{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T00:00:55Z","timestamp":1793318455783,"version":"4.5.0"},"reference-count":76,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Lipids Health Dis"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1186\/1476-511x-13-134","type":"journal-article","created":{"date-parts":[[2014,8,21]],"date-time":"2014-08-21T03:02:16Z","timestamp":1408590136000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Notable epigenetic role of hyperhomocysteinemia in atherogenesis"],"prefix":"10.1186","volume":"13","author":[{"given":"Shuyu","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhizhong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gelin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,8,21]]},"reference":[{"key":"1122_CR1","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1101\/gad.1787609","volume":"23","author":"SL Berger","year":"2009","unstructured":"Berger SL, Kouzarides T, Shiekhattar R, Shilatifard A: An operational definition of epigenetics. Genes Dev. 2009, 23: 781-783.","journal-title":"Genes Dev"},{"key":"1122_CR2","doi-asserted-by":"crossref","first-page":"4059","DOI":"10.1182\/blood.V93.12.4059","volume":"93","author":"R Singal","year":"1999","unstructured":"Singal R, Ginder GD: DNA methylation. Blood. 1999, 93: 4059-4070.","journal-title":"Blood"},{"key":"1122_CR3","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1038\/321209a0","volume":"321","author":"AP Bird","year":"1985","unstructured":"Bird AP: CpG-rich islands and the function of DNA methylation. Nature. 1985, 321: 209-213.","journal-title":"Nature"},{"key":"1122_CR4","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1038\/ng.174","volume":"40","author":"K Kerkel","year":"2008","unstructured":"Kerkel K, Spadola A, Yuan E, Kosek J, Jiang L, Hod E, Li K, Murty VV, Schupf N, Vilain E: Genomic surveys by methylation-sensitive SNP analysis identify sequence-dependent allele-specific DNA methylation. Nat Genet. 2008, 40: 904-908.","journal-title":"Nat Genet"},{"key":"1122_CR5","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1101\/gr.104695.109","volume":"20","author":"R Shoemaker","year":"2010","unstructured":"Shoemaker R, Deng J, Wang W, Zhang K: Allele-specific methylation is prevalent and is contributed by CpG-SNPs in the human genome. Genome Res. 2010, 20: 883-889.","journal-title":"Genome Res"},{"key":"1122_CR6","doi-asserted-by":"publisher","first-page":"R10","DOI":"10.1186\/gb-2011-12-1-r10","volume":"12","author":"JT Bell","year":"2011","unstructured":"Bell JT, Pai AA, Pickrell JK, Gaffney DJ, Pique-Regi R, Degner JF, Gilad Y, Pritchard JK: DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines. Genome Biol. 2011, 12: R10-","journal-title":"Genome Biol"},{"key":"1122_CR7","doi-asserted-by":"publisher","first-page":"802","DOI":"10.4161\/epi.25501","volume":"8","author":"DK Arnett","year":"2013","unstructured":"Arnett DK: SNPs located at CpG sites modulate genome-epigenome interaction. Epigenetics. 2013, 8: 802-806.","journal-title":"Epigenetics"},{"key":"1122_CR8","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1097\/MOL.0000000000000059","volume":"25","author":"S Zaina","year":"2014","unstructured":"Zaina S: Unraveling the DNA methylome of atherosclerosis. Curr Opin Lipidol. 2014, 25: 148-153.","journal-title":"Curr Opin Lipidol"},{"key":"1122_CR9","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1054\/mehy.1998.0794","volume":"53","author":"P Newman","year":"1999","unstructured":"Newman P: Can reduced folic acid and vitamin B12 levels cause deficient DNA methylation producing mutations which initiate atherosclerosis?. Med Hypotheses. 