{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:16:09Z","timestamp":1761894969871},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Health Qual Life Outcomes"],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Introduction<\/jats:title>\n            <jats:p>Patients suffering from brain tumours often experience a wide range of cognitive impairments that impair their ability to report on their quality of life and symptom burden. The use of proxy ratings by significant others may be a promising alternative to gain information for medical decision making or research purposes, if self-ratings are not obtainable. Our study investigated the agreement of quality of life and symptom ratings by the patient him\/herself or by a significant other.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Patients with primary brain tumours were recruited at the neurooncological outpatient unit of Innsbruck Medical University. Quality of life self- and proxy-ratings were collected using the EORTC QLQ-C30 and its brain cancer module, the QLQ-BN20.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Between May 2005 and August 2007, 42 pairs consisting of a patient and his\/her significant other were included in the study. Most of the employed quality of life scales showed fairly good agreement between patient- and proxy-ratings (median correlation 0.46). This was especially true for Physical Functioning, Sleeping Disturbances, Appetite Loss, Constipation, Taste Alterations, Visual Disorders, Motor Dysfunction, Communication Deficits, Hair Loss, Itchy Skin, Motor Dysfunction and Hair Loss. Worse rater agreement was found for Social Functioning, Emotional Functioning, Cognitive Functioning, Fatigue, Pain, Dyspnoea and Seizures.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>The assessment of quality of life in brain cancer patients through ratings from their significant others seems to be a feasible strategy to gain information about certain aspects of patient's quality of life and symptom burden, if the patient is not able to provide information himself.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1477-7525-7-87","type":"journal-article","created":{"date-parts":[[2009,10,9]],"date-time":"2009-10-09T18:14:23Z","timestamp":1255112063000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Do neurooncological patients and their significant others agree on quality of life ratings?"],"prefix":"10.1186","volume":"7","author":[{"given":"Johannes M","family":"Giesinger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam","family":"Golser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Astrid","family":"Erharter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg","family":"Kemmler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriele","family":"Schauer-Maurer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guenter","family":"Stockhammer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armin","family":"Muigg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Hutterer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerhard","family":"Rumpold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernhard","family":"Holzner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2009,10,9]]},"reference":[{"issue":"4","key":"604_CR1","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1200\/JCO.2004.06.078","volume":"22","author":"G Velikova","year":"2004","unstructured":"Velikova G, Booth L, Smith AB, Brown PM, Lynch P, Brown JM, Selby PJ: Measuring quality of life in routine oncology practice improves communication and patient well-being: a randomized controlled trial. J Clin Oncol 2004,22(4):714\u201324. 10.1200\/JCO.2004.06.078","journal-title":"J Clin Oncol"},{"issue":"3","key":"604_CR2","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1002\/1099-1611(200005\/06)9:3<203::AID-PON453>3.0.CO;2-Y","volume":"9","author":"P Taenzer","year":"2000","unstructured":"Taenzer P, Bultz BD, Carlson LE, Speca M, DeGagne T, Olson K, Doll R, Rosberger Z: Impact of computerized quality of life screening on physician behaviour and patient satisfaction in lung cancer outpatients. Psychooncology 2000,9(3):203\u201313. 10.1002\/1099-1611(200005\/06)9:3<203::AID-PON453>3.3.CO;2-P","journal-title":"Psychooncology"},{"issue":"2","key":"604_CR3","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1081\/CNV-200050453","volume":"23","author":"D MacDonald","year":"2005","unstructured":"MacDonald D, Kiebert G, Padros M, Yung A, Olson J: Benefit of temozolamide compared to procarbazine treatment of glioblastoma multiforme at first relapse: effect on neurological functioning, performance status, and health related quality of life. Cancer Invest 2005,23(2):138\u2013144. 