{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T19:11:18Z","timestamp":1758395478425},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod Biol Endocrinol"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Myometrial growth and remodeling of the cytoskeleton and focal adhesions during late pregnancy may be critical aspects of myometrial activation and thus labour. Yet our understanding of these aspects is inhibited by the paucity of information concerning the components of focal adhesions in the myometrium. The focal adhesion protein <jats:underline>h<\/jats:underline> ydrogen peroxide-<jats:underline>i<\/jats:underline> nducible <jats:underline>c<\/jats:underline> lone-5 (Hic-5) has recently been found in mononuclear smooth muscle but was not examined in the myometrium during pregnancy. Thus, the goal of this study was to characterize Hic-5 mRNA and protein expression in the rat myometrium during pregnancy and labour.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Rat myometrium samples were obtained from non-pregnant animals, pregnant animals on days (d) 6, 12, 15, 17, 19, 21, 22, 23 (active labour) and 1 day postpartum (PP). In addition, myometrium samples were collected from rats within a progesterone-delayed labour paradigm. Hic-5 mRNA expression was analyzed by Northern blot analysis while Hic-5 protein expression was examined by immunoblot and immunofluorescence analysis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Hic-5 mRNA expression on d15, d19 and d21 was found to be significantly elevated compared to d6 and d12 of pregnancy and expression on d23 was significantly elevated over d6 (p &lt; 0.05). Immunofluorescence analysis demonstrated that detection of Hic-5 protein in the circular muscle layer appeared to increase from d17 onwards, except PP, and Hic-5 was detectable in the cell cytoplasm and more continuously associated with myometrial cell membranes. In the longitudinal muscle layer Hic-5 was readily detectable by d15 and thereafter and primarily associated at myometrial cell membranes. Co-immunofluorescence analysis of potential Hic-5 and focal adhesion kinase (FAK) association in situ demonstrated a limited level of co-localization on d19, d23 and PP in the circular muscle layer while in the longitudinal muscle layer Hic-5 and FAK were readily co-localized at myometrial cell membranes.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Hic-5 is highly expressed in the rat myometrium during late pregnancy and labour and co-localizes with FAK in situ. Our results are consistent with a potential role for Hic-5 in focal adhesion remodeling in the rat myometrium during late pregnancy.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1477-7827-5-22","type":"journal-article","created":{"date-parts":[[2007,6,5]],"date-time":"2007-06-05T18:13:18Z","timestamp":1181067198000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The focal adhesion protein Hic-5 is highly expressed in the rat myometrium during late pregnancy and labour and co-localizes with FAK"],"prefix":"10.1186","volume":"5","author":[{"given":"Jenn M","family":"Croke","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luke RG","family":"Pike","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel J","family":"MacPhee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2007,6,5]]},"reference":[{"key":"381_CR1","first-page":"79","volume-title":"Maternal-Fetal Medicine: Principles and Practice","author":"JRG Challis","year":"2004","unstructured":"Challis JRG, Lye SJ: Characteristics of Parturition. Maternal-Fetal Medicine: Principles and Practice. Edited by: Creasy RK, Resnik R. 2004, Philadelphia, Pennsylvannia: Saunders, 79-87."