1999, 53: 421-424.","journal-title":"Med Hypotheses"},{"key":"1122_CR10","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1097\/MOL.0b013e3283654e7c","volume":"24","author":"LM Holdt","year":"2013","unstructured":"Holdt LM, Teupser D: From genotype to phenotype in human atherosclerosis-recent findings. Curr Opin Lipidol. 2013, 24: 410-","journal-title":"Curr Opin Lipidol"},{"key":"1122_CR11","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1124\/pr.54.4.599","volume":"54","author":"A De Bree","year":"2002","unstructured":"De Bree A, Verschuren WM, Kromhout D, Kluijtmans L, Blom HJ: Homocysteine determinants and the evidence to what extent homocysteine determines the risk of coronary heart disease. Pharmacol Rev. 2002, 54: 599-618.","journal-title":"Pharmacol Rev"},{"key":"1122_CR12","doi-asserted-by":"publisher","first-page":"2015","DOI":"10.1001\/jama.288.16.2015","volume":"288","author":"HS Collaboration","year":"2002","unstructured":"Collaboration HS: Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis. JAMA. 2002, 288: 2015-2022.","journal-title":"JAMA"},{"key":"1122_CR13","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1136\/bmj.325.7374.1202","volume":"325","author":"DS Wald","year":"2002","unstructured":"Wald DS, Law M, Morris JK: Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis. BMJ. 2002, 325: 1202-","journal-title":"BMJ"},{"key":"1122_CR14","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1056\/NEJM199804093381507","volume":"338","author":"FH Epstein","year":"1998","unstructured":"Epstein FH, Welch GN, Loscalzo J: Homocysteine and atherothrombosis. N Engl J Med. 1998, 338: 1042-1050.","journal-title":"N Engl J Med"},{"key":"1122_CR15","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1097\/00043798-199808000-00006","volume":"5","author":"TB Domagala","year":"1998","unstructured":"Domagala TB, Undas A, Libura M, Szczeklik A: Pathogenesis of vascular disease in hyperhomocysteinaemia. J Cardiovasc Risk. 1998, 5: 239-247.","journal-title":"J Cardiovasc Risk"},{"key":"1122_CR16","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1161\/01.STR.0000115161.10646.67","volume":"35","author":"FM Faraci","year":"2004","unstructured":"Faraci FM, Lentz SR: Hyperhomocysteinemia, oxidative stress, and cerebral vascular dysfunction. Stroke. 2004, 35: 345-347.","journal-title":"Stroke"},{"key":"1122_CR17","doi-asserted-by":"publisher","first-page":"S40","DOI":"10.1007\/PL00014300","volume":"157","author":"J Finkelstein","year":"1998","unstructured":"Finkelstein J: The metabolism of homocysteine: pathways and regulation. Eur J Pediatr. 1998, 157: S40-S44.","journal-title":"Eur J Pediatr"},{"key":"1122_CR18","first-page":"47","volume":"198","author":"G Cantoni","year":"1985","unstructured":"Cantoni G: The role of S-adenosylhomocysteine in the biological utilization of S-adenosylmethionine. Prog Clin Biol Res. 1985, 198: 47-65.","journal-title":"Prog Clin Biol Res"},{"key":"1122_CR19","doi-asserted-by":"publisher","first-page":"1897","DOI":"10.1016\/0006-2952(79)90642-7","volume":"28","author":"PK Chiang","year":"1979","unstructured":"Chiang PK, Cantoni GL: Perturbation of biochemical transmethylations by 3-deazaadenosine in vivo. Biochem Pharmacol. 1979, 28: 1897-1902.","journal-title":"Biochem Pharmacol"},{"key":"1122_CR20","doi-asserted-by":"crossref","first-page":"10822","DOI":"10.1016\/S0021-9258(19)70381-0","volume":"255","author":"D Hoffman","year":"1980","unstructured":"Hoffman D, Marion D, Cornatzer W, Duerre J: S-Adenosylmethionine and S-adenosylhomocystein metabolism in isolated rat liver. Effects of L-methionine, L-homocystein, and adenosine. J Biol Chem. 1980, 255: 10822-10827.","journal-title":"J Biol Chem"},{"key":"1122_CR21","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1139\/o79-007","volume":"57","author":"DR Hoffman","year":"1979","unstructured":"Hoffman DR, Cornatzer WE, Duerre JA: Relationship between tissue levels of S-adenosylmethionine, S-adenosylhomocysteine, and transmethylation reactions. Can J Biochem. 