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These manifestations are accompanied by elevated IgE levels and reduced IL-17 producing CD3+CD4+ T cells. Diagnosis in young children can be challenging as symptoms accumulate over time along with confounding clinical dilemmas. A NIH clinical HIES scoring system was developed in 1999, and a more recent scoring system with fewer but more pathogonomonic clinical findings was reported in 2010. These scoring systems can be used as tools to help in grading the likelihood of HIES diagnosis. We report a young child ultimately presenting with disseminated histoplasmosis and a novel STAT3 variant in the SH2 domain.<\/jats:p>","DOI":"10.1186\/1476-7961-9-14","type":"journal-article","created":{"date-parts":[[2011,11,30]],"date-time":"2011-11-30T22:48:03Z","timestamp":1322693283000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Case report of a young child with disseminated histoplasmosis and review of hyper immunoglobulin e syndrome (HIES)"],"prefix":"10.1186","volume":"9","author":[{"given":"Wilson S","family":"Robinson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra R","family":"Arnold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christie F","family":"Michael","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John D","family":"Vickery","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert A","family":"Schoumacher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eniko K","family":"Pivnick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jewell C","family":"Ward","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vijaya","family":"Nagabhushanam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dukhee B","family":"Lew","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2011,11,29]]},"reference":[{"key":"98_CR1","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1086\/302547","volume":"65","author":"B Grimbacher","year":"1999","unstructured":"Grimbacher B, Sch\u00e4ffer AA, Holland SM, Davis J, Gallin JI, Malech HL: Genetic linkage of hyper-IgE syndrome to chromosome 4. 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