{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T09:36:04Z","timestamp":1790328964702,"version":"4.1.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod Biol Endocrinol"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Rats made hypothyroid with propilthyouracil start showing abnormal cycling on the second cycle after the start of the treatment, with a high proportion of spontaneous pseudopregnancies and reduced fertility.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>To investigate some of the mechanisms involved in these reproductive abnormalities, hypothyroidism was induced in virgin rats by propilthyouracil (0.1 g\/L in the drinking water) and we determined circulating hormones by radioimmunoassay and whole ovary expression of ovarian hormone receptors, growth factors and steroidogenic enzymes using semi-quantitative RT-PCR.<\/jats:p>\n            <jats:p>The study was performed on days 6 to 9 of treatment, corresponding to diestrus I (at 20.00-22.00 h), diestrus II (at 20.00-22.00 h), proestrus and estrus (both at 8.00-10.00 h and 20.00-22.00 h) of the second estrous cycle after beginning propilthyouracil treatment. Another group of rats was mated on day 8 and the treatment continued through the entire pregnancy to evaluate reproductive performance.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Hypothyroidism increased circulating prolactin and estradiol on estrus 5 to 7-fold and 1.2 to 1.4-fold respectively. Growth hormone and insulin-like growth factor 1 diminished 60 and 20% respectively on proestrus morning. Hypothyroidism doubled the ovarian mRNA contents of estrogen receptor-beta on proestrus and estrus evenings, cyp19A1 aromatase mRNA on estrus evening and of growth hormone receptor on proestrus evening. Hypothyroidism did not influence ovulation rate or the number of corpora lutea at term, but a diminished number of implantation sites and pups per litter were observed (Hypothyroid: 11.7 +\/- 0.8 vs. Control: 13.9 +\/- 0.7).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Short term hypothyroidism alters normal hormone profile in the cycling rat increasing the expression of estrogen receptor-beta and cyp19A1 aromatase on estrus, which in turn may stimulate estradiol and prolactin secretion, favouring corpus luteum survival and the subsequent instauration of pseudopregnancy.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1477-7827-8-14","type":"journal-article","created":{"date-parts":[[2010,2,12]],"date-time":"2010-02-12T07:15:02Z","timestamp":1265958902000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Short term hypothyroidism affects ovarian function in the cycling rat"],"prefix":"10.1186","volume":"8","author":[{"given":"Mar\u00eda Bel\u00e9n","family":"Hapon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Gamarra-Luques","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graciela A","family":"Jahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,2,11]]},"reference":[{"key":"639_CR1","first-page":"99","volume":"25","author":"B Elliott","year":"2000","unstructured":"Elliott B: Diagnosing and treating hypothyroidism. Nurse Pract. 2000, 25: 99-105.","journal-title":"Nurse Pract"},{"key":"639_CR2","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1111\/j.1749-6632.2000.tb06217.x","volume":"900","author":"AG Doufas","year":"2000","unstructured":"Doufas AG, Mastorakos G: The hypothalamic-pituitary-thyroid axis and the female reproductive system. Ann N Y Acad Sci. 2000, 900: 65-76.","journal-title":"Ann N Y Acad Sci"},{"key":"639_CR3","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1111\/j.1365-2265.2007.02752.x","volume":"66","author":"K Poppe","year":"2007","unstructured":"Poppe K, Velkeniers B, Glinoer D: Thyroid disease and female reproduction. Clin Endocrinol (Oxf). 2007, 66: 309-321. 