{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:30:47Z","timestamp":1787837447399,"version":"build-2784847793"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T00:00:00Z","timestamp":1228089600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reprod Biol Endocrinol"],"published-print":{"date-parts":[[2008,12]]},"DOI":"10.1186\/1477-7827-6-58","type":"journal-article","created":{"date-parts":[[2012,5,3]],"date-time":"2012-05-03T10:52:56Z","timestamp":1336042376000},"source":"Crossref","is-referenced-by-count":42,"title":["Reduced developmental competence of immature, in-vitro matured and postovulatory aged mouse oocytes following IVF and ICSI"],"prefix":"10.1186","volume":"6","author":[{"given":"Orly","family":"Lacham-Kaplan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Trounson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,12,1]]},"reference":[{"key":"464_CR1","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1002\/jez.1401550211","volume":"155","author":"JH Marston","year":"1964","unstructured":"Marston JH, Chang MC: The fertilizable life of ova and their morphology following delayed insemination in mature and immature mice. J Exp Zool. 1964, 155: 237-252. 10.1002\/jez.1401550211.","journal-title":"J Exp Zool"},{"key":"464_CR2","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.1095\/biolreprod61.5.1347","volume":"61","author":"JJ Tarin","year":"1999","unstructured":"Tarin JJ, Albala-Perez S, Aguilar A, Minarro J, Hermenegildo C, Cano C: Long-term effects of postovulatory aging of mouse oocytes on offspring: a two-generational study. Biol Reprod. 1999, 61: 1347-1355. 10.1095\/biolreprod61.5.1347.","journal-title":"Biol Reprod"},{"key":"464_CR3","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1017\/S0967199400002999","volume":"4","author":"B Pyrzynska","year":"1996","unstructured":"Pyrzynska B, Maleszewski M, Maluchnik D: Mouse oocytes penetrated by sperm at GV or GVBD stage lose the ability to fuse with additional spermatozoa. Zygote. 1996, 4: 123-128.","journal-title":"Zygote"},{"key":"464_CR4","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/0012-1606(84)90215-X","volume":"102","author":"AC Schroeder","year":"1984","unstructured":"Schroeder AC, Eppig JJ: The developmental capacity of mouse oocytes that matured spontaneously in vitro is normal. Dev Biol. 1984, 102: 493-497. 10.1016\/0012-1606(84)90215-X.","journal-title":"Dev Biol"},{"key":"464_CR5","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1530\/jrf.0.0830753","volume":"83","author":"K Goto","year":"1988","unstructured":"Goto K, Kajihara Y, Kosaka S, Koba M, Nakanishi Y, Ogawa K: Pregnancies after co-culture of cumulus cells with bovine embryos derived from in-vitro fertilization of in-vitro matured follicular oocytes. J Reprod Fertil. 1988, 83: 753-758.","journal-title":"J Reprod Fertil"},{"key":"464_CR6","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1016\/0093-691X(89)90089-7","volume":"31","author":"M Mattioli","year":"1989","unstructured":"Mattioli M, Bacci ML, Galeati G, Seren E: Developmental competence of pig oocytes matured and fertilized in vitro. Theriogenology. 1989, 31: 1201-1207. 10.1016\/0093-691X(89)90089-7.","journal-title":"Theriogenology"},{"key":"464_CR7","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1095\/biolreprod40.4.720","volume":"40","author":"BC Vanderhyden","year":"1989","unstructured":"Vanderhyden BC, Armstrong DT: Role of cumulus cells and serum on the in vitro maturation, fertilization, and subsequent development of rat oocytes. Biol Reprod. 1989, 40: 720-728. 10.1095\/biolreprod40.4.720.","journal-title":"Biol Reprod"},{"key":"464_CR8","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0015-0282(16)54068-0","volume":"55","author":"KY Cha","year":"1991","unstructured":"Cha KY, Koo JJ, Ko JJ, Choi DH, Han SY, Yoon TK: Pregnancy after in vitro fertilization of human follicular oocytes collected from nonstimulated cycles, their culture in vitro and their transfer in a donor oocyte program. Fertil Steril. 