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Therefore, it is needed to seek the contribute to the body of knowledge surrounding examination and characterization in laryngeal carcinoma infiltration.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Excised larynges were collected from 30 male laryngectomy patients with an average age of 43.5\u2009years (ranging 36 to 55\u2009years) and history of smoking (\u226510\u2009years) exhibiting T1, T2, or subglottal (normal vocal fold) carcinomas. Vocal folds were preserved via freezing or immersion in paraffin. The depth of the mucosa, submucosa, and muscular layers in both normal vocal folds and tumor tissues of afflicted vocal folds was measured.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The average depths of the mucosa, submucosa, and muscular layers in normal vocal folds were 0.15\u2009\u00b1\u20090.06\u2009mm, 2.30\u2009\u00b1\u20090.59\u2009mm, and 2.87\u2009\u00b1\u20090.88\u2009mm, respectively. Infiltration measurements of T1 tumors showed a depth of 1.62\u2009\u00b1\u20090.51\u2009mm and 1.32\u2009\u00b1\u20090.49\u2009mm in frozen sections and paraffin-embedded samples, respectively. Similarly, T2 tumors showed a depth of 2.87\u2009\u00b1\u20090.68\u2009mm and 2.58\u2009\u00b1\u20090.67\u2009mm in frozen sections and paraffin-embedded samples, respectively. T1 and T2 tumors occupied 24.8\u2009\u00b1\u200910 and 48.5\u2009\u00b1\u200915 percent of the normal vocal fold depth, respectively.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>This data provides a baseline for estimating infiltration of laryngeal carcinomas in vocal fold tissue layers, of particular interest to surgeons. This information may be used to assess typical depths of infiltration, thus allowing for more appropriate selection of surgical procedures based on individual patient assessment.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1477-7819-10-178","type":"journal-article","created":{"date-parts":[[2012,8,30]],"date-time":"2012-08-30T10:15:16Z","timestamp":1346321716000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Vocal fold composition and early glottic carcinoma infiltration"],"prefix":"10.1186","volume":"10","author":[{"given":"Qin","family":"Fang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luhong","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejun","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lide","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangbin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,8,30]]},"reference":[{"key":"1095_CR1","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1159\/000322592","volume":"73","author":"A Keilmann","year":"2011","unstructured":"Keilmann A, Napiontek U, Engel C, Nakarat T, Schneider A, Mann W: Long-term functional outcome after unilateral cordectomy. 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