{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:07:11Z","timestamp":1760954831019},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2006,1,24]],"date-time":"2006-01-24T00:00:00Z","timestamp":1138060800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cardiovasc Ultrasound"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>The heart transplant is a treatment of the heart failure, which is not responding to medications, and its efficiency is already proved: unfortunately, organ donation is a limiting step of this life-saving procedure.<\/jats:p>\n            <jats:p>To counteract heart donor shortage, we should screen aged potential donor hearts for initial cardiomyopathy and functionally significant coronary artery disease.<\/jats:p>\n            <jats:p>Donors with a history of cardiac disease are generally excluded. Coronary angiography is recommended for most male donors older than 45 years and female donors older than 50 years to evaluate coronary artery stenoses. A simpler way to screen aged potential donor hearts for initial cardiomyopathy and functionally significant coronary artery disease should be stress echocardiography.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Case report<\/jats:title>\n            <jats:p>A marginal donor (A 57 year old woman meeting legal requirements for brain death) underwent a transesophageal (TE) Dipyridamole stress echo (6 minutes accelerated protocol) to rule out moderate or severe heart and coronary artery disease. Wall motion was normal at baseline and at peak stress (WMSI = 1 at baseline and peak stress, without signs of stress inducible ischemia). The pressure\/volume ratio was 9.6 mmHg\/ml\/m<jats:sup>2<\/jats:sup> at baseline, increasing to 14 mmHg\/ml\/m<jats:sup>2<\/jats:sup> at peak stress, demonstrating absence of latent myocardial dysfunction.<\/jats:p>\n            <jats:p>The marginal donor heart was transplanted to a recipient \"marginal\" for co-morbidity ( a 63 year old man with multiple myeloma and cardiac amyloidosis , chronic severe heart failure, NYHA class IV).<\/jats:p>\n            <jats:p>Postoperative treatment and early immunosuppressant regimen were performed according to standard protocols.<\/jats:p>\n            <jats:p>The transplanted heart was assessed normal for dimensions and ventricular function at transthoracic (TT) echocardiography on post-transplant day 7.<\/jats:p>\n            <jats:p>Coronary artery disease was ruled out at coronary angiography one month after transplant; left ventriculography showed normal global and segmental LV function of the transplanted heart.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>For the first time stress echo was successfully used in the critical theater of screening potential donor hearts. This method is enormously more feasible, less expensive, and more environmentally sustainable than any possible alternative strategy based on stress scintigraphy perfusion imaging or coronary angiography. The selection of hearts \"too good to die\" on the basis of bedside resting and stress echo can be a critical way to solve the mismatch between donor need and supply.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1476-7120-4-3","type":"journal-article","created":{"date-parts":[[2006,1,27]],"date-time":"2006-01-27T19:14:39Z","timestamp":1138389279000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Recruitment of aged donor heart with pharmacological stress echo. A case report"],"prefix":"10.1186","volume":"4","author":[{"given":"Giorgio","family":"Arpesella","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"Gherardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tonino","family":"Bombardini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugenio","family":"Picano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2006,1,24]]},"reference":[{"key":"87_CR1","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1016\/S1053-2498(01)00297-2","volume":"20","author":"MV Brock","year":"2001","unstructured":"Brock MV, Salazar D, Cameron DE, Baumgartner WA, Conte J: The changing profile of the cardiac donor. J Heart Lung Transplant. 2001, 20: 1005-1009. 10.1016\/S1053-2498(01)00297-2.","journal-title":"J Heart Lung Transplant"},{"key":"87_CR2","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1161\/01.CIR.0000025587.40373.75","volume":"106","author":"JG Zaroff","year":"2002","unstructured":"Zaroff JG, Rosengard BR, Armstrong WF, Babcock WD, D'Alessandro A, Dec GW, Edwards NM, Higgins RS, Jeevanandum V, Kauffman M, Kirklin JK, Large SR, Marelli D, Peterson TS, Ring WS, Robbins RC, Russell SD, Taylor DO, Van Bakel A, Wallwork J, Young JB: Cosensus conference report: Maximizing Use of Organs Received from Cadaver Donor-Cardiac Recommendations. Crystal City, VA, Circulation. 2002, 106: 836-841. March 28\u201329, 2001","journal-title":"Crystal City, VA, Circulation"},{"key":"87_CR3","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/S1053-2498(98)00059-X","volume":"18","author":"DF Del Rizzo","year":"1999","unstructured":"Del Rizzo DF, Menkis AH, Pflugfelder PW, Novick RJ, McKenzie FN, Boyd WD, Kostuk WJ: The role of the donor age and ischemic time on survival following orthotopic heart transplantation. J Heart Lung Tranplant. 1999, 18: 310-319. 