10.1111\/j.1365-2265.2007.02752.x.","journal-title":"Clin Endocrinol (Oxf)"},{"key":"639_CR4","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1080\/09513590701267651","volume":"23","author":"T Eldar-Geva","year":"2007","unstructured":"Eldar-Geva T, Shoham M, R\u00f6sler A, Margalioth EJ, Livne K, Meirow D: Subclinical hypothyroidism in infertile women: the importance of continuous monitoring and the role of the thyrotropin-releasing hormone stimulation test. Gynecol Endocrinol. 2007, 23: 332-337. 10.1080\/09513590701267651.","journal-title":"Gynecol Endocrinol"},{"key":"639_CR5","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0025-7125(16)30475-8","volume":"75","author":"GP Becks","year":"1991","unstructured":"Becks GP, Burrow GN: Thyroid disease and pregnancy. Med Clin North Am. 1991, 75: 121-150.","journal-title":"Med Clin North Am"},{"key":"639_CR6","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1210\/edrv.18.3.0300","volume":"18","author":"D Glinoer","year":"1997","unstructured":"Glinoer D: The regulation of thyroid function in pregnancy: pathways of endocrine adaptation from physiology to pathology. Endocr Rev. 1997, 18: 404-433. 10.1210\/er.18.3.404.","journal-title":"Endocr Rev"},{"key":"639_CR7","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1055\/s-0029-1212040","volume":"106","author":"D Glinoer","year":"1998","unstructured":"Glinoer D: Iodine supplementation during pregnancy: importance and biochemical assessment. Exp Clin Endocrinol Diabetes. 1998, 106: 3-21. 10.1055\/s-0029-1212040.","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"639_CR8","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1292\/jvms.60.439","volume":"60","author":"A Tohei","year":"1998","unstructured":"Tohei A, Imai A, Watanabe G, Taya K: Influence of thiouracil-induced hypothyroidism on adrenal and gonadal functions in adult female rats. J Vet Med Sci. 1998, 60: 439-446. 10.1292\/jvms.60.439.","journal-title":"J Vet Med Sci"},{"key":"639_CR9","first-page":"297","volume-title":"Textbook of Reproductive Medicine","author":"EW Stradtman","year":"1993","unstructured":"Stradtman EW: Thyroid dysfunction and ovulatory disorders. Textbook of Reproductive Medicine. Edited by: Carr BR, Blackwell RE. 1993, Norwalk: Appleton, 297-321."},{"key":"639_CR10","first-page":"641","volume":"13","author":"LC Giudice","year":"1992","unstructured":"Giudice LC: Insulin-like growth factors and ovarian follicular development. Endocr Rev. 1992, 13: 641-669.","journal-title":"Endocr Rev"},{"key":"639_CR11","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/S0015-0282(16)55974-3","volume":"59","author":"AN Wakim","year":"1993","unstructured":"Wakim AN, Polizotto SL, Buffo MJ, Marrero MA, Burholt DR: Thyroid hormones in human follicular fluid and thyroid hormone receptors in human granulosa cells. Fertil Steril. 1993, 59: 1187-1190.","journal-title":"Fertil Steril"},{"key":"639_CR12","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S0015-0282(16)56941-6","volume":"62","author":"AN Wakim","year":"1994","unstructured":"Wakim AN, Paljug WR, Jasnosz KM, Alhakim N, Brown AB, Burholt DR: Thyroid hormone receptor messenger ribonucleic acid in human granulosa and ovarian stromal cells. Fertil Steril. 1994, 62: 531-534.","journal-title":"Fertil Steril"},{"key":"639_CR13","first-page":"126","volume":"24","author":"PM Rao","year":"1980","unstructured":"Rao PM, Panda JN: Effects of hypothyroidism on pregnancy of rats. Indian J Physiol Pharmacol. 1980, 24: 126-130.","journal-title":"Indian J Physiol Pharmacol"},{"key":"639_CR14","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1530\/rep.0.1260371","volume":"126","author":"MB Hapon","year":"2003","unstructured":"Hapon MB, Simoncini M, Via G, Jahn GA: Effect of hypothyroidism on hormone profiles in virgin, pregnant and lactating rats, and on lactation. Reproduction. 