{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T18:25:35Z","timestamp":1774549535574,"version":"3.50.1"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Cancer"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Centromere protein-F (CENP-F) is a large nuclear protein of 367\u00a0kDa, which is involved in multiple mitosis-related events such as proper assembly of the kinetochores, stabilization of heterochromatin, chromosome alignment and mitotic checkpoint signaling. Several studies have shown a correlation between CENP-F and cancer, e.g. the expression of CENP-F has been described to be upregulated in cancer cells. Furthermore, several studies have described a significant correlation between the expression of autoantibodies to CENP-F and cancer.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Autoantibodies to CENP-F were detected in a small number of samples during routine indirect immunofluorescence (IIF) analysis for anti-nuclear antibodies (ANA) using HEp-2 cells as substrate. Using overlapping synthetic peptides covering a predicted structural maintenance of chromosomes (SMC) domain, we developed an enzyme-linked immunosorbent assay (ELISA) for detection of CENP-F antibodies.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Analyzing the reactivity of the sera positive in IIF for CENP-F antibodies to overlapping CENP-F peptides, we showed that autoantibodies to several peptides correlate with the presence of antibodies to CENP-F and a diagnosis of cancer, as increased CENP-F antibody expression specific for malignant cancer patients to five peptides was found (A9, A12, A14, A16, A27). These antibodies to CENP-F in clinical samples submitted for ANA analysis were found to have a positive predictive value for cancer of 50%. Furthermore, the expression of cancer-correlated CENP-F antibodies seemed to increase as a function of time from diagnosis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>These results conform to previous findings that approximately 50% of those patients clinically tested for ANA analyses who express CENP-F antibodies are diagnosed with cancer, confirming that these antibodies may function as circulating tumor markers. Thus, a peptide-based CENP-F ELISA focused on the SMC domain may aid in identifying individuals with a potential cancer.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1476-4598-12-95","type":"journal-article","created":{"date-parts":[[2013,8,26]],"date-time":"2013-08-26T14:14:17Z","timestamp":1377526457000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Correlation between centromere protein-F autoantibodies and cancer analyzed by enzyme-linked immunosorbent assay"],"prefix":"10.1186","volume":"12","author":[{"given":"Simon","family":"Welner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole Hartwig","family":"Trier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morten","family":"Frisch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henning","family":"Locht","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul Robert","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunnar","family":"Houen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,8,26]]},"reference":[{"key":"1170_CR1","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1038\/nrc1041","volume":"3","author":"R Etzioni","year":"2003","unstructured":"Etzioni R, Urban N, Ramsey S, McIntosh M, Schwartz S, Reid B, Radich J, Anderson G, Hartwell L: The case for early detection. Nat Rev Cancer. 2003, 3: 243-252.","journal-title":"Nat Rev Cancer"},{"key":"1170_CR2","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1159\/000338393","volume":"22","author":"MJ Duffy","year":"2013","unstructured":"Duffy MJ: Tumor markers in clinical practice: a review focusing on common solid cancers. Med Princ Pract. 2013, 22: 4-11. 10.1159\/000338393","journal-title":"Med Princ Pract"},{"key":"1170_CR3","doi-asserted-by":"publisher","first-page":"432","DOI":"10.7150\/jca.4919","volume":"3","author":"MH Mo","year":"2012","unstructured":"Mo MH, Chen L, Fu Y, Wang W, Fu SW: Cell-free circulating miRNA biomarkers in cancer. J Cancer. 