{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T22:09:35Z","timestamp":1772662175037,"version":"3.50.1"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World J Surg Onc"],"published-print":{"date-parts":[[2005,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>As in ulcerative colitis, there is an increased incidence of colorectal carcinoma in Crohn's disease. While carcinoma formation originating from ano-rectal fistulas is generally considered as a rare event there are different publications reporting on mucinous adenocarcinoma formation in association with a neovagina and rectovaginal fistulas. To the best of our knowledge this is the first description of a perianal mucinous adenocarcinoma arising in a patient after Crohn's disease proctocolectomy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Case presentation<\/jats:title>\n            <jats:p>We report the case of a 50-year old female with a mucinous adenocarcinoma forming in the perineum eleven years after proctocolectomy for Crohn's disease. The patient was readmitted with perineal pain, leucocytosis and a perineal mass highly suspicious of abscess formation in the MRI-Scan. Histological examination revealed a mucinous adenocarcinoma. Exenteration including vagina, uterus and ovaries together with the coccygeal-bone was performed.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Mucinous adenocarcinoma formation is a rare complication of Crohn's disease and so far unreported after proctocolectomy.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1477-7819-3-42","type":"journal-article","created":{"date-parts":[[2005,6,29]],"date-time":"2005-06-29T18:13:49Z","timestamp":1120068829000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Case report: late perianal mucinous adenocarcinoma after Crohn's disease proctectomy: an oncological rarity"],"prefix":"10.1186","volume":"3","author":[{"given":"Michael","family":"Keese","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter","family":"Back","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dietmar","family":"Dinter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rainer","family":"Gladisch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Joos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"Palma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2005,6,29]]},"reference":[{"key":"119_CR1","volume-title":"Cochrane Database Syst Rev.","author":"C Mpofu","year":"2004","unstructured":"Mpofu C, Watson AJ, Rhodes JM: Strategies for detecting colon cancer and\/or dysplasia in patients with inflammatory bowel disease. Cochrane Database Syst Rev. 2004, CD000279-2"},{"issue":"Suppl 2","key":"119_CR2","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1046\/j.1365-2036.18.s2.5.x","volume":"18","author":"F Shanahan","year":"2003","unstructured":"Shanahan F: Colitis-associated cancer \u2013 time for new strategies. Aliment Pharmacol Ther. 2003, 18 (Suppl 2): 6-9. 10.1046\/j.1365-2036.18.s2.5.x.","journal-title":"Aliment Pharmacol Ther"},{"key":"119_CR3","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1055\/s-2002-33417","volume":"40","author":"R Winkler","year":"2002","unstructured":"Winkler R, Wittmer A, Heusermann U: Cancer and Crohn's disease. Z Gastroenterol. 2002, 40: 569-76. 10.1055\/s-2002-33417.","journal-title":"Z Gastroenterol"},{"key":"119_CR4","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1007\/BF02237388","volume":"41","author":"A Ky","year":"1998","unstructured":"Ky A, Sohn N, Weinstein MA, Korelitz BI: Carcinoma arising in anorectal fistulas of Crohn's disease. Dis Col Rectum. 1998, 41: 992-996.","journal-title":"Dis Col Rectum"},{"key":"119_CR5","first-page":"516","volume":"84","author":"CA Cuenod","year":"2003","unstructured":"Cuenod CA, de Parades V, Siauve N, Marteau P, Grataloup C, Hernigou A, Berger A, Cugnenc PH, Frija G: MR imaging of ano-perineal suppurations. Radiol. 2003, 84: 516-28.","journal-title":"Radiol"},{"key":"119_CR6","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1097\/00000658-193811000-00007","volume":"108","author":"A Penner","year":"1938","unstructured":"Penner A, Crohn BB: Perianal fistulae as a complication of regional ileitis. Ann Surg. 1938, 108: 867-873.","journal-title":"Ann Surg"},{"key":"119_CR7","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1007\/BF02587272","volume":"18","author":"H Lockhart-Mummery","year":"1975","unstructured":"Lockhart-Mummery H: Crohn's disease: anal lesions. Dis Colon Rectum. 1975, 18: 200-202.","journal-title":"Dis Colon Rectum"},{"key":"119_CR8","first-page":"498","volume-title":"Fundamentals of Anorectal Surgery","author":"O Alabaz","year":"1999","unstructured":"Alabaz O: Anorectal Crohn's disease. Fundamentals of Anorectal Surgery. Edited by: Beck D, Wexner SD. 1999, 498-509."},{"key":"119_CR9","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1007\/BF02258390","volume":"40","author":"F Makowiec","year":"1997","unstructured":"Makowiec F, Makowiec F, Jehle EC, Becker HD, Starlinger M: Perianal abscess in Crohn's disease. Dis Colon Rectum. 