{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T21:00:28Z","timestamp":1793826028446,"version":"4.6.1"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Immune Based Ther Vaccines"],"published-print":{"date-parts":[[2008,12]]},"DOI":"10.1186\/1476-8518-6-7","type":"journal-article","created":{"date-parts":[[2009,1,6]],"date-time":"2009-01-06T07:13:34Z","timestamp":1231226014000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Effects of recombinant human growth hormone on HIV-1-specific T-cell responses, thymic output and proviral DNA in patients on HAART: 48-week follow-up"],"prefix":"10.1186","volume":"6","author":[{"given":"Anna A","family":"Herasimtschuk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha J","family":"Westrop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graeme J","family":"Moyle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jocelyn S","family":"Downey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nesrina","family":"Imami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,10,31]]},"reference":[{"issue":"5","key":"47_CR1","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1517\/14712598.1.5.803","volume":"1","author":"N Imami","year":"2001","unstructured":"Imami N, Hardy G, Gotch F: Development of immunotherapeutic strategies for HIV-1. Expert opinion on biological therapy. 2001, 1 (5): 803-816. 10.1517\/14712598.1.5.803.","journal-title":"Expert opinion on biological therapy"},{"issue":"2","key":"47_CR2","doi-asserted-by":"publisher","first-page":"171","DOI":"10.2217\/17469600.1.2.171","volume":"1","author":"N Imami","year":"2007","unstructured":"Imami N, Westrop S, Cranage A, Burton C, Gotch F: Combined use of cytokines, hormones and therapeutic vaccines during effective antiretroviral therapy. Future HIV Therapy. 2007, 1 (2): 171-179. 10.2217\/17469600.1.2.171.","journal-title":"Future HIV Therapy"},{"issue":"5","key":"47_CR3","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1097\/00042560-199904150-00003","volume":"20","author":"S Chappel","year":"1999","unstructured":"Chappel S: Growth hormone in immune reconstitution. J Acquir Immune Defic Syndr Hum Retrovirol. 1999, 20 (5): 423-431.","journal-title":"J Acquir Immune Defic Syndr Hum Retrovirol"},{"issue":"2","key":"47_CR4","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1210\/edrv.18.2.0296","volume":"18","author":"R Clark","year":"1997","unstructured":"Clark R: The somatogenic hormones and insulin-like growth factor-1: stimulators of lymphopoiesis and immune function. Endocr Rev. 1997, 18 (2): 157-179. 10.1210\/er.18.2.157.","journal-title":"Endocr Rev"},{"issue":"6","key":"47_CR5","doi-asserted-by":"publisher","first-page":"4195","DOI":"10.4049\/jimmunol.166.6.4195","volume":"166","author":"GC Koo","year":"2001","unstructured":"Koo GC, Huang C, Camacho R, Trainor C, Blake JT, Sirotina-Meisher A, Schleim KD, Wu TJ, Cheng K, Nargund R, et al: Immune enhancing effect of a growth hormone secretagogue. J Immunol. 2001, 166 (6): 4195-4201.","journal-title":"J Immunol"},{"issue":"3","key":"47_CR6","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1189\/jlb.71.3.381","volume":"71","author":"LA Welniak","year":"2002","unstructured":"Welniak LA, Sun R, Murphy WJ: The role of growth hormone in T-cell development and reconstitution. J Leukoc Biol. 2002, 71 (3): 381-387.","journal-title":"J Leukoc Biol"},{"issue":"2","key":"47_CR7","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1210\/jc.86.2.504","volume":"86","author":"P Rietschel","year":"2001","unstructured":"Rietschel P, Hadigan C, Corcoran C, Stanley T, Neubauer G, Gertner J, Grinspoon S: Assessment of growth hormone dynamics in human immunodeficiency virus-related lipodystrophy. J Clin Endocrinol Metab. 2001, 86 (2): 504-510. 10.1210\/jc.86.2.504.","journal-title":"J Clin Endocrinol Metab"},{"issue":"10","key":"47_CR8","doi-asserted-by":"publisher","first-page":"1435","DOI":"10.1097\/00002030-200307040-00003","volume":"17","author":"A Vigano","year":"2003","unstructured":"Vigano A, Mora S, Brambilla P, Schneider L, Merlo M, Monti LD, Manzoni P: Impaired growth hormone secretion correlates with visceral adiposity in highly active antiretroviral treated HIV-infected adolescents. Aids. 2003, 17 (10): 1435-1441. 