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The fruiting body of <jats:italic>Panellus serotinus<\/jats:italic> (Mukitake) is recognized in Japan as one of the most delicious edible mushrooms, and previous studies have demonstrated that the dietary intake of powdered whole Mukitake or Mukitake extracts prevents the development of non-alcoholic fatty liver disease (NAFLD) in leptin-resistant <jats:italic>db\/db<\/jats:italic> mice. In the present study, we evaluated the effect of the Mukitake diet on the pathogenesis of metabolic disorders in leptin-deficient <jats:italic>ob\/ob<\/jats:italic> mice.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>After 4 weeks of feeding, hepatomegaly, hepatic lipid accumulation, and elevated hepatic injury markers in the serum were markedly alleviated in Mukitake-fed <jats:italic>ob\/ob<\/jats:italic> mice compared with control mice. Moreover, the mild hyperlipidemia in control <jats:italic>ob\/ob<\/jats:italic> mice was attenuated and the elevated atherogenic index was reduced in Mukitake-fed <jats:italic>ob\/ob<\/jats:italic> mice. These effects were partly attributable to the suppression of hepatic lipogenic enzyme activity due to the Mukitake diet.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>The current results showed that Mukitake supplementation is beneficial for the alleviation of NAFLD and dyslipidemia in obese, diabetic <jats:italic>ob\/ob<\/jats:italic> mice.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1476-511x-12-18","type":"journal-article","created":{"date-parts":[[2013,2,14]],"date-time":"2013-02-14T07:14:06Z","timestamp":1360826046000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Effect of Mukitake mushroom (Panellus serotinus) on the pathogenesis of lipid abnormalities in obese, diabetic ob\/ob mice"],"prefix":"10.1186","volume":"12","author":[{"given":"Nao","family":"Inoue","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Inafuku","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bungo","family":"Shirouchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Nagao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teruyoshi","family":"Yanagita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,2,14]]},"reference":[{"key":"830_CR1","doi-asserted-by":"publisher","first-page":"S91","DOI":"10.1111\/j.1753-4887.1996.tb03825.x","volume":"54","author":"R Chang","year":"1996","unstructured":"Chang R: Functional properties of edible mushrooms. 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