{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T12:09:47Z","timestamp":1790165387635,"version":"4.1.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Cancer"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Aberrant accumulation of \u03b2-catenin plays an important role in a variety of human neoplasms. We recently reported accumulation of \u03b2-catenin in parathyroid adenomas from patients with primary hyperparathyroidism (pHPT). In <jats:italic>CTNNB1<\/jats:italic> exon 3, we detected a stabilizing mutation (S37A) in 3 out of 20 analyzed adenomas. The aim of the present study was to determine the frequency and zygosity of mutations in <jats:italic>CTNNB1<\/jats:italic> exon 3, and \u03b2-catenin accumulation in a large series of parathyroid adenomas of Swedish patients.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The mutation S37A (TCT &gt; GCT) was detected by direct DNA sequencing of PCR fragments in 6 out of 104 sporadic parathyroid adenomas (5.8%). Taking our previous study into account, a total of 9 out of 124 (7.3%) adenomas displayed the same mutation. The mutations were homozygous by DNA sequencing, restriction enzyme cleavage, and gene copy number determination using the GeneChip 500 K Mapping Array Set. All tumors analyzed by immunohistochemistry, including those with mutation, displayed aberrant \u03b2-catenin accumulation. Western blotting revealed a slightly higher expression level of \u03b2-catenin and nonphosphorylated active \u03b2-catenin in tumors with mutation compared to those without. Presence of the mutation was not related to distinct clinical characteristics.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Aberrant accumulation of \u03b2-catenin is very common in parathyroid tumors, and is caused by stabilizing homozygous mutation in 7.3% of Swedish pHPT patients.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1476-4598-7-53","type":"journal-article","created":{"date-parts":[[2008,6,10]],"date-time":"2008-06-10T06:13:03Z","timestamp":1213078383000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Stabilizing mutation of CTNNB1\/beta-catenin and protein accumulation analyzed in a large series of parathyroid tumors of Swedish patients"],"prefix":"10.1186","volume":"7","author":[{"given":"Peyman","family":"Bj\u00f6rklund","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Lindberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6ran","family":"\u00c5kerstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar","family":"Westin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,6,9]]},"reference":[{"key":"344_CR1","doi-asserted-by":"publisher","first-page":"1863","DOI":"10.1056\/NEJM200012213432508","volume":"343","author":"S Marx","year":"2000","unstructured":"Marx S: Hyperparathyroid and hypoparathyroid disorders. 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