{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T18:52:12Z","timestamp":1761418332010},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2005,6,22]],"date-time":"2005-06-22T00:00:00Z","timestamp":1119398400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"},{"start":{"date-parts":[[2005,6,22]],"date-time":"2005-06-22T00:00:00Z","timestamp":1119398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Mol Allergy"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                        <jats:title>Background<\/jats:title>\n                        <jats:p>Animal-derived allergens include lipocalins which play an increasing role in occupational respiratory sensitizations. The prevention of sensitization in stock farming is often difficult due to intense exposure, with traditional milking still requiring close animal contact. Complete avoidance of allergen exposure is only possible if stock farming is abandoned. This is, however, often not feasible in small dairy plants because of the resulting loss of income.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Case presentation<\/jats:title>\n                        <jats:p>In a 37-year-old female farmer daily asthmatic complaints appeared, associated with cow dust-derived allergen exposure by milking with a conventional device. Respiratory symptoms increased during a period of 12 years. Allergic bronchial asthma was diagnosed, caused by sensitization against cow dust-derived allergens, as demonstrated by positive skin prick test and by detection of IgE antibodies. In a separate specific inhalation challenge test using a 10% extract of cow dust-derived allergens a 330% increase of airway resistance was detected. To enable further dairy farming, a milking robot was installed in 1999, i.e., an automatic milking system. The novel milking technique reduced the daily exposure from over 2 hours to approximately 10 min. The clinical course after the installation of the milking robot was favourable, with less frequent allergic and asthmatic symptoms. Furthermore, asthma medication could be reduced. Improvement was noted also in terms of lung-function and decreased total serum IgE.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Conclusion<\/jats:title>\n                        <jats:p>The case presented and the evidence from the literature indicates that the strategy of exposure minimization to allergens at workplaces can be an effective alternative to total elimination. In farmers with cow dust allergy a milking robot is an appropriate technical measure to minimize allergen-exposure.<\/jats:p>\n                     <\/jats:sec>","DOI":"10.1186\/1476-7961-3-8","type":"journal-article","created":{"date-parts":[[2005,6,22]],"date-time":"2005-06-22T18:34:44Z","timestamp":1119465284000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Secondary prevention of allergic symptoms in a dairy farmer by use of a milking robot"],"prefix":"10.1186","volume":"3","author":[{"given":"Gintautas","family":"Korinth","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Horst Christoph","family":"Broding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Uter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"Drexler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2005,6,22]]},"reference":[{"key":"20_CR1","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1111\/j.1365-2222.1992.tb00118.x","volume":"22","author":"J Yl\u00f6nen","year":"1992","unstructured":"Yl\u00f6nen J, M\u00e4ntyj\u00e4rvi R, Taivainen A, Virtanen T: IgG and IgE antibody responses to cow dander and urine in farmers with cow-induced asthma.\n                           Clin Exp Allergy . 1992, 22: 83-90.","journal-title":"Clin Exp Allergy"},{"key":"20_CR2","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1007\/BF00405670","volume":"60","author":"T Virtanen","year":"1988","unstructured":"Virtanen T, Vilhunen P, Husman K, Happonen P, M\u00e4ntyj\u00e4rvi R: Level of airborne bovine epithelial antigen in Finnish cowsheds.\n                           Int Arch Occup Environ Health. 1988, 60: 355-360. 10.1007\/BF00405670","journal-title":"Int Arch Occup Environ Health"},{"key":"20_CR3","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1159\/000234668","volume":"87","author":"T Virtanen","year":"1988","unstructured":"Virtanen T, Vilhunen P, Husman K, Happonen P, M\u00e4ntyj\u00e4rvi R: Sensitization of dairy farmers to bovine antigens and effects of exposure on specific IgG and IgE titers.\n                           Int Arch Allergy Appl Immunol. 1988, 87: 171-177.","journal-title":"Int Arch Allergy Appl Immunol"},{"key":"20_CR4","first-page":"356","volume":"50","author":"R Merget","year":"1996","unstructured":"Merget R, Schultze-Werninghaus G: Occupational asthma: definition \u2013 epidemiology \u2013 etiologic substances \u2013 prognosis \u2013 prevention \u2013 diagnosis \u2013 expert assessment aspects [in German].\n                           Pneumologie. 1996, 50: 356-363.","journal-title":"Pneumologie"},{"key":"20_CR5","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1080\/15298669191364668","volume":"52","author":"J Kongerud","year":"1991","unstructured":"Kongerud J, Rambjor O: The influence of the helmet respirator on peak flow rate in aluminum potroom.\n                           Am Ind Hyg Assoc J. 1991, 52: 243-248.","journal-title":"Am Ind Hyg Assoc J"},{"key":"20_CR6","doi-asserted-by":"publisher","first-page":"503","DOI":"10.5271\/sjweh.375","volume":"24","author":"AI Taivainen","year":"1998","unstructured":"Taivainen AI, Tukiainen HO, Terho EO, Husman KR: Powered dust respirator helmets in the prevention of occupational asthma among farmers.