},{"key":"381_CR2","doi-asserted-by":"publisher","first-page":"2925","DOI":"10.1016\/B978-012515400-0\/50060-9","volume-title":"Knobil and Neill's Physiology of Reproduction","author":"W Gibb","year":"2006","unstructured":"Gibb W, Lye SJ, Challis JRG: Parturition. Knobil and Neill's Physiology of Reproduction. Edited by: Neill JD. 2006, New York: Academic Press, 2925-2974."},{"key":"381_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1530\/rep.0.1240001","volume":"124","author":"JR Challis","year":"2002","unstructured":"Challis JR, Sloboda DM, Alfaidy N, Lye SJ, Gibb W, Patel FA, Whittle WL, Newnham JP: Prostaglandins and mechanisms of preterm birth. Reproduction. 2002, 124: 1-17. 10.1530\/rep.0.1240001.","journal-title":"Reproduction"},{"key":"381_CR4","first-page":"E543","volume":"254","author":"AJ Douglas","year":"1988","unstructured":"Douglas AJ, Clarke EW, Goldspink DF: Influence of mechanical stretch on growth and protein turnover of rat uterus. Am J Physiol. 1988, 254: E543-E548.","journal-title":"Am J Physiol"},{"key":"381_CR5","first-page":"E549","volume":"254","author":"DF Goldspink","year":"1988","unstructured":"Goldspink DF, Douglas AJ: Protein turnover in gravid and nongravid horns of uterus in pregnant rats. Am J Physiol. 1988, 254: E549-E554.","journal-title":"Am J Physiol"},{"key":"381_CR6","first-page":"69","volume-title":"Maternal-Fetal Medicine: Principles and Practice","author":"M Monga","year":"2004","unstructured":"Monga M, Sanborn BM: Biology and physiology of the reproductive tract and control of myometrial contraction. Maternal-Fetal Medicine: Principles and Practice. Edited by: Creasy RK, Resnik R. 2004, Philadelphia, Pennsylvannia: Saunders, 69-78."},{"key":"381_CR7","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1095\/biolreprod.103.023648","volume":"70","author":"O Shynlova","year":"2004","unstructured":"Shynlova O, Mitchell JA, Tsampalieros A, Langille BL, Lye SJ: Progesterone and gravidity differentially regulate expression of ECM components in pregnant rat myometrium. Biol Reprod. 2004, 70: 986-992. 10.1095\/biolreprod.103.023648.","journal-title":"Biol Reprod"},{"key":"381_CR8","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1095\/biolreprod.105.040006","volume":"73","author":"O Shynlova","year":"2005","unstructured":"Shynlova O, Tsui P, Dorogin A, Chow M, Lye SJ: Expression and localization of alpha \u2013 smooth muscle and gamma \u2013 actins in the pregnant rat myometrium. Biol Reprod. 2005, 73: 773-780. 10.1095\/biolreprod.105.040006.","journal-title":"Biol Reprod"},{"key":"381_CR9","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1095\/biolreprod.105.048124","volume":"74","author":"O Shynlova","year":"2006","unstructured":"Shynlova O, Oldenhof A, Dorogin A, Xu Q, Mu J, Nashman N, Lye SJ: Myometrial apoptosis: Activation of the caspase cascade in the pregnant rat myometrium at midgestation. Biol Reprod. 2006, 74: 839-849. 10.1095\/biolreprod.105.048124.","journal-title":"Biol Reprod"},{"key":"381_CR10","first-page":"122","volume":"41","author":"K Nishinaka","year":"1991","unstructured":"Nishinaka K, Fukuda Y: Changes in extracellular matrix materials in the uterine myometrium of rats during pregnancy and postparturition. Acta Pathol Jap. 1991, 41: 122-132.","journal-title":"Acta Pathol Jap"},{"key":"381_CR11","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1152\/jappl.2001.91.2.963","volume":"91","author":"WT Gerthoffer","year":"2001","unstructured":"Gerthoffer WT, Gunst SJ: Focal adhesion and small heat shock proteins in the regulation of actin remodeling and contractility in smooth muscle. J Appl Physiol. 