{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T01:46:55Z","timestamp":1792979215739,"version":"4.5.0"},"reference-count":59,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod Biol Endocrinol"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1186\/1477-7827-12-129","type":"journal-article","created":{"date-parts":[[2015,6,18]],"date-time":"2015-06-18T07:21:23Z","timestamp":1434612083000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Pattern of secretion of pregnancy-associated plasma protein-A (PAPP-A) during pregnancies complicated by fetal aneuploidy, in vivo and in vitro"],"prefix":"10.1186","volume":"12","author":[{"given":"Marie Cl\u00e9mence","family":"Leguy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Brun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Pidoux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houria","family":"Salhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnes","family":"Choiset","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie Claude","family":"Menet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Gil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vassilis","family":"Tsatsaris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Guibourdenche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,12,28]]},"reference":[{"key":"1297_CR1","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/0002-9378(74)90553-5","volume":"118","author":"TM Lin","year":"1974","unstructured":"Lin TM, Halbert SP, Kiefer D, Spellacy WN, Gall S: Characterization of four human pregnancy-associated plasma proteins. Am J Obstet Gynecol. 1974, 118: 223-236.","journal-title":"Am J Obstet Gynecol"},{"key":"1297_CR2","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1095\/biolreprod61.4.1083","volume":"61","author":"MT Overgaard","year":"1999","unstructured":"Overgaard MT, Oxvig C, Christiansen M, Lawrence JB, Conover CA, Boldt HB, Olsen IM, Laursen LS, Gleich GJ, Sottrup-Jensen L, Haaning J: Messenger acid levels of pregnancy associated plasma protein A and the proform of eosinophil major basic protein: expression in human reproductive and non reproductive tissues. Biol Reprod. 1999, 61: 1083-9108. 10.1095\/biolreprod61.4.1083.","journal-title":"Biol Reprod"},{"key":"1297_CR3","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1210\/jcem.87.5.8448","volume":"87","author":"LC Giudice","year":"2002","unstructured":"Giudice LC, Conover CA, Bale L, Faessen GH, Ilg K, Sun I, Imani B, Suen LF, Irwin JC, Christiansen M, Overgaard MT, Oxvig C: Identification and regulation of IGFBP-4 protease and its physiological inhibitor in human trophoblasts and endometrial stroma: evidence for paracrine regulation of IGF-II bioavailability in the placental bed during human implantation. J Clin Endocrinol Metab. 2002, 87: 1359-1366.","journal-title":"J Clin Endocrinol Metab"},{"key":"1297_CR4","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1016\/j.placenta.2012.09.003","volume":"33","author":"P D'Elia","year":"2012","unstructured":"D'Elia P, Marzioni D, Castellucci M, Mocci C, Pala A: Homodimeric pregnancy-associated plasma protein-A in normal human placenta of first and third trimester of pregnancy: biochemical and morphological observations. Placenta. 2012, 33: 942-945. 10.1016\/j.placenta.2012.09.003.","journal-title":"Placenta"},{"key":"1297_CR5","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.jjcc.2012.09.007","volume":"61","author":"A Coskun","year":"2013","unstructured":"Coskun A, Serteser M, Duran S, Inal TC, Erdogan BE, Ozpinar A, Can O, Unsal I: Reference interval of pregnancy-associated plasma protein-a in healthy men and non-pregnant women. J Cardiol. 