{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T22:47:48Z","timestamp":1757544468397},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World J Surg Onc"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>Metastatic leptomeningeal carcinomatosis is estimated to occur in 3% to 8% of solid carcinomas. The most common causes of leptomeningeal carcinomatosis are breast cancer, lung cancer and malignant melanoma. Leptomeningeal carcinomatosis associated with gastric cancer, especially in its early stages, is exceedingly rare. Its presenting symptoms include headache, nauseaand seizures. In this report, we describe a case of leptomeningeal metastasis that presented with early-stage gastric cancer. A 67-year-old woman with a history of early-stage gastric cancer in remission was admitted to our hospital with 3\u2009days of headache and nausea. Her gastric cancer had been treated 29\u2009months prior to presentation by a radical subtotal gastrectomy with a Billroth I anastomosis. She had an uneventful recovery until she was diagnosed with metastases to the left axilla and neck 26\u2009months after surgery. Her presenting symptoms of headache and nausea prompted cytologic examination of the cerebrospinal fluid and measurement of tumor markers, which revealed metastatic leptomeningeal carcinomatosis from her gastric cancer. This report aims to raise awareness of the possibility that even early-stage gastric cancer can lead to leptomeningeal carcinomatosis.<\/jats:p>","DOI":"10.1186\/1477-7819-10-74","type":"journal-article","created":{"date-parts":[[2012,5,3]],"date-time":"2012-05-03T14:22:13Z","timestamp":1336054933000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A case of metastatic leptomeningeal carcinomatosis from early gastric carcinoma"],"prefix":"10.1186","volume":"10","author":[{"given":"Kwang-Kuk","family":"Park","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song-I","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyung-Won","family":"Seo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young-Ok","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ki-Young","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,5,3]]},"reference":[{"key":"1027_CR1","doi-asserted-by":"publisher","first-page":"135","DOI":"10.5230\/jgc.2011.11.3.135","volume":"11","author":"A Shin","year":"2011","unstructured":"Shin A, Kim J, Park S: Gastric cancer epidemiology in Korea. J Gastric Cancer. 2011, 11: 135-140. 10.5230\/jgc.2011.11.3.135.","journal-title":"J Gastric Cancer"},{"key":"1027_CR2","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1007\/s10120-011-0041-5","volume":"14","author":"Japanese Gastric Cancer Association","year":"2011","unstructured":"Japanese Gastric Cancer Association: Japanese classification of gastric carcinoma: 3rd English edition. Gastric Cancer. 2011, 14: 101-112.","journal-title":"Gastric Cancer"},{"key":"1027_CR3","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1002\/jso.20018","volume":"85","author":"WJ Hyung","year":"2004","unstructured":"Hyung WJ, Cheong JH, Kim J, Chen J, Choi SH, Noh SH: Application of minimally invasive treatment for early gastric cancer. J Surg Oncol. 2004, 85: 181-186. 10.1002\/jso.20018.","journal-title":"J Surg Oncol"},{"key":"1027_CR4","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1023\/B:NEON.0000013462.43156.f4","volume":"66","author":"JL Lee","year":"2004","unstructured":"Lee JL, Kang YK, Kim TW, Chang HM, Lee GW, Ryu MH, Kim E, Oh SJ, Lee JH, Kim SB, Kim SW, Suh C, Lee KH, Lee JS, Kim WK, Kim SH: Leptomeningeal carcinomatosis in gastric cancer. J Neurooncol. 2004, 66: 167-174.","journal-title":"J Neurooncol"},{"key":"1027_CR5","first-page":"327","volume":"213","author":"M Lawrence","year":"1991","unstructured":"Lawrence M, Shiu MH: Early gastric cancer. Twenty-eight-year experience. Ann Surg. 1991, 213: 327-334.","journal-title":"Twenty-eight-year experience. Ann Surg"},{"key":"1027_CR6","first-page":"380","volume":"41","author":"H Baba","year":"1994","unstructured":"Baba H, Maehara Y, Okuyama T, Orita H, Anai H, Akazawa K, Sugimachi K: Lymph node metastasis and macroscopic features in early gastric cancer. Hepatogastroenterology. 