{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T22:40:09Z","timestamp":1790980809609,"version":"4.1.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Lipids Health Dis"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Heme oxygenase-1 (HO-1), an antioxidant defense enzyme, has been shown to protect against oxidant-induced liver injury. However, its role on liver fibrosis remains unclear. This study aims to elucidate the effect and the mechanism of HO-1 in nutritional fibrosing steatohepatitis in mice.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Male C57BL\/6J mice were fed with a methionine-choline deficient (MCD) diet for eight weeks to induce hepatic fibrosis. HO-1 chemical inducer (hemin), HO-1 chemical inhibitor zinc protoporphyrin IX (ZnPP-IX) and\/or adenovirus carrying HO-1 gene (Ad-HO-1) were administered to mice, respectively. Liver injury was assessed by serum ALT, AST levels and histological examination; hepatic lipid peroxides levels were determined; the expression levels of several fibrogenic related genes were assayed by real-time quantitative PCR and Western blot.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>MCD feeding mice showed progressive hepatic injury including hepatic steatosis, inflammatory infiltration and fibrosis. Induction of HO-1 by hemin or Ad-HO-1 significantly attenuated the severity of liver injury. This effect was associated with the up-regulation of HO-1, reduction of hepatic lipid peroxides levels, down-regulation of inflammatory factors tumor necrosis factor-alpha, interleukin-6 and suppressor of cytokine signaling-1 as well as the pro-fibrotic genes alpha-smooth muscle actin, transforming growth factor-\u03b21, matrix metallopeptidase-2 and matrix metallopeptidase-9. A contrary effect was observed in mice treated with ZnPP-IX.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>The present study provided the evidence for the protective role of HO-1 in ameliorating MCD diet-induced fibrosing steatohepatitis. Modulation of HO-1 expression might serve as a therapeutic approach for fibrotic steatohepatitis.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1476-511x-10-31","type":"journal-article","created":{"date-parts":[[2011,2,12]],"date-time":"2011-02-12T07:18:27Z","timestamp":1297495107000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Induction of heme oxygenase-1 protects against nutritional fibrosing steatohepatitis in mice"],"prefix":"10.1186","volume":"10","author":[{"given":"Rong Qi","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue Min","family":"Nan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen Juan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling Bo","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su Xian","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,2,12]]},"reference":[{"key":"426_CR1","first-page":"9","volume":"13","author":"P Paschos","year":"2009","unstructured":"Paschos P, Paletas K: Non alcoholic fatty liver disease and metabolic syndrome. Hippokratia. 2009, 13: 9-19.","journal-title":"Hippokratia"},{"key":"426_CR2","first-page":"S17","volume":"40","author":"AJ McCullough","year":"2006","unstructured":"McCullough AJ: Pathophysiology of nonalcoholic steatohepatitis. J Clin Gastroenterol. 2006, 40: S17-S29.","journal-title":"J Clin Gastroenterol"},{"key":"426_CR3","first-page":"S5","volume":"40","author":"JM Clark","year":"2006","unstructured":"Clark JM: The epidemiology of nonalcoholic fatty liver disease in adults. J Clin Gastroenterol. 2006, 40: S5-S10.","journal-title":"J Clin Gastroenterol"},{"key":"426_CR4","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1002\/hep.20683","volume":"41","author":"A Galli","year":"2005","unstructured":"Galli A, Svegliati-Baroni G, Ceni E, Milani S, Ridolfi F, Salzano R, Tarocchi M, Grappone C, Pellegrini G, Benedetti A, Surrenti C, Casini A: Oxidative stress stimulates proliferation and invasiveness of hepatic stellate cells via a MMP2-mediated mechanism. Hepatology. 2005, 41: 1074-1084. 