2013, 61: 128-131. 10.1016\/j.jjcc.2012.09.007.","journal-title":"J Cardiol"},{"key":"1297_CR6","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1056\/NEJMoa003147","volume":"345","author":"A Bayes-Genis","year":"2001","unstructured":"Bayes-Genis A, Conover CA, Overgaard MT, Bailey KR, Christiansen M, Holmes DR, Virmani R, Oxvig C, Schwartz RS: Pregnancy-associated plasma protein A as a marker of acute coronary syndromes. N Engl J Med. 2001, 345: 1022-1029. 10.1056\/NEJMoa003147.","journal-title":"N Engl J Med"},{"key":"1297_CR7","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/j.atherosclerosis.2008.07.042","volume":"203","author":"L Consuegra-Sanchez","year":"2009","unstructured":"Consuegra-Sanchez L, Fredericks S, Kaski JC: Pregnancy-associated plasma protein-A (PAPP-A) and cardiovascular risk. Atherosclerosis. 2009, 203: 346-352. 10.1016\/j.atherosclerosis.2008.07.042.","journal-title":"Atherosclerosis"},{"key":"1297_CR8","doi-asserted-by":"crossref","first-page":"12243","DOI":"10.1016\/S0021-9258(18)31378-4","volume":"268","author":"C Oxvig","year":"1993","unstructured":"Oxvig C, Sand O, Kristensen T, Gleich GJ, Sottrup-Jensen L: Circulating human pregnancy-associated plasma protein A is disulfide-bridged to the proform of eosinophil major basic protein. J Biol Chem. 1993, 268: 12243-12246.","journal-title":"J Biol Chem"},{"key":"1297_CR9","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1007\/BF02114602","volume":"233","author":"JG Westergaard","year":"1983","unstructured":"Westergaard JG, Teisner B, Chemnitz J, Grudzinkas JG: Serum PAPP-A in normal pregnancy: relationship to fetal and maternal characteristics. Arch Gynecol. 1983, 233: 211-215. 10.1007\/BF02114602.","journal-title":"Arch Gynecol"},{"key":"1297_CR10","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.3109\/00016349.2010.505639","volume":"89","author":"I Kirkegaard","year":"2010","unstructured":"Kirkegaard I, Uldbjerg N, Oxvig C: Biology of pregnancy-associated plasma protein-A in relation to prenatal diagnostics: an overview. Acta Obstet Gynecol Scand. 2010, 89: 1118-1125. 10.3109\/00016349.2010.505639.","journal-title":"Acta Obstet Gynecol Scand"},{"key":"1297_CR11","doi-asserted-by":"publisher","first-page":"1446","DOI":"10.1016\/j.ajog.2004.06.052","volume":"191","author":"L Dugoff","year":"2004","unstructured":"Dugoff L, Hobbins JC, Malone FD, Porter TF, Luthy D, Comstock CH, Hankins G, Berkowitz RL, Merkatz I, Craigo SD, Timor-Tritsch IE, Carr SR, Wolfe HM, Vidaver J, D'Alton ME: First trimester maternal serum PAPP-A and free-beta subunit human chorionic gonadotropin concentrations and nuchal translucency are associated with obstetric complications: a population-based screening study (the FASTER Trial). Am J Obstet Gynecol. 2004, 191: 1446-1451. 10.1016\/j.ajog.2004.06.052.","journal-title":"Am J Obstet Gynecol"},{"key":"1297_CR12","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.ejogrb.2011.03.004","volume":"157","author":"JK Ranta","year":"2011","unstructured":"Ranta JK, Raatikainen K, Romppanen J, Pulkki K, Heinonen S: Decreased PAPP-A is associated with preeclampsia, premature delivery and small for gestational age infants but not with placental abruption. Eur J Obstet Gynecol Reprod Biol. 2011, 157: 48-52. 