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The current study was carried out to evaluate the antioxidant activity of <jats:italic>Spirulina maxima<\/jats:italic> against lead acetate-induced hyperlipidemia and oxidative damage in the liver and kidney of male rats. Control animals were fed on a standard diet and did not receive lead acetate (Control group). Experimental animals were fed on a standard laboratory diet with or without <jats:italic>Spirulina maxima<\/jats:italic> 5% in the standard laboratory diet and treated with three doses of lead acetate (25 mg each\/weekly, intraperitoneal injection) (lead acetate with <jats:italic>Spirulina<\/jats:italic>, and lead acetate without <jats:italic>Spirulina<\/jats:italic> groups).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The results showed that <jats:italic>Spirulina maxima<\/jats:italic> prevented the lead acetate-induced significant changes on plasma and liver lipid levels and on the antioxidant status of the liver and kidney. On the other hand, <jats:italic>Spirulina maxima<\/jats:italic> succeeded to improve the biochemical parameters of the liver and kidney towards the normal values of the Control group.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>It was concluded that <jats:italic>Spirulina maxima<\/jats:italic> has protective effects on lead acetate-induced damage, and that the effects are associated with the antioxidant effect of <jats:italic>Spirulina<\/jats:italic>.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1476-511x-9-35","type":"journal-article","created":{"date-parts":[[2010,3,31]],"date-time":"2010-03-31T06:14:02Z","timestamp":1270016042000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":105,"title":["Protective effects of Spirulina maxima on hyperlipidemia and oxidative-stress induced by lead acetate in the liver and kidney"],"prefix":"10.1186","volume":"9","author":[{"given":"Johny C","family":"Ponce-Canchihuam\u00e1n","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"P\u00e9rez-M\u00e9ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolando","family":"Hern\u00e1ndez-Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia V","family":"Torres-Dur\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco A","family":"Ju\u00e1rez-Oropeza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,3,31]]},"reference":[{"key":"284_CR1","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/j.crvi.2007.05.007","volume":"330","author":"A Annabi Berrahal","year":"2007","unstructured":"Annabi Berrahal A, Nehdi A, Hajjaji N, Gharbi N, El-Faz\u00e2a S: Antioxidant enzymes activities and bilirubin level in adult rat treated with lead. 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