{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T06:47:05Z","timestamp":1777445225341,"version":"3.51.4"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cardiovasc Ultrasound"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                        <jats:title>Background<\/jats:title>\n                        <jats:p>Mitral annular calcification (MAC) and aortic annular calcification (AVC) may represent a manifestation of generalized atherosclerosis in the elederly. Alterations in vascular structure, as indexed by the intima media thickness (IMT), are also recognized as independent predictors of adverse cardiovascular outcomes.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Aim<\/jats:title>\n                        <jats:p>To examine the relationship between the degree of calcification at mitral and\/or aortic valve annulus and large artery structure (thickness).<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Methods<\/jats:title>\n                        <jats:p>We evaluated 102 consecutive patients who underwent transthoracic echocardiography and carotid artery echoDoppler for various indications; variables measured were: systemic blood pressure (BP), pulse pressure (PP=SBP-DBP), body mass index (BMI), fasting glucose, total, HDL, LDL chlolesterol, triglycerides, cIMT. The patients were divided according to a grading of valvular\/annular lesions independent scores based on acoustic densitometry: 1 = annular\/valvular sclerosis\/calcification absence; 2 = annular\/valvular sclerosis; 3 = annular calcification; 4 = annular-valvular calcification; 5 = valvular calcification with no recognition of the leaflets.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Results<\/jats:title>\n                        <jats:p>Patient score was the highest observed for either valvular\/annulus. Mean cIMT increased linearly with increasing valvular calcification score, ranging from 3.9 \u00b1 0.48 mm in controls to 12.9 \u00b1 1.8 mm in those subjects scored 5 (p &lt; 0.0001). In the first to fourth quartile of cIMT values the respective maximal percentual of score were: score 1: 76.1%, score 2: 70.1%, score 4: 54.3% and score 5: 69.5% (p &gt; 0.0001).<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Conclusion<\/jats:title>\n                        <jats:p>MAC and AVC score can identify subgroups of patients with different cIMT values which indicate different incidence and prevalence of systemic artery diseases. This data may confirm MAC-AVC as a useful important diagnostic parameter of systemic atherosclerotic disease.<\/jats:p>\n                     <\/jats:sec>","DOI":"10.1186\/1476-7120-2-19","type":"journal-article","created":{"date-parts":[[2004,10,14]],"date-time":"2004-10-14T06:23:56Z","timestamp":1097735036000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Association of mitral annulus calcification, aortic valve calcification with carotid intima media thickness"],"prefix":"10.1186","volume":"2","author":[{"given":"Luca","family":"Sgorbini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelo","family":"Scuteri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Leggio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Leggio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2004,10,8]]},"reference":[{"issue":"58","key":"36_CR1","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1016\/0002-9149(86)90045-7","volume":"1","author":"WC Roberts","year":"1986","unstructured":"Roberts WC: The senile cardiac calcification syndrome.\n                           Am J Cardiol 1986,1(58):572-4. 10.1016\/0002-9149(86)90045-7","journal-title":"Am J Cardiol"},{"key":"36_CR2","doi-asserted-by":"crossref","unstructured":"Otto CM, Burwash IG, Legget ME, Munt BJ, Fujioka M, healy NL, Kraft CD, Miyake-Hull CY, Schwaegler RG: Prospective study of asymptomatic valvular aortic stenosis. 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