10.1016\/j.ejogrb.2011.03.004.","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"1297_CR13","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1111\/j.1471-0528.1994.tb13042.x","volume":"101","author":"NA Bersinger","year":"1994","unstructured":"Bersinger NA, Brizot ML, Johnson A, Snijders RJ, Abbott J, Schneider H, Nicolaides KH: First trimester maternal serum pregnancy-associated plasma protein A and pregnancy-specific \u03b21-glycoprotein in fetal trisomies. Br J Obstet Gynaecol. 1994, 101: 970-974. 10.1111\/j.1471-0528.1994.tb13042.x.","journal-title":"Br J Obstet Gynaecol"},{"key":"1297_CR14","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1056\/NEJM199804023381404","volume":"338","author":"JE Haddow","year":"1998","unstructured":"Haddow JE, Palomaki GE, Knight GJ, Williams J, Miller WA, Johnson A: Screening of maternal serum for fetal Down\u2019s syndrome in the first trimester. N Engl J Med. 1998, 338: 955-961. 10.1056\/NEJM199804023381404.","journal-title":"N Engl J Med"},{"key":"1297_CR15","first-page":"1773","volume":"189","author":"Y Ville","year":"2005","unstructured":"Ville Y: How to improve the screening and diagnosis of fetal aneuploidy?. Bull Acad Med. 2005, 189: 1773-1784.","journal-title":"Bull Acad Med"},{"key":"1297_CR16","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1258\/0004563053026880","volume":"42","author":"K Spencer","year":"2005","unstructured":"Spencer K: First trimester maternal serum screening for Down\u2019s syndrome: an evaluation of the DPC Immulite 2000 free beta-hCG and pregnancy protein-A assays. Ann Clin Biochem. 2005, 42: 30-40. 10.1258\/0004563053026880.","journal-title":"Ann Clin Biochem"},{"key":"1297_CR17","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.1210\/endo-118-4-1567","volume":"118","author":"HJ Klinman","year":"1986","unstructured":"Klinman HJ, Nestler JE, Sermasi E, Sanger JM, Strauss JF: Purification, characterization, and in vitro differentiation of cytotrophoblasts from human term placentae. Endocrinology. 1986, 118: 1567-1582. 10.1210\/endo-118-4-1567.","journal-title":"Endocrinology"},{"key":"1297_CR18","first-page":"1384","volume":"83","author":"J Guibourdenche","year":"1998","unstructured":"Guibourdenche J, Alsat E, Soncin F, Rochette-Egly C, Evain-Brion D: Retinoid receptors expression in human term placenta: involvement of RXR alpha in retinoid induced-hCG secretion. J Clin Endocrinol Metab. 1998, 83: 1384-1387.","journal-title":"J Clin Endocrinol Metab"},{"key":"1297_CR19","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1046\/j.1469-0705.1999.13040231.x","volume":"13","author":"K Spencer","year":"1999","unstructured":"Spencer K, Souter V, Tul N, Snijders R, Nicolaides KH: A screening program for trisomy 21 at 10\u201314 weeks using fetal nuchal translucency, maternal serum free beta-human chorionic gonadotropin and pregnancy associated plasma protein A. Ultrasound Obstet Gynecol. 1999, 13: 231-237. 10.1046\/j.1469-0705.1999.13040231.x.","journal-title":"Ultrasound Obstet Gynecol"},{"key":"1297_CR20","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1002\/uog.10070","volume":"339","author":"M Grande","year":"2012","unstructured":"Grande M, Arigita M, Borobio V, Jimenez JM, Fernandez S, Borrell A: First trimester detection of structural abnormalities and the role of aneuploidy markers. Ultrasound Obstet Gynecol. 2012, 339: 157-163.","journal-title":"Ultrasound Obstet Gynecol"},{"key":"1297_CR21","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s12291-012-0269-9","volume":"28","author":"S Shiefa","year":"2013","unstructured":"Shiefa S, Amargandhi M, Bhupendra J, Moulali S, Kristine T: First trimester maternal screening using biochemical markers PAPP-A and free \u03b2-hCG for Down Syndrome, Patau Syndrome and Edward Syndrome. Indian J Clin Biochem. 