2003, 126: 371-382. 10.1530\/rep.0.1260371.","journal-title":"Reproduction"},{"key":"639_CR15","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1203\/00006450-197509000-00012","volume":"9","author":"JL Bakke","year":"1975","unstructured":"Bakke JL, Lawrence NL, Robinson S, Bennett J: Endocrine studies of the untreated progeny of thyroidectomized rats. Pediatr Res. 1975, 9: 742-748. 10.1203\/00006450-197509000-00012.","journal-title":"Pediatr Res"},{"key":"639_CR16","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1210\/endo-102-1-24","volume":"102","author":"SK Varma","year":"1978","unstructured":"Varma SK, Murray R, Stanbury JB: Effect of maternal hypothyroidism and triiodothyronine on the fetus and newborn in rats. Endocrinology. 1978, 102: 24-30. 10.1210\/endo-102-1-24.","journal-title":"Endocrinology"},{"key":"639_CR17","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1677\/joe.0.1460087","volume":"146","author":"JA Mattheij","year":"1995","unstructured":"Mattheij JA, Swarts JJ, Lokerse P, van Kampen JT, Heide Van der D: Effect of hypothyroidism on the pituitary-gonadal axis in the adult female rat. J Endocrinol. 1995, 146: 87-94. 10.1677\/joe.0.1460087.","journal-title":"J Endocrinol"},{"key":"639_CR18","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1023\/A:1006867109759","volume":"179","author":"A Osorio","year":"1998","unstructured":"Osorio A, Ruiz E, Ortega E: Possible role of GH\/IGF 1 in the ovarian function of adult hypothyroid rats. Mol Cell Biochem. 1998, 179: 7-11. 10.1023\/A:1006867109759.","journal-title":"Mol Cell Biochem"},{"key":"639_CR19","doi-asserted-by":"publisher","first-page":"296","DOI":"10.3181\/00379727-201-43511","volume":"201","author":"CE Hendrich","year":"1992","unstructured":"Hendrich CE, Porterfield SP: Serum growth hormone levels in hypothyroid and GH-treated thyroidectomized rats and their progenies. Proc Soc Exp Biol Med. 1992, 201: 296-302.","journal-title":"Proc Soc Exp Biol Med"},{"key":"639_CR20","volume-title":"Statistical Methods","author":"GW Snedecor","year":"1967","unstructured":"Snedecor GW, Cochran WG: Statistical Methods. 1967, Ames: Iowa State University Press"},{"key":"639_CR21","first-page":"101","volume-title":"Williams Textbook of Endocrinology","author":"FL Malcolm","year":"2008","unstructured":"Malcolm FL: Hypothalamus and Pituitary Neuroendocrinology. Williams Textbook of Endocrinology. Edited by: Kronenberg HM, Melmed S, Polonsky KS, Larsen PR. 2008, Philadelphia: Saunders Elsevier, 101-102. 11","edition":"11"},{"key":"639_CR22","doi-asserted-by":"publisher","first-page":"3146","DOI":"10.1210\/endo-126-6-3146","volume":"126","author":"JT Pan","year":"1990","unstructured":"Pan JT, Chen CW: Increased plasma prolactin levels in ovariectomized thyroidectomised rats treated with Estrogen. Endocrinology. 1990, 126: 3146-3152. 10.1210\/endo-126-6-3146.","journal-title":"Endocrinology"},{"key":"639_CR23","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1210\/endo-98-5-1235","volume":"98","author":"KH Lu","year":"1976","unstructured":"Lu KH, Chen HI, Grandison L, Huang HH, Meites J: Reduced luteinizing hormone release by synthetic luteinizing hormone releasing hormone (LHRH) in postpartum lactating rats. Endocrinology. 1976, 98: 1235-1240. 10.1210\/endo-98-5-1235.","journal-title":"Endocrinology"},{"key":"639_CR24","doi-asserted-by":"publisher","first-page":"3245","DOI":"10.1210\/en.2009-0095","volume":"150","author":"CV Helena","year":"2009","unstructured":"Helena CV, McKee DT, Bertram R, Walker AM, Freeman ME: The Rhythmic Secretion of Mating-Induced Prolactin Secretion Is Controlled by Prolactin Acting Centrally. Endocrinology. 2009, 150: 3245-3251. 