1991, 55: 109-113.","journal-title":"Fertil Steril"},{"key":"464_CR9","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1530\/jrf.0.0950119","volume":"95","author":"JJ Eppig","year":"1992","unstructured":"Eppig JJ, Schroeder AC, O'Brien MJ: Developmental capacity of mouse oocytes matured in vitro: effects of gonadotrophic stimulation, follicular origin and oocyte size. J Reprod Fertil. 1992, 95: 119-127.","journal-title":"J Reprod Fertil"},{"key":"464_CR10","doi-asserted-by":"publisher","first-page":"1828","DOI":"10.1095\/biolreprod66.6.1828","volume":"66","author":"AC Gordo","year":"2002","unstructured":"Gordo AC, Rodrigue P, Kurokawa M, Jellerett , Exley GE, Warner C, Fissore R: Intracellular calcium oscillations signal apoptosis rather than activation in-in-vitro aged mouse eggs. Biol Reprod. 2002, 66: 1828-1837. 10.1095\/biolreprod66.6.1828.","journal-title":"Biol Reprod"},{"key":"464_CR11","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1262\/jrd.50.627","volume":"50","author":"S Wakayama","year":"2004","unstructured":"Wakayama S, Thun NV, Kishigam S, Ohta H, Mizutani E, Hikichi T, Miyake M, Wakayama T: Production of offspring from one-day-old oocytes stored at room temperature. J Reprod Devel. 2004, 50: 627-637. 10.1262\/jrd.50.627.","journal-title":"J Reprod Devel"},{"key":"464_CR12","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1002\/mrd.20779","volume":"75","author":"TW Qiao","year":"2008","unstructured":"Qiao TW, Liu N, Miao DQ, Zhang X, Han D, Ge L, Tan JH: Cumulus cells accelerate aging of mouse oocytes by secreting a soluble factor(s). Mol Reprod Dev. 2008, 75: 521-528. 10.1002\/mrd.20779.","journal-title":"Mol Reprod Dev"},{"key":"464_CR13","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1095\/biolreprod.104.034926","volume":"72","author":"H Igarashi","year":"2005","unstructured":"Igarashi H, Takahashi T, Takahashi E, Tezuka N, Nakahara K, Takahashi K, Kurachi H: Aged mouse oocytes fail to readjust intracellular adenosine triphosphates at fertilization. Bilo Reprod. 2005, 72: 1256-1261. 10.1095\/biolreprod.104.034926.","journal-title":"Bilo Reprod"},{"key":"464_CR14","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1530\/jrf.0.0720373","volume":"72","author":"LR Fraser","year":"1984","unstructured":"Fraser LR: Mouse sperm capacitation in vitro involves loss of a surface-associated inhibitory component. J Reprod Fertil. 1984, 72: 373-384.","journal-title":"J Reprod Fertil"},{"key":"464_CR15","doi-asserted-by":"publisher","first-page":"189","DOI":"10.3109\/01485018208987039","volume":"8","author":"P Quinn","year":"1982","unstructured":"Quinn P, Whittingham D, Stanger J: Interaction of semen with ova in vitro. Arch Androl. 1982, 8: 189-198. 10.3109\/01485018208987039.","journal-title":"Arch Androl"},{"key":"464_CR16","first-page":"7","volume":"14","author":"DG Whittingham","year":"1971","unstructured":"Whittingham DG: Culture of mouse ova. J Reprod Fertil Suppl. 1971, 14: 7-21.","journal-title":"J Reprod Fertil Suppl"},{"key":"464_CR17","doi-asserted-by":"publisher","first-page":"1683","DOI":"10.1095\/biolreprod.103.018184","volume":"69","author":"O Lacham-Kaplan","year":"2003","unstructured":"Lacham-Kaplan O, Shaw J, Sanchez-Partida LG, Trounson A: Oocyte activation after intracytoplasmic injection with sperm frozen without cryoprotectants results in live offspring from inbred and hybrid mouse strains. Biol Reprod. 2003, 69: 1683-1689. 10.1095\/biolreprod.103.018184.","journal-title":"Biol Reprod"},{"key":"464_CR18","doi-asserted-by":"publisher","first-page":"1682","DOI":"10.1095\/biolreprod.102.013029","volume":"68","author":"MJ O'Brien","year":"2003","unstructured":"O'Brien MJ, Pendola JK, Eppig JJ: A revised protocol for in vitro development of mouse oocytes from primordial follicles dramatically improves their developmental competence. Biol Reprod. 2003, 68: 1682-1686. 10.1095\/biolreprod.102.013029.","journal-title":"Biol Reprod"},{"key":"464_CR19","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1262\/jrd.17078","volume":"52","author":"H Miki","year":"2006","unstructured":"Miki H, Ogonuki N, Inoue K, Baba T, Ogura A: Improvement of cumulus-free oocyte maturation in vitro an its application to microinsemination with primary spermatocytes. J Reprod Devel. 