1997, 40: 443-450.","journal-title":"Dis Colon Rectum"},{"key":"119_CR10","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1046\/j.1463-1318.2003.00510.x","volume":"5","author":"RI Sjodahl","year":"2003","unstructured":"Sjodahl RI, Myrelid P, Soderholm JD: Anal and rectal cancer in Crohn's disease. Colorectal Dis. 2003, 5: 490-495. 10.1046\/j.1463-1318.2003.00510.x.","journal-title":"Colorectal Dis"},{"key":"119_CR11","first-page":"681","volume":"54","author":"M Okuno","year":"1988","unstructured":"Okuno M, Ikehara T, Nagayama M: Mucinous colorectal carcinoma: Clinical pathology and prognosis. Am Surg. 1988, 54: 681-685.","journal-title":"Am Surg"},{"key":"119_CR12","doi-asserted-by":"publisher","first-page":"1891","DOI":"10.1002\/1097-0142(197604)37:4<1891::AID-CNCR2820370439>3.0.CO;2-Z","volume":"37","author":"DA Symonds","year":"1976","unstructured":"Symonds DA, Vichery AL: Mucinous adenocarcinoma of the colon and rectum. Cancer. 1976, 37: 1891-1900.","journal-title":"Cancer"},{"key":"119_CR13","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1002\/1097-0142(197703)39:3<1295::AID-CNCR2820390341>3.0.CO;2-N","volume":"39","author":"PG Prioleau","year":"1977","unstructured":"Prioleau PG, Allen MS, Roberts T: Perianal mucinous adenocarcinoma. Cancer. 1977, 39: 1295-1299.","journal-title":"Cancer"},{"key":"119_CR14","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1006\/gyno.1994.1045","volume":"52","author":"A Munkarah","year":"1994","unstructured":"Munkarah A, Malone JM, Budev HD, Evans TN: Mucinous adenocarcinoma arising in a neovagina. Gynecologic Oncology. 1994, 52: 272-275. 10.1006\/gyno.1994.1045.","journal-title":"Gynecologic Oncology"},{"key":"119_CR15","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1002\/jso.1067","volume":"77","author":"H Hiroi","year":"2001","unstructured":"Hiroi H, Yasugi T, Matsumoto K, Fujii T, Watanabe T, Yoshikawa H, Taketani Y: Mucinous adenocarcinoma arising in a neovagina using the sigmoid colon thirty years after operation: a case report. J Surg Oncol. 2001, 77: 61-64. 10.1002\/jso.1067.","journal-title":"J Surg Oncol"},{"key":"119_CR16","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1016\/j.ygyno.2003.11.056","volume":"93","author":"CA Moore-Maxwell","year":"2004","unstructured":"Moore-Maxwell CA, Robboy SJ: Mucinous adenocarcinoma arising in rectovaginal fistulas associated with Crohn's disease. Gynecologic Oncology. 2004, 93: 266-268. 10.1016\/j.ygyno.2003.11.056.","journal-title":"Gynecologic Oncology"},{"key":"119_CR17","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1016\/0002-9610(80)90048-3","volume":"140","author":"P Buchmann","year":"1980","unstructured":"Buchmann P, Allan RN, Thompson H, Alexander-Williams J: Carcinoma in a rectovaginal fistula in a patient with crohn's disease. Am J Surg. 1980, 140: 642-4. 10.1016\/0002-9610(80)90048-3.","journal-title":"Am J Surg"},{"key":"119_CR18","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1007\/BF02253501","volume":"35","author":"ME Sher","year":"1992","unstructured":"Sher ME, Bauer JJ, Gorphine S, Gelernt I: Low Hartmann's procedure for severe anorectal Crohn's disease. Dis Col Rectum. 1992, 35: 975-980.","journal-title":"Dis Col Rectum"},{"key":"119_CR19","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1007\/BF02050327","volume":"35","author":"JG Guillem","year":"1992","unstructured":"Guillem JG, Roberts PL, Murray JJ, Coller JA, Veidenheimer MC, Schoetz DJ: Factors predictive of persistent or recurrent Crohn's disease in excluded rectal segments. Dis Col Rectum. 1992, 35: 768-772.","journal-title":"Dis Col Rectum"},{"key":"119_CR20","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1080\/110241500750009311","volume":"166","author":"J Rius","year":"2000","unstructured":"Rius J, Nessim A, Nogueras JJ, Wexner SD: Gracilis transposition in complicated perianal fistula and unhealed perineal wounds in Crohn's disease. Eur J Surg. 2000, 166: 218-22. 10.1080\/110241500750009311.","journal-title":"Eur J Surg"}],"container-title":["World Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1477-7819-3-42.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T23:25:46Z","timestamp":1630452346000},"score":1,"resource":{"primary":{"URL":"https:\/\/wjso.biomedcentral.com\/articles\/10.1186\/1477-7819-3-42"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,6,29]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,12]]}},"alternative-id":["119"],"URL":"https:\/\/doi.org\/10.1186\/1477-7819-3-42","relation":{},"ISSN":["1477-7819"],"issn-type":[{"value":"1477-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,6,29]]},"assertion":[{"value":"23 February 2005","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 June 2005","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 June 2005","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"42"}}