2012, 3: 432-448.","journal-title":"J Cancer"},{"key":"1170_CR4","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1016\/j.molonc.2012.07.005","volume":"6","author":"A NogueiradaCosta","year":"2012","unstructured":"NogueiradaCosta A, Herceg Z: Detection of cancer-specific epigenomic changes in biofluids: powerful tools in biomarker discovery and application. Mol Oncol. 2012, 6: 704-715. 10.1016\/j.molonc.2012.07.005","journal-title":"Mol Oncol"},{"key":"1170_CR5","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1146\/annurev-med-050311-163404","volume":"64","author":"M Balic","year":"2013","unstructured":"Balic M, Williams A, Lin H, Datar R, Cote RJ: Circulating tumor cells: from bench to bedside. Annu Rev Med. 2013, 64: 31-44. 10.1146\/annurev-med-050311-163404","journal-title":"Annu Rev Med"},{"key":"1170_CR6","doi-asserted-by":"publisher","first-page":"2013","DOI":"10.1111\/j.1582-4934.2011.01355.x","volume":"15","author":"C Desmetz","year":"2011","unstructured":"Desmetz C, Mange A, Maudelonde T, Solassol J: Autoantibody signatures: progress and perspectives for early cancer detection. J Cell Mol Med. 2011, 15: 2013-2024. 10.1111\/j.1582-4934.2011.01355.x","journal-title":"J Cell Mol Med"},{"key":"1170_CR7","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1097\/NRL.0b013e3181870aa2","volume":"15","author":"TB Toothaker","year":"2009","unstructured":"Toothaker TB, Rubin M: Paraneoplastic neurological syndromes: a review. Neurologist. 2009, 15: 21-33. 10.1097\/NRL.0b013e3181870aa2","journal-title":"Neurologist"},{"key":"1170_CR8","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1097\/WCO.0b013e328359da15","volume":"25","author":"F Graus","year":"2012","unstructured":"Graus F, Dalmau J: Paraneoplastic neurological syndromes. Curr Opin Neurol. 2012, 25: 795-801. 10.1097\/WCO.0b013e328359da15","journal-title":"Curr Opin Neurol"},{"key":"1170_CR9","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1016\/0896-8411(95)90009-8","volume":"8","author":"CA Casiano","year":"1995","unstructured":"Casiano CA, Humbel RL, Peebles C, Covini G, Tan EM: Autoimmunity to the cell cycle-dependent centromere protein p330d\/CENP-F in disorders associated with cell proliferation. J Autoimmun. 1995, 8: 575-586. 10.1016\/0896-8411(95)90009-8","journal-title":"J Autoimmun"},{"key":"1170_CR10","first-page":"308","volume":"20","author":"JB Rattner","year":"1997","unstructured":"Rattner JB, Rees J, Whitehead CM, Casiano CA, Tan EM, Humbel RL, Conrad K, Fritzler MJ: High frequency of neoplasia in patients with autoantibodies to centromere protein CENP-F. Clin Invest Med. 1997, 20: 308-319.","journal-title":"Clin Invest Med"},{"key":"1170_CR11","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1196\/annals.1313.034","volume":"1050","author":"C Bencimon","year":"2005","unstructured":"Bencimon C, Salles G, Moreira A, Guyomard S, Coiffier B, Bienvenu J, Fabien N: Prevalence of anticentromere F protein autoantibodies in 347 patients with non-Hodgkin's lymphoma. Ann N Y Acad Sci. 2005, 1050: 319-326. 10.1196\/annals.1313.034","journal-title":"Ann N Y Acad Sci"},{"key":"1170_CR12","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1038\/sj.bmt.1700764","volume":"19","author":"Y Muro","year":"1997","unstructured":"Muro Y, Kamimoto T, Hagiwara M: Anti-mitosin antibodies in a patient with chronic graft-versus-host disease after allogeneic bone marrow transplantation. Bone Marrow Transplantation. 1997, 19: 951-953. 10.1038\/sj.bmt.1700764","journal-title":"Bone Marrow Transplantation"},{"key":"1170_CR13","doi-asserted-by":"publisher","first-page":"5017","DOI":"10.1128\/MCB.15.9.5017","volume":"15","author":"X Zhu","year":"1995","unstructured":"Zhu X, Mancini MA, Chang KH, Liu CY, Chen CF, Shan B, Jones D, Yang-Feng TL, Lee WH: Characterization of a novel 350-kilodalton nuclear phosphoprotein that is specifically involved in mitotic-phase progression. Mol Cell Biol. 1995, 15: 5017-5029.","journal-title":"Mol Cell Biol"},{"key":"1170_CR14","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1007\/s11373-005-9057-3","volume":"13","author":"L Ma","year":"2006","unstructured":"Ma L, Zhao X, Zhu X: Mitosin\/CENP-F in mitosis, transcriptional control, and differentiation. J Biomed Sci. 2006, 13: 205-213. 