2006, 52: 239-248. 10.1262\/jrd.17078.","journal-title":"J Reprod Devel"},{"key":"464_CR20","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1272\/jnms.70.408","volume":"70","author":"Y Nishi","year":"2003","unstructured":"Nishi Y, Takeshita T, Sato K, Araki T: Change of the mitochondrial distribution in mouse ooplasm during in-vitro maturation. J Nippon Med Sch. 2003, 70: 408-415. 10.1272\/jnms.70.408.","journal-title":"J Nippon Med Sch"},{"key":"464_CR21","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1002\/mrd.1080370208","volume":"37","author":"BV Paynton","year":"1994","unstructured":"Paynton BV, Bachvarova R: Polyadenylation and deadenylation of maternal mRNAs during oocyte growth and maturation in the mouse. Mol Reprod Dev. 1994, 37: 172-180. 10.1002\/mrd.1080370208.","journal-title":"Mol Reprod Dev"},{"key":"464_CR22","doi-asserted-by":"publisher","first-page":"4160","DOI":"10.1073\/pnas.75.9.4160","volume":"75","author":"RM Schultz","year":"1978","unstructured":"Schultz RM, Lamarca MJ, Wassarman PM: Absolute rate of protein synthesis during meiotic maturation of mammalian oocytes in-vitro. Proc Natl Acad Sci USA. 1978, 75: 4160-4164. 10.1073\/pnas.75.9.4160.","journal-title":"Proc Natl Acad Sci USA"},{"key":"464_CR23","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1054\/ceca.1999.0053","volume":"26","author":"MS Sato","year":"1999","unstructured":"Sato MS, Yoshitomo M, Mohri T, Miyazaki S: Spatiotemporal analysis of [Ca2+] rises in mouse eggs after intracytoplasmic sperm injection (ICSI). Cell Calcium. 1999, 26: 49-58. 10.1054\/ceca.1999.0053.","journal-title":"Cell Calcium"},{"key":"464_CR24","doi-asserted-by":"publisher","first-page":"1534","DOI":"10.1093\/humrep\/deh768","volume":"20","author":"V Soderstorm-Anttila","year":"2005","unstructured":"Soderstorm-Anttila V, Makinen S, Tuuri T, Suikkari AM: Favourable pregnancy results with insemination of in-vitro matured oocytes from unstimulated patients. Hum Reprod. 2005, 20: 1534-1540. 10.1093\/humrep\/deh768.","journal-title":"Hum Reprod"},{"key":"464_CR25","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1095\/biolreprod51.6.1088","volume":"51","author":"LM Mehlmann","year":"1994","unstructured":"Mehlmann LM, Kline D: Regulation of intracellular calcium in the mouse egg: calcium release in response to sperm or inositol trisphosphate is enhanced maturation. Biol Reprod. 1994, 51: 1088-1098. 10.1095\/biolreprod51.6.1088.","journal-title":"Biol Reprod"},{"key":"464_CR26","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/S1472-6483(10)60292-1","volume":"17","author":"TH Taylor","year":"2008","unstructured":"Taylor TH, Wright G, Jones-Colon S, Mitchell-Leef D, Kort HI, Nagy ZP: Comparison of ICSI and conventional IVF in patients with increased oocyte immaturity. Reprod BioMed Online. 2008, 17: 46-52.","journal-title":"Reprod BioMed Online"},{"key":"464_CR27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1432-1033.1990.tb19297.x","volume":"193","author":"CP Downess","year":"1990","unstructured":"Downess CP, Mecphee CH: Myo-inositol metabolites as cellular signals. Eur J Bioche. 1990, 193: 1-18. 10.1111\/j.1432-1033.1990.tb19297.x.","journal-title":"Eur J Bioche"},{"key":"464_CR28","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/S0012-1606(02)00049-0","volume":"254","author":"Z Xu","year":"2003","unstructured":"Xu Z, Williams CJ, Kopf GS, Schultz RM: Maturation-associated increase in IP3 receptor type 1: role in conferring increased IP3 sensitivity and Ca2+ oscillatory behaviour in mouse eggs. Devel Biol. 2003, 254: 163-171. 10.1016\/S0012-1606(02)00049-0.","journal-title":"Devel Biol"},{"key":"464_CR29","first-page":"219","volume":"42","author":"I DeMeestere","year":"1997","unstructured":"DeMeestere I, Barlow P, Levron F: Hardening of zona pellucida of mouse oocytes and embryos in-vivo and in-vitro. Int J Fertil Womens Med. 1997, 42: 219-222.","journal-title":"Int J Fertil Womens Med"},{"key":"464_CR30","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1023\/B:JARG.0000042008.83699.cc","volume":"21","author":"DH Kim","year":"2004","unstructured":"Kim DH, Ko DS, Lee HC, Lee HJ, Park WI, Kim SS, Park JK, Yang BC, Chang WK, Lee HT: Comparison of maturation, fertilization, development, and gene expression of mouse oocytes grown in-vitro and in-vivo. J Assis Reprod Genet. 