1979, 57: 56-64.","journal-title":"Can J Biochem"},{"key":"1122_CR22","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1146\/annurev.nutr.19.1.217","volume":"19","author":"J Selhub","year":"1999","unstructured":"Selhub J: Homocysteine metabolism. Annu Rev Nutr. 1999, 19: 217-246.","journal-title":"Annu Rev Nutr"},{"key":"1122_CR23","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1016\/j.jacc.2006.04.086","volume":"48","author":"S Kaul","year":"2006","unstructured":"Kaul S, Zadeh AA, Shah PK: Homocysteine Hypothesis for Atherothrombotic Cardiovascular Disease: Not Validated. J Am Coll Cardiol. 2006, 48: 914-923.","journal-title":"J Am Coll Cardiol"},{"key":"1122_CR24","doi-asserted-by":"publisher","first-page":"143","DOI":"10.3132\/dvdr.2007.033","volume":"4","author":"AS Wierzbicki","year":"2007","unstructured":"Wierzbicki AS: Homocysteine and cardiovascular disease: a review of the evidence. Diab Vasc Dis Res. 2007, 4: 143-149.","journal-title":"Diab Vasc Dis Res"},{"key":"1122_CR25","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1038\/ng0595-111","volume":"10","author":"P Frosst","year":"1995","unstructured":"Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, Boers G, den Heijer M, Kluijtmans L, Van Den Heuvel LP: A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet. 1995, 10: 111-113.","journal-title":"Nat Genet"},{"key":"1122_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1590\/S0100-879X2009007500021","volume":"43","author":"S Brustolin","year":"2010","unstructured":"Brustolin S, Giugliani R, F\u00e9lix T: Genetics of homocysteine metabolism and associated disorders. Braz J Med Biol Res. 2010, 43: 1-7.","journal-title":"Braz J Med Biol Res"},{"key":"1122_CR27","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1191\/1358863x02vm428ra","volume":"7","author":"N Weiss","year":"2002","unstructured":"Weiss N, Keller C, Hoffmann U, Loscalzo J: Endothelial dysfunction and atherothrombosis in mild hyperhomocysteinemia. Vasc Med. 2002, 7: 227-239.","journal-title":"Vasc Med"},{"key":"1122_CR28","doi-asserted-by":"publisher","first-page":"29318","DOI":"10.1074\/jbc.M002725200","volume":"275","author":"P Yi","year":"2000","unstructured":"Yi P, Melnyk S, Pogribna M, Pogribny IP, Hine RJ, James SJ: Increase in plasma homocysteine associated with parallel increases in plasma S-adenosylhomocysteine and lymphocyte DNA hypomethylation. J Biol Chem. 2000, 275: 29318-29323.","journal-title":"J Biol Chem"},{"key":"1122_CR29","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/S0021-9150(00)00449-4","volume":"154","author":"FM Loehrer","year":"2001","unstructured":"Loehrer FM, Tsch\u00f6pl M, Angst CP, Litynski P, J\u00e4ger K, Fowler B, Haefeli WE: Disturbed ratio of erythrocyte and plasma S-adenosylmethionine\/ S-adenosylhomocysteine in peripheral arterial occlusive disease. Atherosclerosis. 