{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:20:45Z","timestamp":1759335645185},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Clin Microbiol Antimicrob"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Antibiotic resistance is an increasing problem in isolates of <jats:italic>Staphylococcus aureus (S. aureus)<\/jats:italic> worldwide. In 2001 The National Health Service in the UK introduced a mandatory bacteraemia surveillance scheme for the reporting of <jats:italic>S. aureus<\/jats:italic> and methicillin-resistant <jats:italic>S. aureus<\/jats:italic> (MRSA). This surveillance initiative reports on the percentage of isolates that are methicillin resistant. However, resistance to other antibiotics is not currently reported and therefore the scale of emerging resistance is currently unclear in the UK. In this study, multiple antibiotic resistance (MAR) profiles against fourteen antimicrobial drugs were investigated for 705 isolates of <jats:italic>S. aureus<\/jats:italic> collected from two European study sites in the UK (London) and Malta.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>All isolates were susceptible to linezolid, teicoplanin and vancomycin. Multiple antibiotic resistance profiles from both countries were determined, a total of forty-two and forty-five profiles were seen in the UK cohort (MRSA and MSSA respectively) and comparatively, sixty-two and fifty-two profiles were shown in the Maltese group. The largest MAR profile contained six antibiotics (penicillin G, methicillin, erythromycin, ciprofloxacin, clindamycin and clarithromycin) and was observed in the MRSA isolates in both the UK and Maltese cohorts.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>The data presented here suggests that the monitoring of changing resistance profiles locally in maintaining treatment efficacy to resistant pathogens.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1476-0711-9-20","type":"journal-article","created":{"date-parts":[[2010,7,21]],"date-time":"2010-07-21T18:15:28Z","timestamp":1279736128000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The need for continued monitoring of antibiotic resistance patterns in clinical isolates of Staphylococcus aureus from London and Malta"],"prefix":"10.1186","volume":"9","author":[{"given":"Simon WJ","family":"Gould","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Cuschieri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jess","family":"Rollason","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony C","family":"Hilton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sue","family":"Easmon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark D","family":"Fielder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,7,21]]},"reference":[{"key":"192_CR1","volume-title":"Overcoming antimicrobial resistance world health report on infectious diseases 2000","author":"GH Brundtland","year":"2000","unstructured":"Brundtland GH: Overcoming antimicrobial resistance world health report on infectious diseases 2000. 2000, Source, http:\/\/www.who.int\/infectious-disease-report\/2000\/other_versions\/index-rpt2000_text.html"},{"key":"192_CR2","volume-title":"Getting Ahead of the Curve; A stategy for comating infectious disease (including other aspects of health protection)","author":"Department of Health","year":"2002","unstructured":"Department of Health: Getting Ahead of the Curve; A stategy for comating infectious disease (including other aspects of health protection). 2002, Source, http:\/\/www.pathologyimprovement.nhs.uk\/%5Cdocuments%5Ckey_documents%5CGetting_Ahead_of_the_Curve.pdf"},{"key":"192_CR3","first-page":"6","volume-title":"HPP","author":"Anon 2","year":"2006","unstructured":"Anon 2: Mandatory surveillance of healthcare associated infection report. 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