2004, 21: 233-240. 10.1023\/B:JARG.0000042008.83699.cc.","journal-title":"J Assis Reprod Genet"},{"key":"464_CR31","doi-asserted-by":"publisher","first-page":"4592","DOI":"10.1073\/pnas.0736739100","volume":"100","author":"PL McNeil","year":"2003","unstructured":"McNeil PL, Miyake K, Vogel SS: The endomembrane requirement for cell surface repair. Pross Natl Acad Aci USA. 2003, 100: 4592-4597. 10.1073\/pnas.0736739100.","journal-title":"Pross Natl Acad Aci USA"},{"key":"464_CR32","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1002\/mrd.20162","volume":"69","author":"JH Lee","year":"2004","unstructured":"Lee JH, Yoon SY, Bae IH: Studies on Ca2+-channel distribution in maturation arrest mouse oocytes. Mol Reprod Dev. 2004, 69: 174-185. 10.1002\/mrd.20162.","journal-title":"Mol Reprod Dev"},{"key":"464_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/molehr\/gah125","volume":"11","author":"GB Wortzman","year":"2004","unstructured":"Wortzman GB, Evans JP: Membrane and cortical abnormalities in post-ovulatory aged eggs: analysis of fertilizability and establishment of the membrane block to polyspermy. Mol Hum Reprod. 2004, 11: 1-9. 10.1093\/molehr\/gah125.","journal-title":"Mol Hum Reprod"},{"key":"464_CR34","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1002\/mrd.10341","volume":"66","author":"T Takahashi","year":"2003","unstructured":"Takahashi T, Takahashi E, Igarashi H, Tezuka N, Kurachi H: Impact of oxidative stress in aged mouse oocytes on calcium oscillations at fertilization. Mol Reprod Devel. 2003, 66: 143-152. 10.1002\/mrd.10341.","journal-title":"Mol Reprod Devel"},{"key":"464_CR35","doi-asserted-by":"publisher","first-page":"2889","DOI":"10.1093\/humrep\/deh528","volume":"19","author":"A Sanfins","year":"2004","unstructured":"Sanfins A, Planch CE, Overstrom EW, Albertini DF: Meiotic spindle morphogenesis in in-vivo and in-vitro matured mouse oocytes: insights into the relationship between nuclear and cytoplasmic quality. Hum Reprod. 2004, 19: 2889-2899. 10.1093\/humrep\/deh528.","journal-title":"Hum Reprod"},{"key":"464_CR36","doi-asserted-by":"publisher","first-page":"2207","DOI":"10.1093\/humrep\/dei044","volume":"20","author":"JH Moon","year":"2005","unstructured":"Moon JH, Jee BC, Ku SY, Suh CS, Kin SH, Choi YM, Kim JG, Moon SY: Spindle positions and their distributions in in-vivo and in-vitro matured mouse oocytes. Hum Reprod. 2005, 20: 2207-2210. 10.1093\/humrep\/dei044.","journal-title":"Hum Reprod"},{"key":"464_CR37","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1007\/s10815-008-9201-x","volume":"25","author":"L Liu","year":"2008","unstructured":"Liu L, Aoki VW, Carrel DT: Evaluation of the developmental competence and chromosomal compliment of mouse oocytes derived from in-vitro growth and maturation of preantral follicles. J Assist Reprod Genet. 2008, 25: 107-113. 10.1007\/s10815-008-9201-x.","journal-title":"J Assist Reprod Genet"},{"key":"464_CR38","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1093\/humrep\/13.5.1317","volume":"13","author":"J Van Blerkom","year":"1998","unstructured":"Van Blerkom J, Davis PW: DNA strand breaks and phosphatidylserine redistribution in newly ovulated and cultured mouse and human oocytes: occurrence and relationship to apoptosis. Hum Reprod. 1998, 13: 1317-1324. 10.1093\/humrep\/13.5.1317.","journal-title":"Hum Reprod"},{"key":"464_CR39","doi-asserted-by":"publisher","first-page":"1936","DOI":"10.1095\/biolreprod.104.033589","volume":"71","author":"GA Thouas","year":"2004","unstructured":"Thouas GA, Trounson AO, Wolvetang EJ, Jones GM: Mitochondrial dysfunction in mouse oocytes results in preimplantation embryo arrest in vitro. Biol Reprod. 2004, 71: 1936-1942. 