{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:31:36Z","timestamp":1761895896410},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World J Surg Onc"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>The small bowel rarely suffers from metastatic tumors from outside the abdomen. Small bowel obstructions caused by the metastatic spread of squamous cell carcinoma (SCC) of the hand to the intestines are even rarer. A 71-year-old man with intermittent abdominal distension and pain for 4\u00a0months was diagnosed with partial bowel obstruction. The patient underwent a video capsule endoscopic examination; however, the patient was unable to pass the capsule, which worsened the abdominal distension. He was transferred to our department for acute intestinal obstruction, and an emergency exploratory laparotomy was performed. Intraoperatively, a tumoral stricture of the intestine at a distance of 150\u00a0cm from the ileo-cecum and dilation of the proximal bowel was found. The involved segment was resected, and ileo-ileal anastomosis was performed. The pathological sections confirmed the lesion to be a moderately differentiated SCC with whole bowel layer infiltration. Immunohistochemical staining showed positive expression of cytokeratin 5\/6 and p63. The patient had an uneventful recovery. However, 6\u00a0months later, he was hospitalized again with intestinal obstruction. Reoperation was performed and revealed multiple metastases in the small bowel. He died 4\u00a0months later. In this unusual case, metastasizing SCC of the hand skin led to intestinal obstruction and poor prognosis. Therefore, follow-up procedures regarding intestinal spread should be performed in patients with SCC who present with abdominal symptoms.<\/jats:p>","DOI":"10.1186\/1477-7819-12-166","type":"journal-article","created":{"date-parts":[[2014,5,28]],"date-time":"2014-05-28T01:02:42Z","timestamp":1401238962000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Metastatic squamous cell carcinoma from hand skin causing small bowel obstruction: an unusual case presentation"],"prefix":"10.1186","volume":"12","author":[{"given":"Ruixin","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zihua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiaocheng","family":"Wen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhikang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,5,28]]},"reference":[{"key":"1659_CR1","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1007\/BF00311639","volume":"26","author":"T Yamada","year":"1996","unstructured":"Yamada T, Yagi S, Tatsuzawa Y, Fujioka S, Sato H, Kitagawa S, Nakagawa M, Kurumaya H: Small intestinal metastasis from esophageal carcinoma associated with small intestinal obstruction: report of a case. Surg Today. 1996, 26: 800-802. 10.1007\/BF00311639.","journal-title":"Surg Today"},{"key":"1659_CR2","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1097\/00007611-198507000-00030","volume":"78","author":"M Wang","year":"1985","unstructured":"Wang M, Patel J, Casey TT, Kieffer R, Dunn GD: Metastatic squamous cell carcinoma from the esophagus occurring as small bowel obstruction. South Med J. 1985, 78: 884-886. 10.1097\/00007611-198507000-00030.","journal-title":"South Med J"},{"key":"1659_CR3","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1159\/000292094","volume":"33","author":"T Grenader","year":"2010","unstructured":"Grenader T, Goldberg A: Long-term survival in a patient with non-small cell lung cancer presenting as small intestinal obstruction. Onkologie. 2010, 33: 178-180. 10.1159\/000292094.","journal-title":"Onkologie"},{"key":"1659_CR4","doi-asserted-by":"publisher","first-page":"176","DOI":"10.9738\/1380.1","volume":"96","author":"H Yamada","year":"2011","unstructured":"Yamada H, Akahane T, Horiuchi A, Shimada R, Shibuya H, Hayama T, Nozawa K, Ishihara S, Matsuda K, Watanabe T: A case of lung squamous cell carcinoma with metastases to the duodenum and small intestine. Int Surg. 2011, 96: 176-181. 