10.1007\/s11373-005-9057-3","journal-title":"J Biomed Sci"},{"key":"1170_CR15","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1007\/s00412-005-0046-0","volume":"115","author":"A Varis","year":"2006","unstructured":"Varis A, Salmela AL, Kallio MJ: Cenp-F (mitosin) is more than a mitotic marker. Chromosoma. 2006, 115: 288-295. 10.1007\/s00412-005-0046-0","journal-title":"Chromosoma"},{"key":"1170_CR16","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1002\/(SICI)1097-4644(19970915)66:4<441::AID-JCB3>3.0.CO;2-L","volume":"66","author":"X Zhu","year":"1997","unstructured":"Zhu X, Ding L, Pei G: Carboxyl terminus of mitosin is sufficient to confer spindle pole localization. J Cell Biochem. 1997, 66: 441-449. 10.1002\/(SICI)1097-4644(19970915)66:4<441::AID-JCB3>3.0.CO;2-L","journal-title":"J Cell Biochem"},{"key":"1170_CR17","unstructured":"The national center for biotechnology information database.http:\/\/www.uniprot.org\/uniprot\/P49454,"},{"key":"1170_CR18","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1083\/jcb.130.3.507","volume":"130","author":"H Liao","year":"1995","unstructured":"Liao H, Winkfein RJ, Mack G, Rattner JB, Yen TJ: CENP-F is a protein of the nuclear matrix that assembles onto kinetochores at late G2 and is rapidly degraded after mitosis. J Cell Biol. 1995, 130: 507-518. 10.1083\/jcb.130.3.507","journal-title":"J Cell Biol"},{"key":"1170_CR19","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1128\/MCB.19.2.1016","volume":"19","author":"X Zhu","year":"1999","unstructured":"Zhu X: Structural requirements and dynamics of mitosin-kinetochore interaction in M phase. Mol Cell Biol. 1999, 19: 1016-1024.","journal-title":"Mol Cell Biol"},{"key":"1170_CR20","doi-asserted-by":"publisher","first-page":"13973","DOI":"10.1074\/jbc.M414310200","volume":"280","author":"X Zhou","year":"2005","unstructured":"Zhou X, Wang R, Fan L, Li Y, Ma L, Yang Z, Yu W, Jing N, Zhu X: Mitosin\/CENP-F as a negative regulator of activating transcription factor-4. J Biol Chem. 2005, 280: 13973-13977. 10.1074\/jbc.M414310200","journal-title":"J Biol Chem"},{"key":"1170_CR21","doi-asserted-by":"publisher","first-page":"19545","DOI":"10.1074\/jbc.270.33.19545","volume":"270","author":"X Zhu","year":"1995","unstructured":"Zhu X, Chang KH, He D, Mancini MA, Brinkley WR, Lee WH: The C terminus of mitosin is essential for its nuclear localization, centromere\/kinetochore targeting, and dimerization. J Biol Chem. 1995, 270: 19545-19550. 10.1074\/jbc.270.33.19545","journal-title":"J Biol Chem"},{"key":"1170_CR22","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1126\/science.1175371","volume":"325","author":"C Choudhary","year":"2009","unstructured":"Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M: Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science. 2009, 325: 834-840. 10.1126\/science.1175371","journal-title":"Science"},{"key":"1170_CR23","doi-asserted-by":"publisher","first-page":"30451","DOI":"10.1074\/jbc.M003469200","volume":"275","author":"HR Ashar","year":"2000","unstructured":"Ashar HR, James L, Gray K, Carr D, Black S, Armstrong L, Bishop WR, Kirschmeier P: Farnesyl transferase inhibitors block the farnesylation of CENP-E and CENP-F and alter the association of CENP-E with the microtubules. J Biol Chem. 2000, 275: 30451-30457.","journal-title":"J Biol Chem"},{"key":"1170_CR24","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1002\/psc.2478","volume":"19","author":"SA Welner","year":"2013","unstructured":"Welner SA, Trier NH, Houen G, Hansen PR: Identification and mapping of a linear epitope of centromere protein F using monoclonal antibodies. J Pept Sci. 2013, 19: 96-101.","journal-title":"J Pept Sci"},{"key":"1170_CR25","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.autrev.2010.09.025","volume":"10","author":"MJ Fritzler","year":"2011","unstructured":"Fritzler MJ, Rattner JB, Luft LM, Edworthy SM, Casiano CA, Peebles C, Mahler M: Historical perspectives on the discovery and elucidation of autoantibodies to centromere proteins (CENP) and the emerging importance of antibodies to CENP-F. Autoimmun Rev. 2011, 10: 194-200. 