2001, 91: 963-972.","journal-title":"J Appl Physiol"},{"key":"381_CR12","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/S0079-6107(98)00052-2","volume":"71","author":"DD Schlaepfer","year":"1999","unstructured":"Schlaepfer DD, Hauck CR, Sieg DJ: Signaling through focal adhesion kinase. Prog Biophys Mol Biol. 1999, 71: 435-478. 10.1016\/S0079-6107(98)00052-2.","journal-title":"Prog Biophys Mol Biol"},{"key":"381_CR13","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1152\/physrev.00002.2004","volume":"84","author":"MC Brown","year":"2004","unstructured":"Brown MC, Turner CE: Paxillin: adapting to change. Physiol Rev. 2004, 84: 1315-1339. 10.1152\/physrev.00002.2004.","journal-title":"Physiol Rev"},{"key":"381_CR14","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1210\/en.141.1.274","volume":"141","author":"DJ MacPhee","year":"2000","unstructured":"MacPhee DJ, Lye SJ: Focal adhesion signaling in the rat myometrium is abruptly terminated with the onset of labour. Endocrinology. 2000, 141: 274-283. 10.1210\/en.141.1.274.","journal-title":"Endocrinology"},{"key":"381_CR15","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.1095\/biolreprod.104.035626","volume":"72","author":"SJ Williams","year":"2005","unstructured":"Williams SJ, White BG, MacPhee DJ: Expression of a5 integrin (Itga5) is elevated in the rat myometrium during late pregnancy and labour: implications for development of a mechanical syncytium. Biol Reprod. 2005, 72: 1114-1124. 10.1095\/biolreprod.104.035626.","journal-title":"Biol Reprod"},{"key":"381_CR16","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1242\/jcs.00996","volume":"117","author":"KH Kuo","year":"2004","unstructured":"Kuo KH, Seow C: Contractile filament architecture and force transmission in swine airway smooth muscle. J Cell Sci. 2004, 117: 1503-1511. 10.1242\/jcs.00996.","journal-title":"J Cell Sci"},{"key":"381_CR17","doi-asserted-by":"crossref","first-page":"26767","DOI":"10.1016\/S0021-9258(18)47085-8","volume":"269","author":"M Shibanuma","year":"1994","unstructured":"Shibanuma M, Jun-ichi M, Toshio K, Nose K: Characterization of the TGF\u03b21-inducible hic \u2013 5 gene that encodes a putative novel zinc finger protein and its possible involvement in cellular senescence. J Biol Chem. 1994, 269: 26767-26774.","journal-title":"J Biol Chem"},{"key":"381_CR18","doi-asserted-by":"publisher","first-page":"26516","DOI":"10.1074\/jbc.273.41.26516","volume":"273","author":"H Fujita","year":"1998","unstructured":"Fujita H, Kenjiro K, Cho D, Shibanuma M, Morimoto C, Tachibana K: Interaction of Hic-5, a senescence-related protein, with focal adhesion kinase. J Biol Chem. 1998, 273: 26516-26521. 10.1074\/jbc.273.41.26516.","journal-title":"J Biol Chem"},{"key":"381_CR19","doi-asserted-by":"publisher","first-page":"9847","DOI":"10.1074\/jbc.274.14.9847","volume":"274","author":"N Nishiya","year":"1999","unstructured":"Nishiya N, Iwabuchi Y, Shibanuma M, Cote JF, Tremblay ML, Nose K: Hic-5, a paxillin homologue, binds to the protein-tyrosine phosphatase PEST (PTP-PEST) through its LIM3 domain. J Biol Chem. 1999, 274: 9847-9853. 10.1074\/jbc.274.14.9847.","journal-title":"J Biol Chem"},{"key":"381_CR20","doi-asserted-by":"publisher","first-page":"5332","DOI":"10.1128\/MCB.21.16.5332-5345.2001","volume":"21","author":"N Nishiya","year":"2001","unstructured":"Nishiya N, Tachibana K, Shibanuma M, Mashimo J, Nose K: Hic-5 reduced cell spreading on fibronectin: competitive effects between paxillin and hic-5 through interaction with focal adhesion kinase. Mol Cell Biol. 2001, 21: 5332-5345. 