{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T14:59:46Z","timestamp":1781017186854,"version":"3.54.1"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World J Surg Onc"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                        <jats:title>Background<\/jats:title>\n                        <jats:p>H\u00fcrthle cell carcinoma is a variant of follicular cell carcinoma of thyroid. It may present as a low-grade tumour or as a more aggressive type. Prognosis depends upon the age of the patient, tumour size, extent of invasion and initial nodal or distant metastasis.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Patient and methods<\/jats:title>\n                        <jats:p>The case of H\u00fcrthle cell carcinoma is reported in a 79-year-old man who presented with a rapidly increasing lump on the left side of his neck, having had a right hemithyroidectomy for colloid goitre 24-years-ago. Fine needle aspiration cytology confirmed the presence of H\u00fcrthle cells, raising the possibility of a H\u00fcrthle cell neoplasm. The patient underwent staging and surgery. Histology showed H\u00fcrthle cell carcinoma and the patient underwent adjuvant therapy. The literature on H\u00fcrthle cell neoplasms is reviewed.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Conclusions<\/jats:title>\n                        <jats:p>Fine needle aspiration cytology may recognise H\u00fcrthle cell lesion but final diagnosis of carcinoma depends upon histological confirmation of vascular or capsular invasion. Staging and surgery in H\u00fcrthle cell carcinoma are similar to follicular carcinoma of thyroid with favourable outcome despite the controversy regarding the histological classification and adjuvant therapy. Elderly patients with H\u00fcrthle cell carcinoma need to be made aware of their poorer prognosis and should be offered more radical treatment.<\/jats:p>\n                     <\/jats:sec>","DOI":"10.1186\/1477-7819-2-27","type":"journal-article","created":{"date-parts":[[2004,8,14]],"date-time":"2004-08-14T06:22:48Z","timestamp":1092464568000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["H\u00fcrthle cell carcinoma: diagnostic and therapeutic implications"],"prefix":"10.1186","volume":"2","author":[{"given":"Mohamed R","family":"Hanief","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laszlo","family":"Igali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrie","family":"Grama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2004,8,11]]},"reference":[{"key":"57_CR1","doi-asserted-by":"crossref","first-page":"541","DOI":"10.5858\/2001-125-0541-CTCCAH","volume":"125","author":"ZW Baloch","year":"2001","unstructured":"Baloch ZW, Mandel S, LiVolsi VA: Combined tall cell carcinoma and H\u00fcrthle cell carcinoma (collision tumour) of the thyroid. 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