10.9738\/1380.1.","journal-title":"Int Surg"},{"key":"1659_CR5","doi-asserted-by":"publisher","first-page":"1685","DOI":"10.1023\/A:1025470306597","volume":"48","author":"DA Katz","year":"2003","unstructured":"Katz DA, Martinez-Mier G, Rayhill SC, Mitros FA, Kanchustambam SR, Wu YM: Small bowel obstruction caused by metastatic squamous cell carcinoma of the skin without lymphadenopathy in a renal transplant recipient. Dig Dis Sci. 2003, 48: 1685-1687. 10.1023\/A:1025470306597.","journal-title":"Dig Dis Sci"},{"key":"1659_CR6","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1016\/j.oraloncology.2010.01.013","volume":"46","author":"RC Dwivedi","year":"2010","unstructured":"Dwivedi RC, Kazi R, Agrawal N, Chisholm E, St Rose S, Elmiyeh B, Rennie C, Pepper C, Clarke PM, Kerawala CJ, Rhys-Evans PH, Harrington KJ, Nutting CM: Comprehensive review of small bowel metastasis from head and neck squamous cell carcinoma. Oral Oncol. 2010, 46: 330-335. 10.1016\/j.oraloncology.2010.01.013.","journal-title":"Oral Oncol"},{"key":"1659_CR7","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1097\/PGP.0b013e31823b6f53","volume":"31","author":"W Song","year":"2012","unstructured":"Song W, Conner M: Squamous cell carcinoma arising within a mature cystic teratoma with invasion into the adjacent small intestine: a case report. Int J Gynecol Pathol. 2012, 31: 272-275. 10.1097\/PGP.0b013e31823b6f53.","journal-title":"Int J Gynecol Pathol"},{"key":"1659_CR8","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1159\/000334426","volume":"5","author":"T Tanaka","year":"2011","unstructured":"Tanaka T, Minami S, Tsutsumi R, Azuma T, Matsuo S, Abe K, Hayashi T, Eguchi S: A metastatic jejunal tumor from squamous cell carcinoma of the lung found in an intestinal perforation. Case Rep Gastroenterol. 2011, 5: 636-641. 10.1159\/000334426.","journal-title":"Case Rep Gastroenterol"},{"key":"1659_CR9","doi-asserted-by":"crossref","first-page":"903897","DOI":"10.1155\/2009\/903897","volume":"2009","author":"E Gu\u00e9rin","year":"2009","unstructured":"Gu\u00e9rin E, Gilbert O, Dequanter D: Acute abdomen: a rare presentation of lung cancer metastasis. Case Rep Med. 2009, 2009: 903897-","journal-title":"Case Rep Med"},{"key":"1659_CR10","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1097\/00004836-200203000-00027","volume":"34","author":"E Sapozhnikov","year":"2002","unstructured":"Sapozhnikov E, Zakko S, Remoroza R, Aziz K, Levine J, Shah M, Henisz AK, Giebisch NX: Small bowel obstruction as a unique complication of squamous cell carcinoma of the penis. J Clin Gastroenterol. 2002, 34: 289-290.","journal-title":"J Clin Gastroenterol"},{"key":"1659_CR11","first-page":"203","volume":"5","author":"T Terada","year":"2012","unstructured":"Terada T: Malignant tumors of the small intestine: a histopathologic study of 41 cases among 1312 consecutive specimens of small intestine. Int J Clin Exp Pathol. 2012, 5: 203-209.","journal-title":"Int J Clin Exp Pathol"},{"issue":"Suppl 2","key":"1659_CR12","first-page":"77","volume":"35","author":"N Kraljik","year":"2011","unstructured":"Kraljik N, Rosso M, Ageel A, Sepi\u0107 T, Gmajni\u0107 R: The incidence of skin squamous cell carcinoma in Osijek-Baranja County \u2013 an epidemiological study. Coll Antropol. 2011, 35 (Suppl 2): 77-80.","journal-title":"Coll Antropol"},{"key":"1659_CR13","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1056\/NEJM200103293441306","volume":"344","author":"M Alam","year":"2001","unstructured":"Alam M, Ratner D: Cutaneous squamous-cell carcinoma. N Engl J Med. 2001, 344: 975-983. 