10.1210\/en.2009-0095.","journal-title":"Endocrinology"},{"key":"639_CR25","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1262\/jrd.50.9","volume":"50","author":"A Tohei","year":"2004","unstructured":"Tohei A: Studies on the functional relationship between thyroid, adrenal and gonadal hormones. J Reprod Dev. 2004, 50: 9-20. 10.1262\/jrd.50.9.","journal-title":"J Reprod Dev"},{"key":"639_CR26","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/0960-0760(95)00192-1","volume":"55","author":"G Shetty","year":"1995","unstructured":"Shetty G, Bhatnagar AS, Moudgal NR: Blockade of estrogen synthesis with an aromatase inhibitor affects luteal function of the pseudopregnant rat. J Steroid Biochem Mol Biol. 1995, 55: 347-353. 10.1016\/0960-0760(95)00192-1.","journal-title":"J Steroid Biochem Mol Biol"},{"key":"639_CR27","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1210\/endo-108-4-1293","volume":"108","author":"WC Gorospe","year":"1981","unstructured":"Gorospe WC, Freeman ME: An ovarian role in prolonging and terminating the two surges of prolactin in pseudopregnant rats. Endocrinology. 1981, 108: 1293-1298. 10.1210\/endo-108-4-1293.","journal-title":"Endocrinology"},{"key":"639_CR28","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/S1043-2760(03)00030-4","volume":"14","author":"J Frasor","year":"2003","unstructured":"Frasor J, Gibori G: Prolactin regulation of estrogen receptor expression. Trends Endocrinol Metab. 2003, 14: 118-123. 10.1016\/S1043-2760(03)00030-4.","journal-title":"Trends Endocrinol Metab"},{"key":"639_CR29","doi-asserted-by":"publisher","first-page":"1747","DOI":"10.1095\/biolreprod63.6.1747","volume":"63","author":"B Bao","year":"2000","unstructured":"Bao B, Kumar N, Karp RM, Garverick HA, Sundaram K: Estrogen receptor-beta expression in relation to the expression of luteinizing hormone receptor and cytochrome P450 enzymes in rat ovarian follicles. Biol Reprod. 2000, 63: 1747-1755. 10.1095\/biolreprod63.6.1747.","journal-title":"Biol Reprod"},{"key":"639_CR30","doi-asserted-by":"publisher","first-page":"2594","DOI":"10.1210\/en.133.6.2594","volume":"133","author":"DL Clarke","year":"1993","unstructured":"Clarke DL, Arey BJ, Linzer DI: Prolactin receptor messenger ribonucleic acid expression in the ovary during the rat estrous cycle. Endocrinology. 1993, 133: 2594-2603. 10.1210\/en.133.6.2594.","journal-title":"Endocrinology"},{"key":"639_CR31","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.1095\/biolreprod63.5.1331","volume":"63","author":"H Wang","year":"2000","unstructured":"Wang H, Eriksson H, Sahlin L: Estrogen receptors alpha and beta in the female reproductive tract of the rat during the estrous cycle. Biol Reprod. 2000, 63: 1331-1340. 10.1095\/biolreprod63.5.1331.","journal-title":"Biol Reprod"},{"key":"639_CR32","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1677\/joe.0.1650059","volume":"165","author":"CN Mowa","year":"2000","unstructured":"Mowa CN, Iwanaga T: Differential distribution of oestrogen receptor-alpha and -beta mRNAs in the female reproductive organ of rats as revealed by in situ hybridization. J Endocrinol. 2000, 165: 59-66. 10.1677\/joe.0.1650059.","journal-title":"J Endocrinol"},{"key":"639_CR33","doi-asserted-by":"publisher","first-page":"2432","DOI":"10.1210\/en.139.5.2432","volume":"139","author":"CM Telleria","year":"1998","unstructured":"Telleria CM, Zhong L, Deb S, Srivastava RK, Park KS, Sugino N, Park-Sarge OK, Gibori G: Differential expression of the estrogen receptors alpha and beta in the rat corpus luteum of pregnancy: regulation by prolactin and placental lactogens. Endocrinology. 1998, 139: 2432-2442. 10.1210\/en.139.5.2432.","journal-title":"Endocrinology"},{"key":"639_CR34","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1095\/biolreprod32.1.96","volume":"32","author":"I Khan","year":"1985","unstructured":"Khan I, Belanger A, Chen YD, Gibori G: Influence of high-density lipoprotein on estradiol stimulation of luteal steroidogenesis. Biol Reprod. 