{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T22:39:29Z","timestamp":1790203169690,"version":"4.1.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World J Surg Onc"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Multiple Myeloma (MM) is a B cell neoplasm causing lytic or osteopenic bone abnormalities. Whole body skeletal survey (WBSS), Magnetic resonance (MR) and <jats:sup>18<\/jats:sup>F-FDG PET\/CT are imaging techniques routinely used for the evaluation of bone involvement in MM patients.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Aim<\/jats:title>\n            <jats:p>As MM bone lesions may present low <jats:sup>18<\/jats:sup>F-FDG uptake; the aim of this study was to assess the possible added value and limitations of <jats:sup>11<\/jats:sup>C-Choline to that of <jats:sup>18<\/jats:sup>F-FDG PET\/CT in patients affected with MM.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Ten patients affected with MM underwent a standard <jats:sup>11<\/jats:sup>C-Choline PET\/CT and an <jats:sup>18<\/jats:sup>F-FDG PET\/CT within one week. The results of the two scans were compared in terms of number, sites and SUV<jats:sub>max<\/jats:sub> of lesions.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Four patients (40%) had a negative concordant <jats:sup>11<\/jats:sup>C-Choline and <jats:sup>18<\/jats:sup>F-FDG PET\/CT scans. Two patients (20%) had a positive <jats:sup>11<\/jats:sup>C-Choline and <jats:sup>18<\/jats:sup>F-FDG PET\/CT scans that identified the same number and sites of bone lesions. The remaining four patients (40%) had a positive <jats:sup>11<\/jats:sup>C-Choline and <jats:sup>18<\/jats:sup>F-FDG PET\/CT scan, but the two exams identified different number of lesions. Choline showed a mean SUV<jats:sub>max<\/jats:sub> of 5 while FDG showed a mean SUV<jats:sub>max<\/jats:sub> of 3.8 (P = 0.042). Overall, <jats:sup>11<\/jats:sup>C-Choline PET\/CT scans detected 37 bone lesions and <jats:sup>18<\/jats:sup>F-FDG PET\/CT scans detected 22 bone lesions but the difference was not significant (P = 0.8).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>According to these preliminary data, <jats:sup>11<\/jats:sup>C-Choline PET\/CT appears to be more sensitive than <jats:sup>18<\/jats:sup>F-FDG PET\/CT for the detection of bony myelomatous lesions. If these data are confirmed in larger series of patients, <jats:sup>11<\/jats:sup>C-Choline may be considered a more appropriate functional imaging in association with MRI for MM bone staging.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1477-7819-5-68","type":"journal-article","created":{"date-parts":[[2007,7,10]],"date-time":"2007-07-10T18:13:37Z","timestamp":1184091217000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":101,"title":["11C-choline vs. 18F-FDG PET\/CT in assessing bone involvement in patients with multiple myeloma"],"prefix":"10.1186","volume":"5","author":[{"given":"Cristina","family":"Nanni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Zamagni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Cavo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Rubello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Tacchetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinzia","family":"Pettinato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohsen","family":"Farsad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Castellucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Ambrosini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gian Carlo","family":"Montini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adil","family":"Al-Nahhas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Franchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Fanti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2007,6,20]]},"reference":[{"key":"320_CR1","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1046\/j.1365-2141.1999.01529.x","volume":"106","author":"FE Lecouvet","year":"1999","unstructured":"Lecouvet FE, Malghem J, Michaux L: Skeletal survey in advanced multiple myeloma: radiographic versus MR imaging survey. 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