{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:45:49Z","timestamp":1791380749172,"version":"4.3.3"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Cancer"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Because some of heat shock protein 90's (HSP90) clients are key cell cycle regulators, HSP90 inhibition can affect the cell cycle. Recently, celastrol is identified both as a novel inhibitor of HSP90 and as a potential anti-tumor agent. However, this agent's effects on the cell cycle are rarely investigated. In this study, we observed the effects of celastrol on the human monocytic leukemia cell line U937 cell cycle.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Celastrol affected the proliferation of U937 in a dose-dependent way, arresting the cell cycle at G0\/G1 with 400 nM doses and triggering cell death with doses above 1000 nM. Cell cycle arrest was accompanied by inhibition of HSP90 ATPase activity and elevation in HSP70 levels (a biochemical hallmark of HSP90 inhibition), a reduction in Cyclin D1, Cdk4 and Cdk6 levels, and a disruption of the HSP90\/Cdc37\/Cdk4 complex. The observed effects of celastrol on the U937 cell cycle were thiol-related, firstly because the effects could be countered by pre-loading thiol-containing agents and secondly because celastrol and thiol-containing agents could react with each other to form new compounds.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our results disclose a novel action of celastrol-- causing cell cycle arrest at G0\/G1 phase based upon thiol-related HSP90 inhibition. Our work suggests celastrol's potential in tumor and monocyte-related disease management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/1476-4598-9-79","type":"journal-article","created":{"date-parts":[[2010,4,16]],"date-time":"2010-04-16T14:14:21Z","timestamp":1271427261000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":96,"title":["HSP90 inhibitor, celastrol, arrests human monocytic leukemia cell U937 at G0\/G1 in thiol-containing agents reversible way"],"prefix":"10.1186","volume":"9","author":[{"given":"Bin","family":"Peng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanfan","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingxuan","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunxin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georges","family":"Uzan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denghai","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,4,16]]},"reference":[{"key":"594_CR1","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.drup.2008.12.002","volume":"12","author":"Y Li","year":"2009","unstructured":"Li Y, Zhang T, Schwartz SJ, Sun D: New developments in Hsp90 inhibitors as anti-cancer therapeutics: mechanisms, clinical perspective and more potential. Drug Resist Updat. 2009, 12: 17-27. 10.1016\/j.drup.2008.12.002","journal-title":"Drug Resist Updat"},{"key":"594_CR2","doi-asserted-by":"publisher","first-page":"140","DOI":"10.2174\/138955709787316056","volume":"9","author":"MW Amolins","year":"2009","unstructured":"Amolins MW, Blagg BS: Natural product inhibitors of Hsp90: potential leads for drug discovery. Mini Rev Med Chem. 2009, 9: 140-152. 10.2174\/138955709787316056","journal-title":"Mini Rev Med Chem"},{"key":"594_CR3","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.drudis.2007.10.007","volume":"13","author":"DB Solit","year":"2008","unstructured":"Solit DB, Chiosis G: Development and application of Hsp90 inhibitors. Drug Discov Today. 2008, 13: 38-43. 10.1016\/j.drudis.2007.10.007","journal-title":"Drug Discov Today"},{"key":"594_CR4","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1021\/cb600224w","volume":"1","author":"G Chiosis","year":"2006","unstructured":"Chiosis G, Neckers L: Tumor selectivity of Hsp90 inhibitors: the explanation remains elusive. ACS Chem Biol. 2006, 1: 279-284. 