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We therefore investigated the effect of <jats:italic>Odontella aurita<\/jats:italic>, a microalga rich in EPA, which is already used as a food supplement, on the risk factors for high-fat diet induced metabolic syndrome in rats.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Male Wistar rats were divided into 4 groups and were fed with a standard diet (control); with the standard diet supplemented with 3% freeze-dried <jats:italic>O. aurita<\/jats:italic> (COA); with a high-fat diet (HF); or with the high-fat diet supplemented with 3% of freeze-dried <jats:italic>O. aurita<\/jats:italic> (HFOA) for 7 weeks. In this study we evaluated the impact of these different diets on the risk factors for metabolic syndrome, such as hyperlipidemia, platelet aggregation, thromboxane B<jats:sub>2<\/jats:sub> production, and oxidative stress.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>After 7 weeks of treatment, high fat feeding had increased final body weight, glycemia, triacylglycerol, and total cholesterol levels in plasma and liver compared to the control diet. Collagen-induced platelet aggregation and basal platelet thromboxane B<jats:sub>2<\/jats:sub> were also higher in the high-fat fed rats than in those in the control group. In the liver, oxidative stress was greater in the HF group than in the control group. <jats:italic>O. aurita<\/jats:italic> intake in HFOA-fed rats resulted in lower glycemia and lipid levels in the plasma and liver relative than in the HF group. Thus, in the HFOA group, <jats:italic>n<\/jats:italic>-3 polyunsaturated fatty acid levels in the tissues studied (plasma, liver, and platelets) were higher than in the HF group. Platelet hyper-aggregability tended to decrease in HFOA-fed rats as basal platelet thromboxane B<jats:sub>2<\/jats:sub> production decreased. Finally, <jats:italic>O. aurita<\/jats:italic> reduced oxidative stress in the liver, with lower malondialdehyde levels and increased glutathione peroxidase activity.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>\n              <jats:italic>O. aurita<\/jats:italic> is a marine diatom rich in EPA as well as in other bioactive molecules, such as pigments. The synergistic effect of these microalgal compounds, displayed a beneficial effect in reducing the risk factors for high-fat induced metabolic syndrome: hyperlipidemia, platelet aggregation, and oxidative stress.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1476-511x-11-147","type":"journal-article","created":{"date-parts":[[2012,10,31]],"date-time":"2012-10-31T17:18:36Z","timestamp":1351703916000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":77,"title":["The role of Odontella aurita, a marine diatom rich in EPA, as a dietary supplement in dyslipidemia, platelet function and oxidative stress in high-fat fed rats"],"prefix":"10.1186","volume":"11","author":[{"given":"Adil","family":"Haimeur","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lionel","family":"Ulmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Mimouni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9rique","family":"Gu\u00e9no","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabienne","family":"Pineau-Vincent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Meskini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9rard","family":"Tremblin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,10,31]]},"reference":[{"key":"789_CR1","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/j.patbio.2006.07.002","volume":"54","author":"T Fulop","year":"2006","unstructured":"Fulop T, Tessier D, Carpentier A: The metabolic syndrome. 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