\n                           Scand J Work Environ Health. 1998, 24: 503-507.","journal-title":"Scand J Work Environ Health"},{"key":"20_CR7","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1080\/15298668591395085","volume":"46","author":"AJ Slovak","year":"1985","unstructured":"Slovak AJ, Orr RG, Teasdale EL: Efficacy of the helmet respirator in occupational asthma due to laboratory animal allergy (LAA).\n                           Am Ind Hyg Assoc J. 1985, 46: 411-415.","journal-title":"Am Ind Hyg Assoc J"},{"key":"20_CR8","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1164\/ajrccm\/141.2.373","volume":"141","author":"J Cote","year":"1990","unstructured":"Cote J, Kennedy S, Chan-Yeung M: Outcome of patients with cedar asthma with continuous exposure.\n                           Am Rev Respir Dis. 1990, 141: 373-376.","journal-title":"Am Rev Respir Dis"},{"key":"20_CR9","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1183\/09031936.98.12030569","volume":"12","author":"D M\u00fcller-Wening","year":"1998","unstructured":"M\u00fcller-Wening D, Neuhauss M: Protective effect of respiratory devices in farmers with occupational asthma.\n                           Eur Respir J. 1998, 12: 569-572. 10.1183\/09031936.98.12030569","journal-title":"Eur Respir J"},{"key":"20_CR10","first-page":"523","volume":"51","author":"KC Bergmann","year":"1997","unstructured":"Bergmann KC, Fischer J, Schmitz M, Petermann F, Petro W: Inpatient pneumologic rehabilitation of adults: goals \u2013 diagnostic and therapeutic standards \u2013 research needs [in German].\n                           Pneumologie. 1997, 51: 523-532.","journal-title":"Pneumologie"},{"key":"20_CR11","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/S1081-1206(10)61642-0","volume":"90","author":"X Baur","year":"2003","unstructured":"Baur X: Are we closer to developing threshold limit values for allergens in the workplace?.\n                           Ann Allergy Asthma Immunol. 2003, 90: 11-18.","journal-title":"Ann Allergy Asthma Immunol"},{"key":"20_CR12","doi-asserted-by":"publisher","first-page":"1454","DOI":"10.1046\/j.1365-2745.2002.01499.x","volume":"32","author":"T Zeiler","year":"2002","unstructured":"Zeiler T, Taivainen A, M\u00e4ntyj\u00e4rvi R, Tukiainen H, Rautiainen J, Rytk\u00f6nen-Nissinen M, Virtanen T: Threshold levels of purified natural Bos d 2 for inducing bronchial airway response in asthmatic patients.\n                           Clin Exp Allergy. 2002, 32: 1454-1460. 10.1046\/j.1365-2745.2002.01499.x","journal-title":"Clin Exp Allergy"},{"key":"20_CR13","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1007\/s00420-001-0296-y","volume":"75","author":"G Edelstam","year":"2002","unstructured":"Edelstam G, Arvanius L, Karlsson G: Glove powder in the hospital environment \u2013 consequences for healthcare workers.\n                           Int Arch Occup Environ Health. 2002, 75: 267-271. 10.1007\/s00420-001-0296-y","journal-title":"Int Arch Occup Environ Health"},{"key":"20_CR14","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1016\/S0091-6749(94)70045-1","volume":"93","author":"SM Tarlo","year":"1994","unstructured":"Tarlo SM, Sussman G, Contala A, Swanson MC: Control of airborne latex by use of powder-free latex gloves.\n                           J Allergy Clin Immunol. 1994, 93: 985-989.","journal-title":"J Allergy Clin Immunol"},{"key":"20_CR15","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1093\/annhyg\/mef022","volume":"46","author":"H Thulin","year":"2002","unstructured":"Thulin H, Bj\u00f6rkdahl M, Karlsson AS, Renstr\u00f6m A: Reduction of exposure to laboratory animal allergens in a research laboratory.\n                           Ann Occup Hyg. 2002, 46: 61-68. 10.1093\/annhyg\/mef022","journal-title":"Ann Occup Hyg"},{"key":"20_CR16","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1136\/oem.56.3.202","volume":"56","author":"H Drexler","year":"1999","unstructured":"Drexler H, Schaller KH, Nielsen J, Weber A, Weihrauch M, Welinder H, Skerfving S: Efficacy of measures of hygiene in workers sensitised to acid anhydrides and the influence of selection bias on the results.\n                           Occup Environ Med. 1999, 56: 202-205.","journal-title":"Occup Environ Med"}],"container-title":["Clinical and Molecular Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1476-7961-3-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/1476-7961-3-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1476-7961-3-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T12:57:33Z","timestamp":1728305853000},"score":1,"resource":{"primary":{"URL":"https:\/\/clinicalmolecularallergy.biomedcentral.com\/articles\/10.1186\/1476-7961-3-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,6,22]]},"references-count":16,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2005,12]]}},"alternative-id":["20"],"URL":"https:\/\/doi.org\/10.1186\/1476-7961-3-8","relation":{},"ISSN":["1476-7961"],"issn-type":[{"type":"electronic","value":"1476-7961"}],"subject":[],"published":{"date-parts":[[2005,6,22]]},"assertion":[{"value":"26 August 2004","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 June 2005","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 June 2005","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"8"}}