10.1097\/00002030-200307040-00003.","journal-title":"Aids"},{"issue":"7\u20138","key":"47_CR9","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1016\/S0899-9007(02)00760-8","volume":"18","author":"S Cominelli","year":"2002","unstructured":"Cominelli S, Raguso CA, Karsegard L, Hirschel B, Gaillard R, Genton L, Pichard C: Weight-losing HIV-infected patients on recombinant human growth hormone for 12 wk: a national study. Nutrition. 2002, 18 (7\u20138): 583-586. 10.1016\/S0899-9007(02)00760-8.","journal-title":"Nutrition"},{"issue":"4","key":"47_CR10","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1097\/00126334-200404010-00006","volume":"35","author":"GJ Moyle","year":"2004","unstructured":"Moyle GJ, Daar ES, Gertner JM, Kotler DP, Melchior JC, O'Brien F, Svanberg E: Growth hormone improves lean body mass, physical performance, and quality of life in subjects with HIV-associated weight loss or wasting on highly active antiretroviral therapy. J Acquir Immune Defic Syndr. 2004, 35 (4): 367-375. 10.1097\/00126334-200404010-00006.","journal-title":"J Acquir Immune Defic Syndr"},{"issue":"3","key":"47_CR11","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1086\/315764","volume":"182","author":"JD Wilson","year":"2000","unstructured":"Wilson JD, Imami N, Watkins A, Gill J, Hay P, Gazzard B, Westby M, Gotch FM: Loss of CD4+ T cell proliferative ability but not loss of human immunodeficiency virus type 1 specificity equates with progression to disease. J Infect Dis. 2000, 182 (3): 792-798. 10.1086\/315764.","journal-title":"J Infect Dis"},{"issue":"11","key":"47_CR12","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1038\/ni845","volume":"3","author":"SA Migueles","year":"2002","unstructured":"Migueles SA, Laborico AC, Shupert WL, Sabbaghian MS, Rabin R, Hallahan CW, Van Baarle D, Kostense S, Miedema F, McLaughlin M, et al: HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors. Nat Immunol. 2002, 3 (11): 1061-1068. 10.1038\/ni845.","journal-title":"Nat Immunol"},{"issue":"1\u20132","key":"47_CR13","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/S0165-2478(01)00267-X","volume":"79","author":"N Imami","year":"2001","unstructured":"Imami N, Hardy G, Burton C, Pires A, Pido-Lopez J, Moss R, Gazzard B, Gotch F: Immune responses and reconstitution in HIV-1 infected individuals: impact of anti-retroviral therapy, cytokines and therapeutic vaccination. Immunol Lett. 2001, 79 (1\u20132): 63-76. 10.1016\/S0165-2478(01)00267-X.","journal-title":"Immunol Lett"},{"issue":"9","key":"47_CR14","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1038\/ni969","volume":"4","author":"RA Seder","year":"2003","unstructured":"Seder RA, Ahmed R: Similarities and differences in CD4+ and CD8+ effector and memory T cell generation. Nat Immunol. 2003, 4 (9): 835-842. 10.1038\/ni969.","journal-title":"Nat Immunol"},{"issue":"6884","key":"47_CR15","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1038\/417095a","volume":"417","author":"DC Douek","year":"2002","unstructured":"Douek DC, Brenchley JM, Betts MR, Ambrozak DR, Hill BJ, Okamoto Y, Casazza JP, Kuruppu J, Kunstman K, Wolinsky S, et al: HIV preferentially infects HIV-specific CD4+ T cells. Nature. 2002, 417 (6884): 95-98. 10.1038\/417095a.","journal-title":"Nature"},{"issue":"3","key":"47_CR16","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1016\/j.immuni.2007.08.010","volume":"27","author":"SG Deeks","year":"2007","unstructured":"Deeks SG, Walker BD: Human immunodeficiency virus controllers: mechanisms of durable virus control in the absence of antiretroviral therapy. Immunity. 2007, 27 (3): 406-416. 10.1016\/j.immuni.2007.08.010.","journal-title":"Immunity"},{"issue":"18","key":"47_CR17","doi-asserted-by":"publisher","first-page":"9011","DOI":"10.1128\/JVI.76.18.9011-9023.2002","volume":"76","author":"N Imami","year":"2002","unstructured":"Imami N, Pires A, Hardy G, Wilson J, Gazzard B, Gotch F: A balanced type 1\/type 2 response is associated with long-term nonprogressive human immunodeficiency virus type 1 infection. J Virol. 