10.1021\/cb600224w","journal-title":"ACS Chem Biol"},{"key":"594_CR5","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1007\/s00280-007-0662-x","volume":"62","author":"U Banerji","year":"2008","unstructured":"Banerji U, Sain N, Sharp SY, Valenti M, Asad Y, Ruddle R, Raynaud F, Walton M, Eccles SA, Judson I: An in vitro and in vivo study of the combination of the heat shock protein inhibitor 17-allylamino-17-demethoxygeldanamycin and carboplatin in human ovarian cancer models. Cancer Chemother Pharmacol. 2008, 62: 769-778. 10.1007\/s00280-007-0662-x","journal-title":"Cancer Chemother Pharmacol"},{"key":"594_CR6","doi-asserted-by":"publisher","first-page":"8302","DOI":"10.1158\/1078-0432.CCR-08-1002","volume":"14","author":"DB Solit","year":"2008","unstructured":"Solit DB, Osman I, Polsky D, Panageas KS, Daud A, Goydos JS, Teitcher J, Wolchok JD, Germino FJ, Krown SE: Phase II trial of 17-allylamino-17-demethoxygeldanamycin in patients with metastatic melanoma. Clin Cancer Res. 2008, 14: 8302-8307. 10.1158\/1078-0432.CCR-08-1002","journal-title":"Clin Cancer Res"},{"key":"594_CR7","doi-asserted-by":"publisher","first-page":"6704","DOI":"10.1158\/1078-0432.CCR-08-1006","volume":"14","author":"AN Tse","year":"2008","unstructured":"Tse AN, Klimstra DS, Gonen M, Shah M, Sheikh T, Sikorski R, Carvajal R, Mui J, Tipian C, O'Reilly E: A phase 1 dose-escalation study of irinotecan in combination with 17-allylamino-17-demethoxygeldanamycin in patients with solid tumors. Clin Cancer Res. 2008, 14: 6704-6711. 10.1158\/1078-0432.CCR-08-1006","journal-title":"Clin Cancer Res"},{"key":"594_CR8","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1038\/nrd2590","volume":"7","author":"EM Driggers","year":"2008","unstructured":"Driggers EM, Hale SP, Lee J, Terrett NK: The exploration of macrocycles for drug discovery--an underexploited structural class. Nat Rev Drug Discov. 2008, 7: 608-624. 10.1038\/nrd2590","journal-title":"Nat Rev Drug Discov"},{"key":"594_CR9","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1091\/mbc.E07-10-1004","volume":"19","author":"A Trott","year":"2008","unstructured":"Trott A, West JD, Klaic L, Westerheide SD, Silverman RB, Morimoto RI, Morano KA: Activation of heat shock and antioxidant responses by the natural product celastrol: transcriptional signatures of a thiol-targeted molecule. Mol Biol Cell. 2008, 19: 1104-1112. 10.1091\/mbc.E07-10-1004","journal-title":"Mol Biol Cell"},{"key":"594_CR10","doi-asserted-by":"publisher","first-page":"319","DOI":"10.2478\/s11658-009-0002-8","volume":"14","author":"B Kalmar","year":"2009","unstructured":"Kalmar B, Greensmith L: Activation of the heat shock response in a primary cellular model of motoneuron neurodegeneration-evidence for neuroprotective and neurotoxic effects. Cell Mol Biol Lett. 2009, 14: 319-335. 10.2478\/s11658-009-0002-8","journal-title":"Cell Mol Biol Lett"},{"key":"594_CR11","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.ccr.2006.09.005","volume":"10","author":"H Hieronymus","year":"2006","unstructured":"Hieronymus H, Lamb J, Ross KN, Peng XP, Clement C, Rodina A, Nieto M, Du J, Stegmaier K, Raj SM: Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators. Cancer Cell. 2006, 10: 321-330. 10.1016\/j.ccr.2006.09.005","journal-title":"Cancer Cell"},{"key":"594_CR12","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1158\/1535-7163.MCT-07-0484","volume":"7","author":"T Zhang","year":"2008","unstructured":"Zhang T, Hamza A, Cao X, Wang B, Yu S, Zhan CG, Sun D, Roe SM: A novel H sp90 inhibitor to disrupt Hsp90\/Cdc37 complex against pancreatic cancer cells. Mol Cancer Ther . 2008, 7: 162-170. 10.1158\/1535-7163.MCT-07-0484","journal-title":"Mol Cancer Ther"},{"key":"594_CR13","doi-asserted-by":"publisher","first-page":"1416","DOI":"10.1021\/np030241v","volume":"66","author":"FR Chang","year":"2003","unstructured":"Chang FR, Hayashi K, Chen IH, Liaw CC, Bastow KF, Nakanishi Y, Nozaki H, Cragg GM, Wu YC, Lee KH: Antitumor agents. 228. five new agarofurans, Reissantins A-E, and cytotoxic principles from Reissantia buchananii. J Nat Prod. 2003, 66: 1416-1420. 