2013, 28: 3-12. 10.1007\/s12291-012-0269-9.","journal-title":"Indian J Clin Biochem"},{"key":"1297_CR22","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1001\/jama.285.8.1044","volume":"85","author":"R Smith-Bindman","year":"2001","unstructured":"Smith-Bindman R, Hosmer W, Feldstein VA, Deeks JJ, Goldberg JD: Second-trimester ultrasound to detect fetuses with Down syndrome: a meta-analysis. JAMA. 2001, 85: 1044-1055.","journal-title":"JAMA"},{"key":"1297_CR23","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1002\/pd.2623","volume":"30","author":"S Lai","year":"2010","unstructured":"Lai S, Lau WL, Leung WC, Lai FK, Chin R: Is ultrasound alone enough for prenatal screening of trisomy 18? A single center experience in 69 cases over 10\u00a0years. Prenat Diagn. 2010, 30: 1094-1099. 10.1002\/pd.2623.","journal-title":"Prenat Diagn"},{"key":"1297_CR24","doi-asserted-by":"crossref","first-page":"61","DOI":"10.7863\/jum.2007.26.1.61","volume":"26","author":"Z Szigeti","year":"2007","unstructured":"Szigeti Z, Csaba A, Pete B, Hajd\u00fa J, Papp Z, Papp C: Correlation of prenatal sonographic diagnosis and morphologic findings of fetal autopsy in fetuses with trisomy 21. J Ultrasound Med. 2007, 26: 61-68.","journal-title":"J Ultrasound Med"},{"key":"1297_CR25","first-page":"538","volume":"28","author":"M Jemmali","year":"1999","unstructured":"Jemmali M, Valat AS, Poulain P, Favre R, Bourgeot P, Subtil D, Puech F: Nuchal tranlucency: screening for chromosomal abnormalities and congenital malformations. Multicenter study. J Gynecol Obstet Biol Reprod. 1999, 28: 538-543.","journal-title":"J Gynecol Obstet Biol Reprod"},{"key":"1297_CR26","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1002\/pd.2637","volume":"31","author":"KH Nicolaides","year":"2011","unstructured":"Nicolaides KH: Screening for fetal anuploidies at 11 to 13\u00a0weeks. Prenat Diagn. 2011, 31: 7-15. 10.1002\/pd.2637.","journal-title":"Prenat Diagn"},{"key":"1297_CR27","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1002\/(SICI)1097-0223(199911)19:11<1035::AID-PD694>3.0.CO;2-2","volume":"19","author":"N Tul","year":"1999","unstructured":"Tul N, Spencer K, Noble P, Chan C, Nicolaides K: Screening for trisomy 18 by fetal nuchal translucency and maternal serum free beta-hCG and PAPP-A at 10\u201314 weeks of gestation. Prenat Diagn. 1999, 19: 1035-1042. 10.1002\/(SICI)1097-0223(199911)19:11<1035::AID-PD694>3.0.CO;2-2.","journal-title":"Prenat Diagn"},{"key":"1297_CR28","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1002\/pd.420","volume":"22","author":"K Spencer","year":"2002","unstructured":"Spencer K, Nicolaides KH: A first trimester trisomy 13\/trisomy 18 risk algorithm combining fetal nuchal translucency thickness, maternal serum free \u00df \u2013hCG and PAPP-A. Prenat Diagn. 2002, 22: 877-879. 10.1002\/pd.420.","journal-title":"Prenat Diagn"},{"key":"1297_CR29","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1002\/uog.1860","volume":"25","author":"KH Nicolaides","year":"2005","unstructured":"Nicolaides KH, Spencer K, Avgidou K, Faiola S, Falcon O: Multicenter study of first-trimester screening for trisomy 21 in 75 821 pregnancies: results and estimation of the potential impact of individual risk-orientated two-stage first-trimester screening. Ultrasound Obstet Gynecol. 2005, 25: 221-226. 