10.1016\/j.autrev.2010.09.025","journal-title":"Autoimmun Rev"},{"key":"1170_CR26","first-page":"71","volume":"6","author":"MJ Fritler","year":"2009","unstructured":"Fritler MJ: The clinical paradox of esoteric and novel autoantibodies. Autoantigens, autoantibodies. Autoimmunity. 2009, 6: 71-88.","journal-title":"Autoimmunity"},{"key":"1170_CR27","doi-asserted-by":"publisher","first-page":"1866","DOI":"10.1002\/art.10330","volume":"46","author":"M Mahler","year":"2002","unstructured":"Mahler M, Mierau R, Genth E, Bl\u00fcthner M: Development of a CENP-a\/CENP-B-specific immune response in a patient with systemic sclerosis. Arthritis Rheum. 2002, 46: 1866-1872. 10.1002\/art.10330","journal-title":"Arthritis Rheum"},{"key":"1170_CR28","doi-asserted-by":"publisher","first-page":"2267","DOI":"10.1016\/j.cca.2011.08.024","volume":"412","author":"K Hamdouch","year":"2011","unstructured":"Hamdouch K, Rodr\u00edguez C, P\u00e9rez-Venegas J, Rodr\u00edguez I, Astola A, Ortiz M, Yen TJ, Bennani M, Valdivia MM: Anti-CENPI autoantibodies in scleroderma patients with features of autoimmune liver diseases. Clin Chim Acta. 2011, 412: 2267-2271. 10.1016\/j.cca.2011.08.024","journal-title":"Clin Chim Acta"},{"key":"1170_CR29","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1002\/art.1780390813","volume":"39","author":"JB Rattner","year":"1996","unstructured":"Rattner JB, Rees J, Arnett FC, Reveille JD, Goldstein R, Fritzler MJ: The centromere kinesin-like protein, CENP-E. An autoantigen in systemic sclerosis. Arthritis Rheum. 1996, 39: 1355-1361. 10.1002\/art.1780390813","journal-title":"Arthritis Rheum"},{"key":"1170_CR30","doi-asserted-by":"publisher","first-page":"781","DOI":"10.3899\/jrheum.080726","volume":"36","author":"A Saito","year":"2009","unstructured":"Saito A, Muro Y, Sugiura K, Ikeno M, Yoda K, Tomita Y: CENP-O, a protein localized at the centromere throughout the cell cycle, is a novel target antigen in systemic sclerosis. J Rheumatol. 2009, 36: 781-786. 10.3899\/jrheum.080726","journal-title":"J Rheumatol"},{"key":"1170_CR31","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1007\/s00296-004-0568-4","volume":"26","author":"TC Hsu","year":"2006","unstructured":"Hsu TC, Chang CH, Lin MC, Liu ST, Yen TJ, Tsay GJ: Anti-CENP-H antibodies in patients with Sjogren's syndrome. Rheumatol Int. 2006, 26: 298-303. 10.1007\/s00296-004-0568-4","journal-title":"Rheumatol Int"},{"key":"1170_CR32","first-page":"1419","volume":"25","author":"AL Ford","year":"1998","unstructured":"Ford AL, Kurien BT, Harley JB, Scofield RH: Anti-centromere autoantibody in a patient evolving from a lupus\/Sj\u00f6gren's overlap to the CREST variant of scleroderma. J Rheumatol. 1998, 25: 1419-1424.","journal-title":"J Rheumatol"},{"key":"1170_CR33","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/S0092-8674(00)81683-9","volume":"100","author":"D Hanahan","year":"2000","unstructured":"Hanahan D, Weinberg RA: The hallmarks of cancer. Cell. 2000, 100: 57-70. 10.1016\/S0092-8674(00)81683-9","journal-title":"Cell"},{"key":"1170_CR34","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1038\/sj.cr.7290172","volume":"13","author":"ZY Yang","year":"2003","unstructured":"Yang ZY, Guo J, Li N, Qian M, Wang SN, Zhu XL: Mitosin\/CENP-F is a conserved kinetochore protein subjected to cytoplasmic dynein-mediated poleward transport. Cell Res. 2003, 13: 275-283. 10.1038\/sj.cr.7290172","journal-title":"Cell Res"},{"key":"1170_CR35","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1007\/s00412-006-0049-5","volume":"115","author":"J Feng","year":"2006","unstructured":"Feng J, Huang H, Yen TJ: CENP-F is a novel microtubule-binding protein that is essential for kinetochore attachments and affects the duration of the mitotic checkpoint delay. Chromosoma. 2006, 115: 320-329. 