10.1021\/np030241v","journal-title":"J Nat Prod"},{"key":"594_CR14","doi-asserted-by":"publisher","first-page":"1883","DOI":"10.1271\/bbb.67.1883","volume":"67","author":"M Nagase","year":"2003","unstructured":"Nagase M, Oto J, Sugiyama S, Yube K, Takaishi Y, Sakato N: Apoptosis induction in HL-60 cells and inhibition of topoisomerase II by triterpene celastrol. Biosci Biotechnol Biochem. 2003, 67: 1883-1887. 10.1271\/bbb.67.1883","journal-title":"Biosci Biotechnol Biochem"},{"key":"594_CR15","doi-asserted-by":"publisher","first-page":"4758","DOI":"10.1158\/0008-5472.CAN-05-4529","volume":"66","author":"H Yang","year":"2006","unstructured":"Yang H, Chen D, Cui QC, Yuan X, Dou QP: Celastrol, a triterpene extracted from the Chinese \"Thunder of God Vine, \" is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice. Cancer Res. 2006, 66: 4758-4765. 10.1158\/0008-5472.CAN-05-4529","journal-title":"Cancer Res"},{"key":"594_CR16","doi-asserted-by":"publisher","first-page":"5654","DOI":"10.1182\/blood-2007-11-126003","volume":"111","author":"DC Hassane","year":"2008","unstructured":"Hassane DC, Guzman ML, Corbett C, Li X, Abboud R, Young F, Liesveld JL, Carroll M, Jordan CT: Discovery of agents that eradicate leukemia stem cells using an in silico screen of public gene expression data. Blood. 2008, 111: 5654-5662. 10.1182\/blood-2007-11-126003","journal-title":"Blood"},{"key":"594_CR17","first-page":"3940","volume":"60","author":"M Srethapakdi","year":"2000","unstructured":"Srethapakdi M, Liu F, Tavorath R, Rosen N: Inhibition of Hsp90 function by ansamycins causes retinoblastoma gene product-dependent G1 arrest. Cancer Res. 2000, 60: 3940-3946.","journal-title":"Cancer Res"},{"key":"594_CR18","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1111\/j.1365-2141.2006.06247.x","volume":"135","author":"GV Georgakis","year":"2006","unstructured":"Georgakis GV, Li Y, Younes A: The heat shock protein 90 inhibitor 17-AAG induces cell cycle arrest and apoptosis in mantle cell lymphoma cell lines by depleting cyclin D1, Akt, Bid and activating caspase 9. Br J Haematol. 2006, 135: 68-71. 10.1111\/j.1365-2141.2006.06247.x","journal-title":"Br J Haematol"},{"key":"594_CR19","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1128\/CDLI.8.2.397-401.2001","volume":"8","author":"GM Harrison","year":"2001","unstructured":"Harrison GM, Bennett AJ, Moody M, Read GF, Williams PE: Use of formalin-fixed, propidium iodide-stained human leukocytes as a standard for enumerating CD4+ T lymphocytes in a single-platform assay. Clin Diagn Lab Immunol. 2001, 8: 397-401.","journal-title":"Clin Diagn Lab Immunol"},{"key":"594_CR20","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1002\/cyto.a.20809","volume":"75","author":"FF Cao","year":"2009","unstructured":"Cao FF, Xu LM, Peng B, Xie QH, Uzan G, Zhang DH: A routinely applicable way for using FCM in cell enumeration with CFSE-labeled CellBeads as internal standard. Cytometry A. 2009, 75: 975-978.","journal-title":"Cytometry A"},{"key":"594_CR21","doi-asserted-by":"publisher","first-page":"5853","DOI":"10.1002\/anie.200900929","volume":"48","author":"S Sreeramulu","year":"2009","unstructured":"Sreeramulu S, Gande SL, Gobel M, Schwalbe H: Molecular mechanism of inhibition of the human protein complex Hsp90-Cdc37, a kinome chaperone-cochaperone, by triterpene celastrol. Angew Chem Int Ed Engl. 2009, 48: 5853-5855. 10.1002\/anie.200900929","journal-title":"Angew Chem Int Ed Engl"},{"key":"594_CR22","doi-asserted-by":"publisher","first-page":"2717","DOI":"10.1021\/bi00061a033","volume":"32","author":"JA Ali","year":"1993","unstructured":"Ali JA, Jackson AP, Howells AJ, Maxwell A: The 43-kilodalton N-terminal fragment of the DNA gyrase B protein hydrolyzes ATP and binds coumarin drugs. Biochemistry. 1993, 32: 2717-2724. 