{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T03:12:08Z","timestamp":1722913928966},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Transl Med"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Immunological arguments and historical examples have shown that treatment with cord blood for non-hematopoietic activities, such as growth factor production and stimulation of angiogenesis, may not require matching or immune suppression.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>To study the benefit of blood mononuclear cell therapy, 8 patients with idiopathic osteoporosis were given intermittent treatments with non-matched allogeneic cord blood mononuclear cells for 3\u2009months. Morning fasting samples were collected for measuring urine N telopeptide of type-1 collagen, serum bone-specific alkaline phosphatase, and insulin-like growth factor 1 during one-year study.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Clinical response was striking. Serum insulin-like growth factor 1 significantly increased in all patients at 3\u2009months compared with baseline values, from 264.1\u2009\u00b1\u2009107.0 to 384.4\u2009\u00b1\u200963.1\u2009ng\/mL (<jats:italic>P<\/jats:italic>\u2009=\u20090.002), with a tendency to return to baseline values at 12\u2009months (312.9\u2009\u00b1\u200975.5\u2009ng\/mL, <jats:italic>P<\/jats:italic>\u2009=\u20090.083). In contrast, differences in serum bone-specific alkaline phosphatase and urine N telopeptide of type-1 collagen were not significant at 3 (<jats:italic>P<\/jats:italic>\u2009=\u20090.765, <jats:italic>P<\/jats:italic>\u2009=\u20090.057) or 12\u2009months (<jats:italic>P<\/jats:italic>\u2009=\u20090.889, <jats:italic>P<\/jats:italic>\u2009=\u20090.122). A beneficial effect on bone density was observed in all patients at the lumbar spine. The mean bone mineral density calculated during therapy (0.6811\u2009\u00b1\u20090.1442\u2009g\/cm<jats:sup>2<\/jats:sup>) tended higher than baseline values (0.6239\u2009\u00b1\u20090.1362\u2009g\/cm<jats:sup>2<\/jats:sup>, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090), and percentage change (median) varied from 8.85% at 3\u2009months to 7.85% at one year. All patients are now well after one year.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>The findings indicate that for these patients with idiopathic osteoporosis, treatment with cord blood mononuclear cells led to a significant increase in insulin-like growth factor 1 levels, which favors the increase in bone mineral density.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1479-5876-10-102","type":"journal-article","created":{"date-parts":[[2012,5,21]],"date-time":"2012-05-21T12:14:43Z","timestamp":1337602483000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Beneficial effects of non-matched allogeneic cord blood mononuclear cells upon patients with idiopathic osteoporosis"],"prefix":"10.1186","volume":"10","author":[{"given":"Jun","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng-Ping","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Qi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su-Xia","family":"Zi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"San-Bin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng-Jiang","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing-Hua","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,5,21]]},"reference":[{"key":"1064_CR1","doi-asserted-by":"publisher","first-page":"3951","DOI":"10.1210\/jc.85.11.3951","volume":"85","author":"LA Soyka","year":"2000","unstructured":"Soyka LA, Fairfield WP, Klibanski A: Hormonal determinants and disorders of peak bone mass in children. 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