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This study was to determine the correlation between HBV infection and ApoM expression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Serum ApoM levels in patients with HBV infection and in healthy individuals were measured by ELISA, ApoM mRNA expression were determined by RT-PCR, and the expression of S and E proteins of HBV, as well as the synthesis of viral DNA were measured by ELISA and real-time PCR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The levels of serum ApoM was significantly elevated in patients as compared to healthy individuals (<jats:italic>P<\/jats:italic>&lt; 0.001), ApoM promoter activity, mRNA and protein expression were all stimulated in cells transfected with infectious HBV clone. In addition, ApoM decreases the expression of S and E proteins of HBV and the synthesis of viral DNA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Raised ApoM levels in HBV infection may in turn suppress HBV replication, one of the protective mechanisms of nature.<\/jats:p><\/jats:sec>","DOI":"10.1186\/1476-511x-10-154","type":"journal-article","created":{"date-parts":[[2011,8,30]],"date-time":"2011-08-30T06:19:35Z","timestamp":1314685175000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Enchanced levels of apolipoprotein M during HBV infection feedback suppresses HBV replication"],"prefix":"10.1186","volume":"10","author":[{"given":"Jin-Gang","family":"Gu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng-liang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duo-zhi","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2011,8,29]]},"reference":[{"issue":"Suppl 3","key":"539_CR1","doi-asserted-by":"publisher","first-page":"S351","DOI":"10.1111\/j.1872-034X.2007.00251.x","volume":"37","author":"F Akbar","year":"2007","unstructured":"Akbar F, Yoshida O, Abe M, Hiasa Y, Onji M: Engineering immune therapy against hepatitis B virus. 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