1994, 41: 380-383.","journal-title":"Hepatogastroenterology"},{"key":"1027_CR7","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1007\/s101200050054","volume":"1","author":"FJ Oliveira","year":"1998","unstructured":"Oliveira FJ, Ferrao H, Furtado E, Batista H, Conceicao L: Early gastric cancer: report of 58 cases. Gastric Cancer. 1998, 1: 51-56. 10.1007\/s101200050054.","journal-title":"Gastric Cancer"},{"key":"1027_CR8","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1002\/cncr.10120","volume":"94","author":"WJ Hyung","year":"2002","unstructured":"Hyung WJ, Noh SH, Lee JH, Huh JJ, Lah KH, Choi SH, Min JS: Early gastric carcinoma with signet ring cell histology. Cancer. 2002, 94: 78-83. 10.1002\/cncr.10120.","journal-title":"Cancer"},{"issue":"Suppl 4","key":"1027_CR9","doi-asserted-by":"crossref","first-page":"iv285","DOI":"10.1093\/annonc\/mdh941","volume":"15","author":"N Pavlidis","year":"2004","unstructured":"Pavlidis N: The diagnostic and therapeutic management of leptomeningeal carcinomatosis. Ann Oncol. 2004, 15 (Suppl 4): iv285-iv291.","journal-title":"Ann Oncol"},{"key":"1027_CR10","first-page":"210","volume":"7","author":"KW Kim","year":"1989","unstructured":"Kim KW, Kim SM, Kim JS: Clinical features and prognosis of leptomeningeal carcinomatosis. J Korean Neurol Assoc. 1989, 7: 210-217.","journal-title":"J Korean Neurol Assoc"},{"key":"1027_CR11","first-page":"34","volume":"33","author":"JO Park","year":"2001","unstructured":"Park JO, Shin HJ, Kim HJ, Lee SW, Jeung HC, Kim SM, Yoo NC, Chung HC, Kim JH, Kim BS, Min JS, Roh JK: Leptomeningeal carcinomatosis in solid tumors; clinical manifestation and treatment. J Korean Cancer Assoc. 2001, 33: 34-40.","journal-title":"J Korean Cancer Assoc"},{"key":"1027_CR12","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1097\/00042737-200505000-00016","volume":"17","author":"S Braeuninger","year":"2005","unstructured":"Braeuninger S, Mawrin C, Malfertheiner P, Schildhaus HU, Seiler C, Dietzmann K, Lins H: Gastric adenocarcinoma with leptomeningeal carcinomatosis as the presenting manifestation: an autopsy case report. Eur J Gastroenterol Hepatol. 2005, 17: 577-579. 10.1097\/00042737-200505000-00016.","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"1027_CR13","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1002\/1097-0142(19820215)49:4<759::AID-CNCR2820490427>3.0.CO;2-7","volume":"49","author":"WR Wasserstrom","year":"1982","unstructured":"Wasserstrom WR, Glass JP, Posner JB: Diagnosis and treatment of leptomeningeal metastases from solid tumors: experience with 90 patients. Cancer. 1982, 49: 759-772. 10.1002\/1097-0142(19820215)49:4<759::AID-CNCR2820490427>3.0.CO;2-7.","journal-title":"Cancer"},{"key":"1027_CR14","volume-title":"Int J Clin Oncol","author":"H Tomita","year":"2011","unstructured":"Tomita H, Yasui H, Boku N, Nakasu Y, Mitsuya K, Onozawa Y, Fukutomi A, Yamazaki K, Machida N, Taku K, Todaka A, Taniguchi H, Tsushima T: Leptomeningeal carcinomatosis associated with gastric cancer. Int J Clin Oncol. 2011, in press"}],"container-title":["World Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1477-7819-10-74.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T19:36:52Z","timestamp":1630525012000},"score":1,"resource":{"primary":{"URL":"https:\/\/wjso.biomedcentral.com\/articles\/10.1186\/1477-7819-10-74"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,3]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["1027"],"URL":"https:\/\/doi.org\/10.1186\/1477-7819-10-74","relation":{},"ISSN":["1477-7819"],"issn-type":[{"value":"1477-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,3]]},"assertion":[{"value":"30 November 2011","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 March 2012","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 May 2012","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"74"}}