10.1002\/uog.1860.","journal-title":"Ultrasound Obstet Gynecol"},{"key":"1297_CR30","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1016\/S0046-8177(98)90245-3","volume":"29","author":"E Jauniaux","year":"1998","unstructured":"Jauniaux E, Hustin J: Chromosomally abnormal early ongoing pregnancies: correlation of ultrasound and placental histological findings. Hum Pathol. 1998, 29: 1195-1199. 10.1016\/S0046-8177(98)90245-3.","journal-title":"Hum Pathol"},{"key":"1297_CR31","first-page":"989","volume":"18","author":"S Labb\u00e9","year":"1989","unstructured":"Labb\u00e9 S, Copin H, Choiset A, Girard S, Barbet JP: The placenta and trisomies 13, 18, 21. J Gynecol Obstet Biol Reprod. 1989, 18: 989-996.","journal-title":"J Gynecol Obstet Biol Reprod"},{"key":"1297_CR32","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1097\/00006250-199004001-00012","volume":"75","author":"B Rochelson","year":"1990","unstructured":"Rochelson B, Kaplan C, Guzman E, Arato M, Hansen K, Trunca C: A quantitative analysis of placental vasculature in the third trimester fetus with autosomal trisomy. Obstet Gynecol. 1990, 75: 59-63.","journal-title":"Obstet Gynecol"},{"key":"1297_CR33","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1053\/plac.2000.0553","volume":"21","author":"L Roberts","year":"2000","unstructured":"Roberts L, Sebire NJ, Fowler D, Nicolaides KH: Histomorphological features of chorionic villi at 10\u201314 weeks of gestation in trisomic and chromosomally normal pregnancies. Placenta. 2000, 21: 678-683. 10.1053\/plac.2000.0553.","journal-title":"Placenta"},{"key":"1297_CR34","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1159\/000264470","volume":"12","author":"F Queshsri","year":"1997","unstructured":"Queshsri F, Jacques SM, Johnson MP, Hume RF, Kramer RL, Yaron Y, Evans MI: Trisomy 21 placentas: histopathological and immunohistological finding using proliferating cell nuclear antigen. Fetal Diagn Ther. 1997, 12: 210-215. 10.1159\/000264470.","journal-title":"Fetal Diagn Ther"},{"key":"1297_CR35","doi-asserted-by":"publisher","first-page":"1592","DOI":"10.1021\/bi00172a040","volume":"33","author":"T Kristensen","year":"1994","unstructured":"Kristensen T, Oxvig C, Sand O, Moller L, Sottrup-Jensen GJ: Amino acid sequence of human pregnancy-associated plasma protein A derived from cloned cDNA. Biochemistry. 1994, 33: 1592-1598. 10.1021\/bi00172a040.","journal-title":"Biochemistry"},{"key":"1297_CR36","doi-asserted-by":"publisher","first-page":"31128","DOI":"10.1074\/jbc.M001384200","volume":"275","author":"MT Overgaard","year":"2000","unstructured":"Overgaard MT, Haaning J, Boldt HB, Olsen IM, Laursen LS, Christiansen M, Gleich GJ, Sottrup-Jensen L, Conover CA, Oxvig C: Expression of recombinant human pregnancy-associated plasma protein-A and identification of the proform of eosinophil major basic protein as its physiological inhibitor. J Biol Chem. 2000, 275: 31128-31133. 10.1074\/jbc.M001384200.","journal-title":"J Biol Chem"},{"key":"1297_CR37","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/S0014-5793(01)02760-0","volume":"504","author":"LS Laursen","year":"2001","unstructured":"Laursen LS, Overgaard MT, Soe R, Boldt HB, Sottrup-Jensen L, Giudice LC, Conover CA, Oxvig C: Pregnancy-associated plasma protein-A (PAPP-A) cleaves insulin-like growth factor binding protein (IGFBP)-5 independent of IGF: implications for the mechanism of IGFBP-4 proteolysis by PAPP-A. FEBS Lett. 2001, 504: 36-40. 