10.1081\/CNV-200050453","journal-title":"Cancer Invest"},{"issue":"2","key":"604_CR4","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1215\/15228517-5-2-96","volume":"5","author":"M Prados","year":"2003","unstructured":"Prados M, Schold S, Fine H, Jaeckle K, Hochberg F, Mechtler L, Fetell M, Phuphanich S, Feun L, Janus T, Ford K, Graney W: A randomized, double-blind, placebo-controlled, phase 2 study of RMP-7 in combination with carboplatin administered intravenously for the treatment of recurrent malignant glioma. Neuro-Oncol 2003,5(2):96\u2013103. 10.1215\/15228517-5-2-96","journal-title":"Neuro-Oncol"},{"key":"604_CR5","first-page":"CD007415","volume":"4","author":"M Hart","year":"2008","unstructured":"Hart M, Grant R, Garside R, Rogers G, Somerville M, Stein K: Temozolomide for high grade glioma. Cochrane Database Syst Rev 2008, 4: CD007415.","journal-title":"Cochrane Database Syst Rev"},{"issue":"5","key":"604_CR6","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1097\/00005650-199705000-00006","volume":"35","author":"KC Sneeuw","year":"1997","unstructured":"Sneeuw KC, Aaronson NK, Osoba D, Muller MJ, Hsu MA, Yung WK, Brada M, Newlands ES: The use of significant others as proxy raters of the quality of life of patients with brain cancer. Med Care 1997,35(5):490\u2013506. 10.1097\/00005650-199705000-00006","journal-title":"Med Care"},{"issue":"7","key":"604_CR7","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1016\/S0895-4356(98)00040-7","volume":"51","author":"KC Sneeuw","year":"1998","unstructured":"Sneeuw KC, Aaronson NK, Sprangers MA, Detmar SB, Wever LD, Schornagel JH: Comparison of patient and proxy EORTC QLQ-C30 ratings in assessing the quality of life of cancer patients. J Clin Epidemiol 1998,51(7):617\u201331. 10.1016\/S0895-4356(98)00040-7","journal-title":"J Clin Epidemiol"},{"issue":"8","key":"604_CR8","doi-asserted-by":"publisher","first-page":"1854","DOI":"10.1002\/cncr.23381","volume":"112","author":"M Bakitas","year":"2008","unstructured":"Bakitas M, Ahles T, Skalla K, Brokaw F, Byock I, Hanscom B, Lyons K, Hegel M: Proxy perspectives regarding end-of-life care for persons with cancer. Cancer 2008,112(8):1854\u201361. 10.1002\/cncr.23381","journal-title":"Cancer"},{"issue":"2","key":"604_CR9","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1111\/j.1365-2354.2005.00639.x","volume":"15","author":"DJ Milne","year":"2006","unstructured":"Milne DJ, Mulder LL, Beelen HCM, Schofield P, Kempen GIJM, Aranda S: Patients' self-report and family caregivers' perception of quality of life in patients with advanced cancer: how do they compare? Eur J Cancer Care (Engl) 2006,15(2):125\u201332. 10.1111\/j.1365-2354.2005.00639.x","journal-title":"Eur J Cancer Care (Engl)"},{"issue":"9","key":"604_CR10","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1023\/A:1016647407161","volume":"9","author":"KA Wilson","year":"2000","unstructured":"Wilson KA, Dowling AJ, Abdolell M, Tannock IF: Perception of quality of life by patients, partners and treating physicians. Qual Life Res 2000,9(9):1041\u201352. 10.1023\/A:1016647407161","journal-title":"Qual Life Res"},{"issue":"3","key":"604_CR11","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1258\/jrsm.2008.081002","volume":"101","author":"R Pearcy","year":"2008","unstructured":"Pearcy R, Waldron D, O'Boyle C, MacDonagh R: Proxy assessment of quality of life in patients with prostate cancer: how accurate are partners and urologists? Journal of the Royal Society of Medicine 2008,101(3):133\u2013138. 10.1258\/jrsm.2008.081002","journal-title":"Journal of the Royal Society of Medicine"},{"issue":"2","key":"604_CR12","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1177\/0272989X07311750","volume":"28","author":"N Dawson","year":"2008","unstructured":"Dawson N, Singer M, Lenert L, Patterson M, Sami S, Gonsenhouser I, Lindstrom H, Smyth K, Barber M, Whitehouse P: Health state valuation in mild to moderate cognitive impairment: feasibility of computer-based, direct patient utility assessment. Medical Decision Making 2008,28(2):220\u2013232. 10.1177\/0272989X07311750","journal-title":"Medical Decision Making"},{"issue":"1","key":"604_CR13","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/1477-7525-5-2","volume":"5","author":"J Varni","year":"2007","unstructured":"Varni J, Limbers C, Burwinkle T: Parent proxy-report of their children's health-related quality of life: an analysis of 13,878 parents' reliability and validity across age subgroups using the PedsQLTM 4.0 Generic Core Scales. Health and Quality of Life Outcomes 2007,5(1):2. 