{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:09:37Z","timestamp":1791295777930,"version":"4.1.0"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Lipids Health Dis"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Over the past two decades, a striking increase in the number of people with metabolic syndrome (MS) has taken place worldwide. With the elevated risk of not only diabetes but also cardiovascular morbidity and mortality, there is urgent need for strategies to prevent this emerging global epidemic. The present study was undertaken to investigate the effects of dietary eicosapentaenoic acid-enriched phospholipid (EPA-PL) on metabolic disorders.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Male C57BL\/6J mice (n = 7) were fed one of the following 4 diets for a period of 4 weeks: 1) a modified AIN-96G diet with 5% corn oil (control diet); 2) a high fat (20%, wt\/wt) and high fructose (20%, wt\/wt) diet (HF diet); 3) the HF diet containing 1% SOY-PL (SOY-PL diet); 4) the HF diet containing 1% EPA-PL (EPA-PL diet). The oral glucose tolerance test was performed. Plasma TG, TC, glucose, NEFA, insulin, leptin, adiponectin, TNF-\u03b1 and IL-6 levels were assessed. In addition, hepatic lipid levels, lipogenic, and lipidolytic enzyme activities and gene expressions were evaluated.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Both EPA-PL and SOY-PL significantly inhibited body weight gain and white adipose tissue accumulation, alleviated glucose intolerance, and lowered both serum fasting glucose and NEFA levels substantially. Only EPA-PL significantly reduced serum TNF-\u03b1 and IL-6 levels, and increased serum adiponectin level. EPA-PL was more effective in reducing hepatic and serum TG and TC levels than SOY-PL. Both EPA-PL and SOY-PL reduced the activities of hepatic lipogenic enzymes, such as FAS and G6PDH, but only EPA-PL significantly increased CPT, peroxisomal \u03b2-oxidation enzymes activities and CPT-1a mRNA level. Alterations of hepatic lipogenic gene expressions, such as FAS, G6PDH, ACC, SCD-1 and SREBP-1c were consistent with changes in related enzyme activities.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>According to our study, EPA-PL supplementation was efficacious in suppressing body fat accumulation, and alleviating insulin resistance and hepatic steatosis by modulating the secretion of adipocytokines and inflammatory cytokines, suppression of SREBP-1c mediated lipogenesis and enhancement of fatty acid \u03b2-oxidation. These results demonstrate that EPA-PL is a novel beneficial food component for the prevention and improvement of metabolic disorders.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1476-511x-12-109","type":"journal-article","created":{"date-parts":[[2013,7,23]],"date-time":"2013-07-23T02:14:22Z","timestamp":1374545662000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":124,"title":["Eicosapentaenoic acid-enriched phospholipid ameliorates insulin resistance and lipid metabolism in diet-induced-obese mice"],"prefix":"10.1186","volume":"12","author":[{"given":"Xiaofang","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunhua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoming","family":"Lou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingfeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teruyoshi","family":"Yanagita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changhu","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,7,23]]},"reference":[{"key":"926_CR1","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1038\/nature05487","volume":"444","author":"LF Van Gaal","year":"2006","unstructured":"Van Gaal LF, Mertens IL, De Block CE: Mechanisms linking obesity with cardiovascular disease. Nature. 2006, 444: 875-880. 