{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T13:39:31Z","timestamp":1773322771364,"version":"3.50.1"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World J Surg Onc"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Hepatocellular adenomas are the most common benign liver tumors. They are usually related to oral contraceptive intake.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Case presentation<\/jats:title>\n            <jats:p>This case describes a 58-year-old woman admitted to our institution for a hepatic mass incidentally discovered during a routine examination. The patient, who was never on oral contraceptives, was asymptomatic upon admission. She underwent a thorough diagnostic evaluation and then a hepatic right trisegmentectomy. The histologic evaluation of the mass showed that it was a hepatocellular adenoma with areas of bone marrow metaplasia.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Bone marrow metaplasia has rarely been found associated to liver tumors. The presence of marrow-derived hepatic progenitor cells might be the source of both adenoma hepatocytes and bone marrow differentiated cells. To our knowledge, this is only the second case in the English literature in which areas of bone marrow metaplasia were found in a hepatocellular adenoma.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1477-7819-4-58","type":"journal-article","created":{"date-parts":[[2006,9,5]],"date-time":"2006-09-05T18:40:04Z","timestamp":1157481604000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Giant hepatic adenoma with bone marrow metaplasia not associated with oral contraceptive intake"],"prefix":"10.1186","volume":"4","author":[{"given":"Giovanni","family":"Ramacciato","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe R","family":"Nigri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Aurello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"D'Angelo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Pezzoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuela","family":"Pilozzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio","family":"Ercolani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Ravaioli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2006,8,25]]},"reference":[{"issue":"4","key":"213_CR1","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1007\/s00404-002-0435-z","volume":"269","author":"J Bartley","year":"2004","unstructured":"Bartley J, Loddenkemper C, Lange J, Mechsner S, Radke C, Neuhaus P, Ebert AD: Hepatocellular adenoma and focal nodular hyperplasia after long-term use of danazol for endometriosis: a case report. Arch Gynecol Obstet. 2004, 269 (4): 290-293. 10.1007\/s00404-002-0435-z.","journal-title":"Arch Gynecol Obstet"},{"issue":"4","key":"213_CR2","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1148\/radiographics.21.4.g01jl04877","volume":"21","author":"L Grazioli","year":"2001","unstructured":"Grazioli L, Federle MP, Brancatelli G, Ichikawa T, Olivetti L, Blachar A: Hepatic adenomas: imaging and pathologic findings. Radiographics. 2001, 21 (4): 877-92; discussion 892-4.","journal-title":"Radiographics"},{"issue":"3","key":"213_CR3","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1097\/00004836-200109000-00015","volume":"33","author":"P Aseni","year":"2001","unstructured":"Aseni P, Sansalone CV, Sammartino C, Benedetto FD, Carrafiello G, Giacomoni A, Osio C, Vertemati M, Forti D: Rapid disappearance of hepatic adenoma after contraceptive withdrawal. J Clin Gastroenterol. 2001, 33 (3): 234-236. 10.1097\/00004836-200109000-00015.","journal-title":"J Clin Gastroenterol"},{"key":"213_CR4","doi-asserted-by":"publisher","first-page":"S46","DOI":"10.1007\/BF02679993","volume":"161 Suppl 1","author":"PJ Lee","year":"2002","unstructured":"Lee PJ: Glycogen storage disease type I: pathophysiology of liver adenomas. Eur J Pediatr. 2002, 161 Suppl 1: S46-9. 