{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T23:50:42Z","timestamp":1790898642338,"version":"4.1.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Cancer"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1186\/1476-4598-13-94","type":"journal-article","created":{"date-parts":[[2014,4,28]],"date-time":"2014-04-28T23:02:28Z","timestamp":1398726148000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["The negative interplay between Aurora A\/B and BRCA1\/2 controls cancer cell growth and tumorigenesis via distinct regulation of cell cycle progression, cytokinesis, and tetraploidy"],"prefix":"10.1186","volume":"13","author":[{"given":"Yan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziliang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihao","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingming","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongyu","family":"Zang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,4,28]]},"reference":[{"key":"1308_CR1","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1038\/nrc1526","volume":"5","author":"T Marumoto","year":"2005","unstructured":"Marumoto T, Zhang D, Saya H: Aurora-A - a guardian of poles. Nat Rev Cancer. 2005, 5: 42-50. 10.1038\/nrc1526","journal-title":"Nat Rev Cancer"},{"key":"1308_CR2","doi-asserted-by":"publisher","first-page":"3171","DOI":"10.1158\/1078-0432.CCR-09-3171","volume":"16","author":"G Yang","year":"2010","unstructured":"Yang G, Chang B, Yang F, Guo X, Cai KQ, Xiao XS, Wang H, Sen S, Hung MC, Mills GB, Chang S, Multani AS, Mercado-Uribe I, Liu J: Aurora kinase A promotes ovarian tumorigenesis through dysregulation of the cell cycle and suppression of BRCA2. Clin Cancer Res. 2010, 16: 3171-3181. 10.1158\/1078-0432.CCR-09-3171","journal-title":"Clin Cancer Res"},{"key":"1308_CR3","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1038\/ni1413","volume":"8","author":"J Song","year":"2007","unstructured":"Song J, Salek-Ardakani S, So T, Croft M: The kinases aurora B and mTOR regulate the G1-S cell cycle progression of T lymphocytes. Nat Immunol. 2007, 8: 64-73. 10.1038\/ni1413","journal-title":"Nat Immunol"},{"key":"1308_CR4","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1002\/ijc.28032","volume":"133","author":"G Yang","year":"2013","unstructured":"Yang G, Mercado-Uribe I, Multani AS, Sen S, Shih Ie M, Wong KK, Gershenson DM, Liu J: RAS promotes tumorigenesis through genomic instability induced by imbalanced expression of Aurora-A and BRCA2 in midbody during cytokinesis. Int J Cancer. 2013, 133: 275-285. 10.1002\/ijc.28032","journal-title":"Int J Cancer"},{"key":"1308_CR5","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/j.cell.2008.12.020","volume":"136","author":"P Steigemann","year":"2009","unstructured":"Steigemann P, Wurzenberger C, Schmitz MH, Held M, Guizetti J, Maar S, Gerlich DW: Aurora B-mediated abscission checkpoint protects against tetraploidization. Cell. 2009, 136: 473-484. 10.1016\/j.cell.2008.12.020","journal-title":"Cell"},{"key":"1308_CR6","doi-asserted-by":"publisher","first-page":"5005","DOI":"10.1038\/onc.2012.522","volume":"32","author":"S Shabbeer","year":"2012","unstructured":"Shabbeer S, Omer D, Berneman D, Weitzman O, Alpaugh A, Pietraszkiewicz A, Metsuyanim S, Shainskaya A, Papa MZ, Yarden RI: BRCA1 targets G2\/M cell cycle proteins for ubiquitination and proteasomal degradation. Oncogene. 2012, 32: 5005-5016.","journal-title":"Oncogene"},{"key":"1308_CR7","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1186\/1476-4598-9-50","volume":"9","author":"S Misra","year":"2010","unstructured":"Misra S, Sharma S, Agarwal A, Khedkar SV, Tripathi MK, Mittal MK, Chaudhuri G: Cell cycle-dependent regulation of the bi-directional overlapping promoter of human BRCA2\/ZAR2 genes in breast cancer cells. Mol Cancer. 