2001, 154: 147-154.","journal-title":"Atherosclerosis"},{"key":"1122_CR30","doi-asserted-by":"publisher","first-page":"1292","DOI":"10.1373\/49.8.1292","volume":"49","author":"R Castro","year":"2003","unstructured":"Castro R, Rivera I, Struys EA, Jansen E, Ravasco P, Camilo ME, Blom HJ, Jakobs C, de Almeida IT: Increased homocysteine and S-adenosylhomocysteine concentrations and DNA hypomethylation in vascular disease. Clin Chem. 2003, 49: 1292-1296.","journal-title":"Clin Chem"},{"key":"1122_CR31","doi-asserted-by":"publisher","first-page":"29147","DOI":"10.1074\/jbc.M403618200","volume":"279","author":"G Lund","year":"2004","unstructured":"Lund G, Andersson L, Lauria M, Lindholm M, Fraga MF, Villar-Garea A, Ballestar E, Esteller M, Zaina S: DNA methylation polymorphisms precede any histological sign of atherosclerosis in mice lacking apolipoprotein E. J Biol Chem. 2004, 279: 29147-29154.","journal-title":"J Biol Chem"},{"key":"1122_CR32","doi-asserted-by":"publisher","first-page":"2624","DOI":"10.1182\/blood-2003-09-3078","volume":"103","author":"AM Devlin","year":"2004","unstructured":"Devlin AM, Arning E, Bottiglieri T, Faraci FM, Rozen R, Lentz SR: Effect of Mthfr genotype on diet-induced hyperhomocysteinemia and vascular function in mice. Blood. 2004, 103: 2624-2629.","journal-title":"Blood"},{"key":"1122_CR33","doi-asserted-by":"publisher","first-page":"2709","DOI":"10.1093\/nar\/10.8.2709","volume":"10","author":"M Ehrlich","year":"1982","unstructured":"Ehrlich M, Gama-Sosa MA, Huang L-H, Midgett RM, Kuo KC, McCune RA, Gehrke C: Amount and distribution of 5-methylcytosine in human DNA from different types of tissues or cells. Nucleic Acids Res. 1982, 10: 2709-2721.","journal-title":"Nucleic Acids Res"},{"key":"1122_CR34","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1016\/0168-9525(87)90294-0","volume":"3","author":"AP Bird","year":"1987","unstructured":"Bird AP: CpG islands as gene markers in the vertebrate nucleus. Trends Genet. 1987, 3: 342-347.","journal-title":"Trends Genet"},{"key":"1122_CR35","doi-asserted-by":"publisher","first-page":"28789","DOI":"10.1074\/jbc.M401273200","volume":"279","author":"T Aoyama","year":"2004","unstructured":"Aoyama T, Okamoto T, Nagayama S, Nishijo K, Ishibe T, Yasura K, Nakayama T, Nakamura T, Toguchida J: Methylation in the core-promoter region of the chondromodulin-I gene determines the cell-specific expression by regulating the binding of transcriptional activator Sp3. J Biol Chem. 2004, 279: 28789-28797.","journal-title":"J Biol Chem"},{"key":"1122_CR36","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1002\/jcp.21224","volume":"213","author":"TB Miranda","year":"2007","unstructured":"Miranda TB, Jones PA: DNA methylation: the nuts and bolts of repression. J Cell Physiol. 2007, 213: 384-390.","journal-title":"J Cell Physiol"},{"key":"1122_CR37","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1016\/j.bbagen.2009.02.008","volume":"1790","author":"MP Turunen","year":"2009","unstructured":"Turunen MP, Aavik E, Yl\u00e4-Herttuala S: Epigenetics and atherosclerosis. Biochim Biophys Acta (BBA)-General Subjects. 2009, 1790: 886-891.","journal-title":"Biochim Biophys Acta (BBA)-General Subjects"},{"key":"1122_CR38","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.1111\/j.1582-4934.2010.01022.x","volume":"14","author":"RJ Wierda","year":"2010","unstructured":"Wierda RJ, Geutskens SB, Jukema JW, Quax P, van den Elsen PJ: Epigenetics in atherosclerosis and inflammation. J Cell Mol Med. 2010, 14: 1225-1240.","journal-title":"J Cell Mol Med"},{"key":"1122_CR39","doi-asserted-by":"publisher","first-page":"2145","DOI":"10.1161\/CIRCULATIONAHA.110.956839","volume":"123","author":"DE Handy","year":"2011","unstructured":"Handy DE, Castro R, Loscalzo J: Epigenetic Modifications Basic Mechanisms and Role in Cardiovascular Disease. Circulation. 