1985, 32: 96-104. 10.1095\/biolreprod32.1.96.","journal-title":"Biol Reprod"},{"key":"639_CR35","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.1210\/endo-125-3-1337","volume":"125","author":"MP McLean","year":"1989","unstructured":"McLean MP, Puryear TK, Khan I, Azhar S, Billheimer JT, Orly J, Gibori G: Estradiol regulation of sterol carrier protein-2 independent of cytochrome P450 side-chain cleavage expression in the rat corpus luteum. Endocrinology. 1989, 125: 1337-1344. 10.1210\/endo-125-3-1337.","journal-title":"Endocrinology"},{"key":"639_CR36","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1210\/endo-120-3-1010","volume":"120","author":"MC Rao","year":"1987","unstructured":"Rao MC, Palfrey HC, Nash NT, Greisman A, Jayatilak PG, Gibori G: Effects of estradiol on calcium-specific protein phosphorylation in the rat corpus luteum. Endocrinology. 1987, 120: 1010-1018. 10.1210\/endo-120-3-1010.","journal-title":"Endocrinology"},{"key":"639_CR37","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1095\/biolreprod21.2.419","volume":"21","author":"G Gibori","year":"1979","unstructured":"Gibori G, Richards JS, Keyes L: Synergistic Effects of Prolactin and Estradiol in the Luteotropic Process in the Pregnant Rat: Regulation of Estradiol Receptor by ftolactin. Biol Reprod. 1979, 21: 419-423. 10.1095\/biolreprod21.2.419.","journal-title":"Biol Reprod"},{"key":"639_CR38","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1095\/biolreprod44.3.550","volume":"44","author":"S El-Maasarany","year":"1991","unstructured":"El-Maasarany S, Brandt ME, Majercik MH, Zimniski SJ, Puett D: Immunocytochemical localization and enzymatic distribution of rat ovarian aromatase. Biol Reprod. 1991, 44: 550-560. 10.1095\/biolreprod44.3.550.","journal-title":"Biol Reprod"},{"key":"639_CR39","volume-title":"Growth hormone","author":"S Harvey","year":"1955","unstructured":"Harvey S, Scanes CG, Daughaday WH: Growth hormone. Edited by: Harvey S, Scanes CG, Daughaday WH. 1955, Florida: CRC Press"},{"key":"639_CR40","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1093\/jnci\/56.6.1155","volume":"56","author":"JM Sorrentino","year":"1976","unstructured":"Sorrentino JM, Kirkland WL, Sirbasku DA: Control of cell growth. II. Requirement of thyroid hormones for the in vivo estrogen-dependent growth of rat pituitary tumor cells. J Natl Cancer Inst. 1976, 56: 1155-1158.","journal-title":"J Natl Cancer Inst"},{"key":"639_CR41","first-page":"864","volume-title":"Williams Textbook of Endocrinology","author":"EO Reiter","year":"2008","unstructured":"Reiter EO, Rosenfeld RG: Normal and Aberramt Growth. Williams Textbook of Endocrinology. Edited by: Kronenberg HM, Melmed S, Polonsky KS, Larsen PR. 2008, Philadelphia: Saunders Elsevier, 864-865. 11","edition":"11"},{"key":"639_CR42","doi-asserted-by":"publisher","first-page":"1924","DOI":"10.1210\/mend.11.13.0032","volume":"11","author":"J Zhou","year":"1997","unstructured":"Zhou J, Kumar TR, Matzuk MM, Bondy C: Insulin-like growth factor I regulates gonadotropin responsiveness in the murine ovary. Mol Endocrinol. 1997, 11: 1924-1933. 10.1210\/me.11.13.1924.","journal-title":"Mol Endocrinol"},{"key":"639_CR43","doi-asserted-by":"publisher","first-page":"4104","DOI":"10.1210\/en.2002-220087","volume":"143","author":"A Bachelot","year":"2002","unstructured":"Bachelot A, Monget P, Imbert-Bollore P, Coshigano K, Kopchick JJ, Kelly PA, Binart N: Growth hormone is required for ovarian follicular growth. Endocrinology. 2002, 143: 4104-4112. 10.1210\/en.2002-220087.","journal-title":"Endocrinology"},{"key":"639_CR44","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1017\/S0967199402002125","volume":"10","author":"J Zhao","year":"2002","unstructured":"Zhao J, Taverne MA, Weijden van der GC, Bevers MM, Hurk van den R: Immunohistochemical localisation of growth hormone (GH), GH receptor (GHR), insulin-like growth factor I (IGF 1) and type I IGF 1 receptor, and gene expression of GH and GHR in rat pre-antral follicles. Zygote. 