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In this study, we report the effects of krill powder, which contains proteins (34%) in addition to krill oil (61.8%), on these two parameters. We submitted 11 obese men (average BMI of 32.3 kg\/m<jats:sup>2<\/jats:sup>, age of 42.6 years and plasma triglycerides of 192.5\u2009\u00b1\u200996.3 mg\/dl) to a 24 week dietary supplementation with krill powder (4 g\/day <jats:italic>per os<\/jats:italic>) and measured anthropometric and metabolic parameters, as well as blood endocannabinoid (anandamide and 2-arachidonoylglycerol) and esterified DHA and EPA levels. Six subjects were included as control subjects and not given any supplements. The treatment produced, after 12 and 24 weeks, a significant increase in DHA and EPA in total plasma, a 59 and 84% decrease in anandamide plasma levels, and a 22.5 and 20.6% decrease in triglyceride levels, respectively. There was also a significant decrease in waist\/hip ratio and visceral fat\/skeletal muscle mass ratio at 24 weeks, but no change in body weight. These data confirm that dietary krill powder reduces peripheral endocannabinoid overactivity in obese subjects, and might ameliorate some parameters of the metabolic syndrome.<\/jats:p>","DOI":"10.1186\/1476-511x-12-78","type":"journal-article","created":{"date-parts":[[2013,5,27]],"date-time":"2013-05-27T06:14:26Z","timestamp":1369635266000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["Chronic treatment with krill powder reduces plasma triglyceride and anandamide levels in mildly obese men"],"prefix":"10.1186","volume":"12","author":[{"given":"Kjetil","family":"Berge","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana","family":"Piscitelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils","family":"Hoem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristoforo","family":"Silvestri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingo","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastiano","family":"Banni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Di Marzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,5,27]]},"reference":[{"key":"895_CR1","volume-title":"Cell Metab","author":"C Silvestri","year":"2013","unstructured":"Silvestri C, Di Marzo V: The endocannabinoid system in energy homeostasis and the aetiopathology of metabolic disorders. 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