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We sought to determine echo features predictive of CAD.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>2-D Echo of 328 patients without known CAD performed within one year prior to stress myocardial SPECT and angiography were reviewed. Echo features examined were left ventricular and atrial enlargement, LV hypertrophy, wall motion abnormality (WMA), LV ejection fraction (EF) &lt; 50%, mitral annular calcification (MAC) and aortic sclerosis\/stenosis (AS). High risk myocardial perfusion abnormality (MPA) was defined as &gt;15% LV perfusion defect or multivessel distribution. Severe coronary artery stenosis (CAS) was defined as left main, 3 VD or 2VD involving proximal LAD.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The mean age was 62 \u00b1 13 years, 59% men, 29% diabetic (DM) and 148 (45%) had &gt; 2 risk factors. Pharmacologic stress was performed in 109 patients (33%). MPA was present in 200 pts (60%) of which, 137 were high risk. CAS was present in 166 pts (51%), 75 were severe. Of 87 patients with WMA, 83% had MPA and 78% had CAS. Multivariate analysis identified age &gt;65, male, inability to exercise, DM, WMA, MAC and AS as independent predictors of MPA and CAS. Independent predictors of high risk MPA and severe CAS were age, DM, inability to exercise and WMA.<\/jats:p>\n            <jats:p>2-D echo findings offered incremental value over clinical information in predicting CAD by angiography. (Chi square: 360 vs. 320 p = 0.02).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>2-D Echo was valuable in predicting presence of physiological and anatomical CAD in addition to clinical information.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1476-7120-7-10","type":"journal-article","created":{"date-parts":[[2009,3,6]],"date-time":"2009-03-06T19:14:32Z","timestamp":1236366872000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Predicting clinically unrecognized coronary artery disease: use of two- dimensional echocardiography"],"prefix":"10.1186","volume":"7","author":[{"given":"Su Min","family":"Chang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdul","family":"Hakeem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sherif F","family":"Nagueh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2009,3,6]]},"reference":[{"issue":"5","key":"257_CR1","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1016\/S0735-1097(03)01065-9","volume":"42","author":"MD Cheitlin","year":"2003","unstructured":"Cheitlin MD, Armstrong WF, Aurigemma GP, Beller GA, Bierman FZ, Davis JL, Douglas PS, Faxon DP, Gillam LD, Kimball TR, Kussmaul WG, Pearlman AS, Philbrick JT, Rakowski H, Thys DM: ACC\/AHA\/ASE 2003 guideline update for the clinical application of echocardiography: summary article: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines (ACC\/AHA\/ASE Committee to Update the 1997 Guidelines for the Clinical Application of Echocardiography). 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