2002, 76 (18): 9011-9023. 10.1128\/JVI.76.18.9011-9023.2002.","journal-title":"J Virol"},{"issue":"3","key":"47_CR18","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1086\/314924","volume":"180","author":"RB Moss","year":"1999","unstructured":"Moss RB, Wallace MR, Giermakowska WK, Webb E, Savary J, Chamberlin-Brandt C, Theofan G, Musil R, Richieri SP, Jensen FC, et al: Phenotypic analysis of human immunodeficiency virus (HIV) type 1 cell-mediated immune responses after treatment with an HIV-1 immunogen. J Infect Dis. 1999, 180 (3): 641-648. 10.1086\/314924.","journal-title":"J Infect Dis"},{"issue":"1","key":"47_CR19","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1046\/j.1365-2249.1999.01012.x","volume":"118","author":"N Imami","year":"1999","unstructured":"Imami N, Hardy GA, Nelson MR, Morris-Jones S, Al-Shahi R, Antonopoulos C, Gazzard B, Gotch FM: Induction of HIV-1-specific T cell responses by administration of cytokines in late-stage patients receiving highly active anti-retroviral therapy. Clin Exp Immunol. 1999, 118 (1): 78-86. 10.1046\/j.1365-2249.1999.01012.x.","journal-title":"Clin Exp Immunol"},{"issue":"7","key":"47_CR20","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1097\/00002030-199905070-00005","volume":"13","author":"M Larsson","year":"1999","unstructured":"Larsson M, Jin X, Ramratnam B, Ogg GS, Engelmayer J, Demoitie MA, McMichael AJ, Cox WI, Steinman RM, Nixon D, et al: A recombinant vaccinia virus based ELISPOT assay detects high frequencies of Pol-specific CD8 T cells in HIV-1-positive individuals. Aids. 1999, 13 (7): 767-777. 10.1097\/00002030-199905070-00005.","journal-title":"Aids"},{"issue":"1\u20133","key":"47_CR21","first-page":"59","volume":"121","author":"R Aspinall","year":"2000","unstructured":"Aspinall R, Pido J, Andrew D: A simple method for the measurement of sjTREC levels in blood. Mech Ageing Dev. 2000, 121 (1\u20133): 59-67.","journal-title":"Mech Ageing Dev"},{"issue":"6","key":"47_CR22","first-page":"744","volume":"21","author":"D Douek","year":"2004","unstructured":"Douek D: Thymic output and HIV infection: on the right TREC. Immunity. 2004, 21 (6): 744-745.","journal-title":"Immunity"},{"issue":"2","key":"47_CR23","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1128\/JCM.38.2.630-634.2000","volume":"38","author":"C Christopherson","year":"2000","unstructured":"Christopherson C, Kidane Y, Conway B, Krowka J, Sheppard H, Kwok S: PCR-Based assay to quantify human immunodeficiency virus type 1 DNA in peripheral blood mononuclear cells. J Clin Microbiol. 2000, 38 (2): 630-634.","journal-title":"J Clin Microbiol"},{"issue":"3","key":"47_CR24","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1097\/00126334-200407010-00004","volume":"36","author":"A Pires","year":"2004","unstructured":"Pires A, Hardy G, Gazzard B, Gotch F, Imami N: Initiation of antiretroviral therapy during recent HIV-1 infection results in lower residual viral reservoirs. J Acquir Immune Defic Syndr. 2004, 36 (3): 783-790. 10.1097\/00126334-200407010-00004.","journal-title":"J Acquir Immune Defic Syndr"},{"issue":"5342","key":"47_CR25","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1126\/science.278.5342.1447","volume":"278","author":"ES Rosenberg","year":"1997","unstructured":"Rosenberg ES, Billingsley JM, Caliendo AM, Boswell SL, Sax PE, Kalams SA, Walker BD: Vigorous HIV-1-specific CD4+ T cell responses associated with control of viremia. Science. 1997, 278 (5342): 1447-1450. 10.1126\/science.278.5342.1447.","journal-title":"Science"},{"issue":"1","key":"47_CR26","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1038\/nm0195-59","volume":"1","author":"S Rowland-Jones","year":"1995","unstructured":"Rowland-Jones S, Sutton J, Ariyoshi K, Dong T, Gotch F, McAdam S, Whitby D, Sabally S, Gallimore A, Corrah T, et al: HIV-specific cytotoxic T-cells in HIV-exposed but uninfected Gambian women. Nat Med. 1995, 1 (1): 59-64. 