10.1007\/s00431-002-1002-0.","journal-title":"Eur J Pediatr"},{"issue":"9","key":"213_CR5","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1007\/s002689900337","volume":"21","author":"A Weimann","year":"1997","unstructured":"Weimann A, Ringe B, Klempnauer J, Lamesch P, Gratz KF, Prokop M, Maschek H, Tusch G, Pichlmayr R: Benign liver tumors: differential diagnosis and indications for surgery. World J Surg. 1997, 21 (9): 983-90; discussion 990-1. 10.1007\/s002689900337.","journal-title":"World J Surg"},{"issue":"2","key":"213_CR6","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.amjsurg.2003.11.018","volume":"187","author":"J Kim","year":"2004","unstructured":"Kim J, Ahmad SA, Lowy AM, Buell JF, Pennington LJ, Moulton JS, Matthews JB, Hanto DW: An algorithm for the accurate identification of benign liver lesions. Am J Surg. 2004, 187 (2): 274-279. 10.1016\/j.amjsurg.2003.11.018.","journal-title":"Am J Surg"},{"issue":"2","key":"213_CR7","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.jhep.2004.04.014","volume":"41","author":"G Gouysse","year":"2004","unstructured":"Gouysse G, Frachon S, Hervieu V, Fiorentino M, d'Errico A, Dumortier J, Boillot O, Partensky C, Grigioni WF, Scoazec JY: Endothelial cell differentiation in hepatocellular adenomas: implications for histopathological diagnosis. J Hepatol. 2004, 41 (2): 259-266. 10.1016\/j.jhep.2004.04.014.","journal-title":"J Hepatol"},{"issue":"10","key":"213_CR8","doi-asserted-by":"publisher","first-page":"3483","DOI":"10.1182\/blood-2003-05-1664","volume":"102","author":"EL Herzog","year":"2003","unstructured":"Herzog EL, Chai L, Krause DS: Plasticity of marrow-derived stem cells. Blood. 2003, 102 (10): 3483-3493. 10.1182\/blood-2003-05-1664.","journal-title":"Blood"},{"issue":"11","key":"213_CR9","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.1097\/00000478-200111000-00006","volume":"25","author":"L Libbrecht","year":"2001","unstructured":"Libbrecht L, De Vos R, Cassiman D, Desmet V, Aerts R, Roskams T: Hepatic progenitor cells in hepatocellular adenomas. Am J Surg Pathol. 2001, 25 (11): 1388-1396. 10.1097\/00000478-200111000-00006.","journal-title":"Am J Surg Pathol"},{"issue":"6","key":"213_CR10","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1111\/j.1440-1746.1996.tb01702.x","volume":"11","author":"S Moriura","year":"1996","unstructured":"Moriura S, Kuroda M, Kimura A, Iwatsuka Y, Ikeda S, Sakai T, Usui A: Case report: hepatic adenoma with bone marrow metaplasia in a patient with glycogen storage disease type 1a. J Gastroenterol Hepatol. 1996, 11 (6): 556-559.","journal-title":"J Gastroenterol Hepatol"},{"issue":"7","key":"213_CR11","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1016\/j.gassur.2004.06.001","volume":"8","author":"CL Liu","year":"2004","unstructured":"Liu CL, Fan ST, Lo CM, Chan SC, Tso WK, Ng IO, Wong J: Hepatic resection for incidentaloma. J Gastrointest Surg. 2004, 8 (7): 785-793. 10.1016\/j.gassur.2004.06.001.","journal-title":"J Gastrointest Surg"},{"issue":"36","key":"213_CR12","doi-asserted-by":"crossref","first-page":"5691","DOI":"10.3748\/wjg.v11.i36.5691","volume":"11","author":"C Toso","year":"2005","unstructured":"Toso C, Majno P, Andres A, Rubbia-Brandt L, Berney T, Buhler L, Morel P, Mentha G: Management of hepatocellular adenoma: solitary-uncomplicated, multiple and ruptured tumors. World J Gastroenterol. 2005, 11 (36): 5691-5695.","journal-title":"World J Gastroenterol"}],"container-title":["World Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1477-7819-4-58.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T23:21:14Z","timestamp":1630452074000},"score":1,"resource":{"primary":{"URL":"https:\/\/wjso.biomedcentral.com\/articles\/10.1186\/1477-7819-4-58"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8,25]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["213"],"URL":"https:\/\/doi.org\/10.1186\/1477-7819-4-58","relation":{},"ISSN":["1477-7819"],"issn-type":[{"value":"1477-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,8,25]]},"assertion":[{"value":"17 May 2006","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 August 2006","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 August 2006","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"58"}}