10.1016\/S1053-2498(98)00059-X.","journal-title":"J Heart Lung Tranplant"},{"key":"87_CR4","first-page":"734","volume":"14","author":"DR Wheeldon","year":"1995","unstructured":"Wheeldon DR, Potter CD, Oduro A, Wallwork J, Large SR: Transforming the \"unacceptable\" donor: outcomes from the adoption of a standardized donor management technique. J Heart Lung Tranplant. 1995, 14: 734-742.","journal-title":"J Heart Lung Tranplant"},{"key":"87_CR5","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1067\/mje.2002.121536","volume":"15","author":"JM Gardin","year":"2002","unstructured":"Gardin JM, Adams DB, Douglas PS, Feigenbaum H, Forst DH, Fraser AG, Grayburn PA, Katz AS, Keller AM, Kerber RE, Khandheria BK, Klein AL, Lang RM, Pierard LA, Quinones MA, Schnittger I, American Society of Echocardiography: Recommendations for a standardized report for adult transthoracic echocardiography: a report from the American Society of Echocardiography's Nomenclature and Standards Committee and Task Force for a Standardized Echocardiography Report. J Am Soc Echocardiogr. 2002, 15: 275-290. 10.1067\/mje.2002.121536.","journal-title":"J Am Soc Echocardiogr"},{"key":"87_CR6","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/S0894-7317(98)70132-4","volume":"11","author":"WF Armstrong","year":"1998","unstructured":"Armstrong WF, Pellikka PA, Ryan T, Crouse L, Zoghbi WA: Stress echocardiography: recommendations for performance and interpretation of stress echocardiography. Stress Echocardiography Task Force of the Nomenclature and Standards Committee of the American Society of Echocardiography. J Am Soc Echocardiogr. 1998, 11: 97-104.","journal-title":"J Am Soc Echocardiogr"},{"key":"87_CR7","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/S0002-9343(02)01427-4","volume":"114","author":"E Picano","year":"2003","unstructured":"Picano E: Stress echocardiography: a historical perspective. [Special article]. Am J Med. 2003, 114: 126-130. 10.1016\/S0002-9343(02)01427-4.","journal-title":"Am J Med"},{"key":"87_CR8","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/S0894-7317(03)00221-9","volume":"16","author":"T Bombardini","year":"2003","unstructured":"Bombardini T, Correia MJ, Cicerone C, Agricola E, Ripoli A, Picano E: Force-frequency relationship in the echocardiography laboratory: a noninvasive assessment of Bowditch treppe. J Am Soc Echocardiogr. 2003, 16: 646-655. 10.1016\/S0894-7317(03)00221-9.","journal-title":"J Am Soc Echocardiogr"},{"key":"87_CR9","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1016\/S1053-2498(02)00428-X","volume":"21","author":"TR Cimato","year":"2002","unstructured":"Cimato TR, Jessup M: Recipient selection in cardiac transplantation: Contraindications and risk factors for mortality. J Heart Lung Tranplant. 2002, 21: 1161-1173. 10.1016\/S1053-2498(02)00428-X.","journal-title":"J Heart Lung Tranplant"},{"key":"87_CR10","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1097\/00045415-200105000-00005","volume":"9","author":"DN Miniati","year":"2001","unstructured":"Miniati DN, Robbins RC: Techniques in orthotopic heart transplantation: A Review. Cardiol Rev. 2001, 9: 131-136. 10.1097\/00045415-200105000-00005.","journal-title":"Cardiol Rev"},{"key":"87_CR11","doi-asserted-by":"publisher","first-page":"2428","DOI":"10.1161\/01.CIR.0000127427.03361.5E","volume":"109","author":"R Sicari","year":"2004","unstructured":"Sicari R, Cortigiani L, Bigi R, Landi P, Raciti M, Picano E, on behalf of the Echo-Persantine International Cooperative (EPIC) and Echo-Dobutamine International Cooperative (EDIC) Study Groups: The prognostic value of pharmacological stress echo is affected by concomitant anti-ischemic therapy at the time of testing. Circulation. 2004, 109: 2428-2431. 10.1161\/01.CIR.0000127427.03361.5E.","journal-title":"Circulation"},{"key":"87_CR12","doi-asserted-by":"publisher","first-page":"2404","DOI":"10.1093\/eurheartj\/ehi444","volume":"26","author":"A Grosu","year":"2005","unstructured":"Grosu A, Bombardini T, Senni M, Duino V, Gori M, Picano E: End-systolic Pressure\/Volume relations during dobutamine stress echo a prognostically useful noninvasive index of left ventricular contractility. Eur Heart J. 2005, 26: 2404-2412. 10.1093\/eurheartj\/ehi444.","journal-title":"Eur Heart J"}],"container-title":["Cardiovascular Ultrasound"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1476-7120-4-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1476-7120-4-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1476-7120-4-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1476-7120-4-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T22:53:17Z","timestamp":1630450397000},"score":1,"resource":{"primary":{"URL":"https:\/\/cardiovascularultrasound.biomedcentral.com\/articles\/10.1186\/1476-7120-4-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1,24]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["87"],"URL":"https:\/\/doi.org\/10.1186\/1476-7120-4-3","relation":{},"ISSN":["1476-7120"],"issn-type":[{"value":"1476-7120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,1,24]]},"assertion":[{"value":"11 November 2005","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 January 2006","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 January 2006","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"3"}}