2011, 123: 2145-2156.","journal-title":"Circulation"},{"key":"1122_CR40","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1007\/s11883-011-0174-3","volume":"13","author":"G Lund","year":"2011","unstructured":"Lund G, Zaina S: Atherosclerosis: an epigenetic balancing act that goes wrong. Curr Atheroscler Rep. 2011, 13: 208-214.","journal-title":"Curr Atheroscler Rep"},{"key":"1122_CR41","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1097\/MCO.0b013e328354bf5c","volume":"15","author":"A Baccarelli","year":"2012","unstructured":"Baccarelli A, Ghosh S: Environmental exposures, epigenetics and cardiovascular disease. Curr Opin Clin Nutr Metab Care. 2012, 15: 323-","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"1122_CR42","doi-asserted-by":"publisher","first-page":"2171","DOI":"10.1161\/01.ATV.19.9.2171","volume":"19","author":"MO Laukkanen","year":"1999","unstructured":"Laukkanen MO, Mannermaa S, Hiltunen MO, Aittom\u00e4ki S, Airenne K, J\u00e4nne J, Yl\u00e4-Herttuala S: Local hypomethylation in atherosclerosis found in rabbit ec-sod gene. Arterioscler Thromb Vasc Biol. 1999, 19: 2171-2178.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"1122_CR43","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1191\/1358863x02vm418oa","volume":"7","author":"MO Hiltunen","year":"2002","unstructured":"Hiltunen MO, Turunen MP, H\u00e4kkinen TP, Rutanen J, Hedman M, M\u00e4kinen K, Turunen AM, Aalto-Setal\u00e4 K, Yl\u00e4-Herttuala S: DNA hypomethylation and methyltransferase expression in atherosclerotic lesions. Vasc Med. 2002, 7: 5-11.","journal-title":"Vasc Med"},{"key":"1122_CR44","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1089\/dna.2007.0584","volume":"26","author":"J Yideng","year":"2007","unstructured":"Yideng J, Jianzhong Z, Ying H, Juan S, Jinge Z, Shenglan W, Xiaoqun H, Shuren W: Homocysteine-mediated expression of SAHH, DNMTs, MBD2, and DNA hypomethylation potential pathogenic mechanism in VSMCs. DNA Cell Biol. 2007, 26: 603-611.","journal-title":"DNA Cell Biol"},{"key":"1122_CR45","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1111\/j.1745-7270.2007.00327.x","volume":"39","author":"Y Jiang","year":"2007","unstructured":"Jiang Y, Sun T, Xiong J, Cao J, Li G, Wang S: Hyperhomocysteinemia\u2012mediated DNA Hypomethylation and its Potential Epigenetic Role in Rats. Acta Biochim Biophys Sin. 2007, 39: 657-667.","journal-title":"Acta Biochim Biophys Sin"},{"key":"1122_CR46","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1093\/cvr\/cvs130","volume":"95","author":"X Luo","year":"2012","unstructured":"Luo X, Xiao Y, Song F, Yang Y, Xia M, Ling W: Increased plasma S-adenosyl-homocysteine levels induce the proliferation and migration of VSMCs through an oxidative stress-ERK1\/2 pathway in apoE\u2212\/\u2212mice. Cardiovasc Res. 2012, 95: 241-250.","journal-title":"Cardiovasc Res"},{"key":"1122_CR47","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1161\/01.CIR.94.4.727","volume":"94","author":"CD Venkov","year":"1996","unstructured":"Venkov CD, Rankin AB, Vaughan DE: Identification of Authentic Estrogen Receptor in Cultured Endothelial Cells A Potential Mechanism for Steroid Hormone Regulation of Endothelial Function. Circulation. 1996, 94: 727-733.","journal-title":"Circulation"},{"key":"1122_CR48","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1124\/pr.107.08002","volume":"60","author":"VM Miller","year":"2008","unstructured":"Miller VM, Duckles SP: Vascular actions of estrogens: functional implications. Pharmacol Rev. 2008, 60: 210-241.","journal-title":"Pharmacol Rev"},{"key":"1122_CR49","first-page":"43","volume":"38","author":"J Su","year":"2009","unstructured":"Su J, Wang S, Hunag Y, Jinag Y: A comparative study on pathogenic effects of homocysteine and cysteine on atherosclerosis. Wei Sheng Yan Jiu. 2009, 38: 43-46.","journal-title":"Wei Sheng Yan Jiu"},{"key":"1122_CR50","doi-asserted-by":"publisher","first-page":"1660","DOI":"10.1515\/CCLM.2007.350","volume":"45","author":"MS Jamaluddin","year":"2007","unstructured":"Jamaluddin MS, Yang X, Wang H: Hyperhomocysteinemia, DNA methylation and vascular disease. Clin Chem Lab Med. 2007, 45: 1660-1666.","journal-title":"Clin Chem Lab Med"},{"key":"1122_CR51","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1097\/00041433-199702000-00007","volume":"8","author":"PB Duell","year":"1997","unstructured":"Duell PB, Malinow MR: Homocysteine: an important risk factor for atherosclerotic vascular disease. Curr Opin Lipidol. 