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We tested the ability of this novel synthetic steroid with improved pharmacological properties to limit non-productive lung inflammation in rodents and attempted to gauge its immunological impact.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>In mice, oral treatment with HE3286 (40 mg\/kg) significantly (<jats:italic>p<\/jats:italic>&lt; 0.05) decreased neutrophil counts and exudate volumes (~50%) in carrageenan-induced pleurisy, and myeloperoxidase in lipopolysaccharide-induced lung injury. HE3286 (40 mg\/kg) was not found to be profoundly immune suppressive in any of the classical animal models of immune function, including those used to evaluate antigen specific immune responses<jats:italic>in vivo<\/jats:italic>(ovalbumin immunization). When mice treated for two weeks with HE3286 were challenged with<jats:italic>K. pneumoniae<\/jats:italic>, nearly identical survival kinetics were observed in vehicle-treated, HE3286-treated and untreated groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>HE3286 represents a novel, first-in-class anti-inflammatory agent that may translate certain benefits of \u03b2-AET observed in rodents into treatments for chronic inflammatory pulmonary disease.<\/jats:p><\/jats:sec>","DOI":"10.1186\/1476-9255-7-52","type":"journal-article","created":{"date-parts":[[2010,10,30]],"date-time":"2010-10-30T06:14:14Z","timestamp":1288419254000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["HE3286, an oral synthetic steroid, treats lung inflammation in mice without immune suppression"],"prefix":"10.1186","volume":"7","author":[{"given":"Douglas","family":"Conrad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond","family":"Pieters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferdinando","family":"Nicoletti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katia","family":"Mangano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna M","family":"van Heeckeren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven K","family":"White","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James M","family":"Frincke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher L","family":"Reading","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dwight","family":"Stickney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominick L","family":"Auci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,10,30]]},"reference":[{"key":"170_CR1","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1124\/pr.56.4.2","volume":"56","author":"PJ Barnes","year":"2004","unstructured":"Barnes PJ: Mediators of chronic obstructive pulmonary disease. 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