{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T10:41:26Z","timestamp":1789900886567,"version":"4.0.1"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Cancer"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1186\/1476-4598-13-169","type":"journal-article","created":{"date-parts":[[2014,7,11]],"date-time":"2014-07-11T11:01:18Z","timestamp":1405076478000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":126,"title":["Exosomal shuttling of miR-126 in endothelial cells modulates adhesive and migratory abilities of chronic myelogenous leukemia cells"],"prefix":"10.1186","volume":"13","author":[{"given":"Simona","family":"Taverna","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Amodeo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Saieva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Russo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Giallombardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"De Leo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Alessandro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,7,11]]},"reference":[{"key":"1370_CR1","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1038\/243290a0","volume":"243","author":"J Rowley","year":"1973","unstructured":"Rowley J: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining. Nature. 1973, 243: 290-293.","journal-title":"Nature"},{"key":"1370_CR2","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1182\/asheducation-2013.1.189","volume":"2013","author":"W Ahmed","year":"2013","unstructured":"Ahmed W, Van Etten RA: Alternative approaches to eradicating the malignant clone in chronic myeloid leukemia: tyrosine-kinase inhibitor combinations and beyond. Hematology Am Soc Hematol Educ Program. 2013, 2013: 189-200.","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"1370_CR3","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1158\/1078-0432.CCR-10-1613","volume":"18","author":"D Cilloni","year":"2012","unstructured":"Cilloni D, Saglio G: Molecular pathways: BCR-ABL. Clin Cancer Res. 2012, 18: 930-937.","journal-title":"Clin Cancer Res"},{"key":"1370_CR4","doi-asserted-by":"publisher","first-page":"5338","DOI":"10.3390\/ijms14035338","volume":"14","author":"C Corrado","year":"2013","unstructured":"Corrado C, Raimondo S, Chiesi A, Ciccia F, De Leo G, Alessandro R: Exosomes as intercellular signaling organelles involved in health and disease: basic science and clinical applications. Int J Mol Sci. 2013, 14: 5338-5366.","journal-title":"Int J Mol Sci"},{"key":"1370_CR5","doi-asserted-by":"publisher","first-page":"e42310","DOI":"10.1371\/journal.pone.0042310","volume":"7","author":"C Corrado","year":"2012","unstructured":"Corrado C, Flugy AM, Taverna S, Raimondo S, Guggino G, Karmali R, De Leo G, Alessandro R: Carboxyamidotriazole-orotate inhibits the growth of imatinib-resistant chronic myeloid leukaemia cells and modulates exosomes-stimulated angiogenesis. PLoS One. 2012, 7: e42310","journal-title":"PLoS One"},{"key":"1370_CR6","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1007\/s10456-011-9241-1","volume":"15","author":"M Mineo","year":"2011","unstructured":"Mineo M, Garfield SH, Taverna S, Flugy A, De Leo G, Alessandro R, Kohn EC: Exosomes released by K562 chronic myeloid leukemia cells promote angiogenesis in a src-dependent fashion. Angiogenesis. 2011, 15: 33-45.","journal-title":"Angiogenesis"},{"key":"1370_CR7","doi-asserted-by":"publisher","first-page":"2033","DOI":"10.1002\/ijc.26217","volume":"130","author":"S Taverna","year":"2011","unstructured":"Taverna S, Flugy A, Saieva L, Kohn EC, Santoro A, Meraviglia S, De Leo G, Alessandro R: Role of exosomes released by chronic myelogenous leukemia cells in angiogenesis. Int J Cancer. 