10.1056\/NEJM200103293441306.","journal-title":"N Engl J Med"},{"key":"1659_CR14","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1002\/dc.20975","volume":"37","author":"S Khayyata","year":"2009","unstructured":"Khayyata S, Yun S, Pasha T, Jian B, McGrath C, Yu G, Gupta P, Baloch Z: Value of P63 and CK5\/6 in distinguishing squamous cell carcinoma from adenocarcinoma in lung fine-needle aspiration specimens. Diagn Cytopathol. 2009, 37: 178-183. 10.1002\/dc.20975.","journal-title":"Diagn Cytopathol"},{"key":"1659_CR15","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1016\/j.bjps.2012.01.022","volume":"65","author":"H Wright","year":"2012","unstructured":"Wright H, McKinnell TH, Dunkin C: Recurrence of cutaneous squamous cell carcinoma at remote limb donor site. J Plast Reconstr Aesthet Surg. 2012, 65: 1265-1266. 10.1016\/j.bjps.2012.01.022.","journal-title":"J Plast Reconstr Aesthet Surg"},{"key":"1659_CR16","first-page":"321","volume":"41","author":"H A\u011fir","year":"2007","unstructured":"A\u011fir H, Adams BM, Mackinnon CA: Squamous cell carcinoma of the palm: a case report. Acta Orthop Traumatol Turc. 2007, 41: 321-325.","journal-title":"Acta Orthop Traumatol Turc"},{"key":"1659_CR17","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1186\/1477-7819-3-44","volume":"3","author":"J Lindenmann","year":"2005","unstructured":"Lindenmann J, Gollowitsch F, Matzi V, Porubsky C, Maier A, Smolle-Juettner FM: Occult solitary submucosal jejunal metastasis from esophageal carcinoma. World J Surg Oncol. 2005, 3: 44-10.1186\/1477-7819-3-44.","journal-title":"World J Surg Oncol"},{"key":"1659_CR18","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1007\/s00261-008-9431-5","volume":"34","author":"M Waterman","year":"2009","unstructured":"Waterman M, Eliakim R: Capsule enteroscopy of the small intestine. Abdom Imaging. 2009, 34: 452-458. 10.1007\/s00261-008-9431-5.","journal-title":"Abdom Imaging"},{"key":"1659_CR19","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1089\/lap.2007.0156","volume":"18","author":"M Mason","year":"2008","unstructured":"Mason M, Swain J, Matthews BD, Harold KL: Use of video capsule endoscopy in the setting of recurrent subacute small-bowel obstruction. J Laparoendosc Adv Surg Tech A. 2008, 18: 713-716. 10.1089\/lap.2007.0156.","journal-title":"J Laparoendosc Adv Surg Tech A"},{"key":"1659_CR20","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1111\/j.1445-2197.2005.03590.x","volume":"75","author":"F Catena","year":"2005","unstructured":"Catena F, Ansaloni L, Gazzotti F, Gagliardi S, Di Saverio S, De Cataldis A, Taffurelli M: Small bowel tumours in emergency surgery: specificity of clinical presentation. ANZ J Surg. 2005, 75: 997-999. 10.1111\/j.1445-2197.2005.03590.x.","journal-title":"ANZ J Surg"},{"key":"1659_CR21","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1097\/00007611-197312000-00012","volume":"66","author":"RE Richie","year":"1973","unstructured":"Richie RE, Reynolds VH, Sawyers JL: Tumor metastases to the small bowel from extra- abdominal sites. South Med J. 1973, 66: 1383-1387. 10.1097\/00007611-197312000-00012.","journal-title":"South Med J"}],"container-title":["World Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1477-7819-12-166.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T04:12:26Z","timestamp":1630555946000},"score":1,"resource":{"primary":{"URL":"https:\/\/wjso.biomedcentral.com\/articles\/10.1186\/1477-7819-12-166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,28]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["1659"],"URL":"https:\/\/doi.org\/10.1186\/1477-7819-12-166","relation":{},"ISSN":["1477-7819"],"issn-type":[{"value":"1477-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,28]]},"assertion":[{"value":"8 May 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 May 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 May 2014","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"166"}}