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Using pharmacological and siRNA methodologies we show that increased methylation of histone H3 is a general consequence of SDH loss-of-function in cultured mammalian cells and can be reversed by overexpression of the JMJD3 histone demethylase. ChIP analysis revealed that the core promoter of\n                    <jats:italic>IGFBP7<\/jats:italic>\n                    , which encodes a secreted protein upregulated after loss of\n                    <jats:italic>SDHB<\/jats:italic>\n                    , showed decreased occupancy by H3K27me3 in the absence of\n                    <jats:italic>SDH<\/jats:italic>\n                    . Finally, we provide the first evidence that the chief (type I) cell is the major methylated histone-immunoreactive constituent of paraganglioma. These results support the notion that loss of mitochondrial function alters epigenetic processes and might provide a signature methylation mark for paraganglioma.\n                  <\/jats:p>","DOI":"10.1186\/1476-4598-8-89","type":"journal-article","created":{"date-parts":[[2009,10,23]],"date-time":"2009-10-23T05:37:51Z","timestamp":1256276271000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":146,"title":["Inhibition of succinate dehydrogenase dysregulates histone modification in mammalian cells"],"prefix":"10.1186","volume":"8","author":[{"given":"Ana M","family":"Cervera","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pierre","family":"Bayley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Devilee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth J","family":"McCreath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,10,22]]},"reference":[{"key":"474_CR1","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1126\/science.287.5454.848","volume":"287","author":"BE Baysal","year":"2000","unstructured":"Baysal BE, Ferrell RE, Willet-Brozick JE, Lawrence EC, Myssiorek D, Bosch A, Mey van der A, Taschner PE, Rubinstein WS, Myers EN, Richard CW, Cornelisse CJ, Devile P, Devlin B: Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma. 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