10.1021\/bi00061a033","journal-title":"Biochemistry"},{"key":"594_CR23","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1002\/jcp.21565","volume":"217","author":"H Yang","year":"2008","unstructured":"Yang H, Murthy S, Sarkar FH, Sheng S, Reddy GP, Dou QP: Calpain-mediated androgen receptor breakdown in apoptotic prostate cancer cells. J Cell Physiol. 2008, 217: 569-576. 10.1002\/jcp.21565","journal-title":"J Cell Physiol"},{"key":"594_CR24","doi-asserted-by":"publisher","first-page":"2339","DOI":"10.1158\/1535-7163.MCT-09-0133","volume":"8","author":"AI Idris","year":"2009","unstructured":"Idris AI, Libouban H, Nyangoga H, Landao-Bassonga E, Chappard D, Ralston SH: Pharmacologic inhibitors of IkappaB kinase suppress growth and migration of mammary carcinosarcoma cells in vitro and prevent osteolytic bone metastasis in vivo. Mol Cancer Ther. 2009, 8: 2339-2347. 10.1158\/1535-7163.MCT-09-0133","journal-title":"Mol Cancer Ther"},{"key":"594_CR25","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1101\/gad.7.5.812","volume":"7","author":"V Baldin","year":"1993","unstructured":"Baldin V, Lukas J, Marcote MJ, Pagano M, Draetta G: Cyclin D1 is a nuclear protein required for cell cycle progression in G1. Genes Dev. 1993, 7: 812-821. 10.1101\/gad.7.5.812","journal-title":"Genes Dev"},{"key":"594_CR26","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1038\/nm779","volume":"8","author":"M Lazarov","year":"2002","unstructured":"Lazarov M, Kubo Y, Cai T, Dajee M, Tarutani M, Lin Q, Fang M, Tao S, Green CL, Khavari PA: CDK4 coexpression with Ras generates malignant human epidermal tumorigenesis. Nat Med. 2002, 8: 1105-1114. 10.1038\/nm779","journal-title":"Nat Med"},{"key":"594_CR27","doi-asserted-by":"publisher","first-page":"4272","DOI":"10.1016\/j.bmcl.2006.05.065","volume":"16","author":"S Mahale","year":"2006","unstructured":"Mahale S, Aubry C, James Wilson A, Jenkins PR, Marechal JD, Sutcliffe MJ, Chaudhuri B: CA224, a non-planar analogue of fascaplysin, inhibits Cdk4 but not Cdk2 and arrests cells at G0\/G1 inhibiting pRB phosphorylation. Bioorg Med Chem Lett. 2006, 16: 4272-4278. 10.1016\/j.bmcl.2006.05.065","journal-title":"Bioorg Med Chem Lett"},{"key":"594_CR28","doi-asserted-by":"publisher","first-page":"35381","DOI":"10.1074\/jbc.M109.051532","volume":"18","author":"T Zhang","year":"2009","unstructured":"Zhang T, Li Y, Yu Y, Zou P, Jiang Y, Sun D: Characterization of celastrol to inhibit HSP90 and CDC37 interaction. J Biol Chem. 2009, 18: 35381-35389. 10.1074\/jbc.M109.051532.","journal-title":"J Biol Chem"},{"key":"594_CR29","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.ejphar.2009.03.071","volume":"612","author":"Y Kim","year":"2009","unstructured":"Kim Y, Kim K, Lee H, Han S, Lee YS, Choe J, Kim YM, Hahn JH, Ro JY, Jeoung D: Celastrol binds to ERK and inhibits FcepsilonRI signaling to exert an anti-allergic effect. Eur J Pharmacol. 2009, 612: 131-142. 10.1016\/j.ejphar.2009.03.071","journal-title":"Eur J Pharmacol"},{"key":"594_CR30","doi-asserted-by":"publisher","first-page":"20608","DOI":"10.1074\/jbc.271.34.20608","volume":"271","author":"JN Lavoie","year":"1996","unstructured":"Lavoie JN, L'Allemain G, Brunet A, Muller R, Pouyssegur J: Cyclin D1 expression is regulated positively by the p42\/p44MAPK and negatively by the p38\/HOGMAPK pathway. J Biol Chem. 1996, 271: 20608-20616. 10.1074\/jbc.271.34.20608","journal-title":"J Biol Chem"},{"key":"594_CR31","doi-asserted-by":"publisher","first-page":"2690","DOI":"10.1128\/MCB.19.4.2690","volume":"19","author":"M Hinz","year":"1999","unstructured":"Hinz M, Krappmann D, Eichten A, Heder A, Scheidereit C, Strauss M: NF-kappaB function in growth control: regulation of cyclin D1 expression and G0\/G1-to-S-phase transition. Mol Cell Biol. 1999, 19: 2690-2698.","journal-title":"Mol Cell Biol"},{"key":"594_CR32","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1677\/joe.1.06160","volume":"188","author":"BN Friedrichsen","year":"2006","unstructured":"Friedrichsen BN, Neubauer N, Lee YC, Gram VK, Blume N, Petersen JS, Nielsen JH, Moldrup A: Stimulation of pancreatic beta-cell replication by incretins involves transcriptional induction of cyclin D1 via multiple signalling pathways. J Endocrinol. 