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The present study sought to establish a similar correlation in patients with RGBS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Oxygen radical production in leukocytes was induced by formyl-Met-Leu-Phe (fMLF), Trp-Lys-Tyr-Met-Val-Met-NH<jats:sub>2<\/jats:sub>(WKYMVM), or phorbol myristate acetate (PMA) and assessed by quantifying superoxide anion formed by the leukocyte NADPH oxidase.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Disease severity, assessed using the MRC score, was negatively correlated to superoxide anion production triggered by fMLF or WKYMVM (p = 0.001 and 0.002, respectively; n = 10). Superoxide anion production also was significantly lower in RGBS patients with incomplete recovery after stimulation with fMLF (p = 0.004) or WKYMVM (p = 0.003).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We conclude that a lower respiratory burst in leukocytes is strongly associated with a severe course of RGBS.<\/jats:p><\/jats:sec>","DOI":"10.1186\/1476-9255-7-40","type":"journal-article","created":{"date-parts":[[2010,8,10]],"date-time":"2010-08-10T06:13:57Z","timestamp":1281420837000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Leukocyte oxygen radical production determines disease severity in the recurrent Guillain-Barr\u00e9 syndrome"],"prefix":"10.1186","volume":"7","author":[{"given":"Natalia","family":"Mossberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oluf","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus","family":"Nordin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Staffan","family":"Nilsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c5ke","family":"Svedhem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Bergstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristoffer","family":"Hellstrand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotta","family":"Movitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,8,8]]},"reference":[{"issue":"Pt 4","key":"159_CR1","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1093\/brain\/115.4.1093","volume":"115","author":"F Grand'Maison","year":"1992","unstructured":"Grand'Maison F, Feasby TE, Hahn AF, Koopman WJ: Recurrent Guillain-Barre syndrome. 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