1997, 8: 28-34.","journal-title":"Curr Opin Lipidol"},{"key":"1122_CR52","first-page":"2132","volume":"120","author":"J Zhang","year":"2007","unstructured":"Zhang J, Liu J, Li Z, Wang L, Jiang Y, Wang S: Dysfunction of endothelial NO system originated from homocysteine-induced aberrant methylation pattern in promoter region of DDAH2 gene. Chin Med J Beijing Engl Ed. 2007, 120: 2132-","journal-title":"Chin Med J Beijing Engl Ed"},{"key":"1122_CR53","first-page":"282","volume":"68","author":"SJ Jia","year":"2013","unstructured":"Jia SJ, Lai YQ, Zhao M, Gong T, Zhang B: Homocysteine-induced hypermethylation of DDAH2 promoter contributes to apoptosis of endothelial cells. Die Pharmazie-An Int J Pharm Sci. 2013, 68: 282-286.","journal-title":"Die Pharmazie-An Int J Pharm Sci"},{"key":"1122_CR54","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1093\/hmg\/10.5.433","volume":"10","author":"Z Chen","year":"2001","unstructured":"Chen Z, Karaplis AC, Ackerman SL, Pogribny IP, Melnyk S, Lussier-Cacan S, Chen MF, Pai A, John S, Smith RS: Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition. Hum Mol Genet. 2001, 10: 433-","journal-title":"Hum Mol Genet"},{"key":"1122_CR55","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1089\/dna.2007.0619","volume":"26","author":"J Yi-Deng","year":"2007","unstructured":"Yi-Deng J, Tao S, Hui-Ping Z, Jian-Tuan X, Jun C, Gui-Zhong L, Shu-Ren W: Folate and ApoE DNA methylation induced by homocysteine in human monocytes. DNA Cell Biol. 2007, 26: 737-744.","journal-title":"DNA Cell Biol"},{"key":"1122_CR56","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1089\/dna.2007.0658","volume":"27","author":"J Yideng","year":"2008","unstructured":"Yideng J, Zhihong L, Jiantuan X, Jun C, Guizhong L, Shuren W: Homocysteine-mediated PPAR\u03b1, \u03b3 DNA methylation and its potential pathogenic mechanism in monocytes. DNA Cell Biol. 2008, 27: 143-150.","journal-title":"DNA Cell Biol"},{"key":"1122_CR57","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1089\/biores.2012.0300","volume":"2","author":"J Wang","year":"2013","unstructured":"Wang J, Jiang Y, Yang A, Sun W, Ma C, Ma S, Gong H, Shi Y, Wei J: Hyperhomocysteinemia-Induced Monocyte Chemoattractant Protein-1 Promoter DNA Methylation by Nuclear Factor-\u03baB\/DNA Methyltransferase 1 in Apolipoprotein E\u2013Deficient Mice. Bio Res Open Access. 2013, 2: 118-127.","journal-title":"Bio Res Open Access"},{"key":"1122_CR58","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1093\/abbs\/gms119","volume":"45","author":"Y Liang","year":"2013","unstructured":"Liang Y, Yang X, Ma L, Cai X, Wang L, Yang C, Li G, Zhang M, Sun W, Jiang Y: Homocysteine-mediated cholesterol efflux via ABCA1 and ACAT1 DNA methylation in THP-1 monocyte-derived foam cells. Acta Biochim Biophys Sin. 2013, 45: 220-228.","journal-title":"Acta Biochim Biophys Sin"},{"key":"1122_CR59","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/jn\/135.1.5","volume":"135","author":"S Zaina","year":"2005","unstructured":"Zaina S, Lindholm MW, Lund G: Nutrition and aberrant DNA methylation patterns in atherosclerosis: more than just hyperhomocysteinemia?. J Nutr. 2005, 135: 