10.1007\/s00412-006-0049-5","journal-title":"Chromosoma"},{"key":"1170_CR36","doi-asserted-by":"publisher","first-page":"3927","DOI":"10.1038\/sj.emboj.7600848","volume":"24","author":"P Bomont","year":"2005","unstructured":"Bomont P, Maddox P, Shah JV, Desai AB, Cleveland DW: Unstable microtubule capture at kinetochores depleted of the centromere-associated protein CENP-F. EMBO J. 2005, 24: 3927-3939. 10.1038\/sj.emboj.7600848","journal-title":"EMBO J"},{"key":"1170_CR37","doi-asserted-by":"publisher","first-page":"4889","DOI":"10.1242\/jcs.02614","volume":"118","author":"SV Holt","year":"2005","unstructured":"Holt SV, Vergnolle MA, Hussein D, Wozniak MJ, Allan VJ, Taylor SS: Silencing cenp-F weakens centromeric cohesion, prevents chromosome alignment and activates the spindle checkpoint. J Cell Sci. 2005, 118: 4889-4900. 10.1242\/jcs.02614","journal-title":"J Cell Sci"},{"key":"1170_CR38","doi-asserted-by":"publisher","first-page":"4062","DOI":"10.1128\/MCB.25.10.4062-4074.2005","volume":"25","author":"Z Yang","year":"2005","unstructured":"Yang Z, Guo J, Chen Q, Ding C, Du J, Zhu X: Silencing mitosin induces misaligned chromosomes, premature chromosome decondensation before anaphase onset, and mitotic cell death. Mol Cell Biol. 2005, 25: 4062-4074. 10.1128\/MCB.25.10.4062-4074.2005","journal-title":"Mol Cell Biol"},{"key":"1170_CR39","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1111\/j.1365-2184.1996.tb00105.x","volume":"29","author":"A B\u00e1ez","year":"1996","unstructured":"B\u00e1ez A, Torres K, Tan EM, Pommier Y, Casiano CA: Expression of proliferation-associated nuclear autoantigens, p330d\/CENP-F and PCNA, in differentiation and in drug-induced growth inhibition using two-parameter flow cytometry. Cell Prolif. 1996, 29: 183-96. 10.1111\/j.1365-2184.1996.tb00105.x","journal-title":"Cell Prolif"},{"key":"1170_CR40","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1186\/1476-4598-9-237","volume":"9","author":"JY Cao","year":"2010","unstructured":"Cao JY, Liu L, Chen SP, Zhang X, Mi YJ, Liu ZG, Li MZ, Zhang H, Qian CN, Shao JY, Fu LW, Xia YF, Zeng MS: Prognostic significance and therapeutic implications of centromere protein F expression in human nasopharyngeal carcinoma. Mol Cancer. 2010, 9: 237- 10.1186\/1476-4598-9-237","journal-title":"Mol Cancer"},{"key":"1170_CR41","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1186\/1471-2407-8-384","volume":"8","author":"S Ueda","year":"2008","unstructured":"Ueda S, Kondoh N, Tsuda H, Yamamoto S, Asakawa H, Fukatsu K, Kobayashi T, Yamamoto J, Tamura K, Ishida J, Abe Y, Yamamoto M, Mochizuki H: Expression of centromere protein F (CENP-F) associated with higher FDG uptake on PET\/CT, detected by cDNA microarray, predicts high-risk patients with primary breast cancer. BMC Cancer. 2008, 8: 384- 10.1186\/1471-2407-8-384","journal-title":"BMC Cancer"},{"key":"1170_CR42","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1002\/(SICI)1097-0320(19960901)25:1<90::AID-CYTO10>3.0.CO;2-P","volume":"25","author":"G Landberg","year":"1996","unstructured":"Landberg G, Erlanson M, Roos G, Tan EM, Casiano CA: Nuclear autoantigen p330d\/CENP-F: a marker for cell proliferation in human malignancies. Cytometry. 1996, 25: 90-98. 10.1002\/(SICI)1097-0320(19960901)25:1<90::AID-CYTO10>3.0.CO;2-P","journal-title":"Cytometry"},{"key":"1170_CR43","first-page":"69","volume":"12","author":"M Erlanson","year":"1999","unstructured":"Erlanson M, Casiano CA, Tan EM, Lindh J, Roos G, Landberg G: Immunohistochemical analysis of the proliferation associated nuclear antigen CENP-F in non-Hodgkin's lymphoma. Mod Pathol. 1999, 12: 69-74.","journal-title":"Mod Pathol"},{"key":"1170_CR44","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1002\/1097-0347(200102)23:2<104::AID-HED1005>3.0.CO;2-0","volume":"23","author":"C de la Guardia","year":"2001","unstructured":"de la Guardia C, Casiano CA, Trinidad-Pinedo J, B\u00e1ez A: CENP-F gene amplification and overexpression in head and neck squamous cell carcinomas. Head Neck. 2001, 23: 104-112. 