2011, 130: 2033-2043.","journal-title":"Int J Cancer"},{"key":"1370_CR8","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/nrd3625","volume":"11","author":"R Kole","year":"2012","unstructured":"Kole R, Krainer AR, Altman S: RNA therapeutics: beyond RNA interference and antisense oligonucleotides. Nat Rev Drug Discov. 2012, 11: 125-140.","journal-title":"Nat Rev Drug Discov"},{"key":"1370_CR9","doi-asserted-by":"publisher","first-page":"2747","DOI":"10.1038\/onc.2012.295","volume":"32","author":"T Umezu","year":"2013","unstructured":"Umezu T, Ohyashiki K, Kuroda M, Ohyashiki JH: Leukemia cell to endothelial cell communication via exosomal miRNAs. Oncogene. 2013, 32: 2747-2755.","journal-title":"Oncogene"},{"key":"1370_CR10","doi-asserted-by":"publisher","first-page":"34343","DOI":"10.1074\/jbc.M113.480822","volume":"288","author":"H Tadokoro","year":"2013","unstructured":"Tadokoro H, Umezu T, Ohyashiki K, Hirano T, Ohyashiki JH: Exosomes derived from hypoxic leukemia cells enhance tube formation in endothelial cells. J Biol Chem. 2013, 288: 34343-34351.","journal-title":"J Biol Chem"},{"key":"1370_CR11","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.devcel.2008.07.002","volume":"15","author":"S Wang","year":"2008","unstructured":"Wang S, Aurora AB, Johnson BA, Qi X, McAnally J, Hill JA, Richardson JA, Bassel-Duby R, Olson EN: The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis. Dev Cell. 2008, 15: 261-271.","journal-title":"Dev Cell"},{"key":"1370_CR12","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.devcel.2008.07.008","volume":"15","author":"JE Fish","year":"2008","unstructured":"Fish JE, Santoro MM, Morton SU, Yu S, Yeh RF, Wythe JD, Ivey KN, Bruneau BG, Stainier DY: Srivastava D: miR-126 regulates angiogenic signaling and vascular integrity. Dev Cell. 2008, 15: 272-284.","journal-title":"Dev Cell"},{"key":"1370_CR13","doi-asserted-by":"publisher","first-page":"1516","DOI":"10.1073\/pnas.0707493105","volume":"105","author":"TA Harris","year":"2008","unstructured":"Harris TA, Yamakuchi M, Ferlito M, Mendell JT, Lowenstein CJ: MicroRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1. Proc Natl Acad Sci U S A. 2008, 105: 1516-1521.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1370_CR14","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1089\/scd.2010.0263","volume":"20","author":"M Sharma","year":"2011","unstructured":"Sharma M, Afrin F, Satija N, Tripathi RP, Gangenahalli GU: Stromal-derived factor-1\/CXCR4 signaling: indispensable role in homing and engraftment of hematopoietic stem cells in bone marrow. Stem Cells Dev. 2011, 20: 933-946.","journal-title":"Stem Cells Dev"},{"key":"1370_CR15","doi-asserted-by":"publisher","first-page":"2676","DOI":"10.1158\/0008-5472.CAN-04-2152","volume":"65","author":"JF Geay","year":"2005","unstructured":"Geay JF, Buet D, Zhang Y, Foudi A, Jarrier P, Berthebaud M, Turhan AG, Vainchenker W, Louache F: p210BCR-ABL inhibits SDF-1 chemotactic response via alteration of CXCR4 signaling and down-regulation of CXCR4 expression. Cancer Res. 2005, 65: 2676-2683.","journal-title":"Cancer Res"},{"key":"1370_CR16","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1158\/1535-7163.MCT-07-0042","volume":"7","author":"L Jin","year":"2008","unstructured":"Jin L, Tabe Y, Konoplev S, Xu Y, Leysath CE, Lu H, Kimura S, Ohsaka A, Rios MB, Calvert L, Kantarjian H, Andreeff M, Konopleva M: CXCR4 up-regulation by imatinib induces chronic myelogenous leukemia (CML) cell migration to bone marrow stroma and promotes survival of quiescent CML cells. Mol Cancer Ther. 2008, 7: 48-58.","journal-title":"Mol Cancer Ther"},{"key":"1370_CR17","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1084\/jem.188.3.465","volume":"188","author":"IB