10.1016\/S0014-5793(01)02760-0.","journal-title":"FEBS Lett"},{"key":"1297_CR38","doi-asserted-by":"publisher","first-page":"3149","DOI":"10.1073\/pnas.96.6.3149","volume":"96","author":"JB Lawrence","year":"1999","unstructured":"Lawrence JB, Oxvig C, Overgaard MT, Sottrup-Jensen L, Gleich GJ, Hays LG, Yates JR, Conover CA: The insulin-like growth factor (IGF)-dependent IGF binding protein-4 protease secreted by human fibroblasts is pregnancy-associated plasma protein A. Proc Natl Acad Sci U S A. 1999, 96: 3149-3153. 10.1073\/pnas.96.6.3149.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1297_CR39","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/0304-4165(94)90071-X","volume":"1201","author":"C Oxvig","year":"1994","unstructured":"Oxvig C, Sand O, Kristensen T, Kristensen L, Sottrup-Jensen L: Isolation and characterization of circulating complex between human pregnancy-associated plasma protein A and proform of eosinophil major basic protein. Biochim Biophys Acta. 1994, 1201: 415-423. 10.1016\/0304-4165(94)90071-X.","journal-title":"Biochim Biophys Acta"},{"key":"1297_CR40","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1111\/j.1471-0528.1982.tb05093.x","volume":"89","author":"P Bischof","year":"1982","unstructured":"Bischof P, Duberg S, Herrmann WL, Sizonenko PC: Amniotic fluid and plasma concentrations of pregnancy-associated plasma protein A (PAPP-A). Br J Obstet Gynaecol. 1982, 89: 701-703. 10.1111\/j.1471-0528.1982.tb05093.x.","journal-title":"Br J Obstet Gynaecol"},{"key":"1297_CR41","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1172\/JCI107794","volume":"54","author":"TM Lin","year":"1974","unstructured":"Lin TM, Halbert SP, Kiefer D, Spellacy WN: Measurement of pregnancy associated plasma proteins during human gestation. J Clin Invest. 1974, 54: 576-582. 10.1172\/JCI107794.","journal-title":"J Clin Invest"},{"key":"1297_CR42","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/0002-9378(81)90957-1","volume":"139","author":"J Folkersen","year":"1981","unstructured":"Folkersen J, Grudzinskas JG, Hindersson P, Teisner B, Westergaard J: Pregnancy-associated plasma protein A: circulating levels during normal pregnancy. Am J Obstet Gynecol. 1981, 139: 910-924.","journal-title":"Am J Obstet Gynecol"},{"key":"1297_CR43","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1002\/pd.2331","volume":"29","author":"K Pihl","year":"2009","unstructured":"Pihl K, Larsen T, Rasmussen S, Krebs L, Christiansen M: The proform of eosinophil major basic protein: a new maternal serum marker for adverse pregnancy outcome. Prenat Diagn. 2009, 29: 1013-1019. 10.1002\/pd.2331.","journal-title":"Prenat Diagn"},{"key":"1297_CR44","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/S0143-4004(84)80023-5","volume":"5","author":"D Tornehave","year":"1984","unstructured":"Tornehave D, Chemnitz J, Teisner B, Folkersen J, Westergaard JG: Immunohistochemical demonstration of pregnancy associated plasma protein A (PAPP-A) in the syncytiotrophoblast of the normal placenta at different gestational ages. Placenta. 1984, 5: 427-431. 10.1016\/S0143-4004(84)80023-5.","journal-title":"Placenta"},{"key":"1297_CR45","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/S0143-4004(84)80032-6","volume":"5","author":"AM Schindler","year":"1984","unstructured":"Schindler AM, Bordignon P, Bischof P: Immunohistochemical localization of pregnancy-associated plasma protein A in decidua and trophoblast: comparison with human chorionic gonadotrophin and fibrin. Placenta. 1984, 5: 227-236. 