10.1038\/nature05487","journal-title":"Nature"},{"issue":"5","key":"926_CR2","doi-asserted-by":"crossref","first-page":"1611S","DOI":"10.1093\/ajcn\/65.5.1611S","volume":"65","author":"WS Harris","year":"1997","unstructured":"Harris WS: n-3 fatty acids and serum lipoproteins: animal studies. Am J Clin Nutr. 1997, 65 (5): 1611S-1616S.","journal-title":"Am J Clin Nutr"},{"issue":"1","key":"926_CR3","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.ijcard.2008.03.092","volume":"136","author":"GD Eslick","year":"2009","unstructured":"Eslick GD, Howe PR, Smith C, Priest R, Bensoussan A: Benefits of fish oil supplementation in hyperlipidemia: a systematic review and meta-analysis. Int J Cardiol. 2009, 136 (1): 4-16. 10.1016\/j.ijcard.2008.03.092","journal-title":"Int J Cardiol"},{"key":"926_CR4","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1093\/ajcn\/83.6.1477S","volume":"83","author":"JL Breslow","year":"2006","unstructured":"Breslow JL: n-3 fatty acids ans cardiovascular disease. Am J Clin Nutr. 2006, 83: 1477-1482.","journal-title":"Am J Clin Nutr"},{"issue":"1","key":"926_CR5","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.atherosclerosis.2007.11.008","volume":"197","author":"WS Harris","year":"2008","unstructured":"Harris WS, Miller M, Tighe AP, Davidson MH, Schaefer EJ: Omega-3 fatty acids and coronary heart disease risk: clinical and mechanistic perspectives. Atherosclerosis. 2008, 197 (1): 12-24. 10.1016\/j.atherosclerosis.2007.11.008","journal-title":"Atherosclerosis"},{"issue":"9","key":"926_CR6","doi-asserted-by":"publisher","first-page":"845","DOI":"10.2165\/00003495-200363090-00001","volume":"63","author":"LG Cleland","year":"2003","unstructured":"Cleland LG, James MJ, Proudman SM: The role of fish oils in the treatment of rheumatoid arthritis. Drugs. 2003, 63 (9): 845-853. 10.2165\/00003495-200363090-00001","journal-title":"Drugs"},{"issue":"1","key":"926_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jnutbio.2008.05.016","volume":"20","author":"C Boudrault","year":"2009","unstructured":"Boudrault C, Bazinet RP, Ma DW: Experimental models and mechanisms underlying the protective effects of n-3 polyunsaturated fatty acids in Alzheimer\u2019s disease. J Nutr Biochem. 2009, 20 (1): 1-10. 10.1016\/j.jnutbio.2008.05.016","journal-title":"J Nutr Biochem"},{"key":"926_CR8","first-page":"1461","volume":"8","author":"EFSA","year":"2010","unstructured":", : Scientific opinion on dietary reference values for fats, including saturated fatty acids, polyunsaturated fatty acids, monounsaturated fatty acids, trans fatty acids, and cholesterol. EFSA J. 2010, 8: 1461.","journal-title":"EFSA J"},{"issue":"5","key":"926_CR9","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1007\/s11745-003-1341-0","volume":"38","author":"M Cansell","year":"2003","unstructured":"Cansell M, Nacka F, Combe N: Marine lipid-based liposomes increase in vivo FA bioavailability. Lipids. 2003, 38 (5): 551-559. 10.1007\/s11745-003-1341-0","journal-title":"Lipids"},{"key":"926_CR10","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1016\/S0022-2275(20)34903-8","volume":"40","author":"D Lemaitre-Delaunay","year":"1999","unstructured":"Lemaitre-Delaunay D, Pachiaudi C, Laville M, Pousin J, Armstrong M, Lagarde M: Blood compartmental metabolism of docosahexaenoic acid (DHA) in humans after ingestion of a single dose of [13C]DHA in phosphatidylcholine. J Lipid Res. 1999, 40: 1867-1874.","journal-title":"J Lipid Res"},{"issue":"3","key":"926_CR11","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1097\/MOL.0b013e3282ffaf96","volume":"19","author":"JS Cohn","year":"2008","unstructured":"Cohn JS, Wat E, Kamili A, Tandy S: Dietary phospholipids, hepatic lipid metabolism and cardiovascular. Curr Opin Lipidol. 2008, 19 (3): 257-262. 10.1097\/MOL.0b013e3282ffaf96","journal-title":"Curr Opin Lipidol"},{"issue":"1","key":"926_CR12","doi-asserted-by":"publisher","first-page":"59","DOI":"10.5650\/jos1996.49.59","volume":"49","author":"KTY Morizawa","year":"2000","unstructured":"Morizawa KTY, Tsuchida M, Nakano Y, Hibino H, Tanaka Y: Dietary oils and phospholipids containing n-3 highly unsaturated fatty acids suppress 2, 4-dinitro-1- fluorobenzene-induced contact dermatitis in mice. J Jpn Oil Chem Soc. 2000, 49 (1): 59-65. 