10.1002\/hep.20683","journal-title":"Hepatology"},{"key":"426_CR5","doi-asserted-by":"publisher","first-page":"S58","DOI":"10.1097\/01.ALC.0000078614.44983.97","volume":"27","author":"J Kato","year":"2003","unstructured":"Kato J, Sato Y, Inui N, Nakano Y, Takimoto R, Takada K, Kobune M, Kuroiwa G, Miyake S, Kohgo Y, Niitsu Y: Ethanol induces transforming growth factor-alpha expression in hepatocytes, leading to stimulation of collagen synthesis by hepatic stellate cells. Alcohol Clin Exp Res. 2003, 27: S58-S63. 10.1097\/01.ALC.0000078614.44983.97.","journal-title":"Alcohol Clin Exp Res"},{"key":"426_CR6","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.1002\/hep.21427","volume":"44","author":"N Nieto","year":"2006","unstructured":"Nieto N: Oxidative-stress and IL-6 mediate the fibrogenic effects of rodent Kupffer cells on stellate cells. Hepatology. 2006, 44: 1487-1501. 10.1002\/hep.21427","journal-title":"Hepatology"},{"key":"426_CR7","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1634\/stemcells.19-5-378","volume":"19","author":"DL Krebs","year":"2001","unstructured":"Krebs DL, Hilton DJ: SOCS proteins: negative regulators of cytokine signaling. Stem Cells. 2001, 19: 378-387. 10.1634\/stemcells.19-5-378","journal-title":"Stem Cells"},{"key":"426_CR8","doi-asserted-by":"publisher","first-page":"1701","DOI":"10.1084\/jem.20031675","volume":"199","author":"T Yoshida","year":"2004","unstructured":"Yoshida T, Ogata H, Kamio M, Joo A, Shiraishi H, Tokunaga Y, Sata M, Nagai H, Yoshimura A: SOCS1 is a suppressor of liver fibrosis and hepatitis-induced carcinogenesis. J Exp Med. 2004, 199: 1701-1707. 10.1084\/jem.20031675","journal-title":"J Exp Med"},{"key":"426_CR9","doi-asserted-by":"publisher","first-page":"3009","DOI":"10.3748\/wjg.15.3009","volume":"15","author":"F Wang","year":"2009","unstructured":"Wang F, Duan ZJ, Sun YJ: Influence of heme oxygenase-1 expression on immune liver fibrosis induced by cobalt protoporphyrin in rats. World J Gastroenterol. 2009, 15: 3009-3014. 10.3748\/wjg.15.3009","journal-title":"World J Gastroenterol"},{"key":"426_CR10","doi-asserted-by":"publisher","first-page":"72","DOI":"10.4103\/1319-3767.45072","volume":"15","author":"MH Ismail","year":"2009","unstructured":"Ismail MH, Pinzani M: Reversal of liver fibrosis. Saudi J Gastroenterol. 2009, 15: 72-79. 10.4103\/1319-3767.45072","journal-title":"Saudi J Gastroenterol"},{"key":"426_CR11","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1002\/hep.510300236","volume":"30","author":"N Th\u00e9ret","year":"1999","unstructured":"Th\u00e9ret N, Lehti K, Musso O, Cl\u00e9ment B: MMP2 activation by collagen I and concanavalin A in cultured human hepatic stellate cells. Hepatology. 1999, 30: 462-468.","journal-title":"Hepatology"},{"key":"426_CR12","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1089\/oli.2007.0097","volume":"17","author":"Z Ye","year":"2007","unstructured":"Ye Z, Houssein HS, Mahato RI: Bioconjugation of oligonucleotides for treating liver fibrosis. Oligonucleotides. 2007, 17: 349-404. 10.1089\/oli.2007.0097","journal-title":"Oligonucleotides"},{"key":"426_CR13","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1038\/12319","volume":"6","author":"DJ Schuller","year":"1999","unstructured":"Schuller DJ, Wilks A, Ortiz de Montellano PR, Poulos TL: Crystal structure of human heme oxygenase-1. Nat Struct Biol. 1999, 6: 860-867. 10.1038\/12319","journal-title":"Nat Struct Biol"},{"key":"426_CR14","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1152\/physrev.00011.2005","volume":"86","author":"SW Ryter","year":"2006","unstructured":"Ryter SW, Alam J, Choi AM: Heme oxygenase-1\/carbon monoxide: from basic science to therapeutic applications. Physiol Rev. 2006, 86: 583-650. 10.1152\/physrev.00011.2005","journal-title":"Physiol Rev"},{"key":"426_CR15","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/0378-1119(94)90749-8","volume":"139","author":"WK McCoubrey Jr","year":"1994","unstructured":"McCoubrey WK, Maines MD: The structure, organization and differential expression of the gene encoding rat heme oxygenase-2. Gene. 1994, 139: 155-161. 