{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T10:57:51Z","timestamp":1792839471649,"version":"4.5.0"},"reference-count":9,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Comp Hepatol"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Most focal nodular hyperplasia (FNH) cases are diagnosed by chance. We studied a case of pre-FNH. We used glutamine synthase as an immunohistochemical marker for perivenous zones.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Neither fibrotic scars nor hepatocytic nodules surrounded by fibrosis with a ductular reaction were observed in the sections studied. Most sections generally displayed preserved architecture. The glutamine synthase-positive hepatocyte areas were wider than those observed in non-tumoural surrounding liver, and they tended to extend outwards. Portal tracts bordering the nodule were more fibrotic, with an absence of portal veins and ducts and with arterial proliferation often in proximity with large draining veins; isolated arteries were present and hepatic veins were rare in the nodule. These features appeared prior to the identification of other major criteria characteristics of FNH, thus supporting the \"hypothesis of Wanless\".<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>The findings confirm that in FNH there is a portal tract injury leading to local portal vein injury. This leads to a cascade of events, including arterial venous shunts, ductular reaction, and scar formation.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1476-5926-7-2","type":"journal-article","created":{"date-parts":[[2008,2,29]],"date-time":"2008-02-29T19:14:05Z","timestamp":1204312445000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Over-expression of glutamine synthase in focal nodular hyperplasia (part 1): Early stages in the formation support the hypothesis of a focal hyper-arterialisation with venous (portal and hepatic) and biliary damage"],"prefix":"10.1186","volume":"7","author":[{"given":"Paulette","family":"Bioulac-Sage","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herv\u00e9","family":"Laumonier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ga\u00eblle","family":"Cubel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Saric","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Balabaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,2,29]]},"reference":[{"key":"112_CR1","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/j.jhep.2006.12.007","volume":"46","author":"P Bioulac-Sage","year":"2007","unstructured":"Bioulac-Sage P, Balabaud C, Bedossa P, Scoazec JY, Chiche L, Dhillon AP, Ferrell L, Paradis V, Roskams T, Vilgrain V, Wanless IR, Zucman-Rossi J: Pathological diagnosis of liver cell adenoma and focal nodular hyperplasia: Bordeaux update. J Hepatol. 2007, 46: 521-527. 10.1016\/j.jhep.2006.12.007.","journal-title":"J Hepatol"},{"key":"112_CR2","doi-asserted-by":"crossref","unstructured":"Terminology of nodular hepatocellular lesions. International Working Party. Hepatology. 1995, 22: 983-993.","DOI":"10.1016\/0270-9139(95)90324-0"},{"key":"112_CR3","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1002\/hep.1840050622","volume":"5","author":"IR Wanless","year":"1985","unstructured":"Wanless IR, Mawdsley C, Adams R: On the pathogenesis of focal nodular hyperplasia of the liver. Hepatology. 1985, 5: 1194-1200. 10.1002\/hep.1840050622.","journal-title":"Hepatology"},{"key":"112_CR4","doi-asserted-by":"publisher","first-page":"1322","DOI":"10.1097\/00000478-200110000-00015","volume":"25","author":"P Bioulac-Sage","year":"2001","unstructured":"Bioulac-Sage P, Balabaud C, Wanless IR: Diagnosis of focal nodular hyperplasia: not so easy. Am J Surg Pathol. 2001, 25: 1322-1325. 10.1097\/00000478-200110000-00015.","journal-title":"Am J Surg Pathol"},{"key":"112_CR5","first-page":"491A","volume":"Suppl 1","author":"IR Wanless","year":"2006","unstructured":"Wanless IR, Sapp H, Guindy M, Olshansky D, Takayama A: The pathogenesis of focal nodular hyperplasia\/ an hypothesis based on histological review of 20 lesions including 3 occurring in early biliary cirrhosis. Hepatology. 2006, Suppl 1: 491A-","journal-title":"Hepatology"},{"key":"112_CR6","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/1476-5926-2-7","volume":"2","author":"S Lepreux","year":"2003","unstructured":"Lepreux S, Laurent C, Balabaud C, Bioulac-Sage P: FNH-like nodules: Possible precursor lesions in patients with focal nodular hyperplasia (FNH). Comp Hepatol. 2003, 2: 7-10.1186\/1476-5926-2-7.","journal-title":"Comp Hepatol"},{"key":"112_CR7","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.proghi.2006.12.001","volume":"41","author":"R Gebhardt","year":"2007","unstructured":"Gebhardt R, Baldysiak-Figiel A, Krugel V, Ueberham E, Gaunitz F: Hepatocellular expression of glutamine synthetase: an indicator of morphogen actions as master regulators of zonation in adult liver. Prog Histochem Cytochem. 2007, 41: 201-266. 10.1016\/j.proghi.2006.12.001.","journal-title":"Prog Histochem Cytochem"},{"key":"112_CR8","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1002\/hep.21743","volume":"46","author":"P Bioulac-Sage","year":"2007","unstructured":"Bioulac-Sage P, Rebouissou S, Thomas C, Blanc JF, Saric J, Sa Cunha A, Rullier A, Cubel G, Couchy G, Imbeaud S, Balabaud C, Zucman-Rossi J: Hepatocellular adenoma subtype classification using molecular markers and immunohistochemistry. Hepatology. 2007, 46: 740-748. 10.1002\/hep.21743.","journal-title":"Hepatology"},{"key":"112_CR9","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1055\/s-2007-1007126","volume":"19","author":"W Ekataksin","year":"1999","unstructured":"Ekataksin W, Kaneda K: Liver microvascular architecture: an insight into the pathophysiology of portal hypertension. Semin Liver Dis. 1999, 19: 359-382.","journal-title":"Semin Liver Dis"}],"container-title":["Comparative Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1476-5926-7-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T22:57:15Z","timestamp":1630450635000},"score":1,"resource":{"primary":{"URL":"https:\/\/comparative-hepatology.biomedcentral.com\/articles\/10.1186\/1476-5926-7-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2,29]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,12]]}},"alternative-id":["112"],"URL":"https:\/\/doi.org\/10.1186\/1476-5926-7-2","relation":{},"ISSN":["1476-5926"],"issn-type":[{"value":"1476-5926","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,2,29]]},"assertion":[{"value":"19 October 2007","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 February 2008","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 February 2008","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"2"}}