2002, 10: 85-94. 10.1017\/S0967199402002125.","journal-title":"Zygote"},{"key":"639_CR45","doi-asserted-by":"publisher","first-page":"1672","DOI":"10.1210\/jcem.85.4.6497","volume":"85","author":"HM Fraser","year":"2000","unstructured":"Fraser HM, Lunn SF, Kim H, Duncan WC, Rodger FE, Illingworth PJ, Erickson GF: Changes in insulin-like growth factor-binding protein-3 messenger ribonucleic acid in endothelial cells of the human corpus luteum: a possible role in luteal development and rescue. J Clin Endocrinol Metab. 2000, 85: 1672-1677. 10.1210\/jc.85.4.1672.","journal-title":"J Clin Endocrinol Metab"},{"key":"639_CR46","doi-asserted-by":"publisher","first-page":"1867","DOI":"10.1210\/en.130.4.1867","volume":"130","author":"GF Erickson","year":"1992","unstructured":"Erickson GF, Nakatani A, Ling N, Shimasaki S: Localization of insulin-like growth factor-binding protein-5 messenger ribonucleic acid in rat ovaries during the estrous cycle. Endocrinology. 1992, 130: 1867-1878. 10.1210\/en.130.4.1867.","journal-title":"Endocrinology"},{"key":"639_CR47","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1016\/1071-5576(95)94689-R","volume":"2","author":"EY Adashi","year":"1995","unstructured":"Adashi EY: Insulin-like Growth Factors as Determinants of Follicular Fate. J Soc Gynecol Investig. 1995, 2: 721-726. 10.1016\/1071-5576(95)94689-R.","journal-title":"J Soc Gynecol Investig"},{"key":"639_CR48","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1080\/09513590701259542","volume":"23","author":"M Abalovich","year":"2007","unstructured":"Abalovich M, Mitelberg L, Allami C, Gutierrez S, Alcaraz G, Otero P, Levalle O: Subclinical hypothyroidism and thyroid autoimmunity in women with infertility. Gynecol Endocrinol. 2007, 23: 279-283. 10.1080\/09513590701259542.","journal-title":"Gynecol Endocrinol"},{"key":"639_CR49","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1530\/eje.0.1460729","volume":"146","author":"R Rosato","year":"2002","unstructured":"Rosato R, Lindenbergh-Kortleve D, van Neck J, Drop S, Jahn G: Effect of chronic thyroxine treatment on IGF-I, IGF-II and IGF-binding protein expression in mammary gland and liver during pregnancy and early lactation in rats. European Journal of Endocrinology. 2002, 146: 729-739. 10.1530\/eje.0.1460729.","journal-title":"European Journal of Endocrinology"},{"key":"639_CR50","doi-asserted-by":"publisher","first-page":"1936","DOI":"10.1210\/en.139.4.1936","volume":"139","author":"N Sugino","year":"1998","unstructured":"Sugino N, Zilberstein M, Srivastava RK, Telleria CM, Nelson SE, Risk M, Chou JY, Gibori G: Establishment and characterization of a simian virus 40-transformed temperature-sensitive rat luteal cell line. Endocrinology. 1998, 139: 1936-1942. 10.1210\/en.139.4.1936.","journal-title":"Endocrinology"}],"container-title":["Reproductive Biology and Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1477-7827-8-14.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T11:53:50Z","timestamp":1630497230000},"score":1,"resource":{"primary":{"URL":"https:\/\/rbej.biomedcentral.com\/articles\/10.1186\/1477-7827-8-14"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2,11]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["639"],"URL":"https:\/\/doi.org\/10.1186\/1477-7827-8-14","relation":{},"ISSN":["1477-7827"],"issn-type":[{"value":"1477-7827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,2,11]]},"assertion":[{"value":"11 October 2009","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 February 2010","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 February 2010","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"14"}}