10.1016\/0378-1119(94)90749-8","journal-title":"Gene"},{"key":"426_CR16","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/S0006-8993(02)03338-3","volume":"954","author":"G Scapagnini","year":"2002","unstructured":"Scapagnini G, D'Agata V, Calabrese V, Pascale A, Colombrita C, Alkon D, Cavallaro S: Gene expression profiles of heme oxygenase isoforms in the rat brain. Brain Res. 2002, 954: 51-59. 10.1016\/S0006-8993(02)03338-3","journal-title":"Brain Res"},{"key":"426_CR17","doi-asserted-by":"publisher","first-page":"479","DOI":"10.5483\/BMBRep.2006.39.5.479","volume":"39","author":"EO Farombi","year":"2006","unstructured":"Farombi EO, Surh YJ: Heme-oxygenase-1 as a potential therapeutic target for hepatoprotection. J Biochem Mol Biol. 2006, 39: 479-491.","journal-title":"J Biochem Mol Biol"},{"key":"426_CR18","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1016\/j.freeradbiomed.2004.11.019","volume":"38","author":"NO Camara","year":"2005","unstructured":"Camara NO, Soares MP: Heme oxygenase-1 (HO-1), a protective gene that prevents chronic graft dysfunction. Free Radic Biol Med. 2005, 38: 426-435. 10.1016\/j.freeradbiomed.2004.11.019","journal-title":"Free Radic Biol Med"},{"key":"426_CR19","doi-asserted-by":"publisher","first-page":"F979","DOI":"10.1152\/ajprenal.00158.2004","volume":"287","author":"JS Neto","year":"2004","unstructured":"Neto JS, Nakao A, Kimizuka K, Romanosky AJ, Stolz DB, Uchiyama T, Nalesnik MA, Otterbein LE, Murase N: Protection of transplant-induced renal ischemia-reperfusion injury with carbon monoxide. Am J Physiol Renal Physiol. 2004, 287: F979-F989. 10.1152\/ajprenal.00158.2004","journal-title":"Am J Physiol Renal Physiol"},{"key":"426_CR20","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1002\/jbt.20177","volume":"21","author":"AJ Lickteig","year":"2007","unstructured":"Lickteig AJ, Fisher CD, Augustine LM, Cherrington NJ: Genes of the antioxidant response undergo upregulation in a rodent model of nonalcoholic steatohepatitis. J Biochem Mol Toxicol. 2007, 21: 216-220. 10.1002\/jbt.20177","journal-title":"J Biochem Mol Toxicol"},{"key":"426_CR21","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1002\/hep.21108","volume":"43","author":"J Yu","year":"2006","unstructured":"Yu J, Ip E, Dela Pe\u00f1a A, Hou JY, Sesha J, Pera N, Hall P, Kirsch R, Leclercq I, Farrell GC: COX-2 induction in mice with experimental nutritional steatohepatitis: Role as pro-inflammatory mediator. Hepatology. 2006, 43: 826-836. 10.1002\/hep.21108","journal-title":"Hepatology"},{"key":"426_CR22","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.cbi.2006.11.003","volume":"165","author":"RL Puntel","year":"2007","unstructured":"Puntel RL, Roos DH, Paix\u00e3o MW, Braga AL, Zeni G, Nogueira CW, Rocha JB: Oxalate modulates thiobarbituric acid reactive species (TBARS) production in supernatants of homogenates from rat brain, liver and kidney: effect of diphenyl diselenide and diphenyl ditelluride. Chem Biol Interact. 2007, 165: 87-98. 10.1016\/j.cbi.2006.11.003","journal-title":"Chem Biol Interact"},{"key":"426_CR23","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1016\/j.biocel.2010.02.006","volume":"42","author":"J Yu","year":"2010","unstructured":"Yu J, Zhang S, Chu ES, Go MY, Lau RH, Zhao J, Wu CW, Tong L, Zhao J, Poon TC, Sung JJ: Peroxisome proliferator-activated receptors gamma reverses hepatic nutritional fibrosis in mice and suppresses activation of hepatic stellate cells in vitro. Int J Biochem Cell Biol. 2010, 42: 948-957. 10.1016\/j.biocel.2010.02.006","journal-title":"Int J Biochem Cell Biol"},{"key":"426_CR24","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1111\/j.1440-1746.2009.05785.x","volume":"24","author":"GC Farrell","year":"2009","unstructured":"Farrell GC, Larter CZ, Hou JY, Zhang RH, Yeh MM, Williams J, dela Pena A, Francisco R, Osvath SR, Brooling J, Teoh N, Sedger LM: Apoptosis in experimental NASH is associated with p53 activation and TRAIL receptor expression. J Gastroenterol Hepatol. 2009, 24: 443-452. 