5-8.","journal-title":"J Nutr"},{"key":"1122_CR60","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1089\/dna.2007.0694","volume":"27","author":"P Sharma","year":"2008","unstructured":"Sharma P, Kumar J, Garg G, Kumar A, Patowary A, Karthikeyan G, Ramakrishnan L, Brahmachari V, Sengupta S: Detection of altered global DNA methylation in coronary artery disease patients. DNA Cell Biol. 2008, 27: 357-365.","journal-title":"DNA Cell Biol"},{"key":"1122_CR61","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1476-511X-5-1","volume":"5","author":"P Sharma","year":"2006","unstructured":"Sharma P, Senthilkumar R, Brahmachari V, Sundaramoorthy E, Mahajan A, Sharma A, Sengupta S: Mining literature for a comprehensive pathway analysis: a case study for retrieval of homocysteine related genes for genetic and epigenetic studies. Lipids Health Dis. 2006, 5: 1-19.","journal-title":"Lipids Health Dis"},{"key":"1122_CR62","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1016\/j.bbagen.2008.11.010","volume":"1790","author":"D Ingrosso","year":"2009","unstructured":"Ingrosso D, Perna AF: Epigenetics in hyperhomocysteinemic states. A special focus on uremia. Biochim Biophys Acta (BBA)-General Subjects. 2009, 1790: 892-899.","journal-title":"Biochim Biophys Acta (BBA)-General Subjects"},{"key":"1122_CR63","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1038\/nature08514","volume":"462","author":"R Lister","year":"2009","unstructured":"Lister R, Pelizzola M, Dowen RH, Hawkins RD, Hon G, Tonti-Filippini J, Nery JR, Lee L, Ye Z, Ngo QM: Human DNA methylomes at base resolution show widespread epigenomic differences. Nature. 2009, 462: 315-322.","journal-title":"Nature"},{"key":"1122_CR64","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1016\/j.cell.2007.02.005","volume":"128","author":"T Kouzarides","year":"2007","unstructured":"Kouzarides T: Chromatin modifications and their function. Cell. 2007, 128: 693-705.","journal-title":"Cell"},{"key":"1122_CR65","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1038\/nrm1761","volume":"6","author":"C Martin","year":"2005","unstructured":"Martin C, Zhang Y: The diverse functions of histone lysine methylation. Nat Rev Mol Cell Biol. 2005, 6: 838-849.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"1122_CR66","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/0092-8674(93)90419-Q","volume":"74","author":"P Jeppesen","year":"1993","unstructured":"Jeppesen P, Turner BM: The inactive X chromosome in female mammals is distinguished by a lack of histone H4 acetylation, a cytogenetic marker for gene expression. Cell. 1993, 74: 281-289.","journal-title":"Cell"},{"key":"1122_CR67","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1101\/gad.7.4.592","volume":"7","author":"M Braunstein","year":"1993","unstructured":"Braunstein M, Rose A, Holmes S, Allis C, Broach J: Transcriptional silencing in yeast is associated with reduced nucleosome acetylation. Genes Dev. 1993, 7: 592-604.","journal-title":"Genes Dev"},{"key":"1122_CR68","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1038\/35065132","volume":"410","author":"M Lachner","year":"2001","unstructured":"Lachner M, O\u2019Carroll D, Rea S, Mechtler K, Jenuwein T: Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. Nature. 2001, 410: 116-120.","journal-title":"Nature"},{"key":"1122_CR69","doi-asserted-by":"publisher","first-page":"1920","DOI":"10.1089\/ars.2012.4926","volume":"18","author":"GH Kim","year":"2013","unstructured":"Kim GH, Ryan JJ, Archer SL: The role of redox signaling in epigenetics and cardiovascular disease. Antioxid Redox Signal. 