10.1016\/S0143-4004(84)80032-6.","journal-title":"Placenta"},{"key":"1297_CR46","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1111\/j.1471-0528.1986.tb08008.x","volume":"93","author":"J Chemnitz","year":"1986","unstructured":"Chemnitz J, Folkersen J, Teisner B, Sinosich MJ, Tornehave D, Wetergaard JG, Bolton AE, Grudzinkas JG: Comparison of different antibody preparations against pregnancy-associated plasma protein A (PAPP-A) for the use in localization and immunoassay studies. Br J Obstet Gynaecol. 1986, 93: 916-923. 10.1111\/j.1471-0528.1986.tb08008.x.","journal-title":"Br J Obstet Gynaecol"},{"key":"1297_CR47","first-page":"560","volume":"71","author":"M Bonno","year":"1994","unstructured":"Bonno M, Oxvig C, Kephart GM, Wagner JM, Kristensen T, Sottrup-Jensen L, Gleich GJ: Localization of pregnancy-associated plasma protein A and colocalization of pregnancy-associated plasma protein A messenger ribonucleic acid and eosinophil granule major basic protein messenger ribonucleic acid in placenta. Lab Invest. 1994, 71: 560-566.","journal-title":"Lab Invest"},{"key":"1297_CR48","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1053\/plac.2002.0944","volume":"24","author":"J Guibourdenche","year":"2003","unstructured":"Guibourdenche J, Frendo JL, Pidoux G, Bertin G, Luton D, Muller F, Porquet D, Evain-Brion D: Expression of pregnancy-associated plasma protein-A (PAPP-A) during villous trophoblast differentiation in vitro. Placenta. 2003, 24: 532-539. 10.1053\/plac.2002.0944.","journal-title":"Placenta"},{"key":"1297_CR49","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1002\/uog.7308","volume":"34","author":"LK Proctor","year":"2009","unstructured":"Proctor LK, Toal M, Keating S, Chitayat D, Okun N, Windrim RC, Smith GCS, Kingdom JC: Placental size and the prediction of severe early-onset intrauterine growth restriction in women with low pregnancy associated plasma protein A. Ultrasound Obstet Gynecol. 2009, 34: 274-82.","journal-title":"Ultrasound Obstet Gynecol"},{"key":"1297_CR50","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1016\/j.placenta.2011.10.005","volume":"32","author":"M Sahraravand","year":"2011","unstructured":"Sahraravand M, J\u00e4rvel\u00e4 IY, Laitinen P, Tekay AH, Ryyn\u00e4nen M: The secretion of PAPP-A, ADAM 12, and PP13 correlates with the size of the placenta for the first month of pregnancy. Placenta. 2011, 32: 999-1003. 10.1016\/j.placenta.2011.10.005.","journal-title":"Placenta"},{"key":"1297_CR51","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/j.placenta.2011.01.016","volume":"32","author":"AO Odibo","year":"2011","unstructured":"Odibo AO, Zhong Y, Longtime M, Tuuli M, Odibo L, Cahill AG, Macones GA, Nelson DM: First trimester serum analytes, biophysical tests and the association with pathological morphometry in the placenta of pregnancies with preeclampsia and fetal growth restriction. Placenta. 2011, 32: 333-338. 10.1016\/j.placenta.2011.01.016.","journal-title":"Placenta"},{"key":"1297_CR52","first-page":"3700","volume":"85","author":"JL Frendo","year":"2000","unstructured":"Frendo JL, Vidaud M, Guibourdenche J, Luton D, Muller F, Bellet D, Giovagrandi Y, Tarrade A, Porquet D, Blot P, Evain-Brion D: Defect of villous cytotrophoblast differentiation into syncytiotrophoblast in Down's syndrome. J Clin Endocrinol Metab. 2000, 85: 3700-3707.","journal-title":"J Clin Endocrinol Metab"},{"key":"1297_CR53","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1210\/jc.2003-030668","volume":"89","author":"J Guibourdenche","year":"2004","unstructured":"Guibourdenche J, Frendo JL, Pidoux G, Vidau M, Luton D, Giovagrandi Y, Porquet D, Muller F, Evain-Brion D: Trophoblast production of a weakly bioactive human chorionic gonadotropin in Trisomy 21-affected pregnancy. J Clin Endocrinol Metab. 