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Gain of short arm of chromosome 5 (5p) is the most frequent karyotypic change in CC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>To examine the role of 5p gain, we performed a combination of single nucleotide polymorphism (SNP) array, fluorescence in situ hybridization (FISH), and gene expression analyses on invasive cancer and in various stages of CC progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The SNP and FISH analyses revealed copy number increase (CNI) of 5p in 63% of invasive CC, which arises at later stages of precancerous lesions in CC development. We integrated chromosome 5 genomic copy number and gene expression data to identify key target over expressed genes as a consequence of 5p gain. One of the candidates identified was Drosha (\n                      <jats:italic>RNASEN<\/jats:italic>\n                      ), a gene that is required in the first step of microRNA (miRNA) processing in the nucleus. Other 5p genes identified as targets of CNI play a role in DNA repair and cell cycle regulation (\n                      <jats:italic>BASP1<\/jats:italic>\n                      ,\n                      <jats:italic>TARS<\/jats:italic>\n                      ,\n                      <jats:italic>PAIP1<\/jats:italic>\n                      ,\n                      <jats:italic>BRD9<\/jats:italic>\n                      ,\n                      <jats:italic>RAD1<\/jats:italic>\n                      ,\n                      <jats:italic>SKP2<\/jats:italic>\n                      , and\n                      <jats:italic>POLS<\/jats:italic>\n                      ), signal transduction (\n                      <jats:italic>OSMR<\/jats:italic>\n                      ), and mitochondrial oxidative phosphorylation (\n                      <jats:italic>NNT<\/jats:italic>\n                      ,\n                      <jats:italic>SDHA<\/jats:italic>\n                      , and\n                      <jats:italic>NDUFS6<\/jats:italic>\n                      ), suggesting that disruption of pathways involving these genes may contribute to CC progression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Taken together, we demonstrate the power of integrating genomics data with expression data in deciphering tumor-related targets of CNI. Identification of 5p gene targets in CC denotes an important step towards biomarker development and forms a framework for testing as molecular therapeutic targets.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/1476-4598-7-58","type":"journal-article","created":{"date-parts":[[2008,6,17]],"date-time":"2008-06-17T14:14:08Z","timestamp":1213712048000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":99,"title":["Integrative genomics analysis of chromosome 5p gain in cervical cancer reveals target over-expressed genes, including Drosha"],"prefix":"10.1186","volume":"7","author":[{"given":"Luigi","family":"Scotto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gopeshwar","family":"Narayan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhadra V","family":"Nandula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivakumar","family":"Subramaniyam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas M","family":"Kaufmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason D","family":"Wright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhavana","family":"Pothuri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahesh","family":"Mansukhani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achim","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo","family":"Arias-Pulido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vundavalli V","family":"Murty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,6,17]]},"reference":[{"key":"349_CR1","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1159\/000056816","volume":"91","author":"NB Atkin","year":"2000","unstructured":"Atkin NB: Significance of chromosome 5 and 17 changes in the development of carcinoma of the cervix uteri. 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