10.1095\/biolreprod.104.033589.","journal-title":"Biol Reprod"},{"key":"464_CR40","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1016\/S0015-0282(16)57973-4","volume":"64","author":"ZP Nagy","year":"1995","unstructured":"Nagy ZP, Staessen C, Liu J, Joris H, Devroey P, Van Steiteghem AC: Prospective, auto-controlled study on re-insemination of failed-fertilized oocytes by intracytoplasmic sperm injection. Fertil Sterl. 1995, 64: 1130-1135.","journal-title":"Fertil Sterl"},{"key":"464_CR41","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/S0015-0282(16)58397-6","volume":"66","author":"K Lundin","year":"1996","unstructured":"Lundin K, Sjogren A, Hamberger L: Reinsemination of one-day-old oocytes by use of intracytoplasmic sperm injection. Fertil Steril. 1996, 66: 118-121.","journal-title":"Fertil Steril"},{"key":"464_CR42","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1016\/S0015-0282(97)00223-9","volume":"68","author":"PC Morton","year":"1997","unstructured":"Morton PC, Yoder CS, Tucker MJ, Wright G, Brockman WDW, Kort HI: Reinsemination by intracytoplasmic sperm injection of 1-day-old oocytes after complete conventional fertilization failure. Fertil Steril. 1997, 68: 488-491. 10.1016\/S0015-0282(97)00223-9.","journal-title":"Fertil Steril"},{"key":"464_CR43","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1016\/S0015-0282(00)00522-7","volume":"73","author":"AA Yuzp","year":"2000","unstructured":"Yuzp AA, Liu Z, Fluker MR: Rescue intracytoplasmic sperm injection (ICSI) \u2013 salvaging in-vitro fertilization (IVF) cycles after total or near-total fertilization failure. Fertil Steril. 2000, 73: 1115-1119. 10.1016\/S0015-0282(00)00522-7.","journal-title":"Fertil Steril"},{"issue":"1","key":"464_CR44","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.bbrc.2008.03.105","volume":"371","author":"XW Liang","year":"2008","unstructured":"Liang XW, Zhu JQ, Miao YL, Liu JH, Wei L, Lu SS, Hou Y, Schatten H, Lu KH, Sun QY: Loss of methylation imprint of Snrpn in postovulatory aging mouse oocyte. Biochem Biophys Res Commun. 2008, 371 (1): 16-21. 10.1016\/j.bbrc.2008.03.105.","journal-title":"Biochem Biophys Res Commun"},{"key":"464_CR45","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1016\/j.fertnstert.2005.09.029","volume":"85","author":"ZP Nagy","year":"2006","unstructured":"Nagy ZP, Rienzi LF, Ubaldi FM, Greco E, Massey JB, Kort HI: Effect of reduced oocyte aging on the outcome of rescue intracytoplasmic sperm injection. Fertil Steril. 2006, 85: 901-906. 10.1016\/j.fertnstert.2005.09.029.","journal-title":"Fertil Steril"},{"key":"464_CR46","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1093\/molehr\/gah231","volume":"11","author":"NM Steuerwald","year":"2005","unstructured":"Steuerwald NM, Steuerwald MD, Mailhes JB: Post-ovulatory aging of mouse oocytes leads to decreased MAD2 transcripts and increased frequencies of premature centromere separation and anaphase. Mol Hum Reprod. 2005, 11: 623-630. 10.1093\/molehr\/gah231.","journal-title":"Mol Hum Reprod"},{"key":"464_CR47","doi-asserted-by":"publisher","first-page":"2010","DOI":"10.1093\/humrep\/den210","volume":"23","author":"WY Son","year":"2008","unstructured":"Son WY, Chung JT, Chian RC, Herrero B, Demirtas E, Elizur S, Gidony Y, Sylvestre C, Dean N, Tan SL: A 38 h interval between hCG priming and oocyte retrieval increases in-vivo oocyte maturation rate in programmed IVM cycles. Hum Reprod. 2008, 23: 2010-2016. 10.1093\/humrep\/den210.","journal-title":"Hum Reprod"}],"container-title":["Reproductive Biology and Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1477-7827-6-58.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1477-7827-6-58\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1477-7827-6-58.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T17:33:02Z","timestamp":1548178382000},"score":1,"resource":{"primary":{"URL":"https:\/\/rbej.biomedcentral.com\/articles\/10.1186\/1477-7827-6-58"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,12]]}},"alternative-id":["464"],"URL":"https:\/\/doi.org\/10.1186\/1477-7827-6-58","relation":{},"ISSN":["1477-7827"],"issn-type":[{"value":"1477-7827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,12]]},"article-number":"58"}}