10.1111\/j.1440-1746.2009.05785.x","journal-title":"J Gastroenterol Hepatol"},{"key":"426_CR25","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1002\/path.1284","volume":"199","author":"CL Wei","year":"2003","unstructured":"Wei CL, Lee KH, Khoo HE, Hon WM: Expression of haem oxygenase in cirrhotic rat liver. J Pathol. 2003, 199: 324-334. 10.1002\/path.1284","journal-title":"J Pathol"},{"key":"426_CR26","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1053\/jhep.2002.32467","volume":"35","author":"F Amersi","year":"2002","unstructured":"Amersi F, Shen XD, Anselmo D, Melinek J, Iyer S, Southard DJ, Katori M, Volk HD, Busuttil RW, Buelow R, Kupiec-Weglinski JW: Ex vivo exposure to carbon monoxide prevents hepatic ischemia\/reperfusion injury through p38 MAP kinase pathway. Hepatology. 2002, 35: 815-823. 10.1053\/jhep.2002.32467","journal-title":"Hepatology"},{"key":"426_CR27","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1007\/s11695-007-9087-1","volume":"17","author":"D Garc\u00eda-Galiano","year":"2007","unstructured":"Garc\u00eda-Galiano D, S\u00e1nchez-Garrido MA, Espejo I, Montero JL, Cost\u00e1n G, Marchal T, Membrives A, Gallardo-Valverde JM, Mu\u00f1oz-Casta\u00f1eda JR, Ar\u00e9valo E, De la Mata M, Muntan\u00e9 J: IL-6 and IGF-1 are independent prognostic factors of liver steatosis and non-alcoholic steatohepatitis in morbidly obese patients. Obes Surg. 2007, 17: 493-503.","journal-title":"Obes Surg"},{"key":"426_CR28","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1016\/j.jhep.2006.09.010","volume":"46","author":"N Nieto","year":"2007","unstructured":"Nieto N, Rojkind M: Repeated whiskey binges promote liver injury in rats fed a choline-deficient diet. J Hepatol. 2007, 46: 330-339. 10.1016\/j.jhep.2006.09.010","journal-title":"J Hepatol"},{"key":"426_CR29","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1111\/j.1478-3231.2004.00885.x","volume":"24","author":"HH Ajamieh","year":"2004","unstructured":"Ajamieh HH, Men\u00e9ndez S, Mart\u00ednez-S\u00e1nchez G, Candelario-Jalil E, Re L, Giuliani A, Fern\u00e1ndez OS: Effects of ozone oxidative preconditioning on nitric oxide generation and cellular redox balance in a rat model of hepatic ischaemia-reperfusion. Liver Int. 2004, 24: 55-62. 10.1111\/j.1478-3231.2004.00885.x","journal-title":"Liver Int"},{"key":"426_CR30","doi-asserted-by":"publisher","first-page":"5384","DOI":"10.3748\/wjg.v13.i40.5384","volume":"13","author":"H Xue","year":"2007","unstructured":"Xue H, Guo H, Li YC, Hao ZM: Heme oxygenase-1 induction by hemin protects liver cells from ischemia\/reperfusion injury in cirrhotic rats. World J Gastroenterol. 2007, 13: 5384-5390.","journal-title":"World J Gastroenterol"},{"key":"426_CR31","doi-asserted-by":"publisher","first-page":"607","DOI":"10.3748\/wjg.14.607","volume":"14","author":"ZX Zhao","year":"2008","unstructured":"Zhao ZX, Cai QX, Peng XM, Chong YT, Gao ZL: Expression of SOCS-1 in the liver tissues of chronic hepatitis B and its clinical significance. World J Gastroenterol. 2008, 14: 607-611. 10.3748\/wjg.14.607","journal-title":"World J Gastroenterol"},{"key":"426_CR32","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1124\/jpet.107.135285","volume":"325","author":"DH Kim","year":"2008","unstructured":"Kim DH, Burgess AP, Li M, Tsenovoy PL, Addabbo F, McClung JA, Puri N, Abraham NG: Heme oxygenase-mediated increases in adiponectin decrease fat content and inflammatory cytokines tumor necrosis factor-alpha and interleukin-6 in Zucker rats and reduce adipogenesis in human mesenchymal stem cells. J Pharmacol Exp Ther. 2008, 325: 833-840. 10.1124\/jpet.107.135285","journal-title":"J Pharmacol Exp Ther"},{"key":"426_CR33","doi-asserted-by":"publisher","first-page":"d808","DOI":"10.2741\/reeves","volume":"7","author":"HL Reeves","year":"2002","unstructured":"Reeves HL, Friedman SL: Activation of hepatic stellate cells--a key issue in liver fibrosis. Front Biosci. 2002, 7: d808-d826. 