2010, 9: 50- 10.1186\/1476-4598-9-50","journal-title":"Mol Cancer"},{"key":"1308_CR8","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1038\/35056553","volume":"2","author":"A Schuldt","year":"2001","unstructured":"Schuldt A: Cell cycle. A complex twist for BRCA2. Nat Rev Mol Cell Biol. 2001, 2: 164-","journal-title":"Nat Rev Mol Cell Biol"},{"key":"1308_CR9","doi-asserted-by":"publisher","first-page":"2495","DOI":"10.1002\/ijc.26309","volume":"130","author":"VM Yu","year":"2012","unstructured":"Yu VM, Marion CM, Austria TM, Yeh J, Schonthal AH, Dubeau L: Role of BRCA1 in controlling mitotic arrest in ovarian cystadenoma cells. Int J Cancer. 2012, 130: 2495-2504. 10.1002\/ijc.26309","journal-title":"Int J Cancer"},{"key":"1308_CR10","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/j.ejca.2011.11.008","volume":"48","author":"AB Jonsdottir","year":"2012","unstructured":"Jonsdottir AB, Stefansson OA, Bjornsson J, Jonasson JG, Ogmundsdottir HM, Eyfjord JE: Tetraploidy in BRCA2 breast tumours. Eur J Cancer. 2012, 48: 305-310.","journal-title":"Eur J Cancer"},{"key":"1308_CR11","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1038\/sj.onc.1206195","volume":"22","author":"BP Schlegel","year":"2003","unstructured":"Schlegel BP, Starita LM, Parvin JD: Overexpression of a protein fragment of RNA helicase A causes inhibition of endogenous BRCA1 function and defects in ploidy and cytokinesis in mammary epithelial cells. Oncogene. 2003, 22: 983-991. 10.1038\/sj.onc.1206195","journal-title":"Oncogene"},{"key":"1308_CR12","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1126\/science.1102574","volume":"306","author":"MJ Daniels","year":"2004","unstructured":"Daniels MJ, Wang Y, Lee M, Venkitaraman AR: Abnormal cytokinesis in cells deficient in the breast cancer susceptibility protein BRCA2. Science. 2004, 306: 876-879. 10.1126\/science.1102574","journal-title":"Science"},{"key":"1308_CR13","doi-asserted-by":"publisher","first-page":"19643","DOI":"10.1074\/jbc.M311780200","volume":"279","author":"M Ouchi","year":"2004","unstructured":"Ouchi M, Fujiuchi N, Sasai K, Katayama H, Minamishima YA, Ongusaha PP, Deng C, Sen S, Lee SW, Ouchi T: BRCA1 phosphorylation by Aurora-A in the regulation of G2 to M transition. J Biol Chem. 2004, 279: 19643-19648. 10.1074\/jbc.M311780200","journal-title":"J Biol Chem"},{"key":"1308_CR14","doi-asserted-by":"publisher","first-page":"28943","DOI":"10.1074\/jbc.M600235200","volume":"281","author":"S Shao","year":"2006","unstructured":"Shao S, Wang Y, Jin S, Song Y, Wang X, Fan W, Zhao Z, Fu M, Tong T, Dong L, Fan F, Xu N, Zhan Q: Gadd45a interacts with aurora-A and inhibits its kinase activity. J Biol Chem. 2006, 281: 28943-28950. 10.1074\/jbc.M600235200","journal-title":"J Biol Chem"},{"key":"1308_CR15","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.canlet.2007.07.003","volume":"257","author":"E Sagulenko","year":"2007","unstructured":"Sagulenko E, Savelyeva L, Ehemann V, Sagulenko V, Hofmann W, Arnold K, Claas A, Scherneck S, Schwab M: Suppression of polyploidy by the BRCA2 protein. Cancer Lett. 2007, 257: 65-72. 10.1016\/j.canlet.2007.07.003","journal-title":"Cancer Lett"},{"key":"1308_CR16","doi-asserted-by":"publisher","first-page":"e79117","DOI":"10.1371\/journal.pone.0079117","volume":"8","author":"Z Wang","year":"2013","unstructured":"Wang Z, Hou J, Lu L, Qi Z, Sun J, Gao W, Meng J, Wang Y, Sun H, Gu H, Xin Y, Guo X, Yang G: Small ribosomal protein subunit S7 suppresses ovarian tumorigenesis through regulation of the PI3K\/AKT and MAPK pathways. PLoS One. 2013, 8: e79117- 10.1371\/journal.pone.0079117","journal-title":"PLoS One"},{"key":"1308_CR17","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1093\/jnci\/djq127","volume":"102","author":"G Liu","year":"2010","unstructured":"Liu G, Yang G, Chang B, Mercado-Uribe I, Huang M, Zheng J, Bast RC, Lin SH, Liu J: Stanniocalcin 1 and ovarian tumorigenesis. J Natl Cancer Inst. 2010, 102: 812-827. 