10.1038\/nm0195-59.","journal-title":"Nat Med"},{"issue":"9","key":"47_CR27","doi-asserted-by":"publisher","first-page":"1705","DOI":"10.1086\/383227","volume":"189","author":"A Kebba","year":"2004","unstructured":"Kebba A, Kaleebu P, Rowland S, Ingram R, Whitworth J, Imami N, Gotch F: Distinct patterns of peripheral HIV-1-specific interferon- gamma responses in exposed HIV-1-seronegative individuals. J Infect Dis. 2004, 189 (9): 1705-1713. 10.1086\/383227.","journal-title":"J Infect Dis"},{"issue":"5617","key":"47_CR28","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1126\/science.1082305","volume":"300","author":"DJ Shedlock","year":"2003","unstructured":"Shedlock DJ, Shen H: Requirement for CD4 T cell help in generating functional CD8 T cell memory. Science. 2003, 300 (5617): 337-339. 10.1126\/science.1082305.","journal-title":"Science"},{"issue":"5617","key":"47_CR29","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1126\/science.1083317","volume":"300","author":"JC Sun","year":"2003","unstructured":"Sun JC, Bevan MJ: Defective CD8 T cell memory following acute infection without CD4 T cell help. Science. 2003, 300 (5617): 339-342. 10.1126\/science.1083317.","journal-title":"Science"},{"issue":"6925","key":"47_CR30","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1038\/nature01441","volume":"421","author":"EM Janssen","year":"2003","unstructured":"Janssen EM, Lemmens EE, Wolfe T, Christen U, von Herrath MG, Schoenberger SP: CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes. Nature. 2003, 421 (6925): 852-856. 10.1038\/nature01441.","journal-title":"Nature"},{"issue":"2","key":"47_CR31","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1093\/infdis\/173.2.321","volume":"173","author":"AD Kelleher","year":"1996","unstructured":"Kelleher AD, Carr A, Zaunders J, Cooper DA: Alterations in the immune response of human immunodeficiency virus (HIV)-infected subjects treated with an HIV-specific protease inhibitor, ritonavir. J Infect Dis. 1996, 173 (2): 321-329.","journal-title":"J Infect Dis"},{"issue":"5322","key":"47_CR32","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1126\/science.277.5322.112","volume":"277","author":"B Autran","year":"1997","unstructured":"Autran B, Carcelain G, Li TS, Blanc C, Mathez D, Tubiana R, Katlama C, Debre P, Leibowitch J: Positive effects of combined antiretroviral therapy on CD4+ T cell homeostasis and function in advanced HIV disease. Science. 1997, 277 (5322): 112-116. 10.1126\/science.277.5322.112.","journal-title":"Science"},{"issue":"9117","key":"47_CR33","doi-asserted-by":"publisher","first-page":"1682","DOI":"10.1016\/S0140-6736(97)10291-4","volume":"351","author":"TS Li","year":"1998","unstructured":"Li TS, Tubiana R, Katlama C, Calvez V, Ait Mohand H, Autran B: Long-lasting recovery in CD4 T-cell function and viral-load reduction after highly active antiretroviral therapy in advanced HIV-1 disease. Lancet. 1998, 351 (9117): 1682-1686. 10.1016\/S0140-6736(97)10291-4.","journal-title":"Lancet"},{"issue":"1","key":"47_CR34","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1046\/j.1365-2249.2003.02256.x","volume":"134","author":"GA Hardy","year":"2003","unstructured":"Hardy GA, Imami N, Sullivan AK, Pires A, Burton CT, Nelson MR, Gazzard BG, Gotch FM: Reconstitution of CD4+ T cell responses in HIV-1 infected individuals initiating highly active antiretroviral therapy (HAART) is associated with renewed interleukin-2 production and responsiveness. Clin Exp Immunol. 2003, 134 (1): 98-106. 10.1046\/j.1365-2249.2003.02256.x.","journal-title":"Clin Exp Immunol"},{"issue":"20","key":"47_CR35","doi-asserted-by":"publisher","first-page":"10900","DOI":"10.1128\/JVI.77.20.10900-10909.2003","volume":"77","author":"C Iyasere","year":"2003","unstructured":"Iyasere C, Tilton JC, Johnson AJ, Younes S, Yassine-Diab B, Sekaly RP, Kwok WW, Migueles SA, Laborico AC, Shupert WL, et al: Diminished proliferation of human immunodeficiency virus-specific CD4+ T cells is associated with diminished interleukin-2 (IL-2) production and is recovered by exogenous IL-2. J Virol. 