10.2741\/reeves","journal-title":"Front Biosci"},{"key":"426_CR34","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.5858\/2007-131-1728-HSCALF","volume":"131","author":"RK Moreira","year":"2007","unstructured":"Moreira RK: Hepatic stellate cells and liver fibrosis. Arch Pathol Lab Med. 2007, 131: 1728-1734.","journal-title":"Arch Pathol Lab Med"},{"key":"426_CR35","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1002\/hep.22365","volume":"48","author":"K Tomita","year":"2008","unstructured":"Tomita K, Oike Y, Teratani T, Taguchi T, Noguchi M, Suzuki T, Mizutani A, Yokoyama H, Irie R, Sumimoto H, Takayanagi A, Miyashita K, Akao M, Tabata M, Tamiya G, Ohkura T, Hibi T: Hepatic AdipoR2 signaling plays a protective role against progression of nonalcoholic steatohepatitis in mice. Hepatology. 2008, 48: 458-473. 10.1002\/hep.22365","journal-title":"Hepatology"},{"key":"426_CR36","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1016\/S0016-5085(03)00906-5","volume":"125","author":"L Li","year":"2003","unstructured":"Li L, Grenard P, Nhieu JT, Julien B, Mallat A, Habib A, Lotersztajn S: Heme oxygenase-1 is an antifibrogenic protein in human hepatic myofibroblasts. Gastroenterology. 2003, 125: 460-469. 10.1016\/S0016-5085(03)00906-5","journal-title":"Gastroenterology"},{"key":"426_CR37","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1111\/j.1478-3231.2008.01825.x","volume":"28","author":"G Svegliati-Baroni","year":"2008","unstructured":"Svegliati-Baroni G, De Minicis S, Marzioni M: Hepatic fibrogenesis in response to chronic liver injury: novel insights on the role of cell-to-cell interaction and transition. Liver Int. 2008, 28: 1052-1064. 10.1111\/j.1478-3231.2008.01825.x","journal-title":"Liver Int"},{"key":"426_CR38","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1002\/hep.20803","volume":"42","author":"TY Tsui","year":"2005","unstructured":"Tsui TY, Lau CK, Ma J, Wu X, Wang YQ, Farkas S, Xu R, Schlitt HJ, Fan ST: rAAV-mediated stable expression of heme oxygenase-1 in stellate cells: a new approach to attenuate liver fibrosis in rats. Hepatology. 2005, 42: 335-342. 10.1002\/hep.20803","journal-title":"Hepatology"},{"key":"426_CR39","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1080\/10428190500126463","volume":"46","author":"JC Wang","year":"2005","unstructured":"Wang JC: Importance of plasma matrix metalloproteinases (MMP) and tissue inhibitors of metalloproteinase (TIMP) in development of fibrosis in agnogenic myeloid metaplasia. Leuk Lymphoma. 2005, 46: 1261-1268. 10.1080\/10428190500126463","journal-title":"Leuk Lymphoma"},{"key":"426_CR40","doi-asserted-by":"crossref","first-page":"6376","DOI":"10.3748\/wjg.v12.i39.6376","volume":"12","author":"XL Zhang","year":"2006","unstructured":"Zhang XL, Liu JM, Yang CC, Zheng YL, Liu L, Wang ZK, Jiang HQ: Dynamic expression of extracellular signal-regulated kinase in rat liver tissue during hepatic fibrogenesis. World J Gastroenterol. 2006, 12: 6376-6381.","journal-title":"World J Gastroenterol"},{"key":"426_CR41","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.tice.2010.04.004","volume":"42","author":"T Shu","year":"2010","unstructured":"Shu T, Zeng B, Ren X, Li Y: HO-1 modified mesenchymal stem cells modulate MMPs\/TIMPs system and adverse remodeling in infarcted myocardium. Tissue Cell. 2010, 42: 217-222. 10.1016\/j.tice.2010.04.004","journal-title":"Tissue Cell"}],"container-title":["Lipids in Health and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1476-511X-10-31.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T13:16:19Z","timestamp":1630502179000},"score":1,"resource":{"primary":{"URL":"https:\/\/lipidworld.biomedcentral.com\/articles\/10.1186\/1476-511X-10-31"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2,12]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["426"],"URL":"https:\/\/doi.org\/10.1186\/1476-511x-10-31","relation":{},"ISSN":["1476-511X"],"issn-type":[{"value":"1476-511X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2,12]]},"assertion":[{"value":"9 January 2011","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 February 2011","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 February 2011","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"31"}}