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Arteriosclerosis involves the accumulation of altered lipids and lipoproteins in large arteries; this drives inflammation and fibrosis and ultimately leads to narrowing of the arteries and hypoperfusion of dependent organs and tissues.<\/jats:p>\n          <jats:p>Knowledge of the causative factors is crucial to the understanding of disease mechanisms and the development of specific treatment. Based on pathogenetic similarities between PSC and arteriosclerosis, we hypothesize that PSC represents <jats:bold>\n              <jats:italic>\"arteriosclerosis of the bile duct\"<\/jats:italic>\n            <\/jats:bold> initiated by toxic biliary lipids. This hypothesis is based on common molecular, cellular, and morphological features providing the conceptual framework for a deeper understanding of their pathogenesis. This hypothesis should stimulate translational research to facilitate the search for novel treatment strategies for both diseases.<\/jats:p>","DOI":"10.1186\/1476-511x-6-3","type":"journal-article","created":{"date-parts":[[2007,1,25]],"date-time":"2007-01-25T19:12:07Z","timestamp":1169752327000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Primary sclerosing cholangitis \u2013 The arteriosclerosis of the bile duct?"],"prefix":"10.1186","volume":"6","author":[{"given":"Peter","family":"Fickert","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tarek","family":"Moustafa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Trauner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2007,1,25]]},"reference":[{"issue":"6801","key":"106_CR1","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1038\/35025203","volume":"407","author":"AJ Lusis","year":"2000","unstructured":"Lusis AJ: Atherosclerosis. 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