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Increased activation of glucocorticoid receptors results in MetS symptoms and is thus speculated to have a role in the pathophysiology of the MetS. Glycyrrhizic acid (GA), the bioactive constituent of licorice roots (<jats:italic>Glycyrrhiza glabra<\/jats:italic>) inhibits 11\u03b2-hydroxysteroid dehydrogenase type 1 that catalyzes the activation of glucocorticoids. Thus, oral administration of GA is postulated to ameliorate the MetS.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>In this study, daily oral administration of 50 mg\/kg of GA for one week led to significant increase in LPL expression in the quadriceps femoris (<jats:italic>p<\/jats:italic> &lt; 0.05) but non-significant increase in the abdominal muscle, kidney, liver, heart and the subcutaneous and visceral adipose tissues (<jats:italic>p<\/jats:italic> &gt; 0.05) of the GA-treated rats compared to the control. Decrease in adipocyte size (<jats:italic>p<\/jats:italic> &gt; 0.05) in both the visceral and subcutaneous adipose tissue depots accompanies such selective induction of LPL expression. Consistent improvement in serum lipid parameters was also observed, with decrease in serum free fatty acid, triacylglycerol, total cholesterol and LDL-cholesterol but elevated HDL-cholesterol (<jats:italic>p<\/jats:italic> &gt; 0.05). Histological analysis using tissue lipid staining with Oil Red O showed significant decrease in lipid deposition in the abdominal muscle and quadriceps femoris (<jats:italic>p<\/jats:italic> &lt; 0.05) but non-significant decrease in the heart, kidney and liver (<jats:italic>p<\/jats:italic> &gt; 0.05).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Results from this study may imply that GA could counteract the development of visceral obesity and improve dyslipidaemia via selective induction of tissue LPL expression and a positive shift in serum lipid parameters respectively, and retard the development of IR associated with tissue steatosis.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1476-511x-8-31","type":"journal-article","created":{"date-parts":[[2009,7,29]],"date-time":"2009-07-29T06:13:42Z","timestamp":1248848022000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Lipoprotein lipase expression, serum lipid and tissue lipid deposition in orally-administered glycyrrhizic acid-treated rats"],"prefix":"10.1186","volume":"8","author":[{"given":"Wai Yen Alfred","family":"Lim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoke Yin","family":"Chia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih Yeen","family":"Liong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So Ha","family":"Ton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalid Abdul","family":"Kadir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharifah Noor Akmal","family":"Syed Husain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,7,29]]},"reference":[{"issue":"5","key":"219_CR1","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1097\/00041433-200210000-00002","volume":"13","author":"K Preiss-Landi","year":"2002","unstructured":"Preiss-Landi K, Zimmermann R, Hammerle G, Zechner R: Lipoprotein lipase: the regulation of tissue specific expression and its role in lipid and energy metabolism. 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