10.1128\/MCB.21.16.5332-5345.2001.","journal-title":"Mol Cell Biol"},{"key":"381_CR21","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1242\/jcs.01683","volume":"118","author":"J Kim-Kaneyama","year":"2005","unstructured":"Kim-Kaneyama J, Suzuki W, Ichikawa K, Ohki T, Kohno Y, Sata M, Nose K, Shibanuma M: Uni-axial stretching regulates intracellular localization of Hic-5 expressed in smooth-muscle cells in vivo. J Cell Sci. 2005, 118: 937-949. 10.1242\/jcs.01683.","journal-title":"J Cell Sci"},{"key":"381_CR22","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1177\/002215540305100413","volume":"51","author":"T Yuminamochi","year":"2003","unstructured":"Yuminamochi T, Yatomi Y, Osada M, Ohmori T, Ishii Y, Nakazawa K, Hosogaya S, Ozaki Y: Expression of the LIM proteins paxillin and Hic-5 in human tissues. J Histochem Cytochem. 2003, 51: 513-521.","journal-title":"J Histochem Cytochem"},{"key":"381_CR23","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1177\/42.8.8027531","volume":"42","author":"JH Beckstead","year":"1994","unstructured":"Beckstead JH: A simple technique for preservation of fixation-sensitive antigens in paraffin embedded tissues. J Histochem Cytochem. 1994, 42: 1127-1134.","journal-title":"J Histochem Cytochem"},{"key":"381_CR24","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1530\/rep.1.00426","volume":"129","author":"BG White","year":"2005","unstructured":"White BG, Williams SJ, Highmore K, MacPhee DJ: Small heat shock protein 27 (Hsp27) expression is highly induced in rat myometrium during late pregnancy and labour. Reproduction. 2005, 129: 115-126. 10.1530\/rep.1.00426.","journal-title":"Reproduction"},{"key":"381_CR25","doi-asserted-by":"publisher","first-page":"C1530","DOI":"10.1152\/ajpcell.00607.2001","volume":"283","author":"AD Oldenhof","year":"2002","unstructured":"Oldenhof AD, Shynlova OP, Liu M, Langille BL, Lye SJ: Mitogen-activated protein kinases mediate stretch-induced c \u2013 fos mRNA expression in myometrial smooth muscle cells. Am J Physiol Cell Physiol. 2002, 283: C1530-C1539.","journal-title":"Am J Physiol Cell Physiol"},{"key":"381_CR26","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","volume":"72","author":"MM Bradford","year":"1976","unstructured":"Bradford MM: A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976, 72: 248-254. 10.1016\/0003-2697(76)90527-3.","journal-title":"Anal Biochem"},{"key":"381_CR27","doi-asserted-by":"publisher","first-page":"2380","DOI":"10.1210\/en.132.6.2380","volume":"132","author":"SJ Lye","year":"1993","unstructured":"Lye SJ, Nicholson BJ, Mascarenhas M, MacKenzie L, Petrocelli T: Increased expression of connexin-43 in the rat myometrium during labour is associated with an increase in the plasma estrogen : progesterone ratio. Endocrinology. 1993, 132: 2380-2386. 10.1210\/en.132.6.2380.","journal-title":"Endocrinology"},{"key":"381_CR28","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.1126\/science.286.5442.1172","volume":"286","author":"LB Smilenov","year":"1999","unstructured":"Smilenov LB, Mikhailov A, Pelham RJ, Marcantonio EE, Gundersen GC: Focal adhesion motility revealed in stationary fibroblasts. Science. 1999, 286: 1172-1174. 10.1126\/science.286.5442.1172.","journal-title":"Science"},{"key":"381_CR29","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/0014-2999(81)90497-0","volume":"76","author":"EH Chow","year":"1981","unstructured":"Chow EH, Marshall JM: Effects of catecholamines on circular and longitudinal uterine muscle of the rat. Eur J Pharmacol. 