":"Infect Immun"},{"key":"28_CR62","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1046\/j.1365-2249.2001.01428.x","volume":"123","author":"Y Luo","year":"2001","unstructured":"Luo Y, Chen X, Han R, O'Donnell MA: Recombinant bacille Calmette-Gu\u00e8rin (BCG) expressing human interferon-alpha 2B demonstrates enhanced immunogenicity. Clin Exp Immunol. 2001, 123: 264-270. 10.1046\/j.1365-2249.2001.01428.x","journal-title":"Clin Exp Immunol"},{"key":"28_CR63","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1046\/j.1440-1711.2002.01078.x","volume":"80","author":"S Young","year":"2002","unstructured":"Young S, O'Donell M, Lockhart E, Buddle B, Slobbe L, Luo Y, DeLisle G, Buchan G: Manipulation of immune responses to Mycobacterium bovis by vaccination with IL-2- and IL-18-secreting recombinant bacillus Calmette Gu\u00e8rin. Immunol Cell Biol. 2002, 80: 209-215. 10.1046\/j.1440-1711.2002.01078.x","journal-title":"Immunol Cell Biol"},{"key":"28_CR64","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1080\/003655401317074473","volume":"33","author":"J Hess","year":"2001","unstructured":"Hess J, Kaufmann SH: Development of live recombinant vaccine candidates against tuberculosis. Scand J Infect Dis. 2001, 33: 723-734. 10.1080\/003655401317074473","journal-title":"Scand J Infect Dis"},{"key":"28_CR65","doi-asserted-by":"publisher","first-page":"13853","DOI":"10.1073\/pnas.250480397","volume":"97","author":"MA Horwitz","year":"2000","unstructured":"Horwitz MA, Harth G, Dillon BJ, Maslesa-Galic' S: Recombinant bacillus Calmette-Gu\u00e8rin (BCG) vaccines expressing the Mycobacterium tuberculosis 30-kDa major secretory protein induce greater protective immunity against tuberculosis than conventional BCG vaccines in a highly susceptible animal model. Proc Natl Acad Sci U S A. 2000, 97: 13853-13858. 10.1073\/pnas.250480397","journal-title":"Proc Natl Acad Sci U S A"},{"key":"28_CR66","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1016\/S0264-410X(00)00300-5","volume":"19","author":"AM Dannenberg","year":"2000","unstructured":"Dannenberg AM, Bishai WR, Parrish N, Ruiz R, Johnson W, Zook BC, Boles JW, Pitt LM: Efficacies of BCG and vole bacillus (Mycobacterium microti) vaccines in preventing clinically apparent pulmonary tuberculosis in rabbits: a preliminary report. Vaccine. 2000, 19: 796-800. 10.1016\/S0264-410X(00)00300-5","journal-title":"Vaccine"},{"key":"28_CR67","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/S0169-409X(01)00168-5","volume":"51","author":"N Mielcarek","year":"2001","unstructured":"Mielcarek N, Alonso S, Locht C: Nasal vaccination using live bacterial vectors. Adv Drug Deliv Rev. 2001, 51: 55-69. 10.1016\/S0169-409X(01)00168-5","journal-title":"Adv Drug Deliv Rev"},{"key":"28_CR68","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1053\/rmed.2001.1065","volume":"95","author":"JL Stanford","year":"2001","unstructured":"Stanford JL, Stanford CA, Grange JM, Lan NN, Etemadi A: Does immunotherapy with heat-killed Mycobacterium vaccae offer hope for the treatment of multi-drug-resistant pulmonary tuberculosis?. Res Med. 2001, 95: 444-447. 10.1053\/rmed.2001.1065.","journal-title":"Res Med"},{"key":"28_CR69","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.1128\/IAI.69.3.1433-1439.2001","volume":"69","author":"FA Post","year":"2001","unstructured":"Post FA, Manca C, Neyrolles O, Ryffel B, Yoong DB, Kaplan G: Mycobacterium tuberculosis 19-kilodalton lipoprotein inhibits Mycobacterium smegmatis-induced cytokine production by human macrophages in vitro. Infect Immun. 2001, 69: 1433-1439. 10.1128\/IAI.69.3.1433-1439.2001","journal-title":"Infect Immun"},{"key":"28_CR70","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1054\/tuld.2000.0252","volume":"80","author":"VV Yeremeev","year":"2000","unstructured":"Yeremeev VV, Stewart GR, Neyrolles O, Skrabal K, Avdienko VG, Apt AS, Young DB: Deletion of the 19 kDa antigen does not alter the protective efficacy of BCG. Tuber Lung Dis. 2000, 80: 243-247. 10.1054\/tuld.2000.0252","journal-title":"Tuber Lung Dis"},{"key":"28_CR71","doi-asserted-by":"publisher","first-page":"S299","DOI":"10.1086\/313878","volume":"Suppl 3","author":"A Williams","year":"2000","unstructured":"Williams A, Davies A, Marsh PD, Chambers MA, Hewinson RG: Comparison of the protective efficacy of bacille Calmette-Gu\u00e8rin vaccination against aerosol challenge with Mycobacterium tuberculosis and Mycobacterium bovis. Clin Infect Dis. 2000, Suppl 3: S299-S301. 10.1086\/313878.","journal-title":"Clin Infect Dis"},{"key":"28_CR72","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/S0378-1135(01)00461-8","volume":"84","author":"LA Corner","year":"2002","unstructured":"Corner LA, Buddle BM, Pfeiffer DU, Morris RS: Vaccination of the brush tail possum (Trichosurus vulpecula) against Mycobacterium bovis infection with bacille Calmette-Guerin: the response to multiple doses. Vet Microbiol. 2002, 84: 327-336. 10.1016\/S0378-1135(01)00461-8","journal-title":"Vet Microbiol"},{"key":"28_CR73","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1542\/peds.96.1.29","volume":"96","author":"GA Colditz","year":"1995","unstructured":"Colditz GA, Berkey CS, Mosteller F, Brewer TF, Wilson ME, Burdick E, Fineber HV: The efficacy of bacillus Calmette-Gu\u00e8rin vaccination of newborns and infants in the prevention of tuberculosis: meta-analysis of the published literature. Pediatrics. 1995, 96: 29-35.","journal-title":"Pediatrics"}],"container-title":["Annals of Clinical Microbiology and Antimicrobials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1476-0711-3-10.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T15:13:30Z","timestamp":1726240410000},"score":1,"resource":{"primary":{"URL":"https:\/\/ann-clinmicrob.biomedcentral.com\/articles\/10.1186\/1476-0711-3-10"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,6,3]]},"references-count":73,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2004,12]]}},"alternative-id":["28"],"URL":"https:\/\/doi.org\/10.1186\/1476-0711-3-10","relation":{},"ISSN":["1476-0711"],"issn-type":[{"type":"electronic","value":"1476-0711"}],"subject":[],"published":{"date-parts":[[2004,6,3]]},"assertion":[{"value":"24 January 2004","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 June 2004","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 June 2004","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"10"}}