Mazo","year":"1998","unstructured":"Mazo IB, Gutierrez-Ramos JC, Frenette PS, Hynes RO, Wagner DD, von Andrian UH: Hematopoietic progenitor cell rolling in bone marrow microvessels: parallel contributions by endothelial selectins and vascular cell adhesion molecule 1. J Exp Med. 1998, 188: 465-474.","journal-title":"J Exp Med"},{"key":"1370_CR18","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1182\/blood.V97.2.346","volume":"97","author":"F Sanz-Rodriguez","year":"2001","unstructured":"Sanz-Rodriguez F, Hidalgo A, Teixido J: Chemokine stromal cell-derived factor-1alpha modulates VLA-4 integrin-mediated multiple myeloma cell adhesion to CS-1\/fibronectin and VCAM-1. Blood. 2001, 97: 346-351.","journal-title":"Blood"},{"key":"1370_CR19","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1186\/1471-2407-11-108","volume":"11","author":"C Escrevente","year":"2011","unstructured":"Escrevente C, Keller S, Altevogt P, Costa J: Interaction and uptake of exosomes by ovarian cancer cells. BMC Cancer. 2011, 11: 108","journal-title":"BMC Cancer"},{"key":"1370_CR20","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1111\/j.1600-0854.2010.01041.x","volume":"11","author":"D Feng","year":"2010","unstructured":"Feng D, Zhao WL, Ye YY, Bai XC, Liu RQ, Chang LF, Zhou Q, Sui SF: Cellular internalization of exosomes occurs through phagocytosis. Traffic. 2010, 11: 675-687.","journal-title":"Traffic"},{"key":"1370_CR21","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1038\/ncb1596","volume":"9","author":"H Valadi","year":"2007","unstructured":"Valadi H, Ekstr\u00f6m K, Bossios A, Sj\u00f6strand M, Lee JJ, L\u00f6tvall JO: Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nature Cell Biology. 2007, 9: 654-659.","journal-title":"Nature Cell Biology"},{"key":"1370_CR22","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1126\/science.1153124","volume":"319","author":"K Trajkovic","year":"2008","unstructured":"Trajkovic K, Hsu C, Chiantia S, Rajendran L, Wenzel D, Wieland F, Schwille P, Brugger B, Simons M: Ceramide triggers budding of exosome vesicles into multivesicular endosomes. Science. 2008, 319: 1244-1247.","journal-title":"Science"},{"key":"1370_CR23","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1016\/j.ccr.2012.02.018","volume":"21","author":"B Zhang","year":"2012","unstructured":"Zhang B, Ho YW, Huang Q, Maeda T, Lin A, Lee SU, Hair A, Holyoake TL, Huettner C, Bhatia R: Altered microenvironmental regulation of leukemic and normal stem cells in chronic myelogenous leukemia. Cancer Cell. 2012, 21: 577-592.","journal-title":"Cancer Cell"},{"key":"1370_CR24","doi-asserted-by":"publisher","first-page":"9545","DOI":"10.3390\/ijms13089545","volume":"13","author":"M Castells","year":"2012","unstructured":"Castells M, Thibault B, Delord JP, Couderc B: Implication of tumor microenvironment in chemoresistance: tumor-associated stromal cells protect tumor cells from cell death. Int J Mol Sci. 2012, 13: 9545-9571.","journal-title":"Int J Mol Sci"},{"key":"1370_CR25","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1038\/ncomms1285","volume":"2","author":"M Mittelbrunn","year":"2011","unstructured":"Mittelbrunn M, Gutierrez-Vazquez C, Villarroya-Beltri C, Gonzalez S, Sanchez-Cabo F, Gonzalez MA, Bernad A, Sanchez-Madrid F: Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells. Nat Commun. 2011, 2: 282-","journal-title":"Nat Commun"},{"key":"1370_CR26","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.yexmp.2013.12.004","volume":"96","author":"F Ebrahimi","year":"2014","unstructured":"Ebrahimi F, Gopalan V, Smith RA, Lam AK: miR-126 in human cancers: Clinical roles and current perspectives. Exp Mol Pathol. 