1981, 76: 157-165. 10.1016\/0014-2999(81)90497-0.","journal-title":"Eur J Pharmacol"},{"key":"381_CR30","doi-asserted-by":"publisher","first-page":"403","DOI":"10.2170\/jjphysiol.26.403","volume":"26","author":"T Kawarabayashi","year":"1976","unstructured":"Kawarabayashi T, Osa T: Comparative investigations of alpha- and beta-effects on the longitudinal and circular muscles of the pregnant rat myometrium. Jap J Physiol. 1976, 26: 403-416.","journal-title":"Jap J Physiol"},{"key":"381_CR31","doi-asserted-by":"publisher","first-page":"1500","DOI":"10.1095\/biolreprod.103.018556","volume":"69","author":"M Mlynarczyk","year":"2003","unstructured":"Mlynarczyk M, Imamura T, Umezaki H, Kaushal KM, Zhang L, Ducsay CA: Long-term hypoxia changes myometrial responsiveness and oxytocin receptors in the pregnant ewe: Differential effects on longitudinal versus circular smooth muscle. Biol Reprod. 2003, 69: 1500-1505. 10.1095\/biolreprod.103.018556.","journal-title":"Biol Reprod"},{"key":"381_CR32","doi-asserted-by":"publisher","first-page":"153","DOI":"10.2170\/jjphysiol.25.153","volume":"25","author":"T Osa","year":"1975","unstructured":"Osa T, Katase T: Physiological comparison of the longitudinal circular muscles of the pregnant rat uterus. Jap J Physiol. 1975, 25: 153-164.","journal-title":"Jap J Physiol"},{"key":"381_CR33","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/j.bbrc.2006.02.162","volume":"343","author":"A Guignandon","year":"2006","unstructured":"Guignandon A, Boutahar N, Rattner A, Vico L, Lafage-Proust M-H: Cyclic strain promotes shuttling of PYK2\/Hic-5 complex from focal contacts in osteoblast-like cells. Biochem Biophys Res Commun. 2006, 343: 407-414. 10.1016\/j.bbrc.2006.02.162.","journal-title":"Biochem Biophys Res Commun"},{"key":"381_CR34","doi-asserted-by":"publisher","first-page":"4849","DOI":"10.1242\/jcs.02615","volume":"118","author":"DA Tumbarello","year":"2005","unstructured":"Tumbarello DA, Brown MC, Hetey SE, Turner CE: Regulation of paxillin family members during epithelial-mesenchymal transformation: a putative role for paxillin \u03b4. J Cell Sci. 2005, 118: 4849-4863. 10.1242\/jcs.02615.","journal-title":"J Cell Sci"},{"key":"381_CR35","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1074\/jbc.273.2.1003","volume":"273","author":"M Matsuya","year":"1998","unstructured":"Matsuya M, Sasaki H, Aoto H, Itaka T, Nagura K, Ohb T, Ishino M, Takahashi S, Suzaki R, Sasaki T: Cell adhesion kinase \u03b2 forms a complex with a new member, Hic-5, of proteins localized at focal adhesions. J Biol Chem. 1998, 273: 1003-1014. 10.1074\/jbc.273.2.1003.","journal-title":"J Biol Chem"},{"key":"381_CR36","doi-asserted-by":"publisher","first-page":"22048","DOI":"10.1074\/jbc.M513111200","volume":"281","author":"K Mori","year":"2006","unstructured":"Mori K, Asakawa M, Hayashi M, Imura M, Ohki T, Hirao E, Kim-Kaneyama J-R, Nose K, Shibanuma M: Oligomerizing potential of a focal adhesion LIM protein Hic-5 organizing a nuclear-cytoplasmic shuttling complex. J Biol Chem. 2006, 281: 22048-22061. 10.1074\/jbc.M513111200.","journal-title":"J Biol Chem"},{"key":"381_CR37","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1016\/j.tcb.2005.07.002","volume":"15","author":"C Wu","year":"2005","unstructured":"Wu C: PINCH, N(i)CK and the ILK: network wiring at cell-matrix adhesions. Trends Cell Biol. 2005, 15: 460-466. 