2013, 18: 1920-1936.","journal-title":"Antioxid Redox Signal"},{"key":"1122_CR70","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11883-013-0319-7","volume":"15","author":"HM Findeisen","year":"2013","unstructured":"Findeisen HM, Kahles FK, Bruemmer D: Epigenetic regulation of vascular smooth muscle cell function in atherosclerosis. Curr Atheroscler Rep. 2013, 15: 1-8.","journal-title":"Curr Atheroscler Rep"},{"key":"1122_CR71","volume-title":"Int J Vasc Med","author":"AZ Fernandez","year":"2010","unstructured":"Fernandez AZ, Siebel AL, El-Osta A: Atherogenic factors and their epigenetic relationships. Int J Vasc Med. 2010, 2010:http:\/\/www.hindawi.com\/journals\/ijvm\/2010\/437809\/,"},{"key":"1122_CR72","doi-asserted-by":"publisher","first-page":"1708","DOI":"10.1016\/j.bbadis.2013.05.013","volume":"1832","author":"R Esse","year":"2013","unstructured":"Esse R, Florindo C, Imbard A, Rocha M, de Vriese A, Smulders Y, Teerlink T, Tavares de Almeida I, Castro R, Blom H: Global protein and histone arginine methylation are affected in a tissue-specific manner in a rat model of diet-induced hyperhomocysteinemia. Biochim Biophys Acta (BBA)-Mol Basis Dis. 2013, 1832: 1708-1714.","journal-title":"Biochim Biophys Acta (BBA)-Mol Basis Dis"},{"key":"1122_CR73","doi-asserted-by":"publisher","first-page":"2686","DOI":"10.1096\/fj.13-246579","volume":"28","author":"R Esse","year":"2014","unstructured":"Esse R, Imbard A, Florindo C, Rocha M, de Vriese A, Smulders Y, Teerlink T, Tavares de Almeida I, Castro R, Blom H: Protein arginine hypomethylation in a mouse model of cystathionine \u03b2-synthase deficiency. FASEB J. 2014, 28: 2686-2695.","journal-title":"FASEB J"},{"key":"1122_CR74","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1242\/jeb.012914","volume":"211","author":"Y Jiang","year":"2008","unstructured":"Jiang Y, Jiang J, Xiong J, Cao J, Li N, Li G, Wang S: Homocysteine-induced extracellular superoxide dismutase and its epigenetic mechanisms in monocytes. J Exp Biol. 2008, 211: 911-920.","journal-title":"J Exp Biol"},{"key":"1122_CR75","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1016\/j.neuint.2011.03.012","volume":"58","author":"Y Jin","year":"2011","unstructured":"Jin Y, Amaral A, McCann A, Brennan L: Homocysteine levels impact directly on epigenetic reprogramming in astrocytes. Neurochem Int. 2011, 58: 833-838.","journal-title":"Neurochem Int"},{"key":"1122_CR76","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1080\/07315724.2011.10719939","volume":"30","author":"F Pizzolo","year":"2011","unstructured":"Pizzolo F, Blom HJ, Choi SW, Girelli D, Guarini P, Martinelli N, Stanzial AM, Corrocher R, Olivieri O, Friso S: Folic acid effects on S-adenosylmethionine, S-adenosylhomocysteine, and DNA methylation in patients with intermediate hyperhomocysteinemia. J Am Coll Nutr. 2011, 30: 11-18.","journal-title":"J Am Coll Nutr"}],"container-title":["Lipids in Health and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1476-511X-13-134.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T19:32:42Z","timestamp":1630611162000},"score":1,"resource":{"primary":{"URL":"https:\/\/lipidworld.biomedcentral.com\/articles\/10.1186\/1476-511X-13-134"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,21]]},"references-count":76,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["1122"],"URL":"https:\/\/doi.org\/10.1186\/1476-511x-13-134","relation":{},"ISSN":["1476-511X"],"issn-type":[{"value":"1476-511X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,21]]},"assertion":[{"value":"16 July 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 August 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 August 2014","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"134"}}