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The acute toxicity study was found that flavone (<jats:italic>M.pruriens<\/jats:italic>) and coumarin (<jats:italic>I.suffruticosum<\/jats:italic>) are safe up to 100mg\/kg, so one tenth of this dose (10mg\/kg) was consider as a evaluation dose. High fat diet group of rats showed significant (p&lt;0.001) elevation in plasma total and LDL-cholesterol, triglycerides and phospholipids. Administration of flavone (<jats:italic>M. pruriens<\/jats:italic>) and coumarin isolated from (<jats:italic>I.suffruticosum<\/jats:italic>) at the dose of 10mg\/kg b.wt\/day along with high fat diet significantly (p&lt;0.001) prevented the rise in the plasma total and LDL-cholesterol, triglycerides and phospholipids than that of other extracts. However, treatment of coumarin isolated from (<jats:italic>I.suffruticosum<\/jats:italic>) had showed more cardio protective effect against hyperlipidemia than that of flavone (<jats:italic>M.pruriens<\/jats:italic>)<jats:italic>.<\/jats:italic><\/jats:p>","DOI":"10.1186\/1476-511x-11-126","type":"journal-article","created":{"date-parts":[[2012,10,2]],"date-time":"2012-10-02T14:14:16Z","timestamp":1349187256000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Comparative evaluation of flavone from Mucuna pruriens and coumarin from Ionidium suffruticosum for hypolipidemic activity in rats fed with high Fat diet"],"prefix":"10.1186","volume":"11","author":[{"given":"Satheesh Kumar","family":"Dharmarajan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kottai Muthu","family":"Arumugam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,10,2]]},"reference":[{"key":"772_CR1","doi-asserted-by":"publisher","first-page":"13049","DOI":"10.1016\/S0040-4020(01)89316-9","volume":"50","author":"D Middlemiss","year":"1994","unstructured":"Middlemiss D, Watson SP: A medicinal chemistry case study: an account of an Angiotensin II antagonist drug discovery programme. 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