10.1016\/j.tcb.2005.07.002.","journal-title":"Trends Cell Biol"},{"key":"381_CR38","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1267\/ahc.34.259","volume":"34","author":"M Shibanuma","year":"2001","unstructured":"Shibanuma M, Ishino K, Sakamoto N, Nose K: Accumulation of focal adhesion protein Hic \u2013 5 in the nucleus by hydrogen peroxide. Acta Histochem Cytochem. 2001, 34: 259-264. 10.1267\/ahc.34.259.","journal-title":"Acta Histochem Cytochem"},{"key":"381_CR39","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1091\/mbc.02-06-0099","volume":"14","author":"M Shibanuma","year":"2003","unstructured":"Shibanuma M, Kim-Kaneyama J, Ishino K, Sakamoto N, Hishiki T, Yamaguchi K, Mori K, Mashimo J, Nose K: Hic-5 communicates between focal adhesions and the nucleus through oxidant-sensitive nuclear export signal. Mol Biol Cell. 2003, 14: 1158-1171. 10.1091\/mbc.02-06-0099.","journal-title":"Mol Biol Cell"},{"key":"381_CR40","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1016\/S0006-291X(02)02644-X","volume":"299","author":"J Kim-Kaneyama","year":"2002","unstructured":"Kim-Kaneyama J, Shibanuma M, Nose K: Transcriptional activation of the c \u2013 fos gene by a LIM protein, Hic-5. Biochim Biophys Res Commun. 2002, 299: 360-365. 10.1016\/S0006-291X(02)02644-X.","journal-title":"Biochim Biophys Res Commun"},{"key":"381_CR41","doi-asserted-by":"publisher","first-page":"2007","DOI":"10.1091\/mbc.11.6.2007","volume":"11","author":"L Yang","year":"2000","unstructured":"Yang L, Guerrero J, Hong H, DeFranco D, Stallcup M: Interaction of the \u03c42 transcriptional activation domain of glucocorticoid receptor with a novel steroid receptor coactivator, Hic-5, which localizes to both focal adhesions and the nuclear matrix. Mol Biol Cell. 2000, 11: 2007-2018.","journal-title":"Mol Biol Cell"},{"key":"381_CR42","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/S0962-8924(03)00105-3","volume":"13","author":"M Balda","year":"2003","unstructured":"Balda M, Matter K: Epithelial cell adhesion and the regulation of gene expression. Trends Cell Biol. 2003, 13: 310-316. 10.1016\/S0962-8924(03)00105-3.","journal-title":"Trends Cell Biol"},{"key":"381_CR43","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1038\/1370","volume":"5","author":"MC Brown","year":"1998","unstructured":"Brown MC, Curtis MS, Turner CE: Paxillin LD motifs may define a new family of protein recognition domains. Nat Struc Biol. 1998, 5: 677-678. 10.1038\/1370.","journal-title":"Nat Struc Biol"},{"key":"381_CR44","doi-asserted-by":"publisher","first-page":"39911","DOI":"10.1074\/jbc.M103510200","volume":"276","author":"Y Jia","year":"2001","unstructured":"Jia Y, Ransom R, Shibanuma M, Liu C, Welsh M, Smoyer W: Identification and characterization of hic-5\/ARA55 as an hsp27 binding protein. J Biol Chem. 2001, 276: 39911-39918. 10.1074\/jbc.M103510200.","journal-title":"J Biol Chem"}],"container-title":["Reproductive Biology and Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1477-7827-5-22.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T07:18:14Z","timestamp":1630480694000},"score":1,"resource":{"primary":{"URL":"https:\/\/rbej.biomedcentral.com\/articles\/10.1186\/1477-7827-5-22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6,5]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["381"],"URL":"https:\/\/doi.org\/10.1186\/1477-7827-5-22","relation":{},"ISSN":["1477-7827"],"issn-type":[{"value":"1477-7827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,6,5]]},"assertion":[{"value":"19 March 2007","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 June 2007","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 June 2007","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"22"}}