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Despite the clear demand for an adult marker of prenatal androgen action and increased use of digit ratios as such a marker, its validity remains controversial. This review (1) evaluates current evidence for the relationship between digit ratios and prenatal androgens (using experimentation with animal models, amniotic testosterone, and congenital adrenal hyperplasia case-control studies), (2) describes opportunities for future validation tests, and (3) compares the potential advantages and disadvantages of digit ratio measures with more established methods for studying the effects of prenatal androgens.<\/jats:p>","DOI":"10.1186\/1477-7827-4-10","type":"journal-article","created":{"date-parts":[[2006,3,4]],"date-time":"2006-03-04T07:35:46Z","timestamp":1141457746000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":225,"title":["The use of digit ratios as markers for perinatal androgen action"],"prefix":"10.1186","volume":"4","author":[{"given":"Matthew H","family":"McIntyre","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2006,2,26]]},"reference":[{"key":"292_CR1","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/j.neubiorev.2004.11.004","volume":"29","author":"CCC Cohen-Bendahan","year":"2005","unstructured":"Cohen-Bendahan CCC, van de Beek C, Berenbaum SA: Prenatal sex hormone effects on child and adult sex-typed behavior: methods and findings. 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