2006, 188: 481-492. 10.1677\/joe.1.06160","journal-title":"J Endocrinol"},{"key":"594_CR33","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1189\/jlb.1005611","volume":"80","author":"DH Zhang","year":"2006","unstructured":"Zhang DH, Marconi A, Xu LM, Yang CX, Sun GW, Feng XL, Ling CQ, Qin WZ, Uzan G, d'Alessio P: Tripterine inhibits the expression of adhesion molecules in activated endothelial cells. J Leukoc Biol. 2006, 80: 309-319. 10.1189\/jlb.1005611","journal-title":"J Leukoc Biol"},{"key":"594_CR34","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1016\/j.bcp.2006.08.014","volume":"72","author":"JH Lee","year":"2006","unstructured":"Lee JH, Koo TH, Yoon H, Jung HS, Jin HZ, Lee K, Hong YS, Lee JJ: Inhibition of NF-kappa B activation through targeting I kappa B kinase by celastrol, a quinone methide triterpenoid. Biochem Pharmacol. 2006, 72: 1311-1321. 10.1016\/j.bcp.2006.08.014","journal-title":"Biochem Pharmacol"},{"key":"594_CR35","doi-asserted-by":"publisher","first-page":"1883","DOI":"10.1016\/S0960-894X(98)00331-X","volume":"8","author":"FC Huang","year":"1998","unstructured":"Huang FC, Chan WK, Moriarty KJ, Zhang DC, Chang MN, He W, Yu KT, Zilberstein A: Novel cytokine release inhibitors. Part I: Triterpenes. Bioorg Med Chem Lett. 1998, 8: 1883-1886. 10.1016\/S0960-894X(98)00331-X","journal-title":"Bioorg Med Chem Lett"},{"key":"594_CR36","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1111\/j.1349-7006.2005.00038.x","volume":"96","author":"Q Zhang","year":"2005","unstructured":"Zhang Q, Tsukahara F, Maru Y: N-acetyl-cysteine enhances growth in BCR-ABL-transformed cells. Cancer Sci. 2005, 96: 240-244. 10.1111\/j.1349-7006.2005.00038.x","journal-title":"Cancer Sci"},{"key":"594_CR37","doi-asserted-by":"publisher","first-page":"8525","DOI":"10.1073\/pnas.0407294102","volume":"102","author":"A Martinez-Ruiz","year":"2005","unstructured":"Martinez-Ruiz A, Villanueva L, Gonzalez de Orduna C, Lopez-Ferrer D, Higueras MA, Tarin C, Rodriguez-Crespo I, Vazquez J, Lamas S: S-nitrosylation of Hsp90 promotes the inhibition of its ATPase and endothelial nitric oxide synthase regulatory activities. Proc Natl Acad Sci USA. 2005, 102: 8525-8530. 10.1073\/pnas.0407294102","journal-title":"Proc Natl Acad Sci USA"},{"key":"594_CR38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2202-6-1","volume":"6","author":"J Wang","year":"2005","unstructured":"Wang J, Gines S, MacDonald ME, Gusella JF: Reversal of a full-length mutant huntingtin neuronal cell phenotype by chemical inhibitors of polyglutamine-mediated aggregation. BMC Neurosci. 2005, 6: 1- 10.1186\/1471-2202-6-1","journal-title":"BMC Neurosci"},{"key":"594_CR39","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1016\/j.bmcl.2007.12.016","volume":"18","author":"H Morita","year":"2008","unstructured":"Morita H, Hirasawa Y, Muto A, Yoshida T, Sekita S, Shirota O: Antimitotic quinoid triterpenes from Maytenus chuchuhuasca. Bioorg Med Chem Lett. 2008, 18: 1050-1052. 10.1016\/j.bmcl.2007.12.016","journal-title":"Bioorg Med Chem Lett"}],"container-title":["Molecular Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1476-4598-9-79.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:59:30Z","timestamp":1630457970000},"score":1,"resource":{"primary":{"URL":"https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/1476-4598-9-79"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4,16]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["594"],"URL":"https:\/\/doi.org\/10.1186\/1476-4598-9-79","relation":{},"ISSN":["1476-4598"],"issn-type":[{"value":"1476-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,4,16]]},"assertion":[{"value":"23 November 2009","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 April 2010","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 April 2010","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"79"}}