2014, 96: 98-107.","journal-title":"Exp Mol Pathol"},{"key":"1370_CR27","doi-asserted-by":"publisher","first-page":"4609","DOI":"10.1128\/MCB.01652-07","volume":"28","author":"WF Shen","year":"2008","unstructured":"Shen WF, Hu YL, Uttarwar L, Passegue E, Largman C: MicroRNA-126 regulates HOXA9 by binding to the homeobox. Mol Cell Biol. 2008, 28: 4609-4619.","journal-title":"Mol Cell Biol"},{"key":"1370_CR28","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1002\/ajh.21667","volume":"85","author":"G Cammarata","year":"2010","unstructured":"Cammarata G, Augugliaro L, Salemi D, Agueli C, La Rosa M, Dagnino L, Civiletto G, Messana F, Marfia A, Bica MG, Cascio L, Floridia PM, Mineo AM, Russo M, Fabbiano F, Santoro A: Differential expression of specific microRNA and their targets in acute myeloid leukemia. Am J Hematol. 2010, 85: 331-339.","journal-title":"Am J Hematol"},{"key":"1370_CR29","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1038\/nature03703","volume":"435","author":"DA Sipkins","year":"2005","unstructured":"Sipkins DA, Wei X, Wu JW, Runnels JM, Cote D, Means TK, Luster AD, Scadden DT, Lin CP: In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment. Nature. 2005, 435: 969-973.","journal-title":"Nature"},{"key":"1370_CR30","doi-asserted-by":"publisher","first-page":"818","DOI":"10.3324\/haematol.2011.056945","volume":"97","author":"O Salvucci","year":"2012","unstructured":"Salvucci O, Jiang K, Gasperini P, Maric D, Zhu J, Sakakibara S, Espigol-Frigole G, Wang S, Tosato G: MicroRNA126 contributes to granulocyte colony-stimulating factor-induced hematopoietic progenitor cell mobilization by reducing the expression of vascular cell adhesion molecule 1. Haematologica. 2012, 97: 818-826.","journal-title":"Haematologica"},{"key":"1370_CR31","doi-asserted-by":"crossref","first-page":"3658","DOI":"10.1182\/blood.V94.11.3658","volume":"94","author":"JA Burger","year":"1999","unstructured":"Burger JA, Burger M, Kipps TJ: Chronic lymphocytic leukemia B cells express functional CXCR4 chemokine receptors that mediate spontaneous migration beneath bone marrow stromal cells. Blood. 1999, 94: 3658-3667.","journal-title":"Blood"},{"key":"1370_CR32","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1016\/j.exphem.2012.05.001","volume":"40","author":"A Zepeda-Moreno","year":"2012","unstructured":"Zepeda-Moreno A, Saffrich R, Walenda T, Hoang VT, Wuchter P, Sanchez-Enriquez S, Corona-Rivera A, Wagner W, Ho AD: Modeling SDF-1-induced mobilization in leukemia cell lines. Exp Hematol. 2012, 40: 666-674.","journal-title":"Exp Hematol"},{"key":"1370_CR33","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1002\/jcp.21290","volume":"215","author":"R Alessandro","year":"2008","unstructured":"Alessandro R, Fontana S, Giordano M, Corrado C, Colomba P, Flugy A, Santoro A, Kohn E, De Leo G: Effects of carboxyamidotriazole on in vitro models of imatinib-resistant chronic myeloid leukemia. J Cell Physiol. 2008, 215: 111-121.","journal-title":"J Cell Physiol"}],"container-title":["Molecular Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1476-4598-13-169.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T22:22:13Z","timestamp":1717021333000},"score":1,"resource":{"primary":{"URL":"https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/1476-4598-13-169"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,11]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["1370"],"URL":"https:\/\/doi.org\/10.1186\/1476-4598-13-169","relation":{},"ISSN":["1476-4598"],"issn-type":[{"value":"1476-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,11]]},"assertion":[{"value":"8 April 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 July 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 July 2014","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"169"}}