10.5650\/jos1996.49.59.","journal-title":"J Jpn Oil Chem Soc"},{"issue":"6","key":"926_CR13","doi-asserted-by":"publisher","first-page":"e38834","DOI":"10.1371\/journal.pone.0038834","volume":"7","author":"M Rossmeisl","year":"2012","unstructured":"Rossmeisl M, Jilkova ZM, Kuda O, Jelenik T, Medrikova D, Stankova B, Kristinsson B, Haraldsson GG, Svensen H, Stoknes I, Sjovall P, Magnusson Y, Balvers MG, Verhoeckx KC, Tvrzicka E, Bryhn M, Kopecky J: Metabolic effects of n-3 PUFA as phospholipids are superior to triglycerides in mice fed a high-fat diet: possible role of endocannabinoids. PLoS One. 2012, 7 (6): e38834- 10.1371\/journal.pone.0038834","journal-title":"PLoS One"},{"issue":"6","key":"926_CR14","doi-asserted-by":"publisher","first-page":"501","DOI":"10.3177\/jnsv.54.501","volume":"54","author":"S Hiratsuka","year":"2008","unstructured":"Hiratsuka S, Ishihara K, Kitagawa T, Wada S, Yokogoshi H: Effect of dietary docosahexaenoic acid connecting phospholipids on the lipid peroxidation of the brain in mice. J Nutr Sci Vitaminol (Tokyo). 2008, 54 (6): 501-506. 10.3177\/jnsv.54.501.","journal-title":"J Nutr Sci Vitaminol (Tokyo)"},{"issue":"4","key":"926_CR15","doi-asserted-by":"publisher","first-page":"374","DOI":"10.3177\/jnsv.55.374","volume":"55","author":"S Hiratsuka","year":"2009","unstructured":"Hiratsuka S, Koizumi K, Ooba T, Yokogoshi H: Effects of dietary docosahexaenoic acid connecting phospholipids on the learning ability and fatty acid composition of the brain. J Nutr Sci Vitaminol (Tokyo). 2009, 55 (4): 374-380. 10.3177\/jnsv.55.374.","journal-title":"J Nutr Sci Vitaminol (Tokyo)"},{"issue":"8","key":"926_CR16","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.3945\/jn.109.104844","volume":"139","author":"B Batetta","year":"2009","unstructured":"Batetta B, Griinari M, Carta G, Murru E, Ligresti A, Cordeddu L, Giordano E, Sanna F, Bisogno T, Uda S, Collu M, Bruheim I, Di Marzo V, Banni S: Endocannabinoids may mediate the ability of (n-3) fatty acids to reduce ectopic fat and inflammatory mediators in obese Zucker rats. J Nutr. 2009, 139 (8): 1495-1501. 10.3945\/jn.109.104844","journal-title":"J Nutr"},{"issue":"4","key":"926_CR17","first-page":"420","volume":"9","author":"R Bunea","year":"2004","unstructured":"Bunea R, El Farrah K, Deutsch L: Evaluation of the effects of Neptune Krill Oil on the clinical course of hyperlipidemia. Altern Med Rev. 2004, 9 (4): 420-428.","journal-title":"Altern Med Rev"},{"key":"926_CR18","unstructured":"Vigerust NF, Bjorndal B, Bohov P, Brattelid T, Svardal A, Berge RK: Krill oil versus fish oil in modulation of inflammation and lipid metabolism in mice transgenic for TNF-alpha. Eur J Nutr. in press."},{"issue":"17","key":"926_CR19","doi-asserted-by":"publisher","first-page":"7170","DOI":"10.1021\/jf071225x","volume":"55","author":"B Shirouchi","year":"2007","unstructured":"Shirouchi B, Nagao K, Inoue N, Ohkubo T, Hibino H, Yanagita T: Effect of dietary omega 3 phosphatidylcholine on obesity-related disorders in obese Otsuka Long-Evans Tokushima fatty rats. J Agric Food Chem. 2007, 55 (17): 7170-7176. 10.1021\/jf071225x","journal-title":"J Agric Food Chem"},{"issue":"1","key":"926_CR20","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1007\/s11745-010-3490-4","volume":"46","author":"SM Ulven","year":"2011","unstructured":"Ulven SM, Kirkhus B, Lamglait A, Basu S, Elind E, Haider T, Berge K, Vik H, Pedersen JI: Metabolic effects of krill oil are essentially similar to those of fish oil but at lower dose of EPA and DHA, in healthy volunteers. Lipids. 2011, 46 (1): 37-46. 10.1007\/s11745-010-3490-4","journal-title":"Lipids"},{"issue":"9","key":"926_CR21","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1016\/j.nutres.2009.09.004","volume":"29","author":"KC Maki","year":"2009","unstructured":"Maki KC, Reeves MS, Farmer M, Griinari M, Berge K, Vik H, Hubacher R, Rains TM: Krill oil supplementation increases plasma concentrations of eicosapentaenoic and docosahexaenoic acids in overweight and obese men and women. Nutr Res. 2009, 29 (9): 609-615. 