2003, 77 (20): 10900-10909. 10.1128\/JVI.77.20.10900-10909.2003.","journal-title":"J Virol"},{"issue":"12","key":"47_CR36","doi-asserted-by":"publisher","first-page":"1909","DOI":"10.1084\/jem.20031598","volume":"198","author":"SA Younes","year":"2003","unstructured":"Younes SA, Yassine-Diab B, Dumont AR, Boulassel MR, Grossman Z, Routy JP, Sekaly RP: HIV-1 viremia prevents the establishment of interleukin 2-producing HIV-specific memory CD4+ T cells endowed with proliferative capacity. J Exp Med. 2003, 198 (12): 1909-1922. 10.1084\/jem.20031598.","journal-title":"J Exp Med"},{"issue":"9","key":"47_CR37","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1038\/79549","volume":"6","author":"MD Hazenberg","year":"2000","unstructured":"Hazenberg MD, Otto SA, Cohen Stuart JW, Verschuren MC, Borleffs JC, Boucher CA, Coutinho RA, Lange JM, Rinke de Wit TF, Tsegaye A, et al: Increased cell division but not thymic dysfunction rapidly affects the T-cell receptor excision circle content of the naive T cell population in HIV-1 infection. Nat Med. 2000, 6 (9): 1036-1042. 10.1038\/79549.","journal-title":"Nat Med"},{"issue":"6","key":"47_CR38","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1016\/j.immuni.2004.10.013","volume":"21","author":"ML Dion","year":"2004","unstructured":"Dion ML, Poulin JF, Bordi R, Sylvestre M, Corsini R, Kettaf N, Dalloul A, Boulassel MR, Debre P, Routy JP, et al: HIV infection rapidly induces and maintains a substantial suppression of thymocyte proliferation. Immunity. 2004, 21 (6): 757-768. 10.1016\/j.immuni.2004.10.013.","journal-title":"Immunity"},{"issue":"5","key":"47_CR39","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1084\/jem.194.5.591","volume":"194","author":"AR Almeida","year":"2001","unstructured":"Almeida AR, Borghans JA, Freitas AA: T cell homeostasis: thymus regeneration and peripheral T cell restoration in mice with a reduced fraction of competent precursors. J Exp Med. 2001, 194 (5): 591-599. 10.1084\/jem.194.5.591.","journal-title":"J Exp Med"},{"issue":"1","key":"47_CR40","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1038\/nm1520","volume":"13","author":"P Kiepiela","year":"2007","unstructured":"Kiepiela P, Ngumbela K, Thobakgale C, Ramduth D, Honeyborne I, Moodley E, Reddy S, de Pierres C, Mncube Z, Mkhwanazi N, et al: CD8+ T-cell responses to different HIV proteins have discordant associations with viral load. Nat Med. 2007, 13 (1): 46-53. 10.1038\/nm1520.","journal-title":"Nat Med"},{"issue":"18","key":"47_CR41","doi-asserted-by":"publisher","first-page":"2399","DOI":"10.1097\/00002030-200212060-00004","volume":"16","author":"C Chouquet","year":"2002","unstructured":"Chouquet C, Autran B, Gomard E, Bouley JM, Calvez V, Katlama C, Costagliola D, Riviere Y: Correlation between breadth of memory HIV-specific cytotoxic T cells, viral load and disease progression in HIV infection. Aids. 2002, 16 (18): 2399-2407. 10.1097\/00002030-200212060-00004.","journal-title":"Aids"},{"key":"47_CR42","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1146\/annurev.immunol.25.022106.141548","volume":"25","author":"MA Williams","year":"2007","unstructured":"Williams MA, Bevan MJ: Effector and memory CTL differentiation. Annu Rev Immunol. 2007, 25: 171-192. 10.1146\/annurev.immunol.25.022106.141548.","journal-title":"Annu Rev Immunol"},{"issue":"3","key":"47_CR43","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1111\/j.1365-2249.2003.02329.x","volume":"134","author":"MR Goodier","year":"2003","unstructured":"Goodier MR, Imami N, Moyle G, Gazzard B, Gotch F: Loss of the CD56hiCD16- NK cell subset and NK cell interferon-gamma production during antiretroviral therapy for HIV-1: partial recovery by human growth hormone. Clin Exp Immunol. 2003, 134 (3): 470-476. 