10.1093\/jnci\/djq127","journal-title":"J Natl Cancer Inst"},{"key":"1308_CR18","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1158\/1541-7786.MCR-12-0025","volume":"10","author":"YW Kwon","year":"2012","unstructured":"Kwon YW, Kim IJ, Wu D, Lu J, Stock WA, Liu Y, Huang Y, Kang HC, DelRosario R, Jen KY, Perez-Losada J, Wei G, Balmain A, Mao J-H: Pten regulates Aurora-A and cooperates with Fbxw7 in modulating radiation-induced tumor development. Mol Cancer Res. 2012, 10: 834-844. 10.1158\/1541-7786.MCR-12-0025","journal-title":"Mol Cancer Res"},{"key":"1308_CR19","doi-asserted-by":"publisher","first-page":"4059","DOI":"10.4161\/cc.22381","volume":"11","author":"CL Teng","year":"2012","unstructured":"Teng CL, Hsieh YC, Phan L, Shin J, Gully C, Velazquez-Torres G, Skerl S, Yeung SC, Hsu SL, Lee MH: FBXW7 is involved in Aurora B degradation. Cell Cycle. 2012, 11: 4059-4068. 10.4161\/cc.22381","journal-title":"Cell Cycle"},{"key":"1308_CR20","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1002\/path.2458","volume":"217","author":"JL Malone","year":"2009","unstructured":"Malone JL, Nelson AC, Lieberman R, Anderson S, Holt JT: Oestrogen-mediated phosphorylation and stabilization of BRCA2 protein in breast. J Pathol. 2009, 217: 380-388. 10.1002\/path.2458","journal-title":"J Pathol"},{"key":"1308_CR21","first-page":"687","volume":"19","author":"YH Choi","year":"2001","unstructured":"Choi YH: Proteasome-mediated degradation of BRCA1 protein in MCF-7 human breast cancer cells. Int J Oncol. 2001, 19: 687-693.","journal-title":"Int J Oncol"},{"key":"1308_CR22","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.devcel.2012.05.008","volume":"23","author":"G Mondal","year":"2012","unstructured":"Mondal G, Rowley M, Guidugli L, Wu J, Pankratz VS, Couch FJ: BRCA2 localization to the midbody by filamin A regulates cep55 signaling and completion of cytokinesis. Dev Cell. 2012, 23: 137-152. 10.1016\/j.devcel.2012.05.008","journal-title":"Dev Cell"},{"key":"1308_CR23","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1002\/gcc.10105","volume":"35","author":"LV Lotti","year":"2002","unstructured":"Lotti LV, Ottini L, D\u2019Amico C, Gradini R, Cama A, Belleudi F, Frati L, Torrisi MR, Mariani-Costantini R: Subcellular localization of the BRCA1 gene product in mitotic cells. Genes Chromosomes Cancer. 2002, 35: 193-203. 10.1002\/gcc.10105","journal-title":"Genes Chromosomes Cancer"},{"key":"1308_CR24","doi-asserted-by":"publisher","first-page":"2051","DOI":"10.4161\/cc.25100","volume":"12","author":"G Kumari","year":"2013","unstructured":"Kumari G, Ulrich T, Gaubatz S: A role for p38 in transcriptional elongation of p21 (CIP1) in response to Aurora B inhibition. Cell Cycle. 2013, 12: 2051-2060. 10.4161\/cc.25100","journal-title":"Cell Cycle"},{"key":"1308_CR25","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/ng1279","volume":"36","author":"H Katayama","year":"2004","unstructured":"Katayama H, Sasai K, Kawai H, Yuan ZM, Bondaruk J, Suzuki F, Fujii S, Arlinghaus RB, Czerniak BA, Sen S: Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53. Nat Genet. 2004, 36: 55-62. 10.1038\/ng1279","journal-title":"Nat Genet"},{"key":"1308_CR26","doi-asserted-by":"publisher","first-page":"E1513","DOI":"10.1073\/pnas.1110287109","volume":"109","author":"CP Gully","year":"2012","unstructured":"Gully CP, Velazquez-Torres G, Shin JH, Fuentes-Mattei E, Wang E, Carlock C, Chen J, Rothenberg D, Adams HP, Choi HH, Guma S, Phan L, Chou P-C, Su C-H, Zhang F, Chen J-S, Yang T-Y, Yeung S-CJ, Lee M-H: Aurora B kinase phosphorylates and instigates degradation of p53. Proc Natl Acad Sci U S A. 2012, 109: E1513-E1522. 