10.1016\/j.nutres.2009.09.004","journal-title":"Nutr Res"},{"issue":"12","key":"926_CR22","doi-asserted-by":"publisher","first-page":"2588","DOI":"10.1271\/bbb.64.2588","volume":"64","author":"P Hung","year":"2000","unstructured":"Hung P, Gu JY, Kaku S, Yunoki S, Ohkura K, Ikeda I, Tachibana H, Sugano M, Yazawa K: Dietary effects of eicosapentaenoic and docosahexaenoic acid esters on lipid metabolism and immune parameters in Sprague\u2013Dawley rats. Biosci Biotechnol Biochem. 2000, 64 (12): 2588-2593. 10.1271\/bbb.64.2588","journal-title":"Biosci Biotechnol Biochem"},{"issue":"22","key":"926_CR23","doi-asserted-by":"publisher","first-page":"11047","DOI":"10.1021\/jf9026553","volume":"57","author":"N Gotoh","year":"2009","unstructured":"Gotoh N, Nagao K, Onoda S, Shirouchi B, Furuya K, Nagai T, Mizobe H, Ichioka K, Watanabe H, Yanagita T, Wada S: Effects of three different highly purified n-3 series highly unsaturated fatty acids on lipid metabolism in C57BL\/KsJ-db\/db mice. J Agric Food Chem. 2009, 57 (22): 11047-11054. 10.1021\/jf9026553","journal-title":"J Agric Food Chem"},{"key":"926_CR24","doi-asserted-by":"publisher","first-page":"1264","DOI":"10.1161\/01.CIR.102.11.1264","volume":"102","author":"TA Mori","year":"2000","unstructured":"Mori TA, Watts GF, Burke V, Hilme E, Puddey IB, Beilin LJ: Differential effects of eicosapentaenoic acid and docosahexaenoic acid on vascular reactivity of the forearm microcirculation in hyperlipidemic, overweight men. Circulation. 2000, 102: 1264-1269. 10.1161\/01.CIR.102.11.1264","journal-title":"Circulation"},{"issue":"5","key":"926_CR25","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.nut.2007.11.005","volume":"24","author":"S Sierra","year":"2008","unstructured":"Sierra S, Lara-Villoslada F, Comalada M, Olivares M, Xaus J: Dietary eicosapentaenoic acid and docosahexaenoic acid equally incorporate as docosahexaenoic acid but differ in inflammatory effects. Nutrition. 2008, 24 (5): 245-254.","journal-title":"Nutrition"},{"issue":"1","key":"926_CR26","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","volume":"226","author":"J Folch","year":"1957","unstructured":"Folch J, Lees M, Sloane Stanley GH: A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem. 1957, 226 (1): 497-509.","journal-title":"J Biol Chem"},{"issue":"20\u201321","key":"926_CR27","doi-asserted-by":"publisher","first-page":"1815","DOI":"10.1016\/j.jchromb.2009.05.004","volume":"877","author":"M Graeve","year":"2009","unstructured":"Graeve M, Janssen D: Improved separation and quantification of neutral and polar lipid classes by HPLC-ELSD using a monolithic silica phase: application to exceptional marine lipids. J Chromatogr B. 2009, 877 (20\u201321): 1815-1819.","journal-title":"J Chromatogr B"},{"issue":"3","key":"926_CR28","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1111\/j.1745-4514.2011.00544.x","volume":"36","author":"QM Lou","year":"2012","unstructured":"Lou QM, Wang YM, Liu XF, Xue CH: Lipid profile and fatty acid compositions in body wall of Apostichopus Japonicus (Selenka). J Food Biochem. 2012, 36 (3): 317-321. 10.1111\/j.1745-4514.2011.00544.x.","journal-title":"J Food Biochem"},{"key":"926_CR29","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/S0021-9258(18)70226-3","volume":"234","author":"GR Bartlett","year":"1959","unstructured":"Bartlett GR: Phosphorous assay in column chromatography. J Biol Chem. 1959, 234: 466-468.","journal-title":"J Biol Chem"},{"key":"926_CR30","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","volume":"193","author":"OH Lowry","year":"1951","unstructured":"Lowry OH, Rosebrough NJ, Farr AL, Randall RJ: Protein measurement with the Folin phenol reagent. J Biol Chem. 1951, 193: 265-275.","journal-title":"J Biol Chem"},{"issue":"1","key":"926_CR31","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1042\/bj2350087","volume":"235","author":"DS