{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T14:40:20Z","timestamp":1789569620552,"version":"build-2803163510"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World J Surg Onc"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>\n              <jats:italic>Kr\u00fcppel-like factor 4 (KLF4)<\/jats:italic> is involved in many important cellular processes such as growth, development, differentiation, proliferation, and apoptosis. The purpose of this study was to determine the significance of <jats:italic>KLF4<\/jats:italic> in both tumors and normal tissues of patients with colorectal cancer (CRC).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Between January 2003 and June 2005, 125 patients with CRC receiving treatment at the Yonsei Cancer Center were selected. We examined the mRNA level of the <jats:italic>KLF4<\/jats:italic> gene in primary CRC specimens and matched normal colon tissues using real-time RT-PCR. Correlation of survival with clinicopathological parameters, including <jats:italic>KLF4<\/jats:italic> level, was investigated with univariate and multivariate analyses.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>CRC tissue had a significantly lower <jats:italic>KLF4<\/jats:italic> level when compared with matched normal tissues (<jats:italic>KLF4<\/jats:italic> in tumors: 2007\u2009\u00b1\u20091531 copies\/\u03bcl, <jats:italic>KLF4<\/jats:italic> in normal tissues: 6586\u2009\u00b1\u20092834 copies\/\u03bcl; <jats:italic>P<\/jats:italic> &lt;0.0001). However, there was a correlation between the <jats:italic>KLF4<\/jats:italic> level in tumors and normal tissues. Patients with a high <jats:italic>KLF4<\/jats:italic> level in matched normal tissues were more likely than those with a low <jats:italic>KLF4<\/jats:italic> level to develop recurrence and had poorer overall survival (<jats:italic>P<\/jats:italic>\u2009=\u20090.005). Therefore, the <jats:italic>KLF4<\/jats:italic> level in the normal tissue of individuals was associated with prognosis of individuals.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Our data suggest that <jats:italic>KLF4<\/jats:italic> mRNA expression level in normal tissues and tumors may be a useful prognostic marker in patients with CRC.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1477-7819-12-232","type":"journal-article","created":{"date-parts":[[2014,7,24]],"date-time":"2014-07-24T09:35:38Z","timestamp":1406194538000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["High KLF4 level in normal tissue predicts poor survival in colorectal cancer patients"],"prefix":"10.1186","volume":"12","author":[{"given":"Ha-young","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joong Bae","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun Young","family":"Rha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Cheol","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyu Hyun","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Soo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nam Kyu","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Joon","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,7,24]]},"reference":[{"key":"1715_CR1","doi-asserted-by":"publisher","first-page":"69","DOI":"10.3322\/caac.20107","volume":"61","author":"A Jemal","year":"2011","unstructured":"Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D: Global cancer statistics. 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