10.1073\/pnas.1110287109","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1308_CR27","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1002\/j.1460-2075.1992.tb05135.x","volume":"11","author":"M Pagano","year":"1992","unstructured":"Pagano M, Pepperkok R, Verde F, Ansorge W, Draetta G: Cyclin A is required at two points in the human cell cycle. EMBO J. 1992, 11: 961-971.","journal-title":"EMBO J"},{"key":"1308_CR28","doi-asserted-by":"publisher","first-page":"2275","DOI":"10.1172\/JCI117918","volume":"95","author":"M Yoshizumi","year":"1995","unstructured":"Yoshizumi M, Lee WS, Hsieh CM, Tsai JC, Li J, Perrella MA, Patterson C, Endege WO, Schlegel R, Lee ME: Disappearance of cyclin A correlates with permanent withdrawal of cardiomyocytes from the cell cycle in human and rat hearts. J Clin Invest. 1995, 95: 2275-2280. 10.1172\/JCI117918","journal-title":"J Clin Invest"},{"key":"1308_CR29","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.yexcr.2010.08.019","volume":"317","author":"U Singh","year":"2011","unstructured":"Singh U, Westermark B: CGGBP1 is a nuclear and midbody protein regulating abscission. Exp Cell Res. 2011, 317: 143-150. 10.1016\/j.yexcr.2010.08.019","journal-title":"Exp Cell Res"},{"key":"1308_CR30","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1158\/0008-5472.CAN-08-2134","volume":"69","author":"S Ryser","year":"2009","unstructured":"Ryser S, Dizin E, Jefford CE, Delaval B, Gagos S, Christodoulidou A, Krause KH, Birnbaum D, Irminger-Finger I: Distinct roles of BARD1 isoforms in mitosis: full-length BARD1 mediates Aurora B degradation, cancer-associated BARD1beta scaffolds Aurora B and BRCA2. Cancer Res. 2009, 69: 1125-1134. 10.1158\/0008-5472.CAN-08-2134","journal-title":"Cancer Res"},{"key":"1308_CR31","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1038\/sj.cdd.4400795","volume":"8","author":"DC Altieri","year":"2001","unstructured":"Altieri DC: Cytokinesis, apoptosis and survivin: three for tango?. Cell Death Differ. 2001, 8: 4-5. 10.1038\/sj.cdd.4400795","journal-title":"Cell Death Differ"},{"key":"1308_CR32","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.molcel.2012.04.029","volume":"47","author":"C Rinaldo","year":"2012","unstructured":"Rinaldo C, Moncada A, Gradi A, Ciuffini L, D\u2019Eliseo D, Siepi F, Prodosmo A, Giorgi A, Pierantoni GM, Trapasso F, Guarguaglini G, Bartolazzi A, Cundari E, Schinin\u00e0 ME, Fusco A, Soddu S: HIPK2 controls cytokinesis and prevents tetraploidization by phosphorylating histone H2B at the midbody. Mol Cell. 2012, 47: 87-98.","journal-title":"Mol Cell"},{"key":"1308_CR33","doi-asserted-by":"publisher","first-page":"5255","DOI":"10.1074\/jbc.M204591200","volume":"278","author":"Y Xia","year":"2003","unstructured":"Xia Y, Pao GM, Chen HW, Verma IM, Hunter T: Enhancement of BRCA1 E3 ubiquitin ligase activity through direct interaction with the BARD1 protein. J Biol Chem. 2003, 278: 5255-5263. 10.1074\/jbc.M204591200","journal-title":"J Biol Chem"},{"key":"1308_CR34","doi-asserted-by":"publisher","first-page":"11186","DOI":"10.1158\/0008-5472.CAN-07-2578","volume":"67","author":"S Sankaran","year":"2007","unstructured":"Sankaran S, Crone DE, Palazzo RE, Parvin JD: Aurora-A kinase regulates breast cancer associated gene 1 inhibition of centrosome-dependent microtubule nucleation. Cancer Res. 2007, 67: 11186-11194. 10.1158\/0008-5472.CAN-07-2578","journal-title":"Cancer Res"}],"container-title":["Molecular Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1476-4598-13-94.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T03:50:53Z","timestamp":1630554653000},"score":1,"resource":{"primary":{"URL":"https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/1476-4598-13-94"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,28]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["1308"],"URL":"https:\/\/doi.org\/10.1186\/1476-4598-13-94","relation":{},"ISSN":["1476-4598"],"issn-type":[{"value":"1476-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,28]]},"assertion":[{"value":"10 September 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 April 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 April 2014","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"94"}}