10.1111\/j.1365-2249.2003.02329.x.","journal-title":"Clin Exp Immunol"},{"issue":"1","key":"47_CR44","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1177\/135965350400900110","volume":"9","author":"A Pires","year":"2004","unstructured":"Pires A, Pido-Lopez J, Moyle G, Gazzard B, Gotch F, Imami N: Enhanced T-cell maturation, differentiation and function in HIV-1-infected individuals after growth hormone and highly active antiretroviral therapy. Antivir Ther. 2004, 9 (1): 67-75.","journal-title":"Antivir Ther"},{"issue":"15","key":"47_CR45","doi-asserted-by":"publisher","first-page":"2099","DOI":"10.1097\/00002030-199910220-00013","volume":"13","author":"C Wanke","year":"1999","unstructured":"Wanke C, Gerrior J, Kantaros J, Coakley E, Albrecht M: Recombinant human growth hormone improves the fat redistribution syndrome (lipodystrophy) in patients with HIV. Aids. 1999, 13 (15): 2099-2103. 10.1097\/00002030-199910220-00013.","journal-title":"Aids"},{"key":"47_CR46","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1111\/j.1749-6632.1998.tb09589.x","volume":"840","author":"M Dardenne","year":"1998","unstructured":"Dardenne M, Mello-Coelho V, Gagnerault MC, Postel-Vinay MC: Growth hormone receptors and immunocompetent cells. Ann N Y Acad Sci. 1998, 840: 510-517. 10.1111\/j.1749-6632.1998.tb09589.x.","journal-title":"Ann N Y Acad Sci"},{"issue":"1","key":"47_CR47","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1084\/jem.178.1.231","volume":"178","author":"WJ Murphy","year":"1993","unstructured":"Murphy WJ, Durum SK, Longo DL: Differential effects of growth hormone and prolactin on murine T cell development and function. J Exp Med. 1993, 178 (1): 231-236. 10.1084\/jem.178.1.231.","journal-title":"J Exp Med"},{"issue":"8","key":"47_CR48","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1097\/00002030-200205240-00003","volume":"16","author":"LA Napolitano","year":"2002","unstructured":"Napolitano LA, Lo JC, Gotway MB, Mulligan K, Barbour JD, Schmidt D, Grant RM, Halvorsen RA, Schambelan M, McCune JM: Increased thymic mass and circulating naive CD4 T cells in HIV-1-infected adults treated with growth hormone. Aids. 2002, 16 (8): 1103-1111. 10.1097\/00002030-200205240-00003.","journal-title":"Aids"},{"issue":"1","key":"47_CR49","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1210\/jc.75.1.183","volume":"75","author":"J Timsit","year":"1992","unstructured":"Timsit J, Savino W, Safieh B, Chanson P, Gagnerault MC, Bach JF, Dardenne M: Growth hormone and insulin-like growth factor-I stimulate hormonal function and proliferation of thymic epithelial cells. J Clin Endocrinol Metab. 1992, 75 (1): 183-188. 10.1210\/jc.75.1.183.","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"47_CR50","first-page":"1085","volume":"118","author":"LA Napolitano","year":"2008","unstructured":"Napolitano LA, Schmidt D, Gotway MB, Ameli N, Filbert EL, Ng MM, Clor JL, Epling L, Sinclair E, Baum PD, et al: Growth hormone enhances thymic function in HIV-1-infected adults. J Clin Invest. 2008, 118 (3): 1085-1098.","journal-title":"J Clin Invest"},{"issue":"3","key":"47_CR51","first-page":"844","volume":"118","author":"K Tesselaar","year":"2008","unstructured":"Tesselaar K, Miedema F: Growth hormone resurrects adult human thymus during HIV-1 infection. J Clin Invest. 2008, 118 (3): 844-847.","journal-title":"J Clin Invest"}],"container-title":["Journal of Immune Based Therapies and Vaccines"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1476-8518-6-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T11:08:27Z","timestamp":1684840107000},"score":1,"resource":{"primary":{"URL":"https:\/\/jibtherapies.biomedcentral.com\/articles\/10.1186\/1476-8518-6-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10,31]]},"references-count":51,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,12]]}},"alternative-id":["47"],"URL":"https:\/\/doi.org\/10.1186\/1476-8518-6-7","relation":{},"ISSN":["1476-8518"],"issn-type":[{"value":"1476-8518","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,10,31]]},"assertion":[{"value":"25 September 2008","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 October 2008","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 October 2008","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"7"}}