2004, 89: 727-732. 10.1210\/jc.2003-030668.","journal-title":"J Clin Endocrinol Metab"},{"key":"1297_CR54","doi-asserted-by":"publisher","first-page":"S127","DOI":"10.1016\/j.placenta.2005.10.012","volume":"27","author":"K Handschuh","year":"2006","unstructured":"Handschuh K, Guibourdenche J, Guesnon M, Laurendeau I, Evain-Brion D, Fournier T: Modulation of PAPP-A expression by PPAR \u03b3 in human first trimester trophoblast. Placenta. 2006, 27: S127-134.","journal-title":"Placenta"},{"key":"1297_CR55","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1053\/plac.2000.0539","volume":"21","author":"NJ Sebire","year":"2000","unstructured":"Sebire NJ, Fowler D, Roberts L, Mahmood S, Nicolaides KH: Trophoblast proliferation is increased in chorionoic villi from pregnancies with fetal trisomy 18. Placenta. 2000, 21: 584-586. 10.1053\/plac.2000.0539.","journal-title":"Placenta"},{"key":"1297_CR56","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1002\/ajmg.a.30254","volume":"130A","author":"A Wright","year":"2004","unstructured":"Wright A, Zhou Y, Weler F, Caceres E, Kapidzic M, Tabata T, Kahn MM, Nash C, Fisher SJ: Trisomy 21 is associated with variable defects in cytotrophoblast differentiation along the invasive pathway. Am J Med Genet. 2004, 130A: 354-364. 10.1002\/ajmg.a.30254.","journal-title":"Am J Med Genet"},{"key":"1297_CR57","first-page":"e1","volume":"200","author":"LC Poon","year":"2009","unstructured":"Poon LC, Chelemen T, Minekawa R, Frisova V, Nicolaides KH: Maternal serum ADAM 12 (A disintegrin and metalloprotease) in chromosomally abnormal pregnancy at 11\u201313 weeks. Am J Obstet Gynecol. 2009, 200: e1-e6.","journal-title":"Am J Obstet Gynecol"},{"key":"1297_CR58","doi-asserted-by":"publisher","first-page":"S81","DOI":"10.1016\/j.placenta.2011.11.007","volume":"33","author":"G Pidoux","year":"2012","unstructured":"Pidoux G, Gerbaud P, Cocquebert M, Segon N, Badet J, Fournier T, Guibourdenche J, Evain-Brion D: Human trophoblast fusion and differentiation : lessons from trisomy 21 placenta. Placenta. 2012, 33: S81-S86.","journal-title":"Placenta"},{"key":"1297_CR59","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.pbiomolbio.2013.11.007","volume":"114","author":"B Huppertz","year":"2014","unstructured":"Huppertz B, Ghosh D, Sengupta J: An integrative view on the physiology of human early placental villi. Prog Biophys Mol Biol. 2014, 114: 33-48. 10.1016\/j.pbiomolbio.2013.11.007.","journal-title":"Prog Biophys Mol Biol"}],"container-title":["Reproductive Biology and Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1477-7827-12-129.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T07:29:24Z","timestamp":1630567764000},"score":1,"resource":{"primary":{"URL":"https:\/\/rbej.biomedcentral.com\/articles\/10.1186\/1477-7827-12-129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":59,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["1297"],"URL":"https:\/\/doi.org\/10.1186\/1477-7827-12-129","relation":{},"ISSN":["1477-7827"],"issn-type":[{"value":"1477-7827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12]]},"assertion":[{"value":"21 September 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 December 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 December 2014","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"129"}}