Kelley","year":"1986","unstructured":"Kelley DS, Nelson GJ, Hunt JE: Effect of prior nutritional status on the activity of lipogenic enzymes in primary monolayer cultures of rat hepatocytes. Biochem J. 1986, 235 (1): 87-90.","journal-title":"Biochem J"},{"issue":"2","key":"926_CR32","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1042\/bj2170543","volume":"217","author":"DS Kelly","year":"1984","unstructured":"Kelly DS, Kletzien RF: Ethanol modulation of the hormonal and nutritional regulation of glucose 6-phosphate dehydrogenase activity in primary cultures of rat hepatocytes. Biochem J. 1984, 217 (2): 543-549.","journal-title":"Biochem J"},{"key":"926_CR33","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/0076-6879(55)01129-4","volume-title":"Methods in Enzymology","author":"S Ochoa","year":"1955","unstructured":"Ochoa S: Malic enzyme. Methods in Enzymology. Edited by: Colowick SP, Kaplan NO. 1955, 1: 739-753. New York, NY: Academic Press."},{"key":"926_CR34","doi-asserted-by":"crossref","first-page":"3426","DOI":"10.1016\/S0021-9258(19)43946-X","volume":"248","author":"MA Markwell","year":"1973","unstructured":"Markwell MA, McGroarty EJ, Bieber LL, Tolbert NE: The subcellular distribution of carnitine acyltransferase in mammalian liver and kidney A new peroxisomal enzyme. J Biol Chem. 1973, 248: 3426-3432.","journal-title":"J Biol Chem"},{"key":"926_CR35","first-page":"315","volume-title":"Methods in Enzymology","author":"PB Lazarow","year":"1981","unstructured":"Lazarow PB: Assay of Peroxisomal \u03b2-oxidation of fatty acids. Methods in Enzymology. Edited by: Lowenstein JM. 1981, 315-319. New York, NY: Academic Press."},{"key":"926_CR36","doi-asserted-by":"publisher","first-page":"2735","DOI":"10.1161\/CIRCULATIONAHA.105.169404","volume":"112","author":"SM Grundy","year":"2005","unstructured":"Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, Gordon DJ, Krauss RM, Savage PJ, Smith SC, Spertus JA, Costa F: Diagnosis and management of the metabolic syndrome: an American Heart Association\/National Heart, Lung, and Blood Institute Scientific Statement. Circulation. 2005, 112: 2735-2752. 10.1161\/CIRCULATIONAHA.105.169404","journal-title":"Circulation"},{"issue":"3","key":"926_CR37","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1097\/00041433-199306000-00004","volume":"4","author":"KN Frayn","year":"1993","unstructured":"Frayn KN: Insulin resistance and lipid metabolism. Curr Opin Lipidol. 1993, 4 (3): 197-204. 10.1097\/00041433-199306000-00004. 10.1097\/00041433-199306000-00004","journal-title":"Curr Opin Lipidol"},{"issue":"8","key":"926_CR38","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.2337\/diab.37.8.1020","volume":"37","author":"GM Reaven","year":"1988","unstructured":"Reaven GM, Hollenbeck C, Jeng CY, Wu MS, Chen YD: Measurement of plasma glucose, free fatty acid, lactate, and insulin for 24 h in patients with NIDDM. Diabetes. 1988, 37 (8): 1020-1024. 10.2337\/diabetes.37.8.1020","journal-title":"Diabetes"},{"issue":"2","key":"926_CR39","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1038\/nri2921","volume":"11","author":"N Ouchi","year":"2011","unstructured":"Ouchi N, Parker JL, Lugus JJ, Walsh K: Adipokines in inflammation and metabolic disease. Nat Rev Immunol. 2011, 11 (2): 85-97. 10.1038\/nri2921","journal-title":"Nat Rev Immunol"},{"issue":"10","key":"926_CR40","doi-asserted-by":"publisher","first-page":"2137","DOI":"10.1016\/j.biochi.2012.06.008","volume":"94","author":"K Ohashi","year":"2012","unstructured":"Ohashi K, Ouchi N, Matsuzawa Y: Anti-inflammatory and anti-atherogenic properties of adiponectin. Biochimie. 2012, 94 (10): 2137-2142. 10.1016\/j.biochi.2012.06.008","journal-title":"Biochimie"},{"issue":"19","key":"926_CR41","doi-asserted-by":"publisher","first-page":"9339","DOI":"10.1021\/jf9016042","volume":"57","author":"S Tandy","year":"2009","unstructured":"Tandy S, Chung RWS, Wat E, Kamili A, Berge K, Griinari M, Cohn JS: Dietary krill oil supplementation reduces hepatic steatosis, glycemia, and hypercholesterolemia in high-fat-fed mice. J Agric Food Chem. 2009, 57 (19): 9339-9345. 