10.1186\/1477-7525-5-2","journal-title":"Health and Quality of Life Outcomes"},{"issue":"9","key":"604_CR14","first-page":"1523","volume":"13","author":"B Holzner","year":"2004","unstructured":"Holzner B, Zabernigg A, Kemmler G, Baier S, Kopp M, Sperner Unterweger B: Computerized assessment of quality of life in patients undergoing chemotherapy. Qual Life Res 2004,13(9):1523.","journal-title":"Qual Life Res"},{"issue":"5","key":"604_CR15","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1093\/jnci\/85.5.365","volume":"85","author":"NK Aaronson","year":"1993","unstructured":"Aaronson NK, Ahmedzai S, Bergman B, Bullinger M, Cull A, Duez NJ, Filiberti A, Flechtner H, Fleishman SB, de Haes JC: The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst 1993,85(5):365\u201376. 10.1093\/jnci\/85.5.365","journal-title":"J Natl Cancer Inst"},{"issue":"1","key":"604_CR16","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1007\/BF00435979","volume":"5","author":"D Osoba","year":"1996","unstructured":"Osoba D, Aaronson NK, Muller M, Sneeuw K, Hsu MA, Yung WK, Brada M, Newlands E: The development and psychometric validation of a brain cancer quality-of-life questionnaire for use in combination with general cancer-specific questionnaires. Qual Life Res 1996,5(1):139\u201350. 10.1007\/BF00435979","journal-title":"Qual Life Res"},{"issue":"1","key":"604_CR17","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1200\/JCO.1998.16.1.139","volume":"16","author":"D Osoba","year":"1998","unstructured":"Osoba D, Rodrigues G, Myles J, Zee B, Pater J: Interpreting the significance of changes in health-related quality-of-life scores. J Clin Oncol 1998,16(1):139\u201344.","journal-title":"J Clin Oncol"},{"issue":"6","key":"604_CR18","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1007\/BF00439229","volume":"5","author":"MT King","year":"1996","unstructured":"King MT: The interpretation of scores from the EORTC quality of life questionnaire QLQ-C30. Qual Life Res 1996,5(6):555\u201367. 10.1007\/BF00439229","journal-title":"Qual Life Res"},{"key":"604_CR19","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/S0140-6736(86)90837-8","volume":"8476","author":"J Bland","year":"1986","unstructured":"Bland J, Altman D: Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 1986, 8476: 307\u2013310.","journal-title":"Lancet"},{"key":"604_CR20","unstructured":"Erharter A, Giesinger J, Kemmler G, Schauer-Maurer G, Stockhammer G, Muigg A, Rumpold G, Sperner-Unterweger B, Holzner B: Implementation of computer-based quality of life monitoring in brain tumor outpatients in routine clinical practice. J Pain and Symptom Management, in press."},{"issue":"2","key":"604_CR21","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1097\/COC.0b013e318149f1d3","volume":"31","author":"P Brown","year":"2008","unstructured":"Brown P, Decker P, Rummans T, Clark M, Frost M, Ballman K, Arusell R, Buckner J: A prospective study of quality of life in adults with newly diagnosed high-grade gliomas: comparison of patient and caregiver ratings of quality of life. Am J Clin Oncol 2008,31(2):163\u2013168. 10.1097\/COC.0b013e318149f1d3","journal-title":"Am J Clin Oncol"},{"key":"604_CR22","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1002\/1097-0142(19950301)75:5<1151::AID-CNCR2820750515>3.0.CO;2-Q","volume":"75","author":"M Weitzner","year":"1995","unstructured":"Weitzner M, Meyers C, Gelke C, Byrne K, Cella D, Levin V: The functional assessment of cancer therapy (FACT) scale: Development of a brain subscale and the revalidation of the general version (FACT-G) in patients with primary brain tumors. Cancer 1995, 75: 1151\u20131161. 10.1002\/1097-0142(19950301)75:5<1151::AID-CNCR2820750515>3.0.CO;2-Q","journal-title":"Cancer"},{"issue":"2","key":"604_CR23","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1097\/MLR.0b013e318158af13","volume":"46","author":"C Gundy","year":"2008","unstructured":"Gundy C, Aaronson N: The influence of proxy perspective on patient-proxy agreement in the evaluation of health-related quality of life: an empirical study. Medical Care 2008,46(2):209\u2013216. 10.1097\/MLR.0b013e318158af13","journal-title":"Medical Care"}],"container-title":["Health and Quality of Life Outcomes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1477-7525-7-87.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T07:14:15Z","timestamp":1630480455000},"score":1,"resource":{"primary":{"URL":"https:\/\/hqlo.biomedcentral.com\/articles\/10.1186\/1477-7525-7-87"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10,9]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["604"],"URL":"https:\/\/doi.org\/10.1186\/1477-7525-7-87","relation":{},"ISSN":["1477-7525"],"issn-type":[{"value":"1477-7525","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,10,9]]},"assertion":[{"value":"2 April 2009","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 October 2009","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 October 2009","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"87"}}