10.1002\/1097-0347(200102)23:2<104::AID-HED1005>3.0.CO;2-0","journal-title":"Head Neck"},{"key":"1170_CR45","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1111\/j.1440-1827.2004.01596.x","volume":"54","author":"RL Esguerra","year":"2004","unstructured":"Esguerra RL, Jia L, Kaneko T, Sakamoto K, Okada N, Takagi M: Immunohistochemical analysis of centromere protein F expression in buccal and gingival squamous cell carcinoma. Pathol Int. 2004, 54: 82-89. 10.1111\/j.1440-1827.2004.01596.x","journal-title":"Pathol Int"},{"key":"1170_CR46","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1016\/j.oraloncology.2005.03.008","volume":"41","author":"H Shigeishi","year":"2005","unstructured":"Shigeishi H, Mizuta K, Higashikawa K, Yoneda S, Ono S, Kamata N: Correlation of CENP-F gene expression with tumor-proliferating activity in human salivary gland tumors. Oral Oncol. 2005, 41: 716-722. 10.1016\/j.oraloncology.2005.03.008","journal-title":"Oral Oncol"},{"issue":"Suppl 11","key":"1170_CR47","first-page":"27","volume":"12","author":"EM Tan","year":"1994","unstructured":"Tan EM, Muro Y, Pollard KM: Autoantibody-defined epitopes on nuclear antigens are conserved, conformation-dependent and active site regions. Clin Exp Rheumatol. 1994, 12 (Suppl 11): 27-31.","journal-title":"Clin Exp Rheumatol"},{"key":"1170_CR48","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1136\/ard.60.5.433","volume":"60","author":"M Abu-Shakra","year":"2001","unstructured":"Abu-Shakra M, Buskila D, Ehrenfeld M, Conrad K, Shoenfeld Y: Cancer and autoimmunity: autoimmune and rheumatic features in patients with malignancies. Ann Rheum Dis. 2001, 60: 433-41. 10.1136\/ard.60.5.433","journal-title":"Ann Rheum Dis"},{"key":"1170_CR49","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1016\/j.autrev.2008.02.001","volume":"7","author":"V Racanelli","year":"2008","unstructured":"Racanelli V, Prete M, Minoia C, Favoino E, Perosa F: Rheumatic disorders as paraneoplastic syndromes. Autoimmun Rev. 2008, 7: 352-358. 10.1016\/j.autrev.2008.02.001","journal-title":"Autoimmun Rev"},{"key":"1170_CR50","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.canlet.2008.11.009","volume":"281","author":"R Bei","year":"2009","unstructured":"Bei R, Masuelli L, Palumbo C, Modesti M, Modesti A: A common repertoire of autoantibodies is shared by cancer and autoimmune disease patients: inflammation in their induction and impact on tumor growth. Cancer Lett. 2009, 281: 8-23. 10.1016\/j.canlet.2008.11.009","journal-title":"Cancer Lett"},{"key":"1170_CR51","doi-asserted-by":"publisher","first-page":"e30997","DOI":"10.1371\/journal.pone.0030997","volume":"7","author":"NH Heegaard","year":"2012","unstructured":"Heegaard NH, West-N\u00f8rager M, Tanassi JT, Houen G, Nedergaard L, H\u00f8gdall C, H\u00f8gdall E: Circulating antinuclear antibodies in patients with pelvic masses are associated with malignancy and decreased survival. PLoS One. 2012, 7: e30997- 10.1371\/journal.pone.0030997","journal-title":"PLoS One"},{"key":"1170_CR52","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.jaut.2010.06.019","volume":"35","author":"AS Wiik","year":"2010","unstructured":"Wiik AS, H\u00f8ier-Madsen M, Forslid J, Charles P, Meyrowitsch J: Antinuclear antibodies: a contemporary nomenclature using HEp-2 cells. J Autoimmun. 2010, 35: 276-290. 10.1016\/j.jaut.2010.06.019","journal-title":"J Autoimmun"}],"container-title":["Molecular Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1476-4598-12-95.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T01:15:51Z","timestamp":1630545351000},"score":1,"resource":{"primary":{"URL":"https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/1476-4598-12-95"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,26]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["1170"],"URL":"https:\/\/doi.org\/10.1186\/1476-4598-12-95","relation":{},"ISSN":["1476-4598"],"issn-type":[{"value":"1476-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,26]]},"assertion":[{"value":"8 February 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 August 2013","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 August 2013","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"95"}}