10.1021\/jf9016042","journal-title":"J Agric Food Chem"},{"issue":"S11","key":"926_CR42","doi-asserted-by":"publisher","first-page":"263S","DOI":"10.1038\/oby.2001.129","volume":"9","author":"JE Blundell","year":"2001","unstructured":"Blundell JE, Gillett A: Control of food intake in the obese. Obes Res. 2001, 9 (S11): 263S-270S.","journal-title":"Obes Res"},{"issue":"1","key":"926_CR43","doi-asserted-by":"crossref","first-page":"343S","DOI":"10.1093\/ajcn\/71.1.343s","volume":"71","author":"MJ James","year":"2000","unstructured":"James MJ, Gibson RA, Cleland LG: Dietary polyunsaturated fatty acids and inflammatory mediator production. Am J Clin Nutr. 2000, 71 (1): 343S-348S.","journal-title":"Am J Clin Nutr"},{"key":"926_CR44","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1038\/sj.ijo.0803309","volume":"30","author":"JD Krebs","year":"2006","unstructured":"Krebs JD, Browning LM, McLean NK, Rothwell JL, Mishra GD, Moore CS, Jebb SA: Additive benefits of long chain n-3 polyunsaturated fatty acids and weight-loss in the management of cardiovascular disease risk in overweight hyperinsulinemic women. Int J Obes (Lond). 2006, 30: 1535-1544. 10.1038\/sj.ijo.0803309.","journal-title":"Int J Obes (Lond)"},{"issue":"6","key":"926_CR45","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1016\/j.bbi.2012.05.011","volume":"26","author":"JK Kiecolt-Glaser","year":"2012","unstructured":"Kiecolt-Glaser JK, Belury MA, Andridge R, Malarkey WB, Hwang BS, Glaser R: Omega-3 supplementation lowers inflammation in healthy middle-aged and older adults: a randomized controlled trial. Brain Behav Immun. 2012, 26 (6): 988-995. 10.1016\/j.bbi.2012.05.011","journal-title":"Brain Behav Immun"},{"issue":"11","key":"926_CR46","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1093\/jn\/135.11.2503","volume":"135","author":"DB Jump","year":"2005","unstructured":"Jump DB, Botolin D, Wang Y, Xu J, Christian B, Demeure O: Fatty acid regulation of hepatic gene transcription. J Nutr. 2005, 135 (11): 2503-2506.","journal-title":"J Nutr"},{"issue":"2","key":"926_CR47","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1007\/BF02522617","volume":"31","author":"L Froyland","year":"1996","unstructured":"Froyland L, Vaagenes H, Asiedu DK, Garras A, Lie O, Berge RK: Chronic administration of eicosapentaenoic acid and docosahexaenoic acid as ethyl ester reduced plasma cholesterol and changed the fatty acid composition in rat blood and organs. Lipids. 1996, 31 (2): 169-178. 10.1007\/BF02522617","journal-title":"Lipids"},{"issue":"21","key":"926_CR48","doi-asserted-by":"publisher","first-page":"2563","DOI":"10.1016\/S0024-3205(00)00840-7","volume":"67","author":"E Polichetti","year":"2000","unstructured":"Polichetti E, Janisson A, de la Porte PL, Portugal H, Leonardi J, Luna A, La Droitte P, Chanussot F: Dietary polyenylphosphatidylcholine decreases cholesterolemia in hypercholesterolemic rabbits: role of the hepato-biliary axis. Life Sci. 2000, 67 (21): 2563-2576. 10.1016\/S0024-3205(00)00840-7","journal-title":"Life Sci"}],"container-title":["Lipids in Health and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1476-511X-12-109.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T19:14:35Z","timestamp":1630610075000},"score":1,"resource":{"primary":{"URL":"https:\/\/lipidworld.biomedcentral.com\/articles\/10.1186\/1476-511X-12-109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,23]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["926"],"URL":"https:\/\/doi.org\/10.1186\/1476-511x-12-109","relation":{},"ISSN":